Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P80162

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
37	unknown peptidase	1-114	P	release of a signal peptide	NT	Proost et al., 1993
39	dipeptidyl-peptidase IV (eukaryote)	38-114	P			Ajami et al., 2008
41	matrix metallopeptidase-9	38-114	P	normal turnover		Van den Steen et al., 2003
42	matrix metallopeptidase-8	38-114	P	conversion to two-chain form		Van den Steen et al., 2003
42	matrix metallopeptidase-9	38-114	P	normal turnover		Van den Steen et al., 2003
43	matrix metallopeptidase-8	38-114	P			Van den Steen et al., 2003
43	matrix metallopeptidase-9	38-114	P	conversion to two-chain form		Van den Steen et al., 2003
45	unknown peptidase	1-114	P		NT	<%Agarwal et al., 2012[]%>
85	lysyl endopeptidase (bacteria)	1-114	N		MS
100	lysyl endopeptidase (bacteria)	1-114	N		MS