Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence P02775

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
34	unknown peptidase	1-128	P	release of a signal peptide	NT	Zhang & Henzel, 2004
43	kallikrein-related peptidase 4	1-128	P		CS	Matsumura et al., 2005
47	unknown peptidase	1-128	P		NT	<%Agarwal et al., 2012[]%>
54	unknown peptidase	1-128	P		NT	<%Agarwal et al., 2012[]%>
55	unknown peptidase	1-128	P		NT	<%Agarwal et al., 2012[]%>
56	matrix metallopeptidase-9	35-128	P	conversion to two-chain form		Van den Steen et al., 2003
58	chymase (Homo sapiens-type)	44-128	P		AB	Schiemann et al., 2006
60	matrix metallopeptidase-9	35-128	P	normal turnover		Van den Steen et al., 2003
63	matrix metallopeptidase-9	35-128	P	normal turnover		Van den Steen et al., 2003
76	matrix metallopeptidase-9	35-128	P	normal turnover		Van den Steen et al., 2003
81	matrix metallopeptidase-9	35-128	P	normal turnover		Van den Steen et al., 2003
97	matrix metallopeptidase-9	35-128	P	normal turnover		Van den Steen et al., 2003
115	matrix metallopeptidase-9	35-128	P	normal turnover		Van den Steen et al., 2003
121	unknown peptidase	1-128	P		NT	<%Agarwal et al., 2012[]%>
124	unknown peptidase	1-128	P		NT	<%Agarwal et al., 2012[]%>
126	unknown peptidase	1-128	P		NT	<%Agarwal et al., 2012[]%>