Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P60174

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
79	LAST_MAM peptidase (Limulus-type)	76-90	N		MS	Becker-Pauly et al., 2011
111	meprin alpha subunit	108-122	N		MS	Becker-Pauly et al., 2011
112	meprin alpha subunit	109-122	N		MS	Becker-Pauly et al., 2011
141	cathepsin S	138-150	N		MS	Biniossek et al., 2011
156	meprin beta subunit	153-168	N		MS	Becker-Pauly et al., 2011
182	cathepsin S	180-193	N		MS	Biniossek et al., 2011
247	cathepsin L	244-256	N		MS	Biniossek et al., 2011
260	LAST_MAM peptidase (Limulus-type)	257-285	N		MS	Becker-Pauly et al., 2011
268	cathepsin B	257-285	N		MS	Biniossek et al., 2011
270	cathepsin L	257-285	N		MS	Biniossek et al., 2011
270	cathepsin B	257-285	N		MS	Biniossek et al., 2011
273	meprin alpha subunit	270-285	N		MS	Becker-Pauly et al., 2011