Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P52815

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
45	unknown peptidase	1-198	P		NT	<%Agarwal et al., 2012[]%>
49	cathepsin S	45-58	N		MS	Biniossek et al., 2011
86	peptidyl-Lys metallopeptidase	1-198	N		MS
102	matrix metallopeptidase-2	91-125	N		MS	Schilling & Overall, 2008
114	meprin alpha subunit	46-198	N		MS	Becker-Pauly et al., 2011
114	meprin beta subunit	46-198	N		MS	Becker-Pauly et al., 2011
124	peptidyl-Lys metallopeptidase	1-198	N		MS
125	trypsin 1	46-198	N		MS	Schilling & Overall, 2008
151	matrix metallopeptidase-2	148-166	N		MS	Schilling & Overall, 2008
155	matrix metallopeptidase-2	148-166	N		MS	Schilling & Overall, 2008
166	glutamyl endopeptidase I	46-198	N		MS	Schilling & Overall, 2008
171	matrix metallopeptidase-2	164-198	N		MS	Schilling & Overall, 2008