Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence Q14697

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
28	unknown peptidase	1-944	P		NT	<%Agarwal et al., 2012[]%>
100	trypsin 1	29-944	N		MS	Schilling & Overall, 2008
109	trypsin 1	29-944	N		MS	Schilling & Overall, 2008
133	trypsin 1	29-944	N		MS	Schilling & Overall, 2008
148	trypsin 1	29-944	N		MS	Schilling & Overall, 2008
173	trypsin 1	29-944	N		MS	Schilling & Overall, 2008
182	trypsin 1	29-944	N		MS	Schilling & Overall, 2008
257	cathepsin S	238-267	N		MS	Biniossek et al., 2011
257	LAST_MAM peptidase (Limulus-type)	254-267	N		MS	Becker-Pauly et al., 2011
343	cathepsin L	338-354	N		MS	Biniossek et al., 2011
343	cathepsin S	338-354	N		MS	Biniossek et al., 2011
343	cathepsin B	338-354	N		MS	Biniossek et al., 2011
465	cathepsin L	463-472	N		MS	Biniossek et al., 2011
465	cathepsin S	463-492	N		MS	Biniossek et al., 2011
602	trypsin 1	29-944	N		MS	Schilling & Overall, 2008
610	trypsin 1	29-944	N		MS	Schilling & Overall, 2008
615	cathepsin L	611-627	N		MS	Biniossek et al., 2011
615	cathepsin S	611-627	N		MS	Biniossek et al., 2011
691	cathepsin L	685-698	N		MS	Biniossek et al., 2011