Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P42830

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
36	unknown peptidase	1-114	P	release of a signal peptide	NT	Gevaert et al., 2003
41	matrix metallopeptidase-9	37-114	P	release of an amino acid		Van den Steen et al., 2003
42	matrix metallopeptidase-9	37-114	P	normal turnover		Van den Steen et al., 2003
43	matrix metallopeptidase-8	37-114	P			Tester et al., 2007
43	matrix metallopeptidase-9	37-114	P	conversion to two-chain form		Van den Steen et al., 2003
44	unknown peptidase	1-114	P		NT	<%Agarwal et al., 2012[]%>
45	matrix metallopeptidase-1	37-114	P	conversion to two-chain form		Tester et al., 2007
46	matrix metallopeptidase-9	37-114	P	normal turnover		Van den Steen et al., 2003
65	matrix metallopeptidase-9	37-114	P	normal turnover		Van den Steen et al., 2003
75	matrix metallopeptidase-9	37-114	P	normal turnover		Van den Steen et al., 2003
83	matrix metallopeptidase-9	37-114	P	normal turnover		Van den Steen et al., 2003