Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P62280

,

Click here to display alignment and conservation of cleavage sites of this sequence with close homologues. This will take a few moments.

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-158	P		NT	<%Agarwal et al., 2012[]%>
8	granzyme A	1-158	N			Van Damme et al., 2010
27	granzyme B (Homo sapiens-type)	2-158	N		MS	Plasman et al., 2011
35	trypsin 1	2-158	N			Van Damme et al., 2009
47	peptidyl-Lys metallopeptidase	1-158	N		MS
52	cathepsin L	49-59	N		MS	Biniossek et al., 2011
58	peptidyl-Lys metallopeptidase	1-158	N		MS
71	granzyme A	1-158	N			Van Damme et al., 2010
71	trypsin 1	2-158	N		MS	Schilling & Overall, 2008
79	trypsin 1	2-158	N		MS	Schilling & Overall, 2008
118	trypsin 1	2-158	N		MS	Schilling & Overall, 2008
123	meprin alpha subunit	120-136	N		MS	Becker-Pauly et al., 2011
123	meprin beta subunit	120-136	N		MS	Becker-Pauly et al., 2011
123	LAST_MAM peptidase (Limulus-type)	120-136	N		MS	Becker-Pauly et al., 2011
124	matrix metallopeptidase-2	118-136	N		MS	Schilling & Overall, 2008
134	chymotrypsin A (cattle-type)	2-158	N		MS	Schilling & Overall, 2008
136	trypsin 1	2-158	N		MS	Schilling & Overall, 2008