Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P56537

,

Click here to display alignment and conservation of cleavage sites of this sequence with close homologues. This will take a few moments.

Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
71	cathepsin L	68-85	N		MS	Biniossek et al., 2011
71	cathepsin S	68-85	N		MS	Biniossek et al., 2011
113	HIV-1 retropepsin	100-123	N		MS	Schilling & Overall, 2008
123	trypsin 1	1-245	N		MS	Schilling & Overall, 2008
134	trypsin 1	1-245	N		MS	Schilling & Overall, 2008
154	cathepsin L	140-164	N		MS	Biniossek et al., 2011
154	cathepsin S	140-164	N		MS	Biniossek et al., 2011
155	cathepsin B	140-164	N		MS	Biniossek et al., 2011
164	trypsin 1	1-245	N		MS	Schilling & Overall, 2008
172	glutamyl endopeptidase I	164-188	N		MS	Schilling & Overall, 2008
188	trypsin 1	1-245	N		MS	Schilling & Overall, 2008