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Literature for peptidase S01.140: chymase (Homo sapiens-type)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: A Assay, S Structure, T Target, K Knockout, P Specificity, E Expression, V Review, M Mutation, I Inhibitor, L Localization. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Furstner,C., Ackerstaff,J., Meier,H., Straub,A., Mittendorf,J., Schamberger,J., Schafer,M., Borngen,K., Jorissen,H., Zubov,D., Zimmermann,K., Tersteegen,A., Geiss,V., Hartmann,E., Albrecht-Kupper,B., D'Orleans-Juste,P., Lapointe,C., Vincent,L., Heitmeier,S. and Tinel,H.
    Discovery and Preclinical Characterization of Fulacimstat (BAY 1142524), a Potent and Selective Chymase Inhibitor As a New Profibrinolytic Approach for Safe Thrombus Resolution
    J Med Chem PubMed  Europe PubMed DOI  I
    2. 2023
  2. Ferrario,C.M., Ahmad,S., Speth,R. and Dell'Italia,L.J.
    Is chymase 1 a therapeutic target in cardiovascular disease?
    Expert Opin Ther Targets27, 645-656. PubMed  Europe PubMed DOI  V
  3. Morales-Maldonado,A., Humphry,M., Figg,N. and Clarke,M.C.
    Human vascular smooth muscle cells utilise chymase for the atypical cleavage and activation of Interleukin-1beta
    Atherosclerosis117308-117308. PubMed  Europe PubMed DOI
  4. Yapijakis,C., Gintoni,I., Charalampidou,S., Angelopoulou,A., Papakosta,V., Vassiliou,S. and Chrousos,G.P.
    Angiotensinogen, Angiotensin-Converting Enzyme, and Chymase Gene Polymorphisms as Biomarkers for Basal Cell Carcinoma Susceptibility
    Adv Exp Med Biol1423, 175-180. PubMed  Europe PubMed DOI
    5. 2022
  5. Fairhurst-Hunter,Z., Walters,R.G., Zink,A., Lin,K., Guo,Y., Yu,C., Lv,J., Li,L., Freitag,D.F., Chen,Z. and Millwood,I.Y.
    Investigation into the Health Effects of Reduced Chymase Function Using Predicted Loss-of-Function Mutations in CMA1
    J Cardiovasc Transl Res PubMed  Europe PubMed DOI
  6. Lind,T., Melo,F.R., Gustafson,A.M., Sundqvist,A., Zhao,X.O., Moustakas,A., Melhus,H. and Pejler,G.
    Mast cell chymase has a negative impact on human osteoblasts
    Matrix Biol112, 1-19. PubMed  Europe PubMed DOI
  7. Zhang,N., Schumacher,A., Fink,B., Bauer,M., Zenclussen,A.C. and Meyer,N.
    Insights into Early-Pregnancy Mechanisms: Mast Cells and Chymase CMA1 Shape the Phenotype and Modulate the Functionality of Human Trophoblast Cells, Vascular Smooth-Muscle Cells and Endothelial Cells
    Cells11, PubMed  Europe PubMed DOI
    8. 2021
  8. Abassi,Z., Skorecki,K., Hamo-Giladi,D.B., Kruzel-Davila,E. and Heyman,S.N.
    Kinins and Chymase: The Forgotten Components of the Renin angiotensin system and their implications in COVID-19 Disease
    Am J Physiol Lung Cell Mol Physiol PubMed  Europe PubMed DOI
  9. Cruz-Lopez,E.O., Uijl,E. and Danser,A.H.J.
    Cardiac Angiotensin II Is Generated Locally by ACE and Not Chymase
    J Am Coll Cardiol78, 540-541. PubMed  Europe PubMed DOI
  10. Fischer,A., Sellner,M., Mitusinska,K., Bzowka,M., Lill,M.A., Gora,A. and Smiesko,M.
    Computational Selectivity Assessment of Protease Inhibitors against SARS-CoV-2
    Int J Mol Sci22, PubMed  Europe PubMed DOI
  11. Zhao,X.O., Lampinen,M., Rollman,O., Sommerhoff,C.P., Paivandy,A. and Pejler,G.
    Mast cell chymase affects the functional properties of primary human airway fibroblasts: Implications for asthma
    J Allergy Clin Immunol PubMed  Europe PubMed DOI
    12. 2020
  12. Berglund,P., Akula,S., Fu,Z., Thorpe,M. and Hellman,L.
    Extended Cleavage Specificity of the Rat Vascular Chymase, a Potential Blood Pressure Regulating Enzyme Expressed by Rat Vascular Smooth Muscle Cells
    Int J Mol Sci21, PubMed  Europe PubMed DOI
  13. Dungen,H.D., Kim,R.J., Zahger,D., Orvin,K., Kornowski,R., Admon,D., Kettner,J., Shimony,A., Otto,C., Becka,M., Kanefendt,F., Romo,A.I., Hasin,T., Ostadal,P., Rojas,G.C. and Senni,M.
    Effects of the chymase inhibitor fulacimstat on adverse cardiac remodeling after acute myocardial infarction: results of the chymase inhibitor in adverse remodeling after myocardial infarction (CHIARA MIA) 2 trial
    Am Heart J224, 129-137. PubMed  Europe PubMed DOI  I
  14. Ferrario,C.M., Groban,L., Wang,H., Cheng,C.P., VonCannon,J.L., Wright,K.N., Sun,X. and Ahmad,S.
    The Angiotensin-(1-12)/Chymase axis as an alternate component of the tissue renin angiotensin system
    Mol Cell Endocrinol111119-111119. PubMed  Europe PubMed DOI
  15. Li,C.Y., Yap,K., Swedberg,J.E., Craik,D.J. and de Veer,S.J.
    Binding loop substitutions in the cyclic peptide SFTI-1 generate potent and selective chymase inhibitors
    J Med Chem63, 816-826. PubMed  Europe PubMed DOI
  16. Rathore,A.P.S., Senanayake,M., Athapathu,A.S., Gunasena,S., Karunaratna,I., Leong,W.Y., Lim,T., Mantri,C.K., Wilder-Smith,A. and St John,A.L.
    Serum chymase levels correlate with severe dengue warning signs and clinical fluid accumulation in hospitalized pediatric patients
    Sci Rep10, 11856-11856. PubMed  Europe PubMed DOI
  17. Sahu,A.K., Aggarwal,P., Ekka,M., Nayer,J., Bhoi,S., Kumar,A. and Luthra,K.
    Assessing the Serum Chymase Level as an Early Predictor of Dengue Severity
    J Med Virol PubMed  Europe PubMed DOI
  18. Vibhushan,S., Bratti,M., Montero-Hernandez,J.E., El Ghoneimi,A., Benhamou,M., Charles,N., Daugas,E. and Blank,U.
    Mast Cell Chymase and Kidney Disease
    Int J Mol Sci22, PubMed  Europe PubMed DOI  V
    19. 2019
  19. Ahmad,S., Wright,K.N., Sun,X., Groban,L. and Ferrario,C.M.
    Mast cell peptidases (carboxypeptidase A and chymase)-mediated hydrolysis of human angiotensin-(1-12) substrate
    Biochem Biophys Res Commun518, 651-656. PubMed  Europe PubMed DOI
  20. Bivona,B.J., Takai,S., Seth,D.M., Satou,R. and Harrison-Bernard,L.M.
    Chymase inhibition retards albuminuria in type 2 diabetes
    Physiol Rep7, e14302-e14302. PubMed  Europe PubMed DOI  I
  21. Fu,Z., Akula,S., Thorpe,M., Chahal,G., de Garavilla,L., Kervinen,J. and Hellman,L.
    Extended cleavage specificity of sheep mast cell protease-2: a classical chymase with preference to aromatic P1 substrate residues
    Dev Comp Immunol92, 160-169. PubMed  Europe PubMed DOI  P
  22. Fu,Z., Akula,S., Thorpe,M. and Hellman,L.
    Highly selective cleavage of TH2-promoting cytokines by the human and the mouse mast cell tryptases, indicating a potent negative feedback loop on TH2 immunity
    Int J Mol Sci20, PubMed  Europe PubMed DOI  P
  23. Jin,D., Takai,S., Nonaka,Y., Yamazaki,S., Fujiwara,M. and Nakamura,Y.
    A chymase inhibitory RNA aptamer improves cardiac function and survival after myocardial infarction
    Mol Ther Nucleic Acids14, 41-51. PubMed  Europe PubMed DOI  I
  24. Kanefendt,F., Thuss,U., Becka,M., Boxnick,S., Berse,M., Schultz,A. and Otto,C.
    Pharmacokinetics, safety, and tolerability of the novel chymase inhibitor BAY 1142524 in healthy male volunteers
    Clin Pharmacol Drug Dev8, 467-479. PubMed  Europe PubMed DOI  I
  25. Lipitsa,T., Siiskonen,H., Naukkarinen,A. and Harvima,I.T.
    Mast cell chymase degrades fibrinogen and fibrin
    Br J Dermatol181, 296-303. PubMed  Europe PubMed DOI
  26. Ozawa,S.I., Takahashi,M., Yamaotsu,N. and Hirono,S.
    Structure-based virtual screening for novel chymase inhibitors by in silico fragment mapping
    J Mol Graph Model89, 102-108. PubMed  Europe PubMed DOI  I
  27. Tomimori,Y., Manno,A., Tanaka,T., Futamura-Takahashi,J., Muto,T. and Nagahira,K.
    ASB17061, a novel chymase inhibitor, prevented the development of angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-deficient mice
    Eur J Pharmacol856, 172403-172403. PubMed  Europe PubMed DOI  I
    28. 2018
  28. Ahmad,S. and Ferrario,C.M.
    Chymase inhibitors for the treatment of cardiac diseases: a patent review (2010-2018)
    Expert Opin Ther Pat28, 755-764. PubMed  Europe PubMed DOI  I
  29. Ansary,T.M., Urushihara,M., Fujisawa,Y., Nagata,S., Urata,H., Nakano,D., Hirofumi,H., Kitamura,K., Kagami,S. and Nishiyama,A.
    Effects of the selective chymase inhibitor TEI-F00806 on the intrarenal renin-angiotensin system in salt-treated angiotensin I-infused hypertensive mice
    Exp Physiol103, 1524-1531. PubMed  Europe PubMed DOI  I
  30. Dell'Italia,L.J., Collawn,J.F. and Ferrario,C.M.
    Multifunctional role of chymase in acute and chronic tissue injury and remodeling
    Circ Res122, 319-336. PubMed  Europe PubMed DOI  V
  31. Dubey,A., Dotolo,S., Ramteke,P.W., Facchiano,A. and Marabotti,A.
    Searching for chymase inhibitors among chamomile compounds using a computational-based approach
    Biomolecules9, PubMed  Europe PubMed DOI  I
  32. Futamura-Takahashi,J., Tanaka,T., Sugawara,H., Iwashita,S., Imajo,S., Oyama,Y. and Muto,T.
    Structure-based design, synthesis, and binding mode analysis of novel and potent chymase inhibitors
    Bioorg Med Chem Lett28, 188-192. PubMed  Europe PubMed DOI  I
  33. Kareinen,I., Baumann,M., Nguyen,S.D., Maaninka,K., Anisimov,A., Tozuka,M., Jauhiainen,M., Lee-Rueckert,M. and Kovanen,P.T.
    Chymase released from hypoxia-activated cardiac mast cells cleaves human apoA-I at Tyr(192) and compromises its cardioprotective activity
    J Lipid Res59, 945-957. PubMed  Europe PubMed DOI
  34. Zhang,H., Wang,J., Wang,L., Zhan,M., Li,S., Fang,Z., Xu,C., Zheng,Y. and He,S.
    Induction of mast cell accumulation by chymase via an enzymatic activity- and intercellular adhesion molecule-1-dependent mechanism
    Br J Pharmacol175, 678-692. PubMed  Europe PubMed DOI
    35. 2017
  35. Froogh,G., Pinto,J.T., Le,Y., Kandhi,S., Aleligne,Y., Huang,A. and Sun,D.
    Chymase-dependent production of angiotensin II: an old enzyme in old hearts
    Am J Physiol Heart Circ Physiol312, H223-H231. PubMed  Europe PubMed DOI
  36. Fu,Z., Thorpe,M., Alemayehu,R., Roy,A., Kervinen,J., de Garavilla,L., Abrink,M. and Hellman,L.
    Highly selective cleavage of cytokines and chemokines by the human mast cell chymase and neutrophil cathepsin G
    J Immunol198, 1474-1483. PubMed  Europe PubMed DOI  P
  37. Grujic,M., Paivandy,A., Gustafson,A.M., Thomsen,A.R., Ohrvik,H. and Pejler,G.
    The combined action of mast cell chymase, tryptase and carboxypeptidase A3 protects against melanoma colonization of the lung
    Oncotarget8, 25066-25079. PubMed  Europe PubMed DOI
  38. Gu,Y., Lewis,D.F., Alexander,J.S. and Wang,Y.
    Upregulation of cathepsin C expression contributes to endothelial chymase activation in preeclampsia
    Hypertens Res40, 976-981. PubMed  Europe PubMed DOI
  39. Reyes,S., Varagic,J., Ahmad,S., VonCannon,J., Kon,N.D., Wang,H., Groban,L., Cheng,C.P., Dell'Italia,L.J. and Ferrario,C.M.
    Novel cardiac intracrine mechanisms based on Ang-(1-12)/chymase axis require a revision of therapeutic approaches in human heart disease
    Curr Hypertens Rep19, 16-16. PubMed  Europe PubMed DOI
  40. Shubin,N.J., Glukhova,V.A., Clauson,M., Truong,P., Abrink,M., Pejler,G., White,N.J., Deutsch,G.H., Reeves,S.R., Vaisar,T., James,R.G. and Piliponsky,A.M.
    Proteome analysis of mast cell releasates reveals a role for chymase in the regulation of coagulation factor XIIIA levels via proteolytic degradation
    J Allergy Clin Immunol139, 323-334. PubMed  Europe PubMed DOI
  41. Stevens,R.L., McNeil,H.P., Wensing,L.A., Shin,K., Wong,G.W., Hansbro,P.M. and Krilis,S.A.
    Experimental arthritis is dependent on mouse mast cell protease-5
    J Biol Chem292, 5392-5404. PubMed  Europe PubMed DOI  K
  42. Verma,S., Singh,A., Kumari,A., Goyal,S., Jamal,S., Sinha,S. and Grover,A.
    Dissecting the role of mutations in chymase inhibition: free energy and decomposition analysis
    Gene609, 68-79. PubMed  Europe PubMed DOI  M
    43. 2016
  43. Dubey,A., Marabotti,A., Ramteke,P.W. and Facchiano,A.
    Interaction of human chymase with ginkgolides, terpene trilactones of Ginkgo biloba investigated by molecular docking simulations
    Biochem Biophys Res Commun473, 449-454. PubMed  Europe PubMed DOI  I
  44. Dubey,A., Facchiano,A., Ramteke,P.W. and Marabotti,A.
    In silico approach to find chymase inhibitors among biogenic compounds
    Future Med Chem8, 841-851. PubMed  Europe PubMed DOI  I
  45. Sansoe,G., Aragno,M., Mastrocola,R., Mengozzi,G., Novo,E. and Parola,M.
    Role of chymase in the development of liver cirrhosis and its complications: experimental and human data
    PLoS ONE11, e0162644-e0162644. PubMed  Europe PubMed DOI  I
  46. Takai,S. and Jin,D.
    Improvement of cardiovascular remodelling by chymase inhibitor
    Clin Exp Pharmacol Physiol43, 387-393. PubMed  Europe PubMed DOI  I
  47. Zhang,M., Huang,W., Bai,J., Nie,X. and Wang,W.
    Chymase inhibition protects diabetic rats from renal lesions
    Mol Med Rep14, 121-128. PubMed  Europe PubMed DOI  I
  48. Zhang,R., Zhang,C.J., Feng,G., Hu,F., Wang,J. and Liu,B.
    Specific light-up probe with aggregation-induced emission for facile detection of chymase
    Anal Chem88, 9111-9117. PubMed  Europe PubMed DOI  L
    49. 2015
  49. Arooj,M., Sakkiah,S., Cao,G.P., Kim,S., Arulalapperumal,V. and Lee,K.W.
    Finding off-targets, biological pathways, and target diseases for chymase inhibitors via structure-based systems biology approach
    Proteins83, 1209-1224. PubMed  Europe PubMed DOI  I
  50. Devarajan,S., Yahiro,E., Uehara,Y., Habe,S., Nishiyama,A., Miura,S., Saku,K. and Urata,H.
    Depressor effect of chymase inhibitor in mice with high salt-induced moderate hypertension
    Am J Physiol Heart Circ Physiol309, H1987-H1996. PubMed  Europe PubMed DOI  I
  51. Semaan,W., Desbiens,L., Houde,M., Labonte,J., Gagnon,H., Yamamoto,D., Takai,S., Laidlaw,T., Bkaily,G., Schwertani,A., Pejler,G., Levesque,C., Desjardins,R., Day,R. and D'Orleans-Juste,P.
    Chymase inhibitor-sensitive synthesis of endothelin-1 (1-31) by recombinant mouse mast cell protease 4 and human chymase
    Biochem Pharmacol94, 91-100. PubMed  Europe PubMed DOI  I
  52. Wang,R., Chen,J., Zhang,Z. and Cen,Y.
    Role of chymase in the local renin-angiotensin system in keloids: inhibition of chymase may be an effective therapeutic approach to treat keloids
    Drug Des Devel Ther9, 4979-4988. PubMed  Europe PubMed DOI  T
    53. 2014
  53. Ahmad,S., Varagic,J., Groban,L., Dell'Italia,L.J., Nagata,S., Kon,N.D. and Ferrario,C.M.
    Angiotensin-(1-12): a chymase-mediated cellular angiotensin II substrate
    Curr Hypertens Rep16, 429-429. PubMed  Europe PubMed DOI
  54. Fei,X., Yuan,Y., Lee,Y.-M., Jeong,K.W. and Seo,S.-Y.
    Synthesis, biological evaluation of SPF-32629A-based 2- and 4-pyridone analogs as chymase inhibitors
    Bull Korean Chem Soc35, 2547-2550. DOI  I
  55. Lysvand,H., Hagen,L., Klubicka,L., Slupphaug,G. and Iversen,O.J.
    Psoriasis pathogenesis - Pso p27 is generated from SCCA1 with chymase
    Biochim Biophys Acta1842, 734-738. PubMed  Europe PubMed DOI
  56. Rafiq,K., Fan,Y.Y., Sherajee,S.J., Takahashi,Y., Matsuura,J., Hase,N., Mori,H., Nakano,D., Kobara,H., Hitomi,H., Masaki,T., Urata,H. and Nishiyama,A.
    Chymase activities and survival in endotoxin-induced human chymase transgenic mice
    Int J Med Sci11, 222-225. PubMed  Europe PubMed DOI
  57. Smith,E.T., Perry,E.T., Sears,M.B. and Johnson,D.A.
    Expression of recombinant human mast cell chymase with Asn-linked glycans in glycoengineered Pichia pastoris
    Protein Expr Purif102, 69-75. PubMed  Europe PubMed DOI  E
    58. 2013
  58. Ahooghalandari,P., Hanke,N., Thorpe,M., Witte,A., Messinger,J. and Hellman,L.
    Mutations in Arg143 and Lys192 of the human mast cell chymase markedly affect the activity of five potent human chymase inhibitors
    PLoS ONE8, e65988-e65988. PubMed  Europe PubMed DOI  I
  59. Arooj,M., Kim,S., Sakkiah,S., Cao,G.P., Lee,Y. and Lee,K.W.
    Molecular modeling study for inhibition mechanism of human chymase and its application in inhibitor design
    PLoS ONE8, e62740-e62740. PubMed  Europe PubMed DOI  I
  60. Matsumoto,Y., Kakuda,S., Koizumi,M., Mizuno,T., Muroga,Y., Kawamura,T. and Takimoto-Kamimura,M.
    Crystal structure of a complex of human chymase with its benzimidazole derived inhibitor
    J Synchrotron Radiat20, 914-918. PubMed  Europe PubMed DOI  S  I
  61. Tanaka,T., Sugawara,H., Maruoka,H., Imajo,S. and Muto,T.
    Discovery of novel series of 6-benzyl substituted 4-aminocarbonyl-1,4-diazepane-2,5-diones as human chymase inhibitors using structure-based drug design
    Bioorg Med Chem21, 4233-4249. PubMed  Europe PubMed DOI  I
  62. Taylor,S.J., Padyana,A.K., Abeywardane,A., Liang,S., Hao,M.H., De Lombaert,S., Proudfoot,J., Farmer,B.S., III, Li,X., Collins,B., Martin,L., Albaugh,D.R., Hill-Drzewi,M., Pullen,S.S. and Takahashi,H.
    Discovery of potent, selective chymase inhibitors via fragment linking strategies
    J Med Chem56, 4465-4481. PubMed  Europe PubMed DOI  I
  63. Wu,Y., Yang,H., Yang,B., Yang,K. and Xiao,C.
    Association of polymorphisms in prolylcarboxypeptidase and chymase genes with essential hypertension in the Chinese Han population
    J Renin Angiotensin Aldosterone Syst14, 263-270. PubMed  Europe PubMed DOI  M
  64. Yahiro,E., Miura,S., Imaizumi,S., Uehara,Y. and Saku,K.
    Chymase inhibitors
    Curr Pharm Des19, 3065-3071. PubMed  Europe PubMed DOI  I
    65. 2012
  65. Campbell,D.J.
    Angiotensin II generation in vivo: does it involve enzymes other than renin and angiotensin-converting enzyme?
    J Renin Angiotensin Aldosterone Syst13, 314-316. PubMed  Europe PubMed DOI
  66. Caughey,G.H.
    Chymases
    [ISSN:978-0-12-407742-3]3, 2675-2683. DOI
  67. Heuston,S. and Hyland,N.
    Chymase inhibition as a pharmacological target: a role in inflammatory and functional gastrointestinal disorders?
    Br J Pharmacol167, 732-740. PubMed  Europe PubMed DOI  V
  68. Maeda,Y., Inoguchi,T., Takei,R., Hendarto,H., Ide,M., Inoue,T., Kobayashi,K., Urata,H., Nishiyama,A. and Takayanagi,R.
    Chymase inhibition prevents myocardial fibrosis through the attenuation of NOX4-associated oxidative stress in diabetic hamsters
    J Diabetes Investig3, 354-361. PubMed  Europe PubMed DOI  I
  69. Parlee,S.D., McNeil,J.O., Muruganandan,S., Sinal,C.J. and Goralski,K.B.
    Elastase and tryptase govern TNFalpha-mediated production of active chemerin by adipocytes
    PLoS ONE7, e51072-e51072. PubMed  Europe PubMed DOI
  70. Takai,S., Jin,D. and Miyazaki,M.
    Multiple mechanisms for the action of chymase inhibitors
    J Pharmacol Sci118, 311-316. PubMed  Europe PubMed DOI  I
  71. Thorpe,M., Yu,J., Boinapally,V., Ahooghalandari,P., Kervinen,J., Garavilla,L. and Hellman,L.
    Extended cleavage specificity of the mast cell chymase from the crab-eating macaque (Macaca fascicularis): an interesting animal model for the analysis of the function of the human mast cell chymase
    Int Immunol24, 771-782. PubMed  Europe PubMed DOI  P
    72. 2011
  72. Ahmad,S., Simmons,T., Varagic,J., Moniwa,N., Chappell,M.C. and Ferrario,C.M.
    Chymase-dependent generation of angiotensin II from angiotensin-(1-12) in human atrial tissue
    PLoS ONE6, e28501-e28501. PubMed  Europe PubMed DOI  I
  73. Arooj,M., Thangapandian,S., John,S., Hwang,S., Park,J.K. and Lee,K.W.
    3D QSAR pharmacophore modeling, in silico screening, and density functional theory (DFT) approaches for identification of human chymase inhibitors
    Int J Mol Sci12, 9236-9264. PubMed  Europe PubMed DOI  I
  74. Diaconu,N.C., Rummukainen,J., Naukkarinen,A., Matto,M., Harvima,R.J., Pelkonen,J. and Harvima,I.T.
    Mast cell chymase is present in uterine cervical carcinoma and it detaches viable and growing cervical squamous carcinoma cells from substratum in vitro
    Arch Dermatol Res303, 499-512. PubMed  Europe PubMed DOI
  75. Korkmaz,B., Jegot,G., Lau,L.C., Thorpe,M., Pitois,E., Juliano,L., Walls,A.F., Hellman,L. and Gauthier,F.
    Discriminating between the activities of human cathepsin G and chymase using fluorogenic substrates
    FEBS J278, 2635-2646. PubMed  Europe PubMed DOI  A  P
  76. Lo,H.Y., Nemoto,P.A., Kim,J.M., Hao,M.H., Qian,K.C., Farrow,N.A., Albaugh,D.R., Fowler,D.M., Schneiderman,R.D., Michael August,E., Martin,L., Hill-Drzewi,M., Pullen,S.S., Takahashi,H. and De Lombaert,S.
    Benzimidazolone as potent chymase inhibitor: modulation of reactive metabolite formation in the hydrophobic (P1) region
    Bioorg Med Chem Lett21, 4533-4539. PubMed  Europe PubMed DOI  I
  77. Oyamada,S., Bianchi,C., Takai,S., Chu,L.M. and Sellke,F.W.
    Chymase inhibition reduces infarction and matrix metalloproteinase-9 activation and attenuates inflammation and fibrosis after acute myocardial ischemia/reperfusion
    J Pharmacol Exp Ther339, 143-151. PubMed  Europe PubMed DOI  I
  78. Rafiq,K., Sherajee,S.J., Fan,Y.Y., Fujisawa,Y., Takahashi,Y., Matsuura,J., Hase,N., Urata,H., Nakano,D., Hitomi,H. and Nishiyama,A.
    Blood glucose level and survival in streptozotocin-treated human chymase transgenic mice
    Chin J Physiol54, 30-35. PubMed  Europe PubMed DOI
  79. Takai,S., Jin,D. and Miyazaki,M.
    Targets of chymase inhibitors
    Expert Opin Ther Targets15, 519-527. PubMed  Europe PubMed DOI  I
    80. 2010
  80. Andersson,M.K., Thorpe,M. and Hellman,L.
    Arg143 and Lys192 of the human mast cell chymase mediate the preference for acidic amino acids in position P2' of substrates
    FEBS J277, 2255-2267. PubMed  Europe PubMed DOI
  81. Gallwitz,M., Enoksson,M., Thorpe,M., Ge,X. and Hellman,L.
    The extended substrate recognition profile of the dog mast cell chymase reveals similarities and differences to the human chymase
    Int Immunol22, 421-431. PubMed  Europe PubMed DOI  P
  82. Kervinen,J., Crysler,C., Bayoumy,S., Abad,M.C., Spurlino,J., Deckman,I., Greco,M.N., Maryanoff,B.E. and de Garavilla,L.
    Potency variation of small-molecule chymase inhibitors across species
    Biochem Pharmacol80, 1033-1041. PubMed  Europe PubMed DOI  I
  83. Lang,Y.D., Chang,S.F., Wang,L.F. and Chen,C.M.
    Chymase mediates paraquat-induced collagen production in human lung fibroblasts
    Toxicol Lett193, 19-25. PubMed  Europe PubMed DOI
  84. Maeda,Y., Inoguchi,T., Takei,R., Sawada,F., Sasaki,S., Fujii,M., Kobayashi,K., Urata,H., Nishiyama,A. and Takayanagi,R.
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