Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P27708

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-2225	P		NT	<%Agarwal et al., 2012[]%>
155	meprin alpha subunit	152-165	N		MS	Becker-Pauly et al., 2011
500	trypsin 1	2-2225	N		MS	Schilling & Overall, 2008
516	trypsin 1	2-2225	N		MS	Schilling & Overall, 2008
576	matrix metallopeptidase-2	571-592	N		MS	Schilling & Overall, 2008
592	trypsin 1	2-2225	N		MS	Schilling & Overall, 2008
789	cathepsin S	782-797	N		MS	Biniossek et al., 2011
1033	trypsin 1	2-2225	N		MS	Schilling & Overall, 2008
1048	trypsin 1	2-2225	N		MS	Schilling & Overall, 2008
1053	trypsin 1	2-2225	N		MS	Schilling & Overall, 2008
1066	trypsin 1	2-2225	N		MS	Schilling & Overall, 2008
1100	HtrA2 peptidase	2-2225	P			Vande Walle et al., 2007
1143	caspase-3	2-2225	P	normal turnover		Adam-Klages et al., 1998
1371	caspase-3	2-2225	P	normal turnover		Adam-Klages et al., 1998
1438	cathepsin B	1435-1450	N		MS	Biniossek et al., 2011
1722	trypsin 1	2-2225	N		MS	Schilling & Overall, 2008
1731	trypsin 1	2-2225	N		MS	Schilling & Overall, 2008