Structure for peptidase M24.001: methionyl aminopeptidase 1 (Escherichia-type)

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

PDB	Organism	Resolution	Comment
1MAT	Escherichia coli	2.40 Å	mature
The catalytic cobalt ions are shown as light grey CPK spheres. The cobalt ligands are shown in ball-and-stick representation: Asp97 and Asp108 in light pink, His171 in purple, and Glu204 and Glu235 in dark blue. The catalytic His79 is shown in ball-and-stick representation in purple.

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TERTIARY STRUCTURE DATA
Comment	Resolution	PDB	PDBe	SCOP	CATH	PDBSum	Proteopedia	Reference
Escherichia coli
complex with methionine	1.80 Å	1C21	1C21	1C21	1C21	1C21	1C21	Lowther et al., 1999
complex with trifluoromethionine	1.75 Å	1C22	1C22	1C22	1C22	1C22	1C22	Lowther et al., 1999
complex with methionine phosphonate	2.00 Å	1C23	1C23	1C23	1C23	1C23	1C23	Lowther et al., 1999
complex with methionine phosphinate	1.70 Å	1C24	1C24	1C24	1C24	1C24	1C24	Lowther et al., 1999
complex with norleucine phosphonate	1.95 Å	1C27	1C27	1C27	1C27	1C27	1C27	Lowther et al., 1999
mature peptidase	2.40 Å	1MAT	1MAT	1MAT	1MAT	1MAT	1MAT	Roderick & Matthews, 1993
complex with 5-(2-chlorophenyl)furan-2-carboxylic acid	1.52 Å	1XNZ	1XNZ	1XNZ	1XNZ	1XNZ	1XNZ	Ye et al., 2004
mature peptidase	1.60 Å	1YVM	1YVM	1YVM	1YVM	1YVM	1YVM	Schiffmann et al., 2005
mature peptidase	1.70 Å	2BB7	2BB7	2BB7	2BB7	2BB7	2BB7	Huang et al., 2006
complex with 5-(2-(trifluoromethyl)phenyl)furan-2- carboxylic acid	1.60 Å	2EVC	2EVC	2EVC	2EVC	2EVC	2EVC	Xie et al., 2006
complex with 5-(2,5-dichlorophenyl)furan-2-carboxylic acid	1.70 Å	2EVM	2EVM	2EVM	2EVM	2EVM	2EVM	Xie et al., 2006
complex with n-cyclopentyl-n-(thiazol-2-yl)oxalamide	1.70 Å	2EVO	2EVO	2EVO	2EVO	2EVO	2EVO	Xie et al., 2006
novel bacterial methionine aminopeptidase inhibitors	1.28 Å	2GG0	2GG0	2GG0	2GG0	2GG0	2GG0	Evdokimov et al., 2007
novel bacterial methionine aminopeptidase inhibitors	1.00 Å	2GG2	2GG2	2GG2	2GG2	2GG2	2GG2	Evdokimov et al., 2007
novel bacterial methionine aminopeptidase inhibitors	1.45 Å	2GG3	2GG3	2GG3	2GG3	2GG3	2GG3	Evdokimov et al., 2007
novel bacterial methionine aminopeptidase inhibitors	2.12 Å	2GG5	2GG5	2GG5	2GG5	2GG5	2GG5	Evdokimov et al., 2007
novel bacterial methionine aminopeptidase inhibitors	1.12 Å	2GG7	2GG7	2GG7	2GG7	2GG7	2GG7	Evdokimov et al., 2007
novel bacterial methionine aminopeptidase inhibitors	1.80 Å	2GG8	2GG8	2GG8	2GG8	2GG8	2GG8	Evdokimov et al., 2007
novel bacterial methionine aminopeptidase inhibitors	1.05 Å	2GG9	2GG9	2GG9	2GG9	2GG9	2GG9	Evdokimov et al., 2007
novel bacterial methionine aminopeptidase inhibitors	2.13 Å	2GGB	2GGB	2GGB	2GGB	2GGB	2GGB	Evdokimov et al., 2007
novel bacterial methionine aminopeptidase inhibitors	1.00 Å	2GGC	2GGC	2GGC	2GGC	2GGC	2GGC	Evdokimov et al., 2007
structural basis of catalysis by mononuclear methionine aminopeptidase	2.00 Å	2GTX	2GTX	2GTX	2GTX	2GTX	2GTX	Ye et al., 2006
complex with nlep, 1: 0.5, di-metalated	1.80 Å	2GU4	2GU4	2GU4	2GU4	2GU4	2GU4	Ye et al., 2006
complex with nlep, 1: 1, di-metalated	1.60 Å	2GU5	2GU5	2GU5	2GU5	2GU5	2GU5	Ye et al., 2006
complex with nlep, 1: 2, di-metalated	1.70 Å	2GU6	2GU6	2GU6	2GU6	2GU6	2GU6	Ye et al., 2006
e. coli methionine aminopeptidase unliganded, 1:0.5	2.00 Å	2GU7	2GU7	2GU7	2GU7	2GU7	2GU7	Ye et al., 2006
mature peptidase	1.90 Å	2MAT	2MAT	2MAT	2MAT	2MAT	2MAT	Lowther et al., 1999
complex with inhibitor YE7	0.00 Å	2P98	2P98	2P98	2P98	2P98	2P98	Huang et al., 2007
complex with inhibitor YE6	0.00 Å	2P99	2P99	2P99	2P99	2P99	2P99	Huang et al., 2007
complex with inhibitor YE6	0.00 Å	2P9A	2P9A	2P9A	2P9A	2P9A	2P9A	Huang et al., 2007
e. coli methionine aminopeptidase mn-form with inhibitor b23	1.90 Å	2Q92	2Q92	2Q92	2Q92	2Q92	2Q92	Ma et al., 2007
e. coli methionine aminopeptidase mn-form with inhibitor b21	1.60 Å	2Q93	2Q93	2Q93	2Q93	2Q93	2Q93	Ma et al., 2007
e. coli methionine aminopeptidase mn-form with inhibitor a04	1.63 Å	2Q94	2Q94	2Q94	2Q94	2Q94	2Q94	Ma et al., 2007
e. coli methionine aminopeptidase mn-form with inhibitor a05	1.70 Å	2Q95	2Q95	2Q95	2Q95	2Q95	2Q95	Ma et al., 2007
e. coli methionine aminopeptidase mn-form with inhibitor a18	1.60 Å	2Q96	2Q96	2Q96	2Q96	2Q96	2Q96	Ma et al., 2007
e. coli methionine aminopeptidase with fe inhibitor w29	2.20 Å	3D27	3D27	3D27	3D27	3D27	3D27	Wang et al., 2008
Arg175Gln mutant; complex with amino-hydroxyheptanyl-Ala-Leu-Val-Phe	2.00 Å	3MAT	3MAT	3MAT	3MAT	3MAT	3MAT	Lowther et al., 1999
x-ray structures of oxazole hydroxamate ecmetap-mn complexes	1.46 Å	4A6V	4A6V	4A6V	4A6V	4A6V	4A6V
x-ray structures of oxazole hydroxamate ecmetap-mn complexes	1.46 Å	4A6W	4A6W	4A6W	4A6W	4A6W	4A6W
His79Ala mutant	2.00 Å	4MAT	4MAT	4MAT	4MAT	4MAT	4MAT	Lowther et al., 1999
e. coli methionine aminopeptidase in complex with inhibitor 7-methoxy-2-methylen-3,4-dihydronaphthalen-1(2h)-one	1.54 Å	4PNC	4PNC	4PNC	4PNC	4PNC	4PNC
novel inhibitors of bacterial methionine aminopeptidase with broad- spectrum biochemical activity	1.43 Å	4Z7M	4Z7M	4Z7M	4Z7M	4Z7M	4Z7M
e. coli methionine aminopeptidase crystal structure fitted into the cryo-em density map of e. coli 70s ribosome in complex with methionine aminopeptidase	11.80 Å	6IZ7	6IZ7	6IZ7	6IZ7	6IZ7	6IZ7
crystal structure of e. coli peptide deformylase and methionine aminopeptidase fitted into the cryo-em density map of the complex	11.80 Å	6IZI	6IZI	6IZI	6IZI	6IZI	6IZI
crystal structure of e. coli methionine aminopeptidase enzyme and chaperone trigger factor fitted into the cryo-em density map of the complex	14.20 Å	6J0A	6J0A	6J0A	6J0A	6J0A	6J0A
Pseudomonas aeruginosa
pseudomonas aeruginosa metap, in mn form	1.80 Å	4FO7	4FO7	4FO7	4FO7	4FO7	4FO7
pseudomonas aeruginosa metap with met, in mn form	1.90 Å	4FO8	4FO8	4FO8	4FO8	4FO8	4FO8
pseudomonas aeruginosa metap t2n mutant, in mn form	2.20 Å	4JUQ	4JUQ	4JUQ	4JUQ	4JUQ	4JUQ
Rickettsia prowazekii
mature peptidase	2.00 Å	3MR1	3MR1	3MR1	3MR1	3MR1	3MR1
mature peptidase	1.70 Å	3MX6	3MX6	3MX6	3MX6	3MX6	3MX6