Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P16675

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
23	unknown peptidase	1-474	P	release of a signal peptide	MS	Wang et al., 2006
31	caspase-3	24-474	N		MS	Demon et al., 2009
31	caspase-7	24-474	N		MS	Demon et al., 2009
320	unknown peptidase	1-474	P		NT	<%Agarwal et al., 2012[]%>
333	matrix metallopeptidase-2	24-474	N		MS	auf dem Keller et al., 2010
404	cathepsin D	24-474	P		MS	Impens et al., 2010
404	cathepsin E	24-474	P		MS	Impens et al., 2010
409	cathepsin D	24-474	P		MS	Impens et al., 2010