Substrates for peptidase A01.043: histoaspartic peptidase (Plasmodium falciparum)

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are thought to be pathologically relevant are indicated by D. Peptide and protein substrates that are not physiologically relevant are indicated by N. Synthetic substrates are indicated by S. Click on the symbol to show only physiological, non-physiological or synthetic substrates, or here to display all substrates. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a protein substrate, click on the UniProt Accession.

Substrate	Uniprot	Residue range	Cleavage Site	Cleavage type	Evidence	P4	P3	P2	P1	P1'	P2'	P3'	P4'	Reference
Dabcyl-GABA-Glu-Arg-Met-Phe-Leu-Ser-Phe-Pro-GABA-EDANS			Dabcyl-GABA-Glu-Arg-Met-Phe+Leu-Ser-Phe-Pro-GABA-EDANS	S		Glu	Arg	Met	Phe	Leu	Ser	Phe	Pro	Banerjee et al., 2002
EDANS-Ala-Leu-Glu-Arg-Met-Phe-Leu-Ser-Phe-Pro-Dap-Dabcyl-OH			EDANS-Ala-Leu-Glu-Arg-Met-Phe+Leu-Ser-Phe-Pro-Dap-Dabcyl-OH	S		Glu	Arg	Met	Phe	Leu	Ser	Phe	Pro	Xiao et al., 2006
EDANS-CO-CH2-CH2-CO-Ala-Leu-Glu-Arg-Met-Phe-Leu-Ser-Phe-Pro-Dap-(DABCYL)-OH			Glu-Arg-Met-Phe+Leu-Ser-Phe-Pro	S		Glu	Arg	Met	Phe	Leu	Ser	Phe	Pro	Parr et al., 2008
HAP protein	Q8IM15	1-451	Peptide-Lys119+Ser-Peptide	N	NT	Leu	Thr	Lys	Lys	Ser	Tyr	Leu	Gly	Parr et al., 2008