Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence Q99KJ8

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-402	P		NT	<%Agarwal et al., 2012[]%>
38	cathepsin D	2-402	P		MS	Impens et al., 2010
88	cathepsin E	2-402	P		MS	Impens et al., 2010
89	cathepsin D	2-402	P		MS	Impens et al., 2010
89	cathepsin E	2-402	P		MS	Impens et al., 2010
156	matrix metallopeptidase-2	2-402	N		MS	Kleifeld et al., 2010
161	granzyme B (Homo sapiens-type)	2-402	N			Van Damme et al., 2009
176	trypsin 1	2-402	N			Van Damme et al., 2009
371	cathepsin D	2-402	P		MS	Impens et al., 2010
371	cathepsin E	2-402	P		MS	Impens et al., 2010