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Literature for peptidase C18.001: hepatitis C virus peptidase 2

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: S Structure, T Target, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Borges,P.H.O., Gras,E., Ferreira,S.B. and Paes,S.F., Jr.
    Hepatitis C virus (HCV) proteases: structure, function and inhibition strategies
    Enzymes (2025) 58, 151-182. PubMed  Europe PubMed DOI
    2. 2023
  2. Bu,G., Danelius,E., Wieske,L.H. and Gonen,T.
    Polymorphic Structure Determination of the Macrocyclic Drug Paritaprevir by MicroED
    bioRxiv (2023) PubMed  Europe PubMed DOI  PMC  EPMC  I
    3. 2022
  3. Majerova,T. and Konvalinka,J.
    Viral proteases as therapeutic targets
    Mol Aspects Med (2022) 88, 101159-101159. PubMed  Europe PubMed DOI  PMC  EPMC  V  I
    4. 2018
  4. Boukadida,C., Fritz,M., Blumen,B., Fogeron,M.L., Penin,F. and Martin,A.
    NS2 proteases from hepatitis C virus and related hepaciviruses share composite active sites and previously unrecognized intrinsic proteolytic activities
    PLoS Pathog (2018) 14, e1006863-e1006863. PubMed  Europe PubMed DOI
    5. 2015
  5. Fogeron,M.L., Paul,D., Jirasko,V., Montserret,R., Lacabanne,D., Molle,J., Badillo,A., Boukadida,C., Georgeault,S., Roingeard,P., Martin,A., Bartenschlager,R., Penin,F. and Bockmann,A.
    Functional expression, purification, characterization, and membrane reconstitution of non-structural protein 2 from hepatitis C virus
    Protein Expr Purif (2015) 116, 1-6. PubMed  Europe PubMed DOI  E
  6. Isken,O., Langerwisch,U., Jirasko,V., Rehders,D., Redecke,L., Ramanathan,H., Lindenbach,B.D., Bartenschlager,R. and Tautz,N.
    A conserved NS3 surface patch orchestrates NS2 protease stimulation, NS5A hyperphosphorylation and HCV genome replication
    PLoS Pathog (2015) 11, e1004736-e1004736. PubMed  Europe PubMed DOI  PMC  EPMC
  7. Shaw,J., Fishwick,C.W. and Harris,M.
    Epoxide based inhibitors of the hepatitis C virus non-structural 2 autoprotease
    Antiviral Res (2015) 117C, 20-26. PubMed  Europe PubMed DOI  I
    8. 2014
  8. Lange,C.M., Bellecave,P., Dao Thi,V.L., Tran,H.T., Penin,F., Moradpour,D. and Gouttenoire,J.
    Determinants for membrane association of the hepatitis C virus NS2 protease domain
    J Virol (2014) 88, 6519-6523. PubMed  Europe PubMed DOI
    9. 2012
  9. Marcotrigiano,J., Soukhodolets,K.M. and Rice,C.M.
    Hepatitis C virus endopeptidase 2
    [ISSN:978-0-12-407743-0] (2012) 3, 2472-2476. DOI
    10. 2010
  10. Foster,T.L., Tedbury,P.R., Pearson,A.R. and Harris,M.
    A comparative analysis of the fluorescence properties of the wild-type and active site mutants of the hepatitis C virus autoprotease NS2-3
    Biochim Biophys Acta (2010) 1804, 212-222. PubMed  Europe PubMed DOI
    11. 2009
  11. Dentzer,T.G., Lorenz,I.C., Evans,M.J. and Rice,C.M.
    Determinants of the hepatitis C virus nonstructural protein 2 protease domain required for production of infectious virus
    J Virol (2009) 83, 12702-12713. PubMed  Europe PubMed DOI  S
  12. Schregel,V., Jacobi,S., Penin,F. and Tautz,N.
    Hepatitis C virus NS2 is a protease stimulated by cofactor domains in NS3
    Proc Natl Acad Sci U S A (2009) 106, 5342-5347. PubMed  Europe PubMed DOI  PMC  EPMC
  13. Welbourn,S. and Pause,A.
    HCV NS2/3 protease: a future antiviral drug target?
    Future Virol (2009) 4, 463-472. DOI  T
    14. 2007
  14. Jones,C.T., Murray,C.L., Eastman,D.K., Tassello,J. and Rice,C.M.
    Hepatitis C virus p7 and NS2 proteins are essential for production of infectious virus
    J Virol (2007) 81, 8374-8383. PubMed  Europe PubMed DOI  PMC  EPMC
  15. Suo,Z. and Abdullah,M.A.
    Unique composite active site of the hepatitis C virus NS2-3 protease: a new opportunity for antiviral drug design
    ChemMedChem (2007) 2, 283-284. PubMed  Europe PubMed DOI  T
  16. Tedbury,P.R. and Harris,M.
    Characterisation of the role of zinc in the hepatitis C virus NS2/3 auto-cleavage and NS3 protease activities
    J Mol Biol (2007) 366, 1652-1660. PubMed  Europe PubMed DOI
  17. Welbourn,S. and Pause,A.
    The hepatitis C virus NS2/3 protease
    Curr Issues Mol Biol (2007) 9, 63-69. PubMed  Europe PubMed  V
    18. 2006
  18. Gouttenoire,J., Moradpour,D. and Penin,F.
    Surprises from the crystal structure of the hepatitis C virus NS2-3 protease
    Hepatology (2006) 44, 1690-1693. PubMed  Europe PubMed DOI  S
  19. [YEAR:23-7-2006]Lorenz,I.C., Marcotrigiano,J., Dentzer,T.G. and Rice,C.M.
    Structure of the catalytic domain of the hepatitis C virus NS2-3 protease
    Nature (23-7-2006) 442, 831-835. PubMed  Europe PubMed DOI  S
    20. 2004
  20. Marcotrigiano,J., Soukhodolets,K.E. and Rice,C.M.
    Hepatitis C virus endopeptidase 2
    [ISSN:0-12-079610-4] (2004) 2, 2132-2135.  V
    21. 2002
  21. Orsatti,L., Pallaoro,M., Steinkuler,C., Orru',S. and Bonelli,F.
    Reactivity of the NS2/3(907-1206)ASK(4) protein with beta-mercaptoethanol studied by electrospray ion trap mass spectrometry
    Rapid Commun Mass Spectrom (2002) 16, 1919-1927. PubMed  Europe PubMed DOI
  22. Whitney,M., Stack,J.H., Darke,P.L., Zheng,W., Terzo,J., Inglese,J., Strulovici,B., Kuo,L.C. and Pollock,B.A.
    A collaborative screening program for the discovery of inhibitors of HCV NS2/3 cis-cleaving protease activity
    J Biomol Screen (2002) 7, 149-154. PubMed  Europe PubMed DOI  I
    23. 2001
  23. [YEAR:10-8-2001]Mak,P., Palant,O., Labonte,P. and Plotch,S.
    Reconstitution of hepatitis C virus protease activities in yeast
    FEBS Lett (10-8-2001) 503, 13-18. PubMed  Europe PubMed DOI
  24. Pallaoro,M., Lahm,A., Biasiol,G., Brunetti,M., Nardella,C., Orsatti,L., Bonelli,F., Orru,S., Narjes,F. and Steinkuhler,C.
    Characterization of the hepatitis C virus NS2/3 processing reaction by using a purified precursor protein
    J Virol (2001) 75, 9939-9946. PubMed  Europe PubMed DOI  PMC  EPMC
  25. [YEAR:7-12-2001]Thibeault,D., Maurice,R., Pilote,L., Lamarre,D. and Pause,A.
    In vitro characterization of a purified NS2/3 protease variant of hepatitis C virus
    J Biol Chem (7-12-2001) 276, 46678-46684. PubMed  Europe PubMed DOI
  26. [YEAR:20-11-2001]Waxman,L., Whitney,M., Pollok,B.A., Kuo,L.C. and Darke,P.L.
    Host cell factor requirement for hepatitis C virus enzyme maturation
    Proc Natl Acad Sci U S A (20-11-2001) 98, 13931-13935. PubMed  Europe PubMed DOI  PMC  EPMC
    27. 2000
  27. Kolykhalov,A.A., Mihalik,K., Feinstone,S.M. and Rice,C.M.
    Hepatitis C virus-encoded enzymatic activities and conserved RNA elements in the 3' nontranslated region are essential for virus replication in vivo
    J Virol (2000) 74, 2046-2051. PubMed  Europe PubMed DOI  PMC  EPMC
    28. 1999
  28. [YEAR:3-12-1999]Darke,P.L., Jacobs,A.R., Waxman,L. and Kuo,L.C.
    Inhibition of hepatitis C virus NS2/3 processing by NS4A peptides. Implications for control of viral processing
    J Biol Chem (3-12-1999) 274, 34511-34514. PubMed  Europe PubMed DOI
  29. [YEAR:15-2-1999]Shoji,I., Suzuki,T., Sato,M., Aizaki,H., Chiba,T., Matsuura,Y. and Miyamura,T.
    Internal processing of hepatitis C virus NS3 protein
    Virology (15-2-1999) 254, 315-323. PubMed  Europe PubMed DOI
    30. 1998
  30. Blight,K.J., Kolykhalov,A.A., Reed,K.E., Agapov,E.V. and Rice,C.M.
    Molecular virology of hepatitis C virus: an update with respect to potential antiviral targets
    Antivir Ther (1998) 3, 71-81. PubMed  Europe PubMed  V
  31. Wu,Z., Yao,N., Le,H.V. and Weber,P.C.
    Mechanism of autoproteolysis at the NS2-NS3 junction of the hepatitis C virus polyprotein
    Trends Biochem Sci (1998) 23, 92-94. PubMed  Europe PubMed DOI
    32. 1997
  32. Neddermann,P., Tomei,L., Steinkuhler,C., Gallinari,P., Tramontano,A. and De Francesco,R.
    The nonstructural proteins of the hepatitis C virus: structure and functions
    Biol Chem Hoppe Seyler (1997) 378, 469-476. PubMed  Europe PubMed
  33. Pieroni,L., Santolini,E., Fipaldini,C., Pacini,L., Migliaccio,G. and La Monica,N.
    In vitro study of the NS2-3 protease of hepatitis C virus
    J Virol (1997) 71, 6373-6380. PubMed  Europe PubMed  PMC  EPMC
  34. Wilkinson,C.S.
    Hepatitis C virus NS2-3 proteinase
    Biochem Soc Trans (1997) 25, S611-S611. PubMed  Europe PubMed
    35. 1996
  35. De Francesco,R., Urbani,A., Nardi,M.C., Tomei,L., Steinkuhler,C. and Tramontano,A.
    A zinc binding site in viral serine proteinases
    Biochemistry (1996) 35, 13282-13287. PubMed  Europe PubMed DOI
  36. Lohmann,V., Koch,J.O. and Bartenschlager,R.
    Processing pathways of the hepatitis C virus proteins
    J Hepatol (1996) 24 Suppl 2, 11-19. PubMed  Europe PubMed  V
  37. Rice,C.M.
    Flaviridae: the viruses and their replication
     (1996) 3, 931-959.
    38. 1995
  38. Reed,K.E., Grakoui,A. and Rice,C.M.
    Hepatitis C virus-encoded NS2-3 protease: cleavage-site mutagenesis and requirements for bimolecular cleavage
    J Virol (1995) 69, 4127-4136. PubMed  Europe PubMed  PMC  EPMC
    39. 1994
  39. D'Souza,E.D., O'Sullivan,E., Amphlett,E.M., Rowlands,D.J., Sangar,D.V. and Clarke,B.E.
    Analysis of NS3-mediated processing of the hepatitis C virus non-structural region in vitro
    J Gen Virol (1994) 75, 3469-3476. PubMed  Europe PubMed
    40. 1993
  40. Bartenschlager,R., Ahlborn-Laake,L., Mous,J. and Jacobsen,H.
    Nonstructural protein 3 of the hepatitis C virus encodes a serine-type proteinase required for cleavage at the NS3/4 and NS4/5 junctions
    J Virol (1993) 67, 3835-3844. PubMed  Europe PubMed  PMC  EPMC
  41. [YEAR:15-11-1993]Grakoui,A., McCourt,D.W., Wychowski,C., Feinstone,S.M. and Rice,C.M.
    A second hepatitis C virus-encoded proteinase
    Proc Natl Acad Sci U S A (15-11-1993) 90, 10583-10587. PubMed  Europe PubMed DOI  PMC  EPMC
  42. Hijikata,M., Mizushima,H., Akagi,T., Mori,S., Kakiuchi,N., Kato,N., Tanaka,T., Kimura,K. and Shimotohno,K.
    Two distinct proteinase activities required for the processing of a putative nonstructural precursor protein of hepatitis C virus
    J Virol (1993) 67, 4665-4675. PubMed  Europe PubMed  PMC  EPMC
  43. Hirowatari,Y., Hijikata,M., Tanji,Y., Nyunoya,H., Mizushima,H., Kimura,K., Tanaka,T., Kato,N. and Shimotohno,K.
    Two proteinase activities in HCV polypeptide expressed in insect cells using baculovirus vector
    Arch Virol (1993) 133, 349-356. PubMed  Europe PubMed
    44. 1989
  44. [YEAR:25-5-1989]Gorbalenya,A.E., Donchenko,A.P., Koonin,E.V. and Blinov,V.M.
    N-terminal domains of putative helicases of flavi- and pestiviruses may be serine proteases
    Nucleic Acids Res (25-5-1989) 17, 3889-3897. PubMed  Europe PubMed  PMC  EPMC

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