Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P63038

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
26	unknown peptidase	1-573	P		NT	<%Agarwal et al., 2012[]%>
46	cathepsin E	27-573	P		MS	Impens et al., 2010
47	cathepsin D	27-573	P		MS	Impens et al., 2010
49	caspase-1	27-573	P	normal turnover	MS	Lamkanfi et al., 2008
49	matrix metallopeptidase-2	27-573	N		MS	auf dem Keller et al., 2010
100	caspase-1	27-573	P	normal turnover	MS	Lamkanfi et al., 2008
203	caspase-3	27-573	N		MS	Demon et al., 2009
203	caspase-7	27-573	N		MS	Demon et al., 2009
253	matrix metallopeptidase-2	27-573	N		MS	Prudova et al., 2010
279	caspase-3	27-573	N		MS	Demon et al., 2009
279	caspase-7	27-573	N		MS	Demon et al., 2009
299	matrix metallopeptidase-2	27-573	N		MS	auf dem Keller et al., 2010
404	cathepsin D	27-573	P		MS	Impens et al., 2010
404	cathepsin E	27-573	P		MS	Impens et al., 2010
411	cathepsin E	27-573	P		MS	Impens et al., 2010
435	cathepsin E	27-573	P		MS	Impens et al., 2010
513	cathepsin D	27-573	P		MS	Impens et al., 2010
513	cathepsin E	27-573	P		MS	Impens et al., 2010
531	caspase-3	27-573	N		MS	Demon et al., 2009
531	caspase-7	27-573	N		MS	Demon et al., 2009
537	matrix metallopeptidase-2	27-573	N		MS	Kleifeld et al., 2010