Structure for peptidase S01.140: chymase (Homo sapiens-type)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

PDB	Organism	Resolution	Comment
1KLT	Homo sapiens	1.90 Å	complex with PMSF
Catalytic residues are shown in ball-and-stick representation: His66 in purple, Asp110 in pink and Ser203 in orange. Bound inhibitor is shown in grey in ball-and-stick representation.

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TERTIARY STRUCTURE DATA
Comment	Resolution	PDB	PDBe	SCOP	CATH	PDBSum	Proteopedia	Reference
Homo sapiens
complex with PMSF	1.90 Å	1KLT	1KLT	1KLT	1KLT	1KLT	1KLT	McGrath et al., 1997
precursor	1.75 Å	1NN6	1NN6	1NN6	1NN6	1NN6	1NN6	Reiling et al., 2003
complex with succinyl-Ala-Ala-Pro-Phe-chloromethylketone	2.20 Å	1PJP	1PJP	1PJP	1PJP	1PJP	1PJP	Pereira et al., 1999
complex with succinyl-Ala-Ala-Pro-Phe-chloromethylketone	1.90 Å	1T31	1T31	1T31	1T31	1T31	1T31	de et al., 2005
discovery of potent, orally active, nonpeptide inhibitors of human mast cell chymase by using structure-based drug design	2.60 Å	2HVX	2HVX	2HVX	2HVX	2HVX	2HVX	Greco et al., 2007
mature peptidase	1.80 Å	3N7O	3N7O	3N7O	3N7O	3N7O	3N7O	Kervinen et al., 2010
mature peptidase	1.95 Å	3S0N	3S0N	3S0N	3S0N	3S0N	3S0N	Lo et al., 2011
mature peptidase	1.51 Å	4AFQ	4AFQ	4AFQ	4AFQ	4AFQ	4AFQ	Schlatter et al., 2012
mature peptidase	1.90 Å	4AFS	4AFS	4AFS	4AFS	4AFS	4AFS	Schlatter et al., 2012
mature peptidase	1.82 Å	4AFU	4AFU	4AFU	4AFU	4AFU	4AFU	Schlatter et al., 2012
mature peptidase	2.25 Å	4AFZ	4AFZ	4AFZ	4AFZ	4AFZ	4AFZ	Schlatter et al., 2012
mature peptidase	1.40 Å	4AG1	4AG1	4AG1	4AG1	4AG1	4AG1	Schlatter et al., 2012
mature peptidase	1.80 Å	4AG2	4AG2	4AG2	4AG2	4AG2	4AG2	Schlatter et al., 2012
mature peptidase	2.30 Å	4K2Y	4K2Y	4K2Y	4K2Y	4K2Y	4K2Y	Taylor et al., 2013
mature peptidase	1.80 Å	4K5Z	4K5Z	4K5Z	4K5Z	4K5Z	4K5Z	Taylor et al., 2013
mature peptidase	1.50 Å	4K60	4K60	4K60	4K60	4K60	4K60	Taylor et al., 2013
mature peptidase	1.50 Å	4K69	4K69	4K69	4K69	4K69	4K69	Taylor et al., 2013
mature peptidase	2.80 Å	4KP0	4KP0	4KP0	4KP0	4KP0	4KP0	Matsumoto et al., 2013