Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence Q13526

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-163	P	release of an initiating methionine	MS	Bantscheff et al., 2007
29	cathepsin L	22-46	N		MS	Biniossek et al., 2011
29	cathepsin S	22-46	N		MS	Biniossek et al., 2011
85	HIV-1 retropepsin	82-95	N		MS	Schilling & Overall, 2008
95	trypsin 1	1-163	N		MS	Schilling & Overall, 2008
97	trypsin 1	1-163	N		MS	Schilling & Overall, 2008
108	matrix metallopeptidase-2	104-121	N		MS	Schilling & Overall, 2008
117	trypsin 1	1-163	N		MS	Schilling & Overall, 2008
121	glutamyl endopeptidase I	1-163	N		MS	Schilling & Overall, 2008
142	trypsin 1	1-163	N		MS	Schilling & Overall, 2008
145	glutamyl endopeptidase I	142-161	N		MS	Schilling & Overall, 2008
161	trypsin 1	1-163	N		MS	Schilling & Overall, 2008