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Literature for peptidase C18.001: hepatitis C virus peptidase 2

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, T Target, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2023
  1. Bu,G., Danelius,E., Wieske,L.H. and Gonen,T.
    Polymorphic Structure Determination of the Macrocyclic Drug Paritaprevir by MicroED
    bioRxiv PubMed  Europe PubMed DOI  I
    2. 2022
  2. Majerova,T. and Konvalinka,J.
    Viral proteases as therapeutic targets
    Mol Aspects Med88, 101159-101159. PubMed  Europe PubMed DOI  V  I
    3. 2018
  3. Boukadida,C., Fritz,M., Blumen,B., Fogeron,M.L., Penin,F. and Martin,A.
    NS2 proteases from hepatitis C virus and related hepaciviruses share composite active sites and previously unrecognized intrinsic proteolytic activities
    PLoS Pathog14, e1006863-e1006863. PubMed  Europe PubMed DOI
    4. 2015
  4. Fogeron,M.L., Paul,D., Jirasko,V., Montserret,R., Lacabanne,D., Molle,J., Badillo,A., Boukadida,C., Georgeault,S., Roingeard,P., Martin,A., Bartenschlager,R., Penin,F. and Bockmann,A.
    Functional expression, purification, characterization, and membrane reconstitution of non-structural protein 2 from hepatitis C virus
    Protein Expr Purif116, 1-6. PubMed  Europe PubMed DOI  E
  5. Isken,O., Langerwisch,U., Jirasko,V., Rehders,D., Redecke,L., Ramanathan,H., Lindenbach,B.D., Bartenschlager,R. and Tautz,N.
    A conserved NS3 surface patch orchestrates NS2 protease stimulation, NS5A hyperphosphorylation and HCV genome replication
    PLoS Pathog11, e1004736-e1004736. PubMed  Europe PubMed DOI
  6. Shaw,J., Fishwick,C.W. and Harris,M.
    Epoxide based inhibitors of the hepatitis C virus non-structural 2 autoprotease
    Antiviral Res117C, 20-26. PubMed  Europe PubMed DOI  I
    7. 2014
  7. Lange,C.M., Bellecave,P., Dao Thi,V.L., Tran,H.T., Penin,F., Moradpour,D. and Gouttenoire,J.
    Determinants for membrane association of the hepatitis C virus NS2 protease domain
    J Virol88, 6519-6523. PubMed  Europe PubMed DOI
    8. 2012
  8. Marcotrigiano,J., Soukhodolets,K.M. and Rice,C.M.
    Hepatitis C virus endopeptidase 2
    [ISSN:978-0-12-407743-0]3, 2472-2476. DOI
    9. 2010
  9. Foster,T.L., Tedbury,P.R., Pearson,A.R. and Harris,M.
    A comparative analysis of the fluorescence properties of the wild-type and active site mutants of the hepatitis C virus autoprotease NS2-3
    Biochim Biophys Acta1804, 212-222. PubMed  Europe PubMed DOI
    10. 2009
  10. Dentzer,T.G., Lorenz,I.C., Evans,M.J. and Rice,C.M.
    Determinants of the hepatitis C virus nonstructural protein 2 protease domain required for production of infectious virus
    J Virol83, 12702-12713. PubMed  Europe PubMed DOI  S
  11. Schregel,V., Jacobi,S., Penin,F. and Tautz,N.
    Hepatitis C virus NS2 is a protease stimulated by cofactor domains in NS3
    Proc Natl Acad Sci U S A106, 5342-5347. PubMed  Europe PubMed DOI
  12. Welbourn,S. and Pause,A.
    HCV NS2/3 protease: a future antiviral drug target?
    Future Virol4, 463-472. DOI  T
    13. 2007
  13. Jones,C.T., Murray,C.L., Eastman,D.K., Tassello,J. and Rice,C.M.
    Hepatitis C virus p7 and NS2 proteins are essential for production of infectious virus
    J Virol81, 8374-8383. PubMed  Europe PubMed DOI
  14. Suo,Z. and Abdullah,M.A.
    Unique composite active site of the hepatitis C virus NS2-3 protease: a new opportunity for antiviral drug design
    ChemMedChem2, 283-284. PubMed  Europe PubMed DOI  T
  15. Tedbury,P.R. and Harris,M.
    Characterisation of the role of zinc in the hepatitis C virus NS2/3 auto-cleavage and NS3 protease activities
    J Mol Biol366, 1652-1660. PubMed  Europe PubMed DOI
  16. Welbourn,S. and Pause,A.
    The hepatitis C virus NS2/3 protease
    Curr Issues Mol Biol9, 63-69. PubMed  Europe PubMed  V
    17. 2006
  17. Gouttenoire,J., Moradpour,D. and Penin,F.
    Surprises from the crystal structure of the hepatitis C virus NS2-3 protease
    Hepatology44, 1690-1693. PubMed  Europe PubMed DOI  S
  18. [YEAR:23-7-2006]Lorenz,I.C., Marcotrigiano,J., Dentzer,T.G. and Rice,C.M.
    Structure of the catalytic domain of the hepatitis C virus NS2-3 protease
    Nature442, 831-835. PubMed  Europe PubMed DOI  S
    19. 2004
  19. Marcotrigiano,J., Soukhodolets,K.E. and Rice,C.M.
    Hepatitis C virus endopeptidase 2
    [ISSN:0-12-079610-4]2, 2132-2135.  V
    20. 2002
  20. Orsatti,L., Pallaoro,M., Steinkuler,C., Orru',S. and Bonelli,F.
    Reactivity of the NS2/3(907-1206)ASK(4) protein with beta-mercaptoethanol studied by electrospray ion trap mass spectrometry
    Rapid Commun Mass Spectrom16, 1919-1927. PubMed  Europe PubMed DOI
  21. Whitney,M., Stack,J.H., Darke,P.L., Zheng,W., Terzo,J., Inglese,J., Strulovici,B., Kuo,L.C. and Pollock,B.A.
    A collaborative screening program for the discovery of inhibitors of HCV NS2/3 cis-cleaving protease activity
    J Biomol Screen7, 149-154. PubMed  Europe PubMed DOI  I
    22. 2001
  22. [YEAR:10-8-2001]Mak,P., Palant,O., Labonte,P. and Plotch,S.
    Reconstitution of hepatitis C virus protease activities in yeast
    FEBS Lett503, 13-18. PubMed  Europe PubMed DOI
  23. Pallaoro,M., Lahm,A., Biasiol,G., Brunetti,M., Nardella,C., Orsatti,L., Bonelli,F., Orru,S., Narjes,F. and Steinkuhler,C.
    Characterization of the hepatitis C virus NS2/3 processing reaction by using a purified precursor protein
    J Virol75, 9939-9946. PubMed  Europe PubMed DOI
  24. [YEAR:7-12-2001]Thibeault,D., Maurice,R., Pilote,L., Lamarre,D. and Pause,A.
    In vitro characterization of a purified NS2/3 protease variant of hepatitis C virus
    J Biol Chem276, 46678-46684. PubMed  Europe PubMed DOI
  25. [YEAR:20-11-2001]Waxman,L., Whitney,M., Pollok,B.A., Kuo,L.C. and Darke,P.L.
    Host cell factor requirement for hepatitis C virus enzyme maturation
    Proc Natl Acad Sci U S A98, 13931-13935. PubMed  Europe PubMed DOI
    26. 2000
  26. Kolykhalov,A.A., Mihalik,K., Feinstone,S.M. and Rice,C.M.
    Hepatitis C virus-encoded enzymatic activities and conserved RNA elements in the 3' nontranslated region are essential for virus replication in vivo
    J Virol74, 2046-2051. PubMed  Europe PubMed DOI
    27. 1999
  27. [YEAR:3-12-1999]Darke,P.L., Jacobs,A.R., Waxman,L. and Kuo,L.C.
    Inhibition of hepatitis C virus NS2/3 processing by NS4A peptides. Implications for control of viral processing
    J Biol Chem274, 34511-34514. PubMed  Europe PubMed DOI
  28. [YEAR:15-2-1999]Shoji,I., Suzuki,T., Sato,M., Aizaki,H., Chiba,T., Matsuura,Y. and Miyamura,T.
    Internal processing of hepatitis C virus NS3 protein
    Virology254, 315-323. PubMed  Europe PubMed DOI
    29. 1998
  29. Blight,K.J., Kolykhalov,A.A., Reed,K.E., Agapov,E.V. and Rice,C.M.
    Molecular virology of hepatitis C virus: an update with respect to potential antiviral targets
    Antivir Ther3, 71-81. PubMed  Europe PubMed  V
  30. Wu,Z., Yao,N., Le,H.V. and Weber,P.C.
    Mechanism of autoproteolysis at the NS2-NS3 junction of the hepatitis C virus polyprotein
    Trends Biochem Sci23, 92-94. PubMed  Europe PubMed DOI
    31. 1997
  31. Neddermann,P., Tomei,L., Steinkuhler,C., Gallinari,P., Tramontano,A. and De Francesco,R.
    The nonstructural proteins of the hepatitis C virus: structure and functions
    Biol Chem Hoppe Seyler378, 469-476. PubMed  Europe PubMed
  32. Pieroni,L., Santolini,E., Fipaldini,C., Pacini,L., Migliaccio,G. and La Monica,N.
    In vitro study of the NS2-3 protease of hepatitis C virus
    J Virol71, 6373-6380. PubMed  Europe PubMed
  33. Wilkinson,C.S.
    Hepatitis C virus NS2-3 proteinase
    Biochem Soc Trans25, S611-S611. PubMed  Europe PubMed
    34. 1996
  34. De Francesco,R., Urbani,A., Nardi,M.C., Tomei,L., Steinkuhler,C. and Tramontano,A.
    A zinc binding site in viral serine proteinases
    Biochemistry35, 13282-13287. PubMed  Europe PubMed DOI
  35. Lohmann,V., Koch,J.O. and Bartenschlager,R.
    Processing pathways of the hepatitis C virus proteins
    J Hepatol24 Suppl 2, 11-19. PubMed  Europe PubMed  V
  36. Rice,C.M.
    Flaviridae: the viruses and their replication
    3, 931-959.
    37. 1995
  37. Reed,K.E., Grakoui,A. and Rice,C.M.
    Hepatitis C virus-encoded NS2-3 protease: cleavage-site mutagenesis and requirements for bimolecular cleavage
    J Virol69, 4127-4136. PubMed  Europe PubMed
    38. 1994
  38. D'Souza,E.D., O'Sullivan,E., Amphlett,E.M., Rowlands,D.J., Sangar,D.V. and Clarke,B.E.
    Analysis of NS3-mediated processing of the hepatitis C virus non-structural region in vitro
    J Gen Virol75, 3469-3476. PubMed  Europe PubMed
    39. 1993
  39. Bartenschlager,R., Ahlborn-Laake,L., Mous,J. and Jacobsen,H.
    Nonstructural protein 3 of the hepatitis C virus encodes a serine-type proteinase required for cleavage at the NS3/4 and NS4/5 junctions
    J Virol67, 3835-3844. PubMed  Europe PubMed
  40. [YEAR:15-11-1993]Grakoui,A., McCourt,D.W., Wychowski,C., Feinstone,S.M. and Rice,C.M.
    A second hepatitis C virus-encoded proteinase
    Proc Natl Acad Sci U S A90, 10583-10587. PubMed  Europe PubMed DOI
  41. Hijikata,M., Mizushima,H., Akagi,T., Mori,S., Kakiuchi,N., Kato,N., Tanaka,T., Kimura,K. and Shimotohno,K.
    Two distinct proteinase activities required for the processing of a putative nonstructural precursor protein of hepatitis C virus
    J Virol67, 4665-4675. PubMed  Europe PubMed
  42. Hirowatari,Y., Hijikata,M., Tanji,Y., Nyunoya,H., Mizushima,H., Kimura,K., Tanaka,T., Kato,N. and Shimotohno,K.
    Two proteinase activities in HCV polypeptide expressed in insect cells using baculovirus vector
    Arch Virol133, 349-356. PubMed  Europe PubMed
    43. 1989
  43. [YEAR:25-5-1989]Gorbalenya,A.E., Donchenko,A.P., Koonin,E.V. and Blinov,V.M.
    N-terminal domains of putative helicases of flavi- and pestiviruses may be serine proteases
    Nucleic Acids Res17, 3889-3897. PubMed  Europe PubMed

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