Structure for peptidase M10.008: matrix metallopeptidase-7

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

 

PDB Organism Resolution Comment
1MMQ Homo sapiens 1.90 Å complex with N4-hydroxy-2-isobutyl-N1-(9-oxo-1,8-diaza-tricyclo[10.6.1.013,18]nonadeca-12(19),13,15,17-tetraen-10-yl)-succinamide
The catalytic zinc is shown as a light grey CPK sphere. Structural calcium ions are shown as yellow CPK spheres. The zinc ligands are shown in ball-and-stick representation: His214, His218 and His224 in purple. The catalytic Glu215 is shown in blue. Bound inhibitor is shown in grey in ball-and-stick representation.
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TERTIARY STRUCTURE DATA
Comment Resolution PDB PDBe SCOP CATH PDBSum Proteopedia Reference
Homo sapiens
complex with 5-methyl-3-(9-oxo-1,8-diaza-tricyclo[10.6.1.013,18]nonadeca-12(19),13,15,17-tetraen-10-ylcarbamoyl)-hexanoic acid 2.30 Å 1MMP 1MMP 1MMP 1MMP 1MMP 1MMP Browner et al., 1995
complex with N4-hydroxy-2-isobutyl-N1-(9-oxo-1,8-diaza-tricyclo[10.6.1.013,18]nonadeca-12(19),13,15,17-tetraen-10-yl)-succinamide 1.90 Å 1MMQ 1MMQ 1MMQ 1MMQ 1MMQ 1MMQ Browner et al., 1995
complex with 4-methyl-3-(9-oxo-1,8-diaza-tricyclo[10.6.1.0(13,18)]nonadeca-12(19),13(18),15,17-tetraene-10-carbamoyl)penta-methylsulfonediimine 2.30 Å 1MMR 1MMR 1MMR 1MMR 1MMR 1MMR Browner et al., 1995
mature  peptidase 0.00 Å 2DDY 2DDY 2DDY 2DDY 2DDY 2DDY
mature  peptidase 0.00 Å 2MZE 2MZE 2MZE 2MZE 2MZE 2MZE
mature  peptidase 0.00 Å 2MZH 2MZH 2MZH 2MZH 2MZH 2MZH
mature  peptidase 1.70 Å 2Y6C 2Y6C 2Y6C 2Y6C 2Y6C 2Y6C Edman et al., 2011
mature  peptidase 1.60 Å 2Y6D 2Y6D 2Y6D 2Y6D 2Y6D 2Y6D Edman et al., 2011