Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence Q04760

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-184	P		NT	<%Agarwal et al., 2012[]%>
18	cathepsin S	2-28	N		MS	Biniossek et al., 2011
23	meprin alpha subunit	2-184	N		MS	Becker-Pauly et al., 2011
23	meprin beta subunit	2-184	N		MS	Becker-Pauly et al., 2011
28	trypsin 1	2-184	N		MS	Schilling & Overall, 2008
38	trypsin 1	2-184	N		MS	Schilling & Overall, 2008
51	trypsin 1	2-184	N		MS	Schilling & Overall, 2008
60	trypsin 1	2-184	N		MS	Schilling & Overall, 2008
102	cathepsin S	97-115	N		MS	Biniossek et al., 2011
123	thrombin	111-134	N		MS	Schilling & Overall, 2008
134	glutamyl endopeptidase I	2-184	N		MS	Schilling & Overall, 2008
159	trypsin 1	2-184	N		MS	Schilling & Overall, 2008
163	matrix metallopeptidase-2	159-179	N		MS	Schilling & Overall, 2008
169	matrix metallopeptidase-2	159-179	N		MS	Schilling & Overall, 2008
170	HIV-1 retropepsin	159-179	N		MS	Schilling & Overall, 2008
171	HIV-1 retropepsin	159-179	N		MS	Schilling & Overall, 2008
179	trypsin 1	2-184	N		MS	Schilling & Overall, 2008