Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P08708

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-135	P		NT	<%Agarwal et al., 2012[]%>
19	lysyl endopeptidase (bacteria)	1-135	N		MS
32	lysyl endopeptidase (bacteria)	1-135	N		MS
33	trypsin 1	2-135	N		MS	Schilling & Overall, 2008
35	meprin beta subunit	32-45	N		MS	Becker-Pauly et al., 2011
44	trypsin 1	2-135	N		MS	Schilling & Overall, 2008
48	peptidyl-Lys metallopeptidase	1-135	N		MS
49	trypsin 1	2-135	N		MS	Schilling & Overall, 2008
51	cathepsin B	50-59	N		MS	Biniossek et al., 2011
58	peptidyl-Lys metallopeptidase	1-135	N		MS
59	trypsin 1	2-135	N		MS	Schilling & Overall, 2008
91	granzyme B (Homo sapiens-type)	2-135	N		MS	Van Damme et al., 2010
92	cathepsin K	88-107	N		MS	Schilling & Overall, 2008
92	granzyme B (Homo sapiens-type)	2-135	N		MS	Van Damme et al., 2010
107	trypsin 1	2-135	N		MS	Schilling & Overall, 2008
110	glutamyl endopeptidase I	107-129	N		MS	Schilling & Overall, 2008
116	matrix metallopeptidase-2	110-135	N		MS	Schilling & Overall, 2008
129	trypsin 1	2-135	N		MS	Schilling & Overall, 2008