Peptide and protein substrates that are thought to be physiologically relevant are indicated by P.
Peptide and protein substrates that are not physiologically relevant are indicated by N.
How cleavage sites have been identified are indicated by the following evidence codes:
NT = N-terminal sequencing,
MS = mass spectroscopy,
MU = mutation,
CS = consensus sequence,
LC = liquid chromatography.
To see all annotated cleavages for a peptidase, click on the peptidase name.
| Cleavage Site |
Peptidase |
Residue range |
Cleavage type |
Description |
Evidence |
Reference |
|---|
| 1 |
unknown peptidase |
1-375 |
P |
|
NT |
<%Agarwal et al., 2012[]%> |
| 11 |
caspase-3 |
1-375 |
P |
|
MS |
Impens et al., 2010 |
| 17 |
peptidyl-Lys metallopeptidase |
1-375 |
N |
|
MS |
|
| 18 |
trypsin 1 |
2-375 |
N |
|
MS |
Schilling & Overall, 2008 |
| 28 |
trypsin 1 |
2-375 |
N |
|
MS |
Schilling & Overall, 2008 |
| 39 |
thrombin |
25-57 |
N |
|
MS |
Schilling & Overall, 2008 |
| 40 |
matrix metallopeptidase-2 |
25-57 |
N |
|
MS |
Schilling & Overall, 2008 |
| 47 |
matrix metallopeptidase-2 |
31-65 |
N |
|
MS |
Schilling & Overall, 2008 |
| 49 |
peptidyl-Lys metallopeptidase |
1-375 |
N |
|
MS |
|
| 50 |
trypsin 1 |
2-375 |
N |
|
MS |
Schilling & Overall, 2008 |
| 51 |
caspase-3 |
1-375 |
P |
|
MS |
Impens et al., 2010 |
| 57 |
glutamyl endopeptidase I |
2-375 |
N |
|
MS |
Schilling & Overall, 2008 |
| 60 |
peptidyl-Lys metallopeptidase |
1-375 |
N |
|
MS |
|
| 61 |
trypsin 1 |
2-375 |
N |
|
MS |
Schilling & Overall, 2008 |
| 62 |
trypsin 1 |
2-375 |
N |
|
MS |
Schilling & Overall, 2008 |
| 63 |
matrix metallopeptidase-2 |
62-72 |
N |
|
MS |
Schilling & Overall, 2008 |
| 65 |
chymotrypsin A (cattle-type) |
2-375 |
N |
|
MS |
Schilling & Overall, 2008 |
| 68 |
trypsin 1 |
2-375 |
N |
|
MS |
Schilling & Overall, 2008 |
| 72 |
glutamyl endopeptidase I |
2-375 |
N |
|
MS |
Schilling & Overall, 2008 |
| 74 |
matrix metallopeptidase-2 |
68-84 |
N |
|
MS |
Schilling & Overall, 2008 |
| 84 |
trypsin 1 |
2-375 |
N |
|
MS |
Schilling & Overall, 2008 |
| 183 |
trypsin 1 |
2-375 |
N |
|
MS |
Schilling & Overall, 2008 |
| 191 |
trypsin 1 |
2-375 |
N |
|
MS |
Schilling & Overall, 2008 |
| 196 |
trypsin 1 |
2-375 |
N |
|
MS |
Schilling & Overall, 2008 |
| 206 |
trypsin 1 |
2-375 |
N |
|
MS |
Schilling & Overall, 2008 |
| 215 |
trypsin 1 |
2-375 |
N |
|
MS |
Schilling & Overall, 2008 |
| 222 |
HIV-1 retropepsin |
215-238 |
N |
|
MS |
Schilling & Overall, 2008 |
| 223 |
HIV-1 retropepsin |
215-238 |
N |
|
MS |
Schilling & Overall, 2008 |
| 226 |
glutamyl endopeptidase I |
225-238 |
N |
|
MS |
Schilling & Overall, 2008 |
| 227 |
HIV-1 retropepsin |
225-238 |
N |
|
MS |
Schilling & Overall, 2008 |
| 227 |
cathepsin G |
225-238 |
N |
|
MS |
Schilling & Overall, 2008 |
| 238 |
trypsin 1 |
2-375 |
N |
|
MS |
Schilling & Overall, 2008 |
| 241 |
chymotrypsin A (cattle-type) |
2-375 |
N |
|
MS |
Schilling & Overall, 2008 |
| 244 |
caspase-3 |
241-254 |
N |
|
MS |
Schilling & Overall, 2008 |
| 244 |
caspase-7 |
241-254 |
N |
|
MS |
Schilling & Overall, 2008 |
| 244 |
matrix metallopeptidase-2 |
241-255 |
N |
|
MS |
Schilling & Overall, 2008 |
| 244 |
glutamyl endopeptidase I |
241-254 |
N |
|
MS |
Schilling & Overall, 2008 |
| 254 |
trypsin 1 |
2-375 |
N |
|
MS |
Schilling & Overall, 2008 |
| 255 |
chymotrypsin A (cattle-type) |
2-375 |
N |
|
MS |
Schilling & Overall, 2008 |
| 260 |
matrix metallopeptidase-2 |
256-284 |
N |
|
MS |
Schilling & Overall, 2008 |
| 284 |
trypsin 1 |
2-375 |
N |
|
MS |
Schilling & Overall, 2008 |
| 290 |
trypsin 1 |
2-375 |
N |
|
MS |
Schilling & Overall, 2008 |
| 292 |
matrix metallopeptidase-2 |
291-312 |
N |
|
MS |
Schilling & Overall, 2008 |
| 296 |
HIV-1 retropepsin |
291-312 |
N |
|
MS |
Schilling & Overall, 2008 |
| 296 |
matrix metallopeptidase-2 |
291-312 |
N |
|
MS |
Schilling & Overall, 2008 |
| 312 |
trypsin 1 |
2-375 |
N |
|
MS |
Schilling & Overall, 2008 |
| 314 |
peptidyl-Lys metallopeptidase |
1-375 |
N |
|
MS |
|
| 315 |
trypsin 1 |
2-375 |
N |
|
MS |
Schilling & Overall, 2008 |
| 325 |
peptidyl-Lys metallopeptidase |
1-375 |
N |
|
MS |
|
| 326 |
trypsin 1 |
2-375 |
N |
|
MS |
Schilling & Overall, 2008 |
| 358 |
peptidyl-Lys metallopeptidase |
1-375 |
N |
|
MS |
|
| 359 |
trypsin 1 |
2-375 |
N |
|
MS |
Schilling & Overall, 2008 |
| 362 |
HIV-1 retropepsin |
359-372 |
N |
|
MS |
Schilling & Overall, 2008 |
| 372 |
trypsin 1 |
2-375 |
N |
|
MS |
Schilling & Overall, 2008 |
