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Literature for peptidase S07.003: Zika virus NS2B-NS3 peptidase

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, A Assay, T Target, P Specificity, E Expression, V Review, I Inhibitor, L Localization. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. von Delft,F., Ni,X., Richardson,R., Godoy,A., Ferla,M., Kikawa,C., Scheen,J., Hannon,W., Capkin,E., Lahav,N., Balcomb,B., Marples,P., Fairhead,M., Wang,S., Williams,E., Tomlinson,C., Aschenbrenner,J., Lithgo,R., Winokan,M., Giroud,C., Chandran,A., Walsh,M., Thompson,W., Bloom,J., Barr,H., Kirkegaard,K., Koekemoer,L., Fearon,D. and Evans,M.
    Crystallographic fragment screening and deep mutational scanning of Zika virus NS2B-NS3 protease enable development of resistance-resilient inhibitors
    Res Sq PubMed  Europe PubMed DOI
    2. 2024
  2. Altayb,H.N. and Alatawi,H.A.
    Employing Machine Learning-Based QSAR for Targeting Zika Virus NS3 Protease: Molecular Insights and Inhibitor Discovery
    Pharmaceuticals (Basel)17, PubMed  Europe PubMed DOI
  3. Anindita,P.D., Otsuka,Y., Lattmann,S., Ngo,K.H., Liew,C.W., Kang,C., Harris,R.S., Scampavia,L., Spicer,T.P. and Luo,D.
    A high-throughput cell-based screening method for Zika virus protease inhibitor discovery
    SLAS Discov100164-100164. PubMed  Europe PubMed DOI
  4. Cavina,L., Bouma,M.J., Girones,D. and Feiters,M.C.
    Orthoflaviviral Inhibitors in Clinical Trials, Preclinical In Vivo Efficacy Targeting NS2B-NS3 and Cellular Antiviral Activity via Competitive Protease Inhibition
    Molecules29, PubMed  Europe PubMed DOI  V  I
  5. Cruz,K.G., Alexander,K., Makhaik,S. and Hardy,J.A.
    FRET Probes for Detection of Both Active and Inactive Zika Virus Protease
    Biochemistry PubMed  Europe PubMed DOI
  6. Cruz,K.G., Hill Eron,M., Makhaik,S., Savinov,S. and Hardy,J.A.
    A Non-Active-Site Inhibitor with Selectivity for Zika Virus NS2B-NS3 Protease
    ACS Infect Dis10, 412-425. PubMed  Europe PubMed DOI  I
  7. Feng,Y.
    Recent advances in the study of zika virus structure, drug targets, and inhibitors
    Front Pharmacol15, 1418516-1418516. PubMed  Europe PubMed DOI
  8. Huber,S., Braun,N.J., Schmacke,L.C., Murra,R., Bender,D., Hildt,E., Heine,A. and Steinmetzer,T.
    Synthesis and structural characterization of new macrocyclic inhibitors of the Zika virus NS2B-NS3 protease
    Arch Pharm (Weinheim)e2400250-e2400250. PubMed  Europe PubMed DOI
  9. Ni,X., Godoy,A.S., Marples,P.G., Fairhead,M., Balcomb,B.H., Ferla,M.P., Tomlinson,C.W.E., Wang,S., Giroud,C., Aschenbrenner,J.C., Lithgo,R.M., Winokan,M., Chandran,A.V., Thompson,W., Xavier,M.A., Williams,E.P., Walsh,M., Fearon,D., Koekemoer,L. and von Delft,F.
    Crystallographic fragment screening delivers diverse chemical scaffolds for Zika virus NS2B-NS3 protease inhibitor development
    bioRxiv PubMed  Europe PubMed DOI
  10. Savino,D.F., Silva,J.V., da Silva Santos,S., Lourenco,F.R. and Giarolla,J.
    How do physicochemical properties contribute to inhibitory activity of promising peptides against Zika Virus NS3 protease?
    J Mol Model30, 54-54. PubMed  Europe PubMed DOI
  11. Shorkey,S.A., Zhang,Y., Sharp,J., Clingman,S., Nguyen,L., Chen,J. and Chen,M.
    Tuning single-molecule ClyA nanopore tweezers for real-time tracking of the conformational dynamics of West Nile viral NS2B/NS3 protease
    bioRxiv PubMed  Europe PubMed DOI
  12. Souza,B., Pontes,M., de,O.C., Sousa,F.d., Tizziani,T., Pollo,E., Dambros,B.P., Scotti,M.T., Steindel,M., Braga,A.L., Schirmeister,T., Assis,F.d. and Sandjo,L.P.
    Inhibitory Effects of Mangifera indica Secondary Metabolites and Their Synthetic Derivatives against SARS-CoV-2 M(pro) and NS2B/NS3 (ZIKV and DENV-2)
    ACS Omega9, 44624-44638. PubMed  Europe PubMed DOI
  13. Starvaggi,J., Previti,S., Zappala,M. and Ettari,R.
    The Inhibition of NS2B/NS3 Protease: A New Therapeutic Opportunity to Treat Dengue and Zika Virus Infection
    Int J Mol Sci25, PubMed  Europe PubMed DOI
  14. Sultana,T., Zheng,C., Morton,G. and Megraw,T.L.
    Zika virus NS3 drives the assembly of a viroplasm-like structure
    bioRxiv PubMed  Europe PubMed DOI
  15. Ullah,S., Ullah,F., Rahman,W., Ullah,A., Haider,S. and Yueguang,C.
    Elucidating the inhibitory mechanism of Zika virus NS2B-NS3 protease with dipeptide inhibitors: Insights from molecular docking and molecular dynamics simulations
    PLoS ONE19, e0307902-e0307902. PubMed  Europe PubMed DOI
  16. Zhou,P., Zhang,Q., Yang,Y., Wu,W., Chen,D., Zheng,Z., Jongkaewwattana,A., Jin,H., Zhou,H. and Luo,R.
    Cleavage of SQSTM1/p62 by the Zika virus protease NS2B3 prevents autophagic degradation of viral NS3 and NS5 proteins
    Autophagy1-16. PubMed  Europe PubMed DOI
    17. 2023
  17. Andrade,M.A., Mottin,M., Sousa,B.K.P., Barbosa,J.A.R.G., Dos Santos Azevedo,C., Lasse Silva,C., Goncalves de Andrade,M., Motta,F.N., Maulay-Bailly,C., Amand,S., Santana,J.M., Horta Andrade,C., Grellier,P. and Bastos,I.M.D.
    Identification of novel Zika virus NS3 protease inhibitors with different inhibition modes by integrative experimental and computational approaches
    Biochimie212, 143-152. PubMed  Europe PubMed DOI  I
  18. Braun,N.J., Huber,S., Schmacke,L.C., Heine,A. and Steinmetzer,T.
    Boroleucine-Derived Covalent Inhibitors of the ZIKV Protease
    ChemMedChem18, e202200336-e202200336. PubMed  Europe PubMed DOI
  19. De Jesus-Gonzalez,L.A., Palacios-Rapalo,S.N., Reyes-Ruiz,J.M., Osuna-Ramos,J.F., Farfan-Morales,C.N., Cordero-Rivera,C.D., Cisneros,B., Gutierrez-Escolano,A.L. and Del Angel,R.M.
    Nucleo-Cytoplasmic Transport of ZIKV Non-Structural 3 Protein Is Mediated by Importin-alpha/beta and Exportin CRM-1
    J Virol97, e0177322-e0177322. PubMed  Europe PubMed DOI
  20. Ezzemani,W., Altawalah,H., Windisch,M., Ouladlahsen,A., Saile,R., Kettani,A. and Ezzikouri,S.
    Identification of Zika virus NS2B-NS3 protease and NS5 polymerase inhibitors by structure-based virtual screening of FDA-approved drugs
    J Biomol Struct Dyn1-16. PubMed  Europe PubMed DOI
  21. Hammerschmidt,S.J., Huber,S., Braun,N.J., Lander,M., Steinmetzer,T. and Kersten,C.
    Thermodynamic characterization of a macrocyclic Zika virus NS2B/NS3 protease inhibitor and its acyclic analogs
    Arch Pharm (Weinheim)356, e2200518-e2200518. PubMed  Europe PubMed DOI
  22. Kumar,A., Kumar,P., Mishra,P.M. and Giri,R.
    Investigating the folding dynamics of NS2B protein of Zika virus
    Virology584, 24-36. PubMed  Europe PubMed DOI
  23. Lin,W.W., Huang,Y.J., Wang,Y.T., Lin,Y.S., Mazibuko,N., Chen,C.S., Cheng,T.L., Chang,C.S., Leu,Y.L., Chen,C.Y. and Chuang,C.H.
    Development of NS2B-NS3 protease inhibitor that impairs Zika virus replication
    Virus Res329, 199092-199092. PubMed  Europe PubMed DOI
  24. Manzato,V.M., Di Santo,C., Torquato,R.J.S., Coelho,C., Gallo,G., Hardy,L., Wurtele,M. and Tanaka,A.S.
    Boophilin D1, a Kunitz type protease inhibitor, as a source of inhibitors for the ZIKA virus NS2B-NS3 protease
    Biochimie214, 96-101. PubMed  Europe PubMed DOI
  25. Maus,H., Hammerschmidt,S.J., Hinze,G., Barthels,F., Perez Carrillo,V.H., Hellmich,U.A., Basche,T. and Schirmeister,T.
    The effects of allosteric and competitive inhibitors on ZIKV protease conformational dynamics explored through smFRET, nanoDSF, DSF, and (19)F NMR
    Eur J Med Chem258, 115573-115573. PubMed  Europe PubMed DOI
  26. Meewan,I., Shiryaev,S.A., Kattoula,J., Huang,C.T., Lin,V., Chuang,C.H., Terskikh,A.V. and Abagyan,R.
    Allosteric Inhibitors of Zika Virus NS2B-NS3 Protease Targeting Protease in "Super-Open" Conformation
    Viruses15, PubMed  Europe PubMed DOI
  27. Pant,S. and Jena,N.R.
    Repurposing of antiparasitic drugs against the NS2B-NS3 protease of the Zika virus
    J Biomol Struct Dyn1-13. PubMed  Europe PubMed DOI
  28. Shiryaev,S.A., Cieplak,P., Cheltsov,A., Liddington,R.C. and Terskikh,A.V.
    Dual function of Zika virus NS2B-NS3 protease
    PLoS Pathog19, e1011795-e1011795. PubMed  Europe PubMed DOI
    29. 2022
  29. Cao,X., Liu,K., Yan,S., Li,S., Li,Y., Jin,T. and Liu,S.
    Mechanical regulation of the helicase activity of Zika virus NS3
    Biophys J121, 4900-4908. PubMed  Europe PubMed DOI
  30. Coelho,C., Gallo,G., Hardy,L., Bottazzi,M.E., Campos,C. and Wurtele,M.
    Biochemical Screening of Potent Zika Virus Protease Inhibitors
    ChemMedCheme202100695-e202100695. PubMed  Europe PubMed DOI  I
  31. Colarusso,S., Ferrigno,F., Ponzi,S., Pavone,F., Conte,I., Abate,L., Beghetto,E., Missineo,A., Amaudrut,J., Bresciani,A., Paonessa,G., Tomei,L., Montalbetti,C., Bianchi,E., Toniatti,C. and Ontoria,J.M.
    SAR evolution towards potent C-terminal carboxamide peptide inhibitors of Zika virus NS2B-NS3 protease
    Bioorg Med Chem57, 116631-116631. PubMed  Europe PubMed DOI  I
  32. Huber,S., Braun,N.J., Schmacke,L.C., Quek,J.P., Murra,R., Bender,D., Hildt,E., Luo,D., Heine,A. and Steinmetzer,T.
    Structure-Based Optimization and Characterization of Macrocyclic Zika Virus NS2B-NS3 Protease Inhibitors
    J Med Chem65, 6555-6572. PubMed  Europe PubMed DOI
  33. Jiang,H., Zhang,Y., Wu,Y., Cheng,J., Feng,S., Wang,J., Wang,X. and Cheng,M.
    Identification of Montelukast as flavivirus NS2B-NS3 protease inhibitor by inverse virtual screening and experimental validation
    Biochem Biophys Res Commun606, 87-93. PubMed  Europe PubMed DOI  I
  34. Kumar,S., El-Kafrawy,S.A., Bharadwaj,S., Maitra,S.S., Alandijany,T.A., Faizo,A.A., Khateb,A.M., Dwivedi,V.D. and Azhar,E.I.
    Discovery of Bispecific Lead Compounds from Azadirachta indica against ZIKA NS2B-NS3 Protease and NS5 RNA Dependent RNA Polymerase Using Molecular Simulations
    Molecules27, PubMed  Europe PubMed DOI
  35. Miao,J., Yuan,H., Rao,J., Zou,J., Yang,K., Peng,G., Cao,S., Chen,H. and Song,Y.
    Identification of a small compound that specifically inhibits Zika virus in vitro and in vivo by targeting the NS2B-NS3 protease
    Antiviral Res199, 105255-105255. PubMed  Europe PubMed DOI  I
  36. Mottin,M., de Paula Sousa,B.K., de Moraes Roso Mesquita,N.C., de Oliveira,K.I.Z., Noske,G.D., Sartori,G.R., de Oliveira Albuquerque,A., Urbina,F., Puhl,A.C., Moreira-Filho,J.T., Souza,G.E., Guido,R.V.C., Muratov,E., Neves,B.J., Martins da Silva,J.H., Clark,A.E., Siqueira-Neto,J.L., Perryman,A.L., Oliva,G., Ekins,S. and Andrade,C.H.
    Discovery of New Zika Protease and Polymerase Inhibitors through the Open Science Collaboration Project OpenZika
    J Chem Inf Model62, 6825-6843. PubMed  Europe PubMed DOI  I
  37. Mottin,M., Caesar,L.K., Brodsky,D., Mesquita,N.C.M.R., de Oliveira,K.Z., Noske,G.D., Sousa,B.K.P., Ramos,P.R.P.S., Jarmer,H., Loh,B., Zorn,K.M., Foil,D.H., Torres,P.M., Guido,R.V.C., Oliva,G., Scholle,F., Ekins,S., Cech,N.B., Andrade,C.H. and Laster,S.M.
    Chalcones from Angelica keiskei (ashitaba) inhibit key Zika virus replication proteins
    Bioorg Chem120, 105649-105649. PubMed  Europe PubMed DOI  I
  38. Pant,S., Bhattacharya,G. and Jena,N.R.
    Structures and dynamics of peptide and peptidomimetic inhibitors bound to the NS2B-NS3 protease of the ZIKA virus
    J Biomol Struct Dyn1-13. PubMed  Europe PubMed DOI  I
  39. Samrat,S.K., Xu,J., Li,Z., Zhou,J. and Li,H.
    Antiviral Agents against Flavivirus Protease: Prospect and Future Direction
    Pathogens11, PubMed  Europe PubMed DOI  V
  40. Santos,N.P., Santos,L.H., Torquato Quezado de Magalhaes,M., Lei,J., Hilgenfeld,R., Salgado Ferreira,R. and Bleicher,L.
    Characterization of an Allosteric Pocket in Zika Virus NS2B-NS3 Protease
    J Chem Inf Model62, 945-957. PubMed  Europe PubMed DOI
  41. Silva,J.V., Savino,D., Hirata,M.H., Ferreira,G.M. and Giarolla,J.
    Zika Virus NS2B-NS3 Protease: Quantum Chemical Properties Insights into Designing Inhibitory Peptides
    Protein Pept Lett29, 901-910. PubMed  Europe PubMed DOI
  42. Xiong,Y., Cheng,F., Zhang,J., Su,H., Hu,H., Zou,Y., Li,M. and Xu,Y.
    Structure-based design of a novel inhibitor of the ZIKA virus NS2B/NS3 protease
    Bioorg Chem128, 106109-106109. PubMed  Europe PubMed DOI
    43. 2021
  43. Baltina,L.A., Lai,H.C., Liu,Y.C., Huang,S.H., Hour,M.J., Baltina,L.A., Nugumanov,T.R., Borisevich,S.S., Khalilov,L.M., Petrova,S.F., Khursan,S.L. and Lin,C.W.
    Glycyrrhetinic acid derivatives as Zika virus inhibitors: Synthesis and antiviral activity in vitro
    Bioorg Med Chem41, 116204-116204. PubMed  Europe PubMed DOI  I
  44. Chen,W., Foo,S.S., Hong,E., Wu,C., Lee,W.S., Lee,S.A., Evseenko,D., Moreira,M.E.L., Garcia-Sastre,A., Cheng,G., Nielsen-Saines,K., Brasil,P., Avvad-Portari,E. and Jung,J.U.
    Zika virus NS3 protease induces bone morphogenetic protein-dependent brain calcification in human fetuses
    Nat Microbiol PubMed  Europe PubMed DOI
  45. Chong Teoh,T., Al-Harbi,J., Abdulrahman,A.Y. and Rothan,H.A.
    Doxycycline Interferes with Zika Virus Serine Protease and Inhibits Virus Replication in Human Skin Fibroblasts
    Molecules26, PubMed  Europe PubMed DOI  I
  46. Dabrowska,A., Milewska,A., Ner-Kluza,J., Suder,P. and Pyrc,K.
    Mass Spectrometry versus Conventional Techniques of Protein Detection: Zika Virus NS3 Protease Activity towards Cellular Proteins
    Molecules26, PubMed  Europe PubMed DOI
  47. Kumar,A., Kumar,P., Aarthy,M., Singh,S.K. and Giri,R.
    Experiments and simulation on ZIKV NS2B-NS3 protease reveal its complex folding
    Virology556, 110-123. PubMed  Europe PubMed DOI
  48. Li,Q. and Kang,C.
    Structure and Dynamics of Zika Virus Protease and Its Insights into Inhibitor Design
    Biomedicines9, PubMed  Europe PubMed DOI
  49. Lima,C.S., Mottin,M., de Assis,L.R., Mesquita,N.C.M.R., Sousa,B.K.P., Coimbra,L.D., Santos,K.B., Zorn,K.M., Guido,R.V.C., Ekins,S., Marques,R.E., Proenca-Modena,J.L., Oliva,G., Andrade,C.H. and Regasini,L.O.
    Flavonoids from Pterogyne nitens as Zika virus NS2B-NS3 protease inhibitors
    Bioorg Chem109, 104719-104719. PubMed  Europe PubMed DOI  I
  50. Liu,L., Downs,M., Guidry,J. and Wojcik,E.J.
    Inter-organelle interactions between the ER and mitotic spindle facilitates Zika protease cleavage of human Kinesin-5 and results in mitotic defects
    iScience24, 102385-102385. PubMed  Europe PubMed DOI
  51. Nie,S., Zhao,J., Wu,X., Yao,Y., Wu,F., Lin,Y.L., Li,X., Kneubehl,A.R., Vogt,M.B., Rico-Hesse,R. and Song,Y.
    Synthesis, structure-activity relationship and antiviral activity of indole-containing inhibitors of Flavivirus NS2B-NS3 protease
    Eur J Med Chem225, 113767-113767. PubMed  Europe PubMed DOI  I
  52. Nunes,D.A.F., Santos,F.R.D.S., da Fonseca,S.T.D., de Lima,W.G., Nizer,W.S.D.C., Ferreira,J.M.S. and de Magalhaes,J.C.
    NS2B-NS3 protease inhibitors as promising compounds in the development of antivirals against Zika virus: A systematic review
    J Med Virol PubMed  Europe PubMed DOI  I
  53. Patil,N.A., Quek,J.P., Schroeder,B., Morewood,R., Rademann,J., Luo,D. and Nitsche,C.
    2-Cyanoisonicotinamide Conjugation: A Facile Approach to Generate Potent Peptide Inhibitors of the Zika Virus Protease
    ACS Med Chem Lett12, 732-737. PubMed  Europe PubMed DOI  I
  54. Santos,L.H., Caffarena,E.R. and Ferreira,R.S.
    pH and non-covalent ligand binding modulate Zika virus NS2B/NS3 protease binding site residues: Discoveries from MD and constant pH MD simulations
    J Biomol Struct Dyn1-14. PubMed  Europe PubMed DOI
  55. Yamaoka,Y., Matsunaga,S., Jeremiah,S.S., Nishi,M., Miyakawa,K., Morita,T., Khatun,H., Shimizu,H., Okabe,N., Kimura,H., Hasegawa,H. and Ryo,A.
    Zika virus protease induces caspase-independent pyroptotic cell death by directly cleaving gasdermin D
    Biochem Biophys Res Commun534, 666-671. PubMed  Europe PubMed DOI
  56. Yu,X., Shan,C., Zhu,Y., Ma,E., Wang,J., Wang,P., Shi,P.Y. and Cheng,G.
    A mutation-mediated evolutionary adaptation of Zika virus in mosquito and mammalian host
    Proc Natl Acad Sci U S A118, PubMed  Europe PubMed DOI
    57. 2020
  57. Abrams,R.P.M., Yasgar,A., Teramoto,T., Lee,M.H., Dorjsuren,D., Eastman,R.T., Malik,N., Zakharov,A.V., Li,W., Bachani,M., Brimacombe,K., Steiner,J.P., Hall,M.D., Balasubramanian,A., Jadhav,A., Padmanabhan,R., Simeonov,A. and Nath,A.
    Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors
    Proc Natl Acad Sci U S A117, 31365-31375. PubMed  Europe PubMed DOI
  58. Arias-Arias,J.L., MacPherson,D.J., Hill,M.E., Hardy,J.A. and Mora-Rodriguez,R.
    A fluorescence-activatable reporter of flavivirus NS2B-NS3 protease activity enables live imaging of infection in single cells and viral plaques
    J Biol Chem295, 2212-2226. PubMed  Europe PubMed DOI  A  L
  59. Behnam,M.A.M. and Klein,C.D.P.
    Conformational selection in the flaviviral NS2B-NS3 protease
    Biochimie174, 117-125. PubMed  Europe PubMed DOI  S  I
  60. Campos,D.M.O., Bezerra,K.S., Esmaile,S.C., Fulco,U.L., Albuquerque,E.L. and Oliveira,J.I.N.
    Intermolecular interactions of cn-716 and acyl-KR-aldehyde dipeptide inhibitors against Zika virus
    Phys Chem Chem Phys22, 15683-15695. PubMed  Europe PubMed DOI
  61. Cui,X., Zhou,R., Huang,C., Zhang,R., Wang,J., Zhang,Y., Ding,J., Li,X., Zhou,J. and Cen,S.
    Identification of Theaflavin-3,3'-Digallate as a Novel Zika Virus Protease Inhibitor
    Front Pharmacol11, 514313-514313. PubMed  Europe PubMed DOI  I
  62. Li,Z., Xu,J., Lang,Y., Fan,X., Kuo,L., D'Brant,L., Hu,S., Samrat,S.K., Trudeau,N., Tharappel,A.M., Rugenstein,N., Koetzner,C.A., Zhang,J., Chen,H., Kramer,L.D., Butler,D., Zhang,Q.Y., Zhou,J. and Li,H.
    JMX0207, a Niclosamide Derivative with Improved Pharmacokinetics, Suppresses Zika Virus Infection Both In Vitro and In Vivo
    ACS Infect Dis PubMed  Europe PubMed DOI  I
  63. Morewood,R. and Nitsche,C.
    A biocompatible stapling reaction for in situ generation of constrained peptides
    Chem Sci12, 669-674. PubMed  Europe PubMed DOI
  64. Pach,S., Sarter,T.M., Yousef,R., Schaller,D., Bergemann,S., Arkona,C., Rademann,J., Nitsche,C. and Wolber,G.
    Catching a moving target: comparative modeling of flaviviral NS2B-NS3 reveals small molecule Zika protease inhibitors
    ACS Med Chem Lett11, 514-520. PubMed  Europe PubMed DOI  I
  65. Quek,J.P., Liu,S., Zhang,Z., Li,Y., Ng,E.Y., Loh,Y.R., Hung,A.W., Luo,D. and Kang,C.
    Identification and structural characterization of small molecule fragments targeting Zika virus NS2B-NS3 protease
    Antiviral Res175, 104707-104707. PubMed  Europe PubMed DOI  I
  66. Ren,J., Lee,H., Kotak,A. and Johnson,M.E.
    MD simulations reveal alternate conformations of the oxyanion hole in the Zika virus NS2B/NS3 protease
    Proteins88, 345-354. PubMed  Europe PubMed DOI
  67. Rut,W., Groborz,K., Zhang,L., Modrzycka,S., Poreba,M., Hilgenfeld,R. and Drag,M.
    Profiling of flaviviral NS2B-NS3 protease specificity provides a structural basis for the development of selective chemical tools that differentiate Dengue from Zika and West Nile viruses
    Antiviral Res175, 104731-104731. PubMed  Europe PubMed DOI  P
  68. Santos,F.R.S., Nunes,D.A.F., Lima,W.G., Davyt,D., Santos,L.L., Taranto,A.G. and M S Ferreira,J.
    Identification of Zika virus NS2B-NS3 protease inhibitors by structure-based virtual screening and drug repurposing approaches
    J Chem Inf Model60, 731-737. PubMed  Europe PubMed DOI  I
  69. Voss,S. and Nitsche,C.
    Inhibitors of the Zika virus protease NS2B-NS3
    Bioorg Med Chem Lett30, 126965-126965. PubMed  Europe PubMed DOI  I
  70. Xing,H., Xu,S., Jia,F., Yang,Y., Xu,C., Qin,C. and Shi,L.
    Zika NS2B is a crucial factor recruiting NS3 to the ER and activating its protease activity
    Virus Res275, 197793-197793. PubMed  Europe PubMed DOI
    71. 2019
  71. Akaberi,D., Chinthakindi,P.K., Bahlstrom,A., Palanisamy,N., Sandstrom,A., Lundkvist,A. and Lennerstrand,J.
    Identification of a C2-symmetric diol based human immunodeficiency virus protease inhibitor targeting Zika virus NS2B-NS3 protease
    J Biomol Struct Dyn1-11. PubMed  Europe PubMed DOI  I
  72. Bowen,L.R., Li,D.J., Nola,D.T., Anderson,M.O., Heying,M., Groves,A.T. and Eagon,S.
    Identification of potential Zika virus NS2B-NS3 protease inhibitors via docking, molecular dynamics and consensus scoring-based virtual screening
    J Mol Model25, 194-194. PubMed  Europe PubMed DOI  I
  73. Chiramel,A.I., Meyerson,N.R., McNally,K.L., Broeckel,R.M., Montoya,V.R., Mendez-Solis,O., Robertson,S.J., Sturdevant,G.L., Lubick,K.J., Nair,V., Youseff,B.H., Ireland,R.M., Bosio,C.M., Kim,K., Luban,J., Hirsch,V.M., Taylor,R.T., Bouamr,F., Sawyer,S.L. and Best,S.M.
    TRIM5alpha Restricts Flavivirus Replication by Targeting the Viral Protease for Proteasomal Degradation
    Cell Rep27, 3269-3283. PubMed  Europe PubMed DOI
  74. Choudhry,H., Alzahrani,F.A., Hassan,M.A., Alghamdi,A., Abdulaal,W.H., Bakhrebah,M.A., Zamzami,M.A., Helmi,N., Bokhari,F.F., Zeyadi,M., Baothman,O.A., Kamal,M.A., Warsi,M.K., Ali,A., Jarullah,B. and Jamal,M.S.
    Zika virus targeting by screening inhibitors against NS2B/NS3 protease
    Biomed Res Int2019, 3947245-3947245. PubMed  Europe PubMed DOI  I
  75. da Silva-Junior,E.F. and de Araujo-Junior,J.X.
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