Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence Q96AE4

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-644	P		NT	<%Agarwal et al., 2012[]%>
13	cathepsin B	2-32	N		MS	Biniossek et al., 2011
101	meprin alpha subunit	2-644	N		MS	Becker-Pauly et al., 2011
101	meprin beta subunit	2-644	N		MS	Becker-Pauly et al., 2011
102	meprin beta subunit	2-644	N		MS	Becker-Pauly et al., 2011
128	meprin alpha subunit	2-644	N		MS	Becker-Pauly et al., 2011
128	meprin beta subunit	2-644	N		MS	Becker-Pauly et al., 2011
146	trypsin 1	1-644	N		MS	Schilling & Overall, 2008
161	trypsin 1	1-644	N		MS	Schilling & Overall, 2008
221	cathepsin L	219-236	N		MS	Biniossek et al., 2011
223	cathepsin L	219-236	N		MS	Biniossek et al., 2011
223	cathepsin S	219-236	N		MS	Biniossek et al., 2011
224	LAST_MAM peptidase (Limulus-type)	221-236	N		MS	Becker-Pauly et al., 2011
271	trypsin 1	1-644	N		MS	Schilling & Overall, 2008
284	trypsin 1	1-644	N		MS	Schilling & Overall, 2008
377	meprin beta subunit	373-387	N		MS	Becker-Pauly et al., 2011
448	cathepsin L	441-464	N		MS	Biniossek et al., 2011
574	LAST_MAM peptidase (Limulus-type)	571-584	N		MS	Becker-Pauly et al., 2011
584	trypsin 1	1-644	N		MS	Schilling & Overall, 2008
591	trypsin 1	1-644	N		MS	Schilling & Overall, 2008