Structure for peptidase C18.001: hepatitis C virus peptidase 2

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

PDB	Organism	Resolution	Comment
2HD0	hepatitis C virus	2.28 Å	catalytic domain of the NS2 protein only
One homodimer is shown. Catalytic residues are shown in ball-and-stick representation for each monomer: His952 in purple, Glu972 in blue and Cys993 in yellow.

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TERTIARY STRUCTURE DATA
Comment	Resolution	PDB	PDBe	SCOP	CATH	PDBSum	Proteopedia	Reference
hepatitis C virus
mature peptidase	2.50 Å	2A4G	2A4G	2A4G	2A4G	2A4G	2A4G	Arasappan et al., 2005
mature peptidase	2.50 Å	2GVF	2GVF	2GVF	2GVF	2GVF	2GVF	Arasappan et al., 2006
catalytic domain of the NS2 protein only	2.28 Å	2HD0	2HD0	2HD0	2HD0	2HD0	2HD0	Lorenz et al., 2006
mature peptidase	1.55 Å	3HKW	3HKW	3HKW	3HKW	3HKW	3HKW	Nyanguile et al., 2010
mature peptidase	2.30 Å	3KN2	3KN2	3KN2	3KN2	3KN2	3KN2	Nair et al., 2010
avoiding drug resistance against hcv ns3/4a protease inhibitors	1.70 Å	3M5M	3M5M	3M5M	3M5M	3M5M	3M5M
visualizing atp-dependent rna translocation by the ns3 helicase from hcv	1.95 Å	3O8B	3O8B	3O8B	3O8B	3O8B	3O8B
visualizing atp-dependent rna translocation by the ns3 helicase from hcv	2.00 Å	3O8C	3O8C	3O8C	3O8C	3O8C	3O8C
visualizing atp-dependent rna translocation by the ns3 helicase from hcv	2.05 Å	3O8D	3O8D	3O8D	3O8D	3O8D	3O8D
visualizing atp-dependent rna translocation by the ns3 helicase from hcv	2.30 Å	3O8R	3O8R	3O8R	3O8R	3O8R	3O8R
mature peptidase	2.14 Å	3QGH	3QGH	3QGH	3QGH	3QGH	3QGH	Gentles et al., 2011
mature peptidase	1.80 Å	3QGI	3QGI	3QGI	3QGI	3QGI	3QGI	Gentles et al., 2011
mature peptidase	1.50 Å	3RC4	3RC4	3RC4	3RC4	3RC4	3RC4	Romano et al., 2011
mature peptidase	1.60 Å	3RC5	3RC5	3RC5	3RC5	3RC5	3RC5	Romano et al., 2011
crystal structure of hepatitis c virus ns3 helicase inhibitor co- complex with fragment 1 [(5-bromo-1h-indol-3-yl)acetic acid]	2.25 Å	4OJQ	4OJQ	4OJQ	4OJQ	4OJQ	4OJQ
crystal structure of hepatitis c virus ns3 helicase inhibitor co- complex with compound 7 [[1-(3-chlorobenzyl)-1h-indol-3-yl]acetic acid]	2.30 Å	4OK3	4OK3	4OK3	4OK3	4OK3	4OK3
crystal structure of hepatitis c virus ns3 helicase inhibitor co- complex with compound 9 [1-(3-ethynylbenzyl)-1h-indol-3-yl]acetic acid]	2.15 Å	4OK5	4OK5	4OK5	4OK5	4OK5	4OK5
crystal structure of hepatitis c virus ns3 helicase inhibitor co- complex with compound 13 [[1-(2-methoxy-5-nitrobenzyl)-1h-indol-3- yl]acetic acid]	2.40 Å	4OK6	4OK6	4OK6	4OK6	4OK6	4OK6
crystal structure of hepatitis c virus ns3 helicase inhibitor co- complex with compound 19 [[6-(3,5-diaminophenyl)-1-(2-methoxy-5- nitrobenzyl)-1h-indol-3-yl]acetic acid]	2.25 Å	4OKS	4OKS	4OKS	4OKS	4OKS	4OKS