Searches of the MEROPS database

Display Known Cleavages for a Protein

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Accession:

Sequence P23528

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-166	P		NT	<%Agarwal et al., 2012[]%>
4	cathepsin B	2-13	N		MS	Biniossek et al., 2011
8	meprin alpha subunit	2-166	N		MS	Becker-Pauly et al., 2011
8	meprin beta subunit	2-166	N		MS	Becker-Pauly et al., 2011
9	meprin beta subunit	2-166	N		MS	Becker-Pauly et al., 2011
17	caspase-6	2-166	P		MS	Klaiman et al., 2008
34	trypsin 1	2-166	N		MS	Schilling & Overall, 2008
37	HIV-1 retropepsin	34-45	N		MS	Schilling & Overall, 2008
43	peptidyl-Lys metallopeptidase	1-166	N		MS
45	trypsin 1	2-166	N		MS	Schilling & Overall, 2008
52	peptidyl-Lys metallopeptidase	1-166	N		MS
53	trypsin 1	2-166	N		MS	Schilling & Overall, 2008
54	glutamyl endopeptidase I	53-73	N		MS	Schilling & Overall, 2008
58	cathepsin B	54-69	N		MS	Biniossek et al., 2011
58	meprin alpha subunit	2-166	N		MS	Becker-Pauly et al., 2011
58	meprin beta subunit	2-166	N		MS	Becker-Pauly et al., 2011
61	cathepsin S	54-73	N		MS	Biniossek et al., 2011
61	cathepsin K	53-73	N		MS	Schilling & Overall, 2008
69	meprin alpha subunit	2-166	N		MS	Becker-Pauly et al., 2011
69	meprin beta subunit	2-166	N		MS	Becker-Pauly et al., 2011
72	peptidyl-Lys metallopeptidase	1-166	N		MS
73	trypsin 1	2-166	N		MS	Schilling & Overall, 2008
77	peptidyl-Lys metallopeptidase	1-166	N		MS
98	matrix metallopeptidase-2	96-112	N		MS	Schilling & Overall, 2008
101	HIV-1 retropepsin	96-112	N		MS	Schilling & Overall, 2008
101	matrix metallopeptidase-2	96-112	N		MS	Schilling & Overall, 2008
103	HIV-1 retropepsin	96-112	N		MS	Schilling & Overall, 2008
103	cathepsin S	97-112	N		MS	Biniossek et al., 2011
111	peptidyl-Lys metallopeptidase	1-166	N		MS
112	trypsin 1	2-166	N		MS	Schilling & Overall, 2008
128	meprin alpha subunit	2-166	N		MS	Becker-Pauly et al., 2011
133	meprin alpha subunit	2-166	N		MS	Becker-Pauly et al., 2011
133	meprin beta subunit	2-166	N		MS	Becker-Pauly et al., 2011
134	meprin alpha subunit	2-166	N		MS	Becker-Pauly et al., 2011
134	meprin beta subunit	2-166	N		MS	Becker-Pauly et al., 2011
136	cathepsin L	132-144	N		MS	Biniossek et al., 2011
136	meprin alpha subunit	2-166	N		MS	Becker-Pauly et al., 2011
136	meprin beta subunit	2-166	N		MS	Becker-Pauly et al., 2011
155	astacin	152-166	N		MS	Becker-Pauly et al., 2011
156	astacin	153-166	N		MS	Becker-Pauly et al., 2011
156	meprin alpha subunit	153-166	N		MS	Becker-Pauly et al., 2011
157	matrix metallopeptidase-2	152-166	N		MS	Schilling & Overall, 2008