Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P08621

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
16	trypsin 1	1-437	N		MS	Schilling & Overall, 2008
27	trypsin 1	1-437	N		MS	Schilling & Overall, 2008
144	trypsin 1	1-437	N		MS	Schilling & Overall, 2008
146	astacin	143-155	N		MS	Becker-Pauly et al., 2011
147	cathepsin L	145-155	N		MS	Biniossek et al., 2011
147	cathepsin B	145-155	N		MS	Biniossek et al., 2011
155	trypsin 1	1-437	N		MS	Schilling & Overall, 2008
220	meprin alpha subunit	217-231	N		MS	Becker-Pauly et al., 2011
316	unknown peptidase	1-437	P			Van Damme et al., 2009
341	caspase-3	1-437	P			Teraoka et al., 1996
348	trypsin 1	1-437	N			Van Damme et al., 2009
393	granzyme A	1-437	N			Van Damme et al., 2010
409	granzyme B (Homo sapiens-type)	1-437	P			Casciola-Rosen et al., 1999
427	granzyme B (Homo sapiens-type)	1-437	N		MS	Van Damme et al., 2010