Structure for peptidase S07.003: Zika virus NS2B-NS3 peptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

PDB	Organism	Resolution	Comment
2FP7	West Nile virus	1.68 Å	complex with Bz-Nle-Lys- Arg-Arg-H
Catalytic residues are shown in ball-and-stick representation: His1537 in purple, Asp1561 in pink and Ser1622 in orange. The bound inhibitor is shown in grey ball-and-stick representation.

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TERTIARY STRUCTURE DATA
Comment	Resolution	PDB	PDBe	SCOP	CATH	PDBSum	Proteopedia	Reference
Japanese encephalitis virus
catalytic domain	1.80 Å	2Z83	2Z83	2Z83	2Z83	2Z83	2Z83
mature peptidase	2.10 Å	3P54	3P54	3P54	3P54	3P54	3P54	Luca et al., 2012
mature peptidase	2.38 Å	4HDG	4HDG	4HDG	4HDG	4HDG	4HDG	Surana et al., 2014
mature peptidase	2.28 Å	4HDH	4HDH	4HDH	4HDH	4HDH	4HDH	Surana et al., 2014
mature peptidase	2.60 Å	4K6M	4K6M	4K6M	4K6M	4K6M	4K6M	Lu & Gong, 2013
mature peptidase	3.65 Å	4MTP	4MTP	4MTP	4MTP	4MTP	4MTP	Surana et al., 2014
structure of jev protease	2.13 Å	4R8T	4R8T	4R8T	4R8T	4R8T	4R8T
Kunjin virus
mature peptidase	3.20 Å	1SFK	1SFK	1SFK	1SFK	1SFK	1SFK	Dokland et al., 2004
mature peptidase	2.35 Å	2HCN	2HCN	2HCN	2HCN	2HCN	2HCN	Malet et al., 2007
mature peptidase	2.50 Å	2HCS	2HCS	2HCS	2HCS	2HCS	2HCS	Malet et al., 2007
mature peptidase	3.00 Å	2HFZ	2HFZ	2HFZ	2HFZ	2HFZ	2HFZ	Malet et al., 2007
mature peptidase	24.00 Å	2OF6	2OF6	2OF6	2OF6	2OF6	2OF6	Zhang et al., 2007
mature peptidase	3.10 Å	2QEQ	2QEQ	2QEQ	2QEQ	2QEQ	2QEQ	Mastrangelo et al., 2007
Murray Valley encephalitis virus
mature peptidase	2.00 Å	2PX2	2PX2	2PX2	2PX2	2PX2	2PX2	Assenberg et al., 2007
mature peptidase	2.20 Å	2PX4	2PX4	2PX4	2PX4	2PX4	2PX4	Assenberg et al., 2007
mature peptidase	2.30 Å	2PX5	2PX5	2PX5	2PX5	2PX5	2PX5	Assenberg et al., 2007
mature peptidase	2.20 Å	2PX8	2PX8	2PX8	2PX8	2PX8	2PX8	Assenberg et al., 2007
mature peptidase	2.30 Å	2PXA	2PXA	2PXA	2PXA	2PXA	2PXA	Assenberg et al., 2007
mature peptidase	2.80 Å	2PXC	2PXC	2PXC	2PXC	2PXC	2PXC	Assenberg et al., 2007
structure of the murray valley encephalitis virus rna helicase to 1.9a resolution	1.90 Å	2V8O	2V8O	2V8O	2V8O	2V8O	2V8O	Mancini et al., 2007
mature peptidase	2.75 Å	2WV9	2WV9	2WV9	2WV9	2WV9	2WV9	Assenberg et al., 2009
St. Louis encephalitis virus
mature peptidase	3.90 Å	4FG0	4FG0	4FG0	4FG0	4FG0	4FG0	Luca et al., 2013
West Nile virus
complex with Bz-Nle-Lys- Arg-Arg-H	1.68 Å	2FP7	2FP7	2FP7	2FP7	2FP7	2FP7	Erbel et al., 2006
mature peptidase	0.00 Å	2G05	2G05	2G05	2G05	2G05	2G05
mature peptidase	0.00 Å	2G2G	2G2G	2G2G	2G2G	2G2G	2G2G
His51Ala mutant	1.80 Å	2GGV	2GGV	2GGV	2GGV	2GGV	2GGV	Aleshin et al., 2007
complex with bovine pancreatic trypsin inhibitor	2.30 Å	2IJO	2IJO	2IJO	2IJO	2IJO	2IJO	Aleshin et al., 2007
mature peptidase	2.80 Å	2P5P	2P5P	2P5P	2P5P	2P5P	2P5P
mature peptidase	3.20 Å	2YOL	2YOL	2YOL	2YOL	2YOL	2YOL	Hammamy et al., 2013
mature peptidase	2.45 Å	3E90	3E90	3E90	3E90	3E90	3E90	Robin et al., 2009
mature peptidase	3.00 Å	3I50	3I50	3I50	3I50	3I50	3I50	Cherrier et al., 2009
complex witha capped dipeptide boronate inhibitor	1.50 Å	5IDK	5IDK	5IDK	5IDK	5IDK	5IDK
Zika virus
after self-cleavage	1.84 Å	5GJ4	5GJ4	5GJ4	5GJ4	5GJ4	5GJ4
complex with a reverse peptide inhibitor	1.58 Å	5GPI	5GPI	5GPI	5GPI	5GPI	5GPI
comolex with a compound fragment	2.00 Å	5H4I	5H4I	5H4I	5H4I	5H4I	5H4I
complex with a dipeptide inhibitor	2.42 Å	5H6V	5H6V	5H6V	5H6V	5H6V	5H6V
complex with a boronate inhibitor	2.70 Å	5LC0	5LC0	5LC0	5LC0	5LC0	5LC0
apo-form	3.10 Å	5T1V	5T1V	5T1V	5T1V	5T1V	5T1V
crystal structure of the zika virus ns2b-ns3 protease in super-open conformation	3.00 Å	5TFN	5TFN	5TFN	5TFN	5TFN	5TFN
crystal structure of the zika virus ns2b-ns3 protease with a deletion v76-l86 in ns2b	2.51 Å	5TFO	5TFO	5TFO	5TFO	5TFO	5TFO
crystal structure of zika ns3 protease with phenylacetyl-lys-lys-arg- cooh inhibitor	1.99 Å	5ZMQ	5ZMQ	5ZMQ	5ZMQ	5ZMQ	5ZMQ
crystal structure of zika ns3 protease with phenylacetyl-lys-lys-arg- cooh inhibitor	1.99 Å	5ZMQ	5ZMQ	5ZMQ	5ZMQ	5ZMQ	5ZMQ
complex with 4- guanidinomethyl-phenylacetyl-lys-lys-arg-h	1.80 Å	5ZMS	5ZMS	5ZMS	5ZMS	5ZMS	5ZMS
complex with 4- guanidinomethyl-phenylacetyl-lys-lys-arg-h	1.80 Å	5ZMS	5ZMS	5ZMS	5ZMS	5ZMS	5ZMS
crystal structure of zika ns3 protease with 4-guanidinomethyl- phenylacetyl-arg-arg-arg-4-amidinobenzylamide	2.00 Å	5ZOB	5ZOB	5ZOB	5ZOB	5ZOB	5ZOB
crystal structure of zika ns2b-ns3 protease with compound 1c	1.95 Å	6JPW	6JPW	6JPW	6JPW	6JPW	6JPW