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Literature for peptidase S01.140: chymase (Homo sapiens-type)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors Pharma

(Topics flags: A Assay, S Structure, T Target, K Knockout, P Specificity, E Expression, V Review, M Mutation, I Inhibitor, L Localization. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Pejler,G., Paivandy,A., Rabelo Melo,F., Allam,V.S.R.R., Oberg,A., Wen,Q., Bergsten,P. and Zhao,X.O.
    Mast Cell Chymase and Human Lung Fibroblast Interaction: Mechanisms and Implications for Asthma
    Inflammation (2026) 49 PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2025
  2. Chen,X., Guo,Y., Qing,Y., Li,R., Luo,H., Ieong,H.C., Guo,B., Huang,Z., Teng,Y., Li,R., Li,W., Chen,D., Cao,Y., Wang,W. and Zhou,C.
    Non-Syndromic Hereditary Gingival Fibromatosis Driven by Chymase Deficiency Is Attenuated by Verteporfin-Loaded Exosomes
    J Clin Periodontol (2025) PubMed  Europe PubMed DOI
    3. 2024
  3. Furstner,C., Ackerstaff,J., Meier,H., Straub,A., Mittendorf,J., Schamberger,J., Schafer,M., Borngen,K., Jorissen,H., Zubov,D., Zimmermann,K., Tersteegen,A., Geiss,V., Hartmann,E., Albrecht-Kupper,B., D'Orleans-Juste,P., Lapointe,C., Vincent,L., Heitmeier,S. and Tinel,H.
    Discovery and Preclinical Characterization of Fulacimstat (BAY 1142524), a Potent and Selective Chymase Inhibitor As a New Profibrinolytic Approach for Safe Thrombus Resolution
    J Med Chem (2024) PubMed  Europe PubMed DOI  I
    4. 2023
  4. Ferrario,C.M., Ahmad,S., Speth,R. and Dell'Italia,L.J.
    Is chymase 1 a therapeutic target in cardiovascular disease?
    Expert Opin Ther Targets (2023) 27, 645-656. PubMed  Europe PubMed DOI  PMC  EPMC  V
  5. Morales-Maldonado,A., Humphry,M., Figg,N. and Clarke,M.C.
    Human vascular smooth muscle cells utilise chymase for the atypical cleavage and activation of Interleukin-1beta
    Atherosclerosis (2023) , 117308-117308. PubMed  Europe PubMed DOI
  6. Yapijakis,C., Gintoni,I., Charalampidou,S., Angelopoulou,A., Papakosta,V., Vassiliou,S. and Chrousos,G.P.
    Angiotensinogen, Angiotensin-Converting Enzyme, and Chymase Gene Polymorphisms as Biomarkers for Basal Cell Carcinoma Susceptibility
    Adv Exp Med Biol (2023) 1423, 175-180. PubMed  Europe PubMed DOI
    7. 2022
  7. Fairhurst-Hunter,Z., Walters,R.G., Zink,A., Lin,K., Guo,Y., Yu,C., Lv,J., Li,L., Freitag,D.F., Chen,Z. and Millwood,I.Y.
    Investigation into the Health Effects of Reduced Chymase Function Using Predicted Loss-of-Function Mutations in CMA1
    J Cardiovasc Transl Res (2022) PubMed  Europe PubMed DOI
  8. Lind,T., Melo,F.R., Gustafson,A.M., Sundqvist,A., Zhao,X.O., Moustakas,A., Melhus,H. and Pejler,G.
    Mast cell chymase has a negative impact on human osteoblasts
    Matrix Biol (2022) 112, 1-19. PubMed  Europe PubMed DOI
  9. Zhang,N., Schumacher,A., Fink,B., Bauer,M., Zenclussen,A.C. and Meyer,N.
    Insights into Early-Pregnancy Mechanisms: Mast Cells and Chymase CMA1 Shape the Phenotype and Modulate the Functionality of Human Trophoblast Cells, Vascular Smooth-Muscle Cells and Endothelial Cells
    Cells (2022) 11 PubMed  Europe PubMed DOI  PMC  EPMC
    10. 2021
  10. Abassi,Z., Skorecki,K., Hamo-Giladi,D.B., Kruzel-Davila,E. and Heyman,S.N.
    Kinins and Chymase: The Forgotten Components of the Renin angiotensin system and their implications in COVID-19 Disease
    Am J Physiol Lung Cell Mol Physiol (2021) PubMed  Europe PubMed DOI
  11. Cruz-Lopez,E.O., Uijl,E. and Danser,A.H.J.
    Cardiac Angiotensin II Is Generated Locally by ACE and Not Chymase
    J Am Coll Cardiol (2021) 78, 540-541. PubMed  Europe PubMed DOI
  12. Fischer,A., Sellner,M., Mitusinska,K., Bzowka,M., Lill,M.A., Gora,A. and Smiesko,M.
    Computational Selectivity Assessment of Protease Inhibitors against SARS-CoV-2
    Int J Mol Sci (2021) 22 PubMed  Europe PubMed DOI  PMC  EPMC
  13. Zhao,X.O., Lampinen,M., Rollman,O., Sommerhoff,C.P., Paivandy,A. and Pejler,G.
    Mast cell chymase affects the functional properties of primary human airway fibroblasts: Implications for asthma
    J Allergy Clin Immunol (2021) PubMed  Europe PubMed DOI
    14. 2020
  14. Berglund,P., Akula,S., Fu,Z., Thorpe,M. and Hellman,L.
    Extended Cleavage Specificity of the Rat Vascular Chymase, a Potential Blood Pressure Regulating Enzyme Expressed by Rat Vascular Smooth Muscle Cells
    Int J Mol Sci (2020) 21 PubMed  Europe PubMed DOI  PMC  EPMC
  15. Dungen,H.D., Kim,R.J., Zahger,D., Orvin,K., Kornowski,R., Admon,D., Kettner,J., Shimony,A., Otto,C., Becka,M., Kanefendt,F., Romo,A.I., Hasin,T., Ostadal,P., Rojas,G.C. and Senni,M.
    Effects of the chymase inhibitor fulacimstat on adverse cardiac remodeling after acute myocardial infarction: results of the chymase inhibitor in adverse remodeling after myocardial infarction (CHIARA MIA) 2 trial
    Am Heart J (2020) 224, 129-137. PubMed  Europe PubMed DOI  I
  16. Ferrario,C.M., Groban,L., Wang,H., Cheng,C.P., VonCannon,J.L., Wright,K.N., Sun,X. and Ahmad,S.
    The Angiotensin-(1-12)/Chymase axis as an alternate component of the tissue renin angiotensin system
    Mol Cell Endocrinol (2020) , 111119-111119. PubMed  Europe PubMed DOI
  17. Li,C.Y., Yap,K., Swedberg,J.E., Craik,D.J. and de Veer,S.J.
    Binding loop substitutions in the cyclic peptide SFTI-1 generate potent and selective chymase inhibitors
    J Med Chem (2020) 63, 816-826. PubMed  Europe PubMed DOI
  18. Rathore,A.P.S., Senanayake,M., Athapathu,A.S., Gunasena,S., Karunaratna,I., Leong,W.Y., Lim,T., Mantri,C.K., Wilder-Smith,A. and St John,A.L.
    Serum chymase levels correlate with severe dengue warning signs and clinical fluid accumulation in hospitalized pediatric patients
    Sci Rep (2020) 10, 11856-11856. PubMed  Europe PubMed DOI  PMC  EPMC
  19. Sahu,A.K., Aggarwal,P., Ekka,M., Nayer,J., Bhoi,S., Kumar,A. and Luthra,K.
    Assessing the Serum Chymase Level as an Early Predictor of Dengue Severity
    J Med Virol (2020) PubMed  Europe PubMed DOI
  20. Vibhushan,S., Bratti,M., Montero-Hernandez,J.E., El Ghoneimi,A., Benhamou,M., Charles,N., Daugas,E. and Blank,U.
    Mast Cell Chymase and Kidney Disease
    Int J Mol Sci (2020) 22 PubMed  Europe PubMed DOI  PMC  EPMC  V
    21. 2019
  21. Ahmad,S., Wright,K.N., Sun,X., Groban,L. and Ferrario,C.M.
    Mast cell peptidases (carboxypeptidase A and chymase)-mediated hydrolysis of human angiotensin-(1-12) substrate
    Biochem Biophys Res Commun (2019) 518, 651-656. PubMed  Europe PubMed DOI
  22. Bivona,B.J., Takai,S., Seth,D.M., Satou,R. and Harrison-Bernard,L.M.
    Chymase inhibition retards albuminuria in type 2 diabetes
    Physiol Rep (2019) 7, e14302-e14302. PubMed  Europe PubMed DOI  PMC  EPMC  I
  23. Fu,Z., Akula,S., Thorpe,M., Chahal,G., de Garavilla,L., Kervinen,J. and Hellman,L.
    Extended cleavage specificity of sheep mast cell protease-2: a classical chymase with preference to aromatic P1 substrate residues
    Dev Comp Immunol (2019) 92, 160-169. PubMed  Europe PubMed DOI  P
  24. Fu,Z., Akula,S., Thorpe,M. and Hellman,L.
    Highly selective cleavage of TH2-promoting cytokines by the human and the mouse mast cell tryptases, indicating a potent negative feedback loop on TH2 immunity
    Int J Mol Sci (2019) 20 PubMed  Europe PubMed DOI  P
  25. Jin,D., Takai,S., Nonaka,Y., Yamazaki,S., Fujiwara,M. and Nakamura,Y.
    A chymase inhibitory RNA aptamer improves cardiac function and survival after myocardial infarction
    Mol Ther Nucleic Acids (2019) 14, 41-51. PubMed  Europe PubMed DOI  PMC  EPMC  I
  26. Kanefendt,F., Thuss,U., Becka,M., Boxnick,S., Berse,M., Schultz,A. and Otto,C.
    Pharmacokinetics, safety, and tolerability of the novel chymase inhibitor BAY 1142524 in healthy male volunteers
    Clin Pharmacol Drug Dev (2019) 8, 467-479. PubMed  Europe PubMed DOI  I
  27. Lipitsa,T., Siiskonen,H., Naukkarinen,A. and Harvima,I.T.
    Mast cell chymase degrades fibrinogen and fibrin
    Br J Dermatol (2019) 181, 296-303. PubMed  Europe PubMed DOI
  28. Ozawa,S.I., Takahashi,M., Yamaotsu,N. and Hirono,S.
    Structure-based virtual screening for novel chymase inhibitors by in silico fragment mapping
    J Mol Graph Model (2019) 89, 102-108. PubMed  Europe PubMed DOI  I
  29. Tomimori,Y., Manno,A., Tanaka,T., Futamura-Takahashi,J., Muto,T. and Nagahira,K.
    ASB17061, a novel chymase inhibitor, prevented the development of angiotensin II-induced abdominal aortic aneurysm in apolipoprotein E-deficient mice
    Eur J Pharmacol (2019) 856, 172403-172403. PubMed  Europe PubMed DOI  I
    30. 2018
  30. Ahmad,S. and Ferrario,C.M.
    Chymase inhibitors for the treatment of cardiac diseases: a patent review (2010-2018)
    Expert Opin Ther Pat (2018) 28, 755-764. PubMed  Europe PubMed DOI  I
  31. Ansary,T.M., Urushihara,M., Fujisawa,Y., Nagata,S., Urata,H., Nakano,D., Hirofumi,H., Kitamura,K., Kagami,S. and Nishiyama,A.
    Effects of the selective chymase inhibitor TEI-F00806 on the intrarenal renin-angiotensin system in salt-treated angiotensin I-infused hypertensive mice
    Exp Physiol (2018) 103, 1524-1531. PubMed  Europe PubMed DOI  I
  32. Dell'Italia,L.J., Collawn,J.F. and Ferrario,C.M.
    Multifunctional role of chymase in acute and chronic tissue injury and remodeling
    Circ Res (2018) 122, 319-336. PubMed  Europe PubMed DOI  PMC  EPMC  V
  33. Dubey,A., Dotolo,S., Ramteke,P.W., Facchiano,A. and Marabotti,A.
    Searching for chymase inhibitors among chamomile compounds using a computational-based approach
    Biomolecules (2018) 9 PubMed  Europe PubMed DOI  I
  34. Futamura-Takahashi,J., Tanaka,T., Sugawara,H., Iwashita,S., Imajo,S., Oyama,Y. and Muto,T.
    Structure-based design, synthesis, and binding mode analysis of novel and potent chymase inhibitors
    Bioorg Med Chem Lett (2018) 28, 188-192. PubMed  Europe PubMed DOI  I
  35. Kareinen,I., Baumann,M., Nguyen,S.D., Maaninka,K., Anisimov,A., Tozuka,M., Jauhiainen,M., Lee-Rueckert,M. and Kovanen,P.T.
    Chymase released from hypoxia-activated cardiac mast cells cleaves human apoA-I at Tyr(192) and compromises its cardioprotective activity
    J Lipid Res (2018) 59, 945-957. PubMed  Europe PubMed DOI
  36. Zhang,H., Wang,J., Wang,L., Zhan,M., Li,S., Fang,Z., Xu,C., Zheng,Y. and He,S.
    Induction of mast cell accumulation by chymase via an enzymatic activity- and intercellular adhesion molecule-1-dependent mechanism
    Br J Pharmacol (2018) 175, 678-692. PubMed  Europe PubMed DOI
    37. 2017
  37. Froogh,G., Pinto,J.T., Le,Y., Kandhi,S., Aleligne,Y., Huang,A. and Sun,D.
    Chymase-dependent production of angiotensin II: an old enzyme in old hearts
    Am J Physiol Heart Circ Physiol (2017) 312, H223-H231. PubMed  Europe PubMed DOI
  38. Fu,Z., Thorpe,M., Alemayehu,R., Roy,A., Kervinen,J., de Garavilla,L., Abrink,M. and Hellman,L.
    Highly selective cleavage of cytokines and chemokines by the human mast cell chymase and neutrophil cathepsin G
    J Immunol (2017) 198, 1474-1483. PubMed  Europe PubMed DOI  P
  39. Grujic,M., Paivandy,A., Gustafson,A.M., Thomsen,A.R., Ohrvik,H. and Pejler,G.
    The combined action of mast cell chymase, tryptase and carboxypeptidase A3 protects against melanoma colonization of the lung
    Oncotarget (2017) 8, 25066-25079. PubMed  Europe PubMed DOI
  40. Gu,Y., Lewis,D.F., Alexander,J.S. and Wang,Y.
    Upregulation of cathepsin C expression contributes to endothelial chymase activation in preeclampsia
    Hypertens Res (2017) 40, 976-981. PubMed  Europe PubMed DOI
  41. Reyes,S., Varagic,J., Ahmad,S., VonCannon,J., Kon,N.D., Wang,H., Groban,L., Cheng,C.P., Dell'Italia,L.J. and Ferrario,C.M.
    Novel cardiac intracrine mechanisms based on Ang-(1-12)/chymase axis require a revision of therapeutic approaches in human heart disease
    Curr Hypertens Rep (2017) 19, 16-16. PubMed  Europe PubMed DOI
  42. Shubin,N.J., Glukhova,V.A., Clauson,M., Truong,P., Abrink,M., Pejler,G., White,N.J., Deutsch,G.H., Reeves,S.R., Vaisar,T., James,R.G. and Piliponsky,A.M.
    Proteome analysis of mast cell releasates reveals a role for chymase in the regulation of coagulation factor XIIIA levels via proteolytic degradation
    J Allergy Clin Immunol (2017) 139, 323-334. PubMed  Europe PubMed DOI
  43. Stevens,R.L., McNeil,H.P., Wensing,L.A., Shin,K., Wong,G.W., Hansbro,P.M. and Krilis,S.A.
    Experimental arthritis is dependent on mouse mast cell protease-5
    J Biol Chem (2017) 292, 5392-5404. PubMed  Europe PubMed DOI  K
  44. Verma,S., Singh,A., Kumari,A., Goyal,S., Jamal,S., Sinha,S. and Grover,A.
    Dissecting the role of mutations in chymase inhibition: free energy and decomposition analysis
    Gene (2017) 609, 68-79. PubMed  Europe PubMed DOI  M
    45. 2016
  45. Dubey,A., Marabotti,A., Ramteke,P.W. and Facchiano,A.
    Interaction of human chymase with ginkgolides, terpene trilactones of Ginkgo biloba investigated by molecular docking simulations
    Biochem Biophys Res Commun (2016) 473, 449-454. PubMed  Europe PubMed DOI  I
  46. Dubey,A., Facchiano,A., Ramteke,P.W. and Marabotti,A.
    In silico approach to find chymase inhibitors among biogenic compounds
    Future Med Chem (2016) 8, 841-851. PubMed  Europe PubMed DOI  I
  47. Sansoe,G., Aragno,M., Mastrocola,R., Mengozzi,G., Novo,E. and Parola,M.
    Role of chymase in the development of liver cirrhosis and its complications: experimental and human data
    PLoS ONE (2016) 11, e0162644-e0162644. PubMed  Europe PubMed DOI  PMC  EPMC  I
  48. Takai,S. and Jin,D.
    Improvement of cardiovascular remodelling by chymase inhibitor
    Clin Exp Pharmacol Physiol (2016) 43, 387-393. PubMed  Europe PubMed DOI  I
  49. Zhang,M., Huang,W., Bai,J., Nie,X. and Wang,W.
    Chymase inhibition protects diabetic rats from renal lesions
    Mol Med Rep (2016) 14, 121-128. PubMed  Europe PubMed DOI  I
  50. Zhang,R., Zhang,C.J., Feng,G., Hu,F., Wang,J. and Liu,B.
    Specific light-up probe with aggregation-induced emission for facile detection of chymase
    Anal Chem (2016) 88, 9111-9117. PubMed  Europe PubMed DOI  L
    51. 2015
  51. Arooj,M., Sakkiah,S., Cao,G.P., Kim,S., Arulalapperumal,V. and Lee,K.W.
    Finding off-targets, biological pathways, and target diseases for chymase inhibitors via structure-based systems biology approach
    Proteins (2015) 83, 1209-1224. PubMed  Europe PubMed DOI  I
  52. Devarajan,S., Yahiro,E., Uehara,Y., Habe,S., Nishiyama,A., Miura,S., Saku,K. and Urata,H.
    Depressor effect of chymase inhibitor in mice with high salt-induced moderate hypertension
    Am J Physiol Heart Circ Physiol (2015) 309, H1987-H1996. PubMed  Europe PubMed DOI  I
  53. Semaan,W., Desbiens,L., Houde,M., Labonte,J., Gagnon,H., Yamamoto,D., Takai,S., Laidlaw,T., Bkaily,G., Schwertani,A., Pejler,G., Levesque,C., Desjardins,R., Day,R. and D'Orleans-Juste,P.
    Chymase inhibitor-sensitive synthesis of endothelin-1 (1-31) by recombinant mouse mast cell protease 4 and human chymase
    Biochem Pharmacol (2015) 94, 91-100. PubMed  Europe PubMed DOI  I
  54. Wang,R., Chen,J., Zhang,Z. and Cen,Y.
    Role of chymase in the local renin-angiotensin system in keloids: inhibition of chymase may be an effective therapeutic approach to treat keloids
    Drug Des Devel Ther (2015) 9, 4979-4988. PubMed  Europe PubMed DOI  PMC  EPMC  T
    55. 2014
  55. Ahmad,S., Varagic,J., Groban,L., Dell'Italia,L.J., Nagata,S., Kon,N.D. and Ferrario,C.M.
    Angiotensin-(1-12): a chymase-mediated cellular angiotensin II substrate
    Curr Hypertens Rep (2014) 16, 429-429. PubMed  Europe PubMed DOI
  56. Fei,X., Yuan,Y., Lee,Y.-M., Jeong,K.W. and Seo,S.-Y.
    Synthesis, biological evaluation of SPF-32629A-based 2- and 4-pyridone analogs as chymase inhibitors
    Bull Korean Chem Soc (2014) 35, 2547-2550. DOI  I
  57. Lysvand,H., Hagen,L., Klubicka,L., Slupphaug,G. and Iversen,O.J.
    Psoriasis pathogenesis - Pso p27 is generated from SCCA1 with chymase
    Biochim Biophys Acta (2014) 1842, 734-738. PubMed  Europe PubMed DOI
  58. Rafiq,K., Fan,Y.Y., Sherajee,S.J., Takahashi,Y., Matsuura,J., Hase,N., Mori,H., Nakano,D., Kobara,H., Hitomi,H., Masaki,T., Urata,H. and Nishiyama,A.
    Chymase activities and survival in endotoxin-induced human chymase transgenic mice
    Int J Med Sci (2014) 11, 222-225. PubMed  Europe PubMed DOI  PMC  EPMC
  59. Smith,E.T., Perry,E.T., Sears,M.B. and Johnson,D.A.
    Expression of recombinant human mast cell chymase with Asn-linked glycans in glycoengineered Pichia pastoris
    Protein Expr Purif (2014) 102, 69-75. PubMed  Europe PubMed DOI  E
    60. 2013
  60. Ahooghalandari,P., Hanke,N., Thorpe,M., Witte,A., Messinger,J. and Hellman,L.
    Mutations in Arg143 and Lys192 of the human mast cell chymase markedly affect the activity of five potent human chymase inhibitors
    PLoS ONE (2013) 8, e65988-e65988. PubMed  Europe PubMed DOI  PMC  EPMC  I
  61. Arooj,M., Kim,S., Sakkiah,S., Cao,G.P., Lee,Y. and Lee,K.W.
    Molecular modeling study for inhibition mechanism of human chymase and its application in inhibitor design
    PLoS ONE (2013) 8, e62740-e62740. PubMed  Europe PubMed DOI  PMC  EPMC  I
  62. Matsumoto,Y., Kakuda,S., Koizumi,M., Mizuno,T., Muroga,Y., Kawamura,T. and Takimoto-Kamimura,M.
    Crystal structure of a complex of human chymase with its benzimidazole derived inhibitor
    J Synchrotron Radiat (2013) 20, 914-918. PubMed  Europe PubMed DOI  PMC  EPMC  S  I
  63. Tanaka,T., Sugawara,H., Maruoka,H., Imajo,S. and Muto,T.
    Discovery of novel series of 6-benzyl substituted 4-aminocarbonyl-1,4-diazepane-2,5-diones as human chymase inhibitors using structure-based drug design
    Bioorg Med Chem (2013) 21, 4233-4249. PubMed  Europe PubMed DOI  I
  64. Taylor,S.J., Padyana,A.K., Abeywardane,A., Liang,S., Hao,M.H., De Lombaert,S., Proudfoot,J., Farmer,B.S., III, Li,X., Collins,B., Martin,L., Albaugh,D.R., Hill-Drzewi,M., Pullen,S.S. and Takahashi,H.
    Discovery of potent, selective chymase inhibitors via fragment linking strategies
    J Med Chem (2013) 56, 4465-4481. PubMed  Europe PubMed DOI  I
  65. Wu,Y., Yang,H., Yang,B., Yang,K. and Xiao,C.
    Association of polymorphisms in prolylcarboxypeptidase and chymase genes with essential hypertension in the Chinese Han population
    J Renin Angiotensin Aldosterone Syst (2013) 14, 263-270. PubMed  Europe PubMed DOI  M
  66. Yahiro,E., Miura,S., Imaizumi,S., Uehara,Y. and Saku,K.
    Chymase inhibitors
    Curr Pharm Des (2013) 19, 3065-3071. PubMed  Europe PubMed DOI  I
    67. 2012
  67. Campbell,D.J.
    Angiotensin II generation in vivo: does it involve enzymes other than renin and angiotensin-converting enzyme?
    J Renin Angiotensin Aldosterone Syst (2012) 13, 314-316. PubMed  Europe PubMed DOI
  68. Caughey,G.H.
    Chymases
    [ISSN:978-0-12-407742-3] (2012) 3, 2675-2683. DOI
  69. Heuston,S. and Hyland,N.
    Chymase inhibition as a pharmacological target: a role in inflammatory and functional gastrointestinal disorders?
    Br J Pharmacol (2012) 167, 732-740. PubMed  Europe PubMed DOI  V
  70. Maeda,Y., Inoguchi,T., Takei,R., Hendarto,H., Ide,M., Inoue,T., Kobayashi,K., Urata,H., Nishiyama,A. and Takayanagi,R.
    Chymase inhibition prevents myocardial fibrosis through the attenuation of NOX4-associated oxidative stress in diabetic hamsters
    J Diabetes Investig (2012) 3, 354-361. PubMed  Europe PubMed DOI  PMC  EPMC  I
  71. Parlee,S.D., McNeil,J.O., Muruganandan,S., Sinal,C.J. and Goralski,K.B.
    Elastase and tryptase govern TNFalpha-mediated production of active chemerin by adipocytes
    PLoS ONE (2012) 7, e51072-e51072. PubMed  Europe PubMed DOI  PMC  EPMC
  72. Takai,S., Jin,D. and Miyazaki,M.
    Multiple mechanisms for the action of chymase inhibitors
    J Pharmacol Sci (2012) 118, 311-316. PubMed  Europe PubMed DOI  I
  73. Thorpe,M., Yu,J., Boinapally,V., Ahooghalandari,P., Kervinen,J., Garavilla,L. and Hellman,L.
    Extended cleavage specificity of the mast cell chymase from the crab-eating macaque (Macaca fascicularis): an interesting animal model for the analysis of the function of the human mast cell chymase
    Int Immunol (2012) 24, 771-782. PubMed  Europe PubMed DOI  P
    74. 2011
  74. Ahmad,S., Simmons,T., Varagic,J., Moniwa,N., Chappell,M.C. and Ferrario,C.M.
    Chymase-dependent generation of angiotensin II from angiotensin-(1-12) in human atrial tissue
    PLoS ONE (2011) 6, e28501-e28501. PubMed  Europe PubMed DOI  PMC  EPMC  I
  75. Arooj,M., Thangapandian,S., John,S., Hwang,S., Park,J.K. and Lee,K.W.
    3D QSAR pharmacophore modeling, in silico screening, and density functional theory (DFT) approaches for identification of human chymase inhibitors
    Int J Mol Sci (2011) 12, 9236-9264. PubMed  Europe PubMed DOI  PMC  EPMC  I
  76. Diaconu,N.C., Rummukainen,J., Naukkarinen,A., Matto,M., Harvima,R.J., Pelkonen,J. and Harvima,I.T.
    Mast cell chymase is present in uterine cervical carcinoma and it detaches viable and growing cervical squamous carcinoma cells from substratum in vitro
    Arch Dermatol Res (2011) 303, 499-512. PubMed  Europe PubMed DOI
  77. Korkmaz,B., Jegot,G., Lau,L.C., Thorpe,M., Pitois,E., Juliano,L., Walls,A.F., Hellman,L. and Gauthier,F.
    Discriminating between the activities of human cathepsin G and chymase using fluorogenic substrates
    FEBS J (2011) 278, 2635-2646. PubMed  Europe PubMed DOI  A  P
  78. Lo,H.Y., Nemoto,P.A., Kim,J.M., Hao,M.H., Qian,K.C., Farrow,N.A., Albaugh,D.R., Fowler,D.M., Schneiderman,R.D., Michael August,E., Martin,L., Hill-Drzewi,M., Pullen,S.S., Takahashi,H. and De Lombaert,S.
    Benzimidazolone as potent chymase inhibitor: modulation of reactive metabolite formation in the hydrophobic (P1) region
    Bioorg Med Chem Lett (2011) 21, 4533-4539. PubMed  Europe PubMed DOI  I
  79. Oyamada,S., Bianchi,C., Takai,S., Chu,L.M. and Sellke,F.W.
    Chymase inhibition reduces infarction and matrix metalloproteinase-9 activation and attenuates inflammation and fibrosis after acute myocardial ischemia/reperfusion
    J Pharmacol Exp Ther (2011) 339, 143-151. PubMed  Europe PubMed DOI  I
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