PDBe 2y6d

X-ray diffraction
1.6Å resolution

The Discovery of MMP7 Inhibitors Exploiting a Novel Selectivity Trigger

Released:

Function and Biology Details

Reaction catalysed:
Cleavage of 14-Ala-|-Leu-15 and 16-Tyr-|-Leu-17 in B chain of insulin. No action on collagen types I, II, IV, V. Cleaves gelatin chain alpha-2(I) > alpha-1(I).
Biochemical function:
  • not assigned
Biological process:
  • not assigned
Cellular component:
  • not assigned

Structure analysis Details

Assembly composition:
homo tetramer (preferred)
Entry contents:
1 distinct polypeptide molecule
Macromolecule:
Matrilysin Chain: A
Molecule details ›
Chain: A
Length: 174 amino acids
Theoretical weight: 19.21 KDa
Source organism: Homo sapiens
Expression system: Escherichia coli
UniProt:
  • Canonical: P09237 (Residues: 95-267; Coverage: 69%)
Gene names: MMP7, MPSL1, PUMP1
Sequence domains: Matrixin
Structure domains: Collagenase (Catalytic Domain)

Ligands and Environments


No modified residues

Experiments and Validation Details

Entry percentile scores
X-ray source: ESRF
Spacegroup: I4
Unit cell:
a: 76.59Å b: 76.59Å c: 60.924Å
α: 90° β: 90° γ: 90°
R-values:
R R work R free
0.197 0.196 0.216
Expression system: Escherichia coli