Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence Q96AG4

,

Click here to display alignment and conservation of cleavage sites of this sequence with close homologues. This will take a few moments.

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-307	P	release of an initiating methionine	MS	Flikka et al., 2006
10	matrix metallopeptidase-2	1-19	N		MS	Schilling & Overall, 2008
19	glutamyl endopeptidase I	14-33	N		MS	Schilling & Overall, 2008
20	LAST_MAM peptidase (Limulus-type)	17-33	N		MS	Becker-Pauly et al., 2011
22	HIV-1 retropepsin	14-33	N		MS	Schilling & Overall, 2008
33	trypsin 1	1-307	N		MS	Schilling & Overall, 2008
55	astacin	52-66	N		MS	Becker-Pauly et al., 2011
56	meprin beta subunit	53-66	N		MS	Becker-Pauly et al., 2011
88	cathepsin L	84-96	N		MS	Biniossek et al., 2011
147	matrix metallopeptidase-2	134-156	N		MS	Schilling & Overall, 2008
156	glutamyl endopeptidase I	1-307	N		MS	Schilling & Overall, 2008