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Literature for peptidase S07.003: Zika virus NS2B-NS3 peptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, A Assay, T Target, P Specificity, K Knockout, E Expression, V Review, I Inhibitor, L Localization. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Ontoria,J.M., Torrente,E., Missineo,A., Alli,C., Graziani,R., Conti,S., Bisbocci,M., Quotadamo,A., Ferrigno,F., Corio,A., Ievoli,G., Bencheva,L., Amaudrut,J., Vasile,S., Beghetto,E., Paolini,C., Alaimo,N., Veneziano,M., Nibbio,M., Orsale,M.V., Proto,G., Colaceci,F., Orsatti,L., Pucci,V., Di Fabio,R., Tomei,L., Montalbetti,C., Bresciani,A., Toniatti,C. and Paonessa,G.
    An allosteric inhibitor of the Zika virus NS2B-NS3 protease with oral efficacy in mouse models
    Nat Commun (2026) 17, 1439-1439. PubMed  Europe PubMed DOI  PMC  EPMC
  2. Smith,A.J., Rahat,M.A., Scaramozza,L.J., Eyles,S.J. and Hardy,J.A.
    Inhibition of Zika Virus Protease by Modulating NS2B-NS3 Interactions
    Biochemistry (2026) 65, 64-76. PubMed  Europe PubMed DOI
    3. 2025
  3. Bonardi,A.
    Computational approaches for designing viral protease inhibitors
    Enzymes (2025) 58, 59-91. PubMed  Europe PubMed DOI
  4. Cavina,L., Alocen Portillo,A., Balmer,M.P.A., Dammer,J.C., Schillemans,D., Hamdani,S.H., Ackerschott,B., Dieteren,C.E.J., Martina,B.E.E., van Buuren,B.N.M., Rockstroh,A., Ulbert,S., Hermkens,P.H.H., Llinas Brunet,M., Girones,D., Feiters,M.C. and Rutjes,F.P.J.T.
    Development of Lipopeptides as Orthoflavivirin Inhibitors with Low Micromolar Broad-Spectrum Antiorthoflaviviral Activity
    J Med Chem (2025) PubMed  Europe PubMed DOI  I
  5. He,Y., Shi,Y., Wu,Z., Wang,T., Wang,M., Jia,R., Zhu,D., Liu,M., Zhao,X., Yang,Q., Wu,Y., Zhang,S., Huang,J., Ou,X., Sun,D., Tian,B., Cheng,A. and Chen,S.
    NS2B is indispensable for NS3/NS5 interaction of Tembusu virus in living cells
    Poult Sci (2025) 105, 106287-106287. PubMed  Europe PubMed DOI
  6. Ni,X., Richardson,R.B., Godoy,A.S., Ferla,M.P., Kikawa,C., Scheen,J., Hannon,W.W., Capkin,E., Lahav,N., Balcomb,B.H., Marples,P.G., Fairhead,M., Wang,S., Williams,E.P., Tomlinson,C.W.E., Aschenbrenner,J.C., Lithgo,R.M., Winokan,M., Giroud,C., Dolci,I., Fernandes,R.S., Oliva,G., Chandran,A.V., Xavier,M.A., Walsh,M.A., Thompson,W., Bloom,J.D., Kenton,N.T., Lee,A.A., von Delft,A., Barr,H., Kirkegaard,K., Koekemoer,L., Fearon,D., Evans,M.J. and von Delft,F.
    Combined crystallographic fragment screening and deep mutational scanning enable discovery of Zika virus NS2B-NS3 protease inhibitors
    Nat Commun (2025) 16, 8930-8930. PubMed  Europe PubMed DOI  PMC  EPMC
  7. Peng,J., Zou,W., Zhou,L., Liu,R. and Peng,H.J.
    Host S100A6 inhibits ZIKV replication by degrading NS3 through lysosomal pathway
    Front Cell Infect Microbiol (2025) 15, 1602743-1602743. PubMed  Europe PubMed DOI  PMC  EPMC  K
  8. Somathilake,U., Shang,M. and Nitsche,C.
    De Novo Discovery of Bicyclic Competitive Inhibitors of Zika Virus Protease from Peptide-Bismuth Phage Display Screening
    Chembiochem (2025) , e202500674-e202500674. PubMed  Europe PubMed DOI
  9. Starvaggi,J., Di Chio,C., Lang,J., Belgiovine,V., Trisciuzzi,D., Previti,S., Klein,C., Nicolotti,O., Di Maro,S., Zappala,M. and Ettari,R.
    Development of Novel Proline- and Pipecolic Acid-Based Allosteric Inhibitors of Dengue and Zika Virus NS2B/NS3 Protease
    Pharmaceuticals (Basel) (2025) 19 PubMed  Europe PubMed DOI  PMC  EPMC
  10. von Delft,F., Ni,X., Richardson,R., Godoy,A., Ferla,M., Kikawa,C., Scheen,J., Hannon,W., Capkin,E., Lahav,N., Balcomb,B., Marples,P., Fairhead,M., Wang,S., Williams,E., Tomlinson,C., Aschenbrenner,J., Lithgo,R., Winokan,M., Giroud,C., Chandran,A., Walsh,M., Thompson,W., Bloom,J., Barr,H., Kirkegaard,K., Koekemoer,L., Fearon,D. and Evans,M.
    Crystallographic fragment screening and deep mutational scanning of Zika virus NS2B-NS3 protease enable development of resistance-resilient inhibitors
    Res Sq (2025) PubMed  Europe PubMed DOI  PMC  EPMC
  11. Zammarchi,L., Chechi,F., Spinicci,M. and Bartoloni,A.
    Flaviviruses proteases
    Enzymes (2025) 58, 251-278. PubMed  Europe PubMed DOI
    12. 2024
  12. Altayb,H.N. and Alatawi,H.A.
    Employing Machine Learning-Based QSAR for Targeting Zika Virus NS3 Protease: Molecular Insights and Inhibitor Discovery
    Pharmaceuticals (Basel) (2024) 17 PubMed  Europe PubMed DOI  PMC  EPMC
  13. Anindita,P.D., Otsuka,Y., Lattmann,S., Ngo,K.H., Liew,C.W., Kang,C., Harris,R.S., Scampavia,L., Spicer,T.P. and Luo,D.
    A high-throughput cell-based screening method for Zika virus protease inhibitor discovery
    SLAS Discov (2024) , 100164-100164. PubMed  Europe PubMed DOI
  14. Cavina,L., Bouma,M.J., Girones,D. and Feiters,M.C.
    Orthoflaviviral Inhibitors in Clinical Trials, Preclinical In Vivo Efficacy Targeting NS2B-NS3 and Cellular Antiviral Activity via Competitive Protease Inhibition
    Molecules (2024) 29 PubMed  Europe PubMed DOI  PMC  EPMC  V  I
  15. Cruz,K.G., Hill Eron,M., Makhaik,S., Savinov,S. and Hardy,J.A.
    A Non-Active-Site Inhibitor with Selectivity for Zika Virus NS2B-NS3 Protease
    ACS Infect Dis (2024) 10, 412-425. PubMed  Europe PubMed DOI  I
  16. Cruz,K.G., Alexander,K., Makhaik,S. and Hardy,J.A.
    FRET Probes for Detection of Both Active and Inactive Zika Virus Protease
    Biochemistry (2024) PubMed  Europe PubMed DOI
  17. Feng,Y.
    Recent advances in the study of zika virus structure, drug targets, and inhibitors
    Front Pharmacol (2024) 15, 1418516-1418516. PubMed  Europe PubMed DOI  PMC  EPMC
  18. Huber,S., Braun,N.J., Schmacke,L.C., Murra,R., Bender,D., Hildt,E., Heine,A. and Steinmetzer,T.
    Synthesis and structural characterization of new macrocyclic inhibitors of the Zika virus NS2B-NS3 protease
    Arch Pharm (Weinheim) (2024) , e2400250-e2400250. PubMed  Europe PubMed DOI
  19. Ni,X., Godoy,A.S., Marples,P.G., Fairhead,M., Balcomb,B.H., Ferla,M.P., Tomlinson,C.W.E., Wang,S., Giroud,C., Aschenbrenner,J.C., Lithgo,R.M., Winokan,M., Chandran,A.V., Thompson,W., Xavier,M.A., Williams,E.P., Walsh,M., Fearon,D., Koekemoer,L. and von Delft,F.
    Crystallographic fragment screening delivers diverse chemical scaffolds for Zika virus NS2B-NS3 protease inhibitor development
    bioRxiv (2024) PubMed  Europe PubMed DOI  PMC  EPMC
  20. Savino,D.F., Silva,J.V., da Silva Santos,S., Lourenco,F.R. and Giarolla,J.
    How do physicochemical properties contribute to inhibitory activity of promising peptides against Zika Virus NS3 protease?
    J Mol Model (2024) 30, 54-54. PubMed  Europe PubMed DOI
  21. Shorkey,S.A., Zhang,Y., Sharp,J., Clingman,S., Nguyen,L., Chen,J. and Chen,M.
    Tuning single-molecule ClyA nanopore tweezers for real-time tracking of the conformational dynamics of West Nile viral NS2B/NS3 protease
    bioRxiv (2024) PubMed  Europe PubMed DOI  PMC  EPMC
  22. Souza,B., Pontes,M., de,O.C., Sousa,F.d., Tizziani,T., Pollo,E., Dambros,B.P., Scotti,M.T., Steindel,M., Braga,A.L., Schirmeister,T., Assis,F.d. and Sandjo,L.P.
    Inhibitory Effects of Mangifera indica Secondary Metabolites and Their Synthetic Derivatives against SARS-CoV-2 M(pro) and NS2B/NS3 (ZIKV and DENV-2)
    ACS Omega (2024) 9, 44624-44638. PubMed  Europe PubMed DOI  PMC  EPMC
  23. Starvaggi,J., Previti,S., Zappala,M. and Ettari,R.
    The Inhibition of NS2B/NS3 Protease: A New Therapeutic Opportunity to Treat Dengue and Zika Virus Infection
    Int J Mol Sci (2024) 25 PubMed  Europe PubMed DOI  PMC  EPMC
  24. Sultana,T., Zheng,C., Morton,G. and Megraw,T.L.
    Zika virus NS3 drives the assembly of a viroplasm-like structure
    bioRxiv (2024) PubMed  Europe PubMed DOI  PMC  EPMC
  25. Ullah,S., Ullah,F., Rahman,W., Ullah,A., Haider,S. and Yueguang,C.
    Elucidating the inhibitory mechanism of Zika virus NS2B-NS3 protease with dipeptide inhibitors: Insights from molecular docking and molecular dynamics simulations
    PLoS ONE (2024) 19, e0307902-e0307902. PubMed  Europe PubMed DOI  PMC  EPMC
  26. Zhou,P., Zhang,Q., Yang,Y., Wu,W., Chen,D., Zheng,Z., Jongkaewwattana,A., Jin,H., Zhou,H. and Luo,R.
    Cleavage of SQSTM1/p62 by the Zika virus protease NS2B3 prevents autophagic degradation of viral NS3 and NS5 proteins
    Autophagy (2024) , 1-16. PubMed  Europe PubMed DOI
    27. 2023
  27. Andrade,M.A., Mottin,M., Sousa,B.K.P., Barbosa,J.A.R.G., Dos Santos Azevedo,C., Lasse Silva,C., Goncalves de Andrade,M., Motta,F.N., Maulay-Bailly,C., Amand,S., Santana,J.M., Horta Andrade,C., Grellier,P. and Bastos,I.M.D.
    Identification of novel Zika virus NS3 protease inhibitors with different inhibition modes by integrative experimental and computational approaches
    Biochimie (2023) 212, 143-152. PubMed  Europe PubMed DOI  I
  28. Braun,N.J., Huber,S., Schmacke,L.C., Heine,A. and Steinmetzer,T.
    Boroleucine-Derived Covalent Inhibitors of the ZIKV Protease
    ChemMedChem (2023) 18, e202200336-e202200336. PubMed  Europe PubMed DOI
  29. De Jesus-Gonzalez,L.A., Palacios-Rapalo,S.N., Reyes-Ruiz,J.M., Osuna-Ramos,J.F., Farfan-Morales,C.N., Cordero-Rivera,C.D., Cisneros,B., Gutierrez-Escolano,A.L. and Del Angel,R.M.
    Nucleo-Cytoplasmic Transport of ZIKV Non-Structural 3 Protein Is Mediated by Importin-alpha/beta and Exportin CRM-1
    J Virol (2023) 97, e0177322-e0177322. PubMed  Europe PubMed DOI  PMC  EPMC
  30. Ezzemani,W., Altawalah,H., Windisch,M., Ouladlahsen,A., Saile,R., Kettani,A. and Ezzikouri,S.
    Identification of Zika virus NS2B-NS3 protease and NS5 polymerase inhibitors by structure-based virtual screening of FDA-approved drugs
    J Biomol Struct Dyn (2023) , 1-16. PubMed  Europe PubMed DOI
  31. Hammerschmidt,S.J., Huber,S., Braun,N.J., Lander,M., Steinmetzer,T. and Kersten,C.
    Thermodynamic characterization of a macrocyclic Zika virus NS2B/NS3 protease inhibitor and its acyclic analogs
    Arch Pharm (Weinheim) (2023) 356, e2200518-e2200518. PubMed  Europe PubMed DOI
  32. Kumar,A., Kumar,P., Mishra,P.M. and Giri,R.
    Investigating the folding dynamics of NS2B protein of Zika virus
    Virology (2023) 584, 24-36. PubMed  Europe PubMed DOI
  33. Lin,W.W., Huang,Y.J., Wang,Y.T., Lin,Y.S., Mazibuko,N., Chen,C.S., Cheng,T.L., Chang,C.S., Leu,Y.L., Chen,C.Y. and Chuang,C.H.
    Development of NS2B-NS3 protease inhibitor that impairs Zika virus replication
    Virus Res (2023) 329, 199092-199092. PubMed  Europe PubMed DOI  PMC  EPMC
  34. Manzato,V.M., Di Santo,C., Torquato,R.J.S., Coelho,C., Gallo,G., Hardy,L., Wurtele,M. and Tanaka,A.S.
    Boophilin D1, a Kunitz type protease inhibitor, as a source of inhibitors for the ZIKA virus NS2B-NS3 protease
    Biochimie (2023) 214, 96-101. PubMed  Europe PubMed DOI
  35. Maus,H., Hammerschmidt,S.J., Hinze,G., Barthels,F., Perez Carrillo,V.H., Hellmich,U.A., Basche,T. and Schirmeister,T.
    The effects of allosteric and competitive inhibitors on ZIKV protease conformational dynamics explored through smFRET, nanoDSF, DSF, and (19)F NMR
    Eur J Med Chem (2023) 258, 115573-115573. PubMed  Europe PubMed DOI
  36. Meewan,I., Shiryaev,S.A., Kattoula,J., Huang,C.T., Lin,V., Chuang,C.H., Terskikh,A.V. and Abagyan,R.
    Allosteric Inhibitors of Zika Virus NS2B-NS3 Protease Targeting Protease in "Super-Open" Conformation
    Viruses (2023) 15 PubMed  Europe PubMed DOI  PMC  EPMC
  37. Pant,S. and Jena,N.R.
    Repurposing of antiparasitic drugs against the NS2B-NS3 protease of the Zika virus
    J Biomol Struct Dyn (2023) , 1-13. PubMed  Europe PubMed DOI
  38. Shiryaev,S.A., Cieplak,P., Cheltsov,A., Liddington,R.C. and Terskikh,A.V.
    Dual function of Zika virus NS2B-NS3 protease
    PLoS Pathog (2023) 19, e1011795-e1011795. PubMed  Europe PubMed DOI  PMC  EPMC
    39. 2022
  39. Cao,X., Liu,K., Yan,S., Li,S., Li,Y., Jin,T. and Liu,S.
    Mechanical regulation of the helicase activity of Zika virus NS3
    Biophys J (2022) 121, 4900-4908. PubMed  Europe PubMed DOI
  40. Coelho,C., Gallo,G., Hardy,L., Bottazzi,M.E., Campos,C. and Wurtele,M.
    Biochemical Screening of Potent Zika Virus Protease Inhibitors
    ChemMedChem (2022) , e202100695-e202100695. PubMed  Europe PubMed DOI  I
  41. Colarusso,S., Ferrigno,F., Ponzi,S., Pavone,F., Conte,I., Abate,L., Beghetto,E., Missineo,A., Amaudrut,J., Bresciani,A., Paonessa,G., Tomei,L., Montalbetti,C., Bianchi,E., Toniatti,C. and Ontoria,J.M.
    SAR evolution towards potent C-terminal carboxamide peptide inhibitors of Zika virus NS2B-NS3 protease
    Bioorg Med Chem (2022) 57, 116631-116631. PubMed  Europe PubMed DOI  I
  42. Huber,S., Braun,N.J., Schmacke,L.C., Quek,J.P., Murra,R., Bender,D., Hildt,E., Luo,D., Heine,A. and Steinmetzer,T.
    Structure-Based Optimization and Characterization of Macrocyclic Zika Virus NS2B-NS3 Protease Inhibitors
    J Med Chem (2022) 65, 6555-6572. PubMed  Europe PubMed DOI
  43. Jiang,H., Zhang,Y., Wu,Y., Cheng,J., Feng,S., Wang,J., Wang,X. and Cheng,M.
    Identification of Montelukast as flavivirus NS2B-NS3 protease inhibitor by inverse virtual screening and experimental validation
    Biochem Biophys Res Commun (2022) 606, 87-93. PubMed  Europe PubMed DOI  I
  44. Kumar,S., El-Kafrawy,S.A., Bharadwaj,S., Maitra,S.S., Alandijany,T.A., Faizo,A.A., Khateb,A.M., Dwivedi,V.D. and Azhar,E.I.
    Discovery of Bispecific Lead Compounds from Azadirachta indica against ZIKA NS2B-NS3 Protease and NS5 RNA Dependent RNA Polymerase Using Molecular Simulations
    Molecules (2022) 27 PubMed  Europe PubMed DOI  PMC  EPMC
  45. Miao,J., Yuan,H., Rao,J., Zou,J., Yang,K., Peng,G., Cao,S., Chen,H. and Song,Y.
    Identification of a small compound that specifically inhibits Zika virus in vitro and in vivo by targeting the NS2B-NS3 protease
    Antiviral Res (2022) 199, 105255-105255. PubMed  Europe PubMed DOI  I
  46. Mottin,M., de Paula Sousa,B.K., de Moraes Roso Mesquita,N.C., de Oliveira,K.I.Z., Noske,G.D., Sartori,G.R., de Oliveira Albuquerque,A., Urbina,F., Puhl,A.C., Moreira-Filho,J.T., Souza,G.E., Guido,R.V.C., Muratov,E., Neves,B.J., Martins da Silva,J.H., Clark,A.E., Siqueira-Neto,J.L., Perryman,A.L., Oliva,G., Ekins,S. and Andrade,C.H.
    Discovery of New Zika Protease and Polymerase Inhibitors through the Open Science Collaboration Project OpenZika
    J Chem Inf Model (2022) 62, 6825-6843. PubMed  Europe PubMed DOI  PMC  EPMC  I
  47. Mottin,M., Caesar,L.K., Brodsky,D., Mesquita,N.C.M.R., de Oliveira,K.Z., Noske,G.D., Sousa,B.K.P., Ramos,P.R.P.S., Jarmer,H., Loh,B., Zorn,K.M., Foil,D.H., Torres,P.M., Guido,R.V.C., Oliva,G., Scholle,F., Ekins,S., Cech,N.B., Andrade,C.H. and Laster,S.M.
    Chalcones from Angelica keiskei (ashitaba) inhibit key Zika virus replication proteins
    Bioorg Chem (2022) 120, 105649-105649. PubMed  Europe PubMed DOI  I
  48. Pant,S., Bhattacharya,G. and Jena,N.R.
    Structures and dynamics of peptide and peptidomimetic inhibitors bound to the NS2B-NS3 protease of the ZIKA virus
    J Biomol Struct Dyn (2022) , 1-13. PubMed  Europe PubMed DOI  I
  49. Samrat,S.K., Xu,J., Li,Z., Zhou,J. and Li,H.
    Antiviral Agents against Flavivirus Protease: Prospect and Future Direction
    Pathogens (2022) 11 PubMed  Europe PubMed DOI  PMC  EPMC  V
  50. Santos,N.P., Santos,L.H., Torquato Quezado de Magalhaes,M., Lei,J., Hilgenfeld,R., Salgado Ferreira,R. and Bleicher,L.
    Characterization of an Allosteric Pocket in Zika Virus NS2B-NS3 Protease
    J Chem Inf Model (2022) 62, 945-957. PubMed  Europe PubMed DOI
  51. Silva,J.V., Savino,D., Hirata,M.H., Ferreira,G.M. and Giarolla,J.
    Zika Virus NS2B-NS3 Protease: Quantum Chemical Properties Insights into Designing Inhibitory Peptides
    Protein Pept Lett (2022) 29, 901-910. PubMed  Europe PubMed DOI
  52. Xiong,Y., Cheng,F., Zhang,J., Su,H., Hu,H., Zou,Y., Li,M. and Xu,Y.
    Structure-based design of a novel inhibitor of the ZIKA virus NS2B/NS3 protease
    Bioorg Chem (2022) 128, 106109-106109. PubMed  Europe PubMed DOI
    53. 2021
  53. Baltina,L.A., Lai,H.C., Liu,Y.C., Huang,S.H., Hour,M.J., Baltina,L.A., Nugumanov,T.R., Borisevich,S.S., Khalilov,L.M., Petrova,S.F., Khursan,S.L. and Lin,C.W.
    Glycyrrhetinic acid derivatives as Zika virus inhibitors: Synthesis and antiviral activity in vitro
    Bioorg Med Chem (2021) 41, 116204-116204. PubMed  Europe PubMed DOI  I
  54. Chen,W., Foo,S.S., Hong,E., Wu,C., Lee,W.S., Lee,S.A., Evseenko,D., Moreira,M.E.L., Garcia-Sastre,A., Cheng,G., Nielsen-Saines,K., Brasil,P., Avvad-Portari,E. and Jung,J.U.
    Zika virus NS3 protease induces bone morphogenetic protein-dependent brain calcification in human fetuses
    Nat Microbiol (2021) PubMed  Europe PubMed DOI
  55. Chong Teoh,T., Al-Harbi,J., Abdulrahman,A.Y. and Rothan,H.A.
    Doxycycline Interferes with Zika Virus Serine Protease and Inhibits Virus Replication in Human Skin Fibroblasts
    Molecules (2021) 26 PubMed  Europe PubMed DOI  PMC  EPMC  I
  56. Dabrowska,A., Milewska,A., Ner-Kluza,J., Suder,P. and Pyrc,K.
    Mass Spectrometry versus Conventional Techniques of Protein Detection: Zika Virus NS3 Protease Activity towards Cellular Proteins
    Molecules (2021) 26 PubMed  Europe PubMed DOI  PMC  EPMC
  57. Kumar,A., Kumar,P., Aarthy,M., Singh,S.K. and Giri,R.
    Experiments and simulation on ZIKV NS2B-NS3 protease reveal its complex folding
    Virology (2021) 556, 110-123. PubMed  Europe PubMed DOI
  58. Li,Q. and Kang,C.
    Structure and Dynamics of Zika Virus Protease and Its Insights into Inhibitor Design
    Biomedicines (2021) 9 PubMed  Europe PubMed DOI  PMC  EPMC
  59. Lima,C.S., Mottin,M., de Assis,L.R., Mesquita,N.C.M.R., Sousa,B.K.P., Coimbra,L.D., Santos,K.B., Zorn,K.M., Guido,R.V.C., Ekins,S., Marques,R.E., Proenca-Modena,J.L., Oliva,G., Andrade,C.H. and Regasini,L.O.
    Flavonoids from Pterogyne nitens as Zika virus NS2B-NS3 protease inhibitors
    Bioorg Chem (2021) 109, 104719-104719. PubMed  Europe PubMed DOI  I
  60. Liu,L., Downs,M., Guidry,J. and Wojcik,E.J.
    Inter-organelle interactions between the ER and mitotic spindle facilitates Zika protease cleavage of human Kinesin-5 and results in mitotic defects
    iScience (2021) 24, 102385-102385. PubMed  Europe PubMed DOI  PMC  EPMC
  61. Nie,S., Zhao,J., Wu,X., Yao,Y., Wu,F., Lin,Y.L., Li,X., Kneubehl,A.R., Vogt,M.B., Rico-Hesse,R. and Song,Y.
    Synthesis, structure-activity relationship and antiviral activity of indole-containing inhibitors of Flavivirus NS2B-NS3 protease
    Eur J Med Chem (2021) 225, 113767-113767. PubMed  Europe PubMed DOI  I
  62. Nunes,D.A.F., Santos,F.R.D.S., da Fonseca,S.T.D., de Lima,W.G., Nizer,W.S.D.C., Ferreira,J.M.S. and de Magalhaes,J.C.
    NS2B-NS3 protease inhibitors as promising compounds in the development of antivirals against Zika virus: A systematic review
    J Med Virol (2021) PubMed  Europe PubMed DOI  I
  63. Patil,N.A., Quek,J.P., Schroeder,B., Morewood,R., Rademann,J., Luo,D. and Nitsche,C.
    2-Cyanoisonicotinamide Conjugation: A Facile Approach to Generate Potent Peptide Inhibitors of the Zika Virus Protease
    ACS Med Chem Lett (2021) 12, 732-737. PubMed  Europe PubMed DOI  PMC  EPMC  I
  64. Santos,L.H., Caffarena,E.R. and Ferreira,R.S.
    pH and non-covalent ligand binding modulate Zika virus NS2B/NS3 protease binding site residues: Discoveries from MD and constant pH MD simulations
    J Biomol Struct Dyn (2021) , 1-14. PubMed  Europe PubMed DOI
  65. Yamaoka,Y., Matsunaga,S., Jeremiah,S.S., Nishi,M., Miyakawa,K., Morita,T., Khatun,H., Shimizu,H., Okabe,N., Kimura,H., Hasegawa,H. and Ryo,A.
    Zika virus protease induces caspase-independent pyroptotic cell death by directly cleaving gasdermin D
    Biochem Biophys Res Commun (2021) 534, 666-671. PubMed  Europe PubMed DOI
  66. Yu,X., Shan,C., Zhu,Y., Ma,E., Wang,J., Wang,P., Shi,P.Y. and Cheng,G.
    A mutation-mediated evolutionary adaptation of Zika virus in mosquito and mammalian host
    Proc Natl Acad Sci U S A (2021) 118 PubMed  Europe PubMed DOI  PMC  EPMC
    67. 2020
  67. Abrams,R.P.M., Yasgar,A., Teramoto,T., Lee,M.H., Dorjsuren,D., Eastman,R.T., Malik,N., Zakharov,A.V., Li,W., Bachani,M., Brimacombe,K., Steiner,J.P., Hall,M.D., Balasubramanian,A., Jadhav,A., Padmanabhan,R., Simeonov,A. and Nath,A.
    Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors
    Proc Natl Acad Sci U S A (2020) 117, 31365-31375. PubMed  Europe PubMed DOI
  68. Arias-Arias,J.L., MacPherson,D.J., Hill,M.E., Hardy,J.A. and Mora-Rodriguez,R.
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