Structure for peptidase S01.268: alpha-lytic endopeptidase

Summary Alignment Sequences Sequence features Distribution Structure Literature Substrates

PDB	Organism	Resolution	Comment
2ALP	Lysobacter enzymogenes	1.70 Å	mature
Catalytic residues are shown in ball-and-stick representation: His235 in purple, Asp262 in pink and Ser358 in orange.

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TERTIARY STRUCTURE DATA
Comment	Resolution	PDB	PDBe	SCOP	CATH	PDBSum	Proteopedia	Reference
Lysobacter enzymogenes
Val167Ile mutant	2.10 Å	1BOQ	1BOQ	1BOQ	1BOQ	1BOQ	1BOQ	Peters et al., 1998
Met190Ala and Gly216Ala mutant	2.15 Å	1GBA	1GBA	1GBA	1GBA	1GBA	1GBA	Mace & Agard, 1995
Met190Ala and Gly216Ala mutant; complex with MeOSuc-Ala-Ala-Pro-Ala boronic acid	2.15 Å	1GBB	1GBB	1GBB	1GBB	1GBB	1GBB	Mace & Agard, 1995
Met190Ala and Gly216Ala mutant; complex with MeOSuc-Ala-Ala-Pro-Leu boronic acid	2.20 Å	1GBC	1GBC	1GBC	1GBC	1GBC	1GBC	Mace & Agard, 1995
Met190Ala and Gly216Ala mutant; complex with MeOSuc-Ala-Ala-Pro-Phe boronic acid	2.20 Å	1GBD	1GBD	1GBD	1GBD	1GBD	1GBD	Mace & Agard, 1995
Met190Ala and Gly216Leu mutant	2.30 Å	1GBE	1GBE	1GBE	1GBE	1GBE	1GBE	Mace & Agard, 1995
Met190Ala and Gly216Leu mutant; complex with MeOSuc-Ala-Ala-Pro-Ala boronic acid	2.15 Å	1GBF	1GBF	1GBF	1GBF	1GBF	1GBF	Mace & Agard, 1995
Met190Ala and Gly216Leu mutant; complex with MeOSuc-Ala-Ala-Pro-Leu boronic acid	2.20 Å	1GBH	1GBH	1GBH	1GBH	1GBH	1GBH	Mace & Agard, 1995
Met190Ala and Gly216Leu mutant; complex with MeOSuc-Ala-Ala-Pro-Phe boronic acid	2.30 Å	1GBI	1GBI	1GBI	1GBI	1GBI	1GBI	Mace & Agard, 1995
Met190Ala mutant	2.00 Å	1GBJ	1GBJ	1GBJ	1GBJ	1GBJ	1GBJ	Mace & Agard, 1995
Met190Ala mutant; complex with MeOSuc-Ala-Ala-Pro-Ala boronic acid	2.15 Å	1GBK	1GBK	1GBK	1GBK	1GBK	1GBK	Mace & Agard, 1995
Met190Ala mutant; complex with MeOSuc-Ala-Ala-Pro-Leu boronic acid	2.15 Å	1GBL	1GBL	1GBL	1GBL	1GBL	1GBL	Mace & Agard, 1995
Met190Ala mutant; complex with MeOSuc-Ala-Ala-Pro-Phe boronic acid	2.28 Å	1GBM	1GBM	1GBM	1GBM	1GBM	1GBM	Mace & Agard, 1995
complex with BOC-Ala-Pro-Val boronic acid	2.00 Å	1P01	1P01	1P01	1P01	1P01	1P01	Bone et al., 1987
complex with MeOSuc-Ala-Ala-Pro-Ala boronic acid	2.00 Å	1P02	1P02	1P02	1P02	1P02	1P02	Bone et al., 1989
complex with MeOSuc-Ala-Ala-Pro-Val boronic acid	2.15 Å	1P03	1P03	1P03	1P03	1P03	1P03	Bone et al., 1989
complex with MeOSuc-Ala-Ala-Pro-Ile boronic acid	2.55 Å	1P04	1P04	1P04	1P04	1P04	1P04	Bone et al., 1989
complex with MeOSuc-Ala-Ala-Pro-Nle boronic acid	2.10 Å	1P05	1P05	1P05	1P05	1P05	1P05	Bone et al., 1989
complex with MeOSuc-Ala-Ala-Pro-Phe boronic acid	2.34 Å	1P06	1P06	1P06	1P06	1P06	1P06	Bone et al., 1989
Met213Ala mutant	2.20 Å	1P09	1P09	1P09	1P09	1P09	1P09	Bone et al., 1989
Met213Ala mutant; complex with MeOSuc-Ala-Ala-Pro-Val boronic acid	2.25 Å	1P10	1P10	1P10	1P10	1P10	1P10	Bone et al., 1989
complex with N-[(2S)-2-(phenoxy(1-R-(N-T-butyloxycarbonyl-L-Ala-Pro)-1-amino-2-methylpropyl)phosphinyloxy)-propanoyl]-L-Ala methyl ester	1.93 Å	1P11	1P11	1P11	1P11	1P11	1P11	Bone et al., 1991
complex with N-[(2S)-2-(phenoxy(1-R-(N-T-butyloxycarbonyl-L-Ala-Pro)-1-amino-2-methylpropyl)phosphinyloxy)-propanoyl]-L-Ala methyl ester	1.90 Å	1P12	1P12	1P12	1P12	1P12	1P12	Bone et al., 1991
Arg102His, Gly134Ser mutant	1.20 Å	1QQ4	1QQ4	1QQ4	1QQ4	1QQ4	1QQ4
Arg102His, Gly134Ser mutant, pH 8	1.20 Å	1QRW	1QRW	1QRW	1QRW	1QRW	1QRW
pH 5.14	1.60 Å	1QRX	1QRX	1QRX	1QRX	1QRX	1QRX
mature peptidase	0.83 Å	1SSX	1SSX	1SSX	1SSX	1SSX	1SSX	Fuhrmann et al., 2004
single structure model	1.50 Å	1TAL	1TAL	1TAL	1TAL	1TAL	1TAL	Rader & Agard, 1997
mature peptidase	1.70 Å	2ALP	2ALP	2ALP	2ALP	2ALP	2ALP	Fujinaga et al., 1985
mature peptidase	0.82 Å	2H5C	2H5C	2H5C	2H5C	2H5C	2H5C	Fuhrmann et al., 2006
mature peptidase	0.90 Å	2H5D	2H5D	2H5D	2H5D	2H5D	2H5D	Fuhrmann et al., 2006
Met190Ala mutant; complex with MeOSuc-Ala-Ala-Pro-Val boronic acid	2.25 Å	2LPR	2LPR	2LPR	2LPR	2LPR	2LPR	Bone et al., 1991
propeptide	3.00 Å	2PRO	2PRO	2PRO	2PRO	2PRO	2PRO	Sauter et al., 1998
mature peptidase, multiconformer model peptidase	1.50 Å	2ULL	2ULL	2ULL	2ULL	2ULL	2ULL	Rader & Agard, 1997
Met190Ala mutant; complex with MeOSuc-Ala-Ala-Pro-Nle boronic acid	2.15 Å	3LPR	3LPR	3LPR	3LPR	3LPR	3LPR	Bone et al., 1991
mature peptidase	1.55 Å	3M7T	3M7T	3M7T	3M7T	3M7T	3M7T
mature peptidase	1.05 Å	3M7U	3M7U	3M7U	3M7U	3M7U	3M7U
Met213Ala mutant; complex with propeptide truncated C-terminally	1.80 Å	3PRO	3PRO	3PRO	3PRO	3PRO	3PRO	Sauter et al., 1998
mature peptidase	1.30 Å	3QGJ	3QGJ	3QGJ	3QGJ	3QGJ	3QGJ
mature peptidase	1.10 Å	3URC	3URC	3URC	3URC	3URC	3URC	Kelch et al., 2012
mature peptidase	1.08 Å	3URD	3URD	3URD	3URD	3URD	3URD	Kelch et al., 2012
mature peptidase	1.49 Å	3URE	3URE	3URE	3URE	3URE	3URE	Kelch et al., 2012
Met213Ala mutant; complex with propeptide	2.40 Å	4PRO	4PRO	4PRO	4PRO	4PRO	4PRO	Sauter et al., 1998
Met213Ala mutant; complex with MeOSuc-Ala-Ala-Pro-Ala boronic acid	2.13 Å	5LPR	5LPR	5LPR	5LPR	5LPR	5LPR	Bone et al., 1991
Met213Ala mutant; complex with MeOSuc-Ala-Ala-Pro-Nle boronic acid	2.10 Å	6LPR	6LPR	6LPR	6LPR	6LPR	6LPR	Bone et al., 1991
Met213Ala mutant; complex with MeOSuc-Ala-Ala-Pro-Leu boronic acid	2.05 Å	7LPR	7LPR	7LPR	7LPR	7LPR	7LPR	Bone et al., 1991
Met213Ala mutant; complex with MeOSuc-Ala-Ala-Pro-Phe boronic acid	2.25 Å	8LPR	8LPR	8LPR	8LPR	8LPR	8LPR	Bone et al., 1991
complex with MeoSuc-Ala-Ala-Pro-Leu boronic acid	2.20 Å	9LPR	9LPR	9LPR	9LPR	9LPR	9LPR	Bone et al., 1991
Lysobacter sp. XL1
crystal structure of l1 protease of lysobacter sp. xl1	1.35 Å	5MRR	5MRR	5MRR	5MRR	5MRR	5MRR
complex with aebsf	1.90 Å	5MRS	5MRS	5MRS	5MRS	5MRS	5MRS
crystal structure of l5 protease lysobacter sp. xl1	1.60 Å	5MRT	5MRT	5MRT	5MRT	5MRT	5MRT