Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P31150

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
6	caspase-6	1-447	P			Klaiman et al., 2008
79	trypsin 1	1-447	N		MS	Schilling & Overall, 2008
89	trypsin 1	1-447	N		MS	Schilling & Overall, 2008
154	caspase-6	1-447	P			Klaiman et al., 2008
210	trypsin 1	1-447	N		MS	Schilling & Overall, 2008
218	trypsin 1	1-447	N		MS	Schilling & Overall, 2008
221	trypsin 1	1-447	N		MS	Schilling & Overall, 2008
227	matrix metallopeptidase-2	221-240	N		MS	Schilling & Overall, 2008
228	elastase-2	221-240	N		MS	Schilling & Overall, 2008
240	trypsin 1	1-447	N		MS	Schilling & Overall, 2008
277	peptidyl-Lys metallopeptidase	1-447	N		MS
292	peptidyl-Lys metallopeptidase	1-447	N		MS
302	matrix metallopeptidase-2	300-309	N		MS	Schilling & Overall, 2008
309	trypsin 1	1-447	N		MS	Schilling & Overall, 2008
328	trypsin 1	1-447	N		MS	Schilling & Overall, 2008
416	caspase-6	1-447	P			Klaiman et al., 2008
425	astacin	422-436	N		MS	Becker-Pauly et al., 2011
426	cathepsin S	424-435	N		MS	Biniossek et al., 2011