Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence Q00341

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-1268	P		NT	<%Agarwal et al., 2012[]%>
23	matrix metallopeptidase-2	14-34	N		MS	Schilling & Overall, 2008
34	glutamyl endopeptidase I	2-1268	N		MS	Schilling & Overall, 2008
70	matrix metallopeptidase-2	59-86	N		MS	Schilling & Overall, 2008
86	glutamyl endopeptidase I	2-1268	N		MS	Schilling & Overall, 2008
185	cathepsin K	183-197	N		MS	Schilling & Overall, 2008
197	trypsin 1	2-1268	N		MS	Schilling & Overall, 2008
539	glutamyl endopeptidase I	536-550	N		MS	Schilling & Overall, 2008
550	trypsin 1	2-1268	N		MS	Schilling & Overall, 2008
773	HIV-1 retropepsin	769-784	N		MS	Schilling & Overall, 2008
784	trypsin 1	2-1268	N		MS	Schilling & Overall, 2008
803	granzyme B (Homo sapiens-type)	2-1268	N		MS	Van Damme et al., 2010
845	peptidyl-Lys metallopeptidase	1-1268	N		MS
859	peptidyl-Lys metallopeptidase	1-1268	N		MS
1019	matrix metallopeptidase-2	1016-1036	N		MS	Schilling & Overall, 2008
1036	glutamyl endopeptidase I	2-1268	N		MS	Schilling & Overall, 2008
1260	trypsin 1	2-1268	N		MS	Schilling & Overall, 2008
1267	trypsin 1	2-1268	N		MS	Schilling & Overall, 2008