Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P50914

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-215	P		NT	<%Agarwal et al., 2012[]%>
11	trypsin 1	2-213	N		MS	Schilling & Overall, 2008
15	cathepsin L	12-23	N		MS	Biniossek et al., 2011
23	trypsin 1	2-213	N		MS	Schilling & Overall, 2008
26	HIV-1 retropepsin	23-35	N		MS	Schilling & Overall, 2008
26	cathepsin L	24-35	N		MS	Biniossek et al., 2011
26	cathepsin S	24-35	N		MS	Biniossek et al., 2011
35	trypsin 1	2-213	N		MS	Schilling & Overall, 2008
100	granzyme A	1-215	N			Van Damme et al., 2010
102	peptidyl-Lys metallopeptidase	1-215	N		MS
108	granzyme B (Homo sapiens-type)	2-215	N		MS	Van Damme et al., 2010
110	peptidyl-Lys metallopeptidase	1-215	N		MS