Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P15259

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-253	P		NT	<%Agarwal et al., 2012[]%>
90	trypsin 1	2-253	N		MS	Schilling & Overall, 2008
93	cathepsin L	91-106	N		MS	Biniossek et al., 2011
94	matrix metallopeptidase-2	90-106	N		MS	Schilling & Overall, 2008
100	trypsin 1	2-253	N		MS	Schilling & Overall, 2008
102	glutamyl endopeptidase I	2-253	N		MS	Schilling & Overall, 2008
106	trypsin 1	2-253	N		MS	Schilling & Overall, 2008
162	trypsin 1	2-253	N		MS	Schilling & Overall, 2008
166	cathepsin G	162-176	N		MS	Schilling & Overall, 2008
176	trypsin 1	2-253	N		MS	Schilling & Overall, 2008
231	cathepsin S	223-241	N		MS	Biniossek et al., 2011
231	cathepsin B	225-241	N		MS	Biniossek et al., 2011