Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P30086

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-187	P		NT	<%Agarwal et al., 2012[]%>
18	cathepsin S	8-28	N		MS	Biniossek et al., 2011
26	matrix metallopeptidase-2	7-39	N		MS	Schilling & Overall, 2008
27	elastase-2	7-39	N		MS	Schilling & Overall, 2008
28	cathepsin S	8-39	N		MS	Biniossek et al., 2011
28	cathepsin B	8-39	N		MS	Biniossek et al., 2011
39	trypsin 1	2-187	N		MS	Schilling & Overall, 2008
47	trypsin 1	2-187	N		MS	Schilling & Overall, 2008
52	matrix metallopeptidase-2	47-62	N		MS	Schilling & Overall, 2008
61	peptidyl-Lys metallopeptidase	2-187	N		MS
62	trypsin 1	2-187	N		MS	Schilling & Overall, 2008
65	cathepsin B	2-187	N		MS	Biniossek et al., 2011
66	HIV-1 retropepsin	62-76	N		MS	Schilling & Overall, 2008
76	trypsin 1	2-187	N		MS	Schilling & Overall, 2008
77	trypsin 1	2-187	N		MS	Schilling & Overall, 2008
119	trypsin 1	2-187	N		MS	Schilling & Overall, 2008
122	HIV-1 retropepsin	119-132	N		MS	Schilling & Overall, 2008
132	trypsin 1	2-187	N		MS	Schilling & Overall, 2008
161	trypsin 1	2-187	N		MS	Schilling & Overall, 2008
179	trypsin 1	2-187	N		MS	Schilling & Overall, 2008