Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P50228

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
40	unknown peptidase	1-132	P	release of a signal peptide	NT	Wuyts et al., 1996
44	matrix metallopeptidase-1	41-132	P		NT	Tester et al., 2007
44	matrix metallopeptidase-8	41-132	P		NT	Tester et al., 2007
44	matrix metallopeptidase-2	41-132	P		NT	Tester et al., 2007
44	matrix metallopeptidase-9	41-132	P	normal turnover		Van den Steen et al., 2003
44	matrix metallopeptidase-13	41-132	P		NT	Tester et al., 2007
48	unknown peptidase	1-132	P		NT	<%Agarwal et al., 2012[]%>
118	unknown peptidase	1-132	P		NT	<%Agarwal et al., 2012[]%>
119	matrix metallopeptidase-8	41-132	P		NT	Tester et al., 2007