Substrates for peptidase A01.046: napsin A

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate Uniprot Residue range Cleavage Site Cleavage type Evidence P4 P3 P2 P1 P1' P2' P3' P4' Reference CutDB MERNUM
Lys(Dabsyl)-Pro-Gln-Leu-Phe-Thr-Glu-Gln-Lucifer yellow Lys(Dabsyl)-Pro-Gln-Leu+Phe-Thr-Glu-Gln-Lucifer yellow S - Pro Gln Leu Phe Thr Glu Gln Schauer-Vukasinovic et al., 2000
Lys(Dabsyl)-Pro-Gln-Phe-Phe-Thr-Glu-Gln-Lucifer yellow Lys(Dabsyl)-Pro-Gln-Phe+Phe-Thr-Glu-Gln-Lucifer yellow S - Pro Gln Phe Phe Thr Glu Gln Schauer-Vukasinovic et al., 2000
Lys(Dabsyl)-Thr-Ser-Leu-Leu-Met-Ala-Ala-Pro-Gln-Lucifer yellow Lys(Dabsyl)-Thr-Ser-Leu-Leu+Met-Ala-Ala-Pro-Gln-Lucifer yellow S Thr Ser Leu Leu Met Ala Ala Pro Schauer-Vukasinovic et al., 2000
Lys(Dabsyl)-Thr-Ser-Val-Leu-Met-Ala-Ala-Pro-Gln-Lucifer yellow Lys(Dabsyl)-Thr-Ser-Val-Leu+Met-Ala-Ala-Pro-Gln-Lucifer yellow S Thr Ser Val Leu Met Ala Ala Pro Schauer-Vukasinovic et al., 2000
pulmonary surfactant-associated protein B P07988 25-381 peptide-Leu178+Pro-peptide P Lys Leu Val Leu Pro Val Leu Pro Ueno et al., 2004
Pulmonary surfactant-associated protein B P07988 1-381 Peptide-Val180+leu-Peptide P MS Val Leu Pro Val Leu Pro Gly Ala Brasch et al., 2003
Pulmonary surfactant-associated protein B P07988 1-381 Peptide-Try354+Asp-Peptide P MS Pro Arg Gly Trp Asp Ala His Thr Brasch et al., 2003