Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P55145

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
24	unknown peptidase	1-182	P	release of a signal peptide	NT	Gevaert et al., 2003
51	astacin	47-62	N		MS	Becker-Pauly et al., 2011
51	LAST_MAM peptidase (Limulus-type)	47-62	N		MS	Becker-Pauly et al., 2011
51	cathepsin G	47-62	N		MS	Schilling & Overall, 2008
62	trypsin 1	22-182	N		MS	Schilling & Overall, 2008
97	matrix metallopeptidase-2	94-107	N		MS	Schilling & Overall, 2008
107	glutamyl endopeptidase I	22-182	N		MS	Schilling & Overall, 2008
123	trypsin 1	22-182	N		MS	Schilling & Overall, 2008
133	trypsin 1	22-182	N		MS	Schilling & Overall, 2008