Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence O60841

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
14	trypsin 1	1-1220	N		MS	Schilling & Overall, 2008
20	unknown peptidase		P		MS	Mahrus et al., 2008
33	trypsin 1	1-1220	N		MS	Schilling & Overall, 2008
62	meprin beta subunit	1-1220	N		MS	Becker-Pauly et al., 2011
76	trypsin 1	1-1220	N		MS	Schilling & Overall, 2008
80	cathepsin L	77-94	N		MS	Biniossek et al., 2011
80	cathepsin S	77-94	N		MS	Biniossek et al., 2011
94	trypsin 1	1-1220	N		MS	Schilling & Overall, 2008
288	unknown peptidase	1-1220	P		MS	Dix et al., 2008
903	matrix metallopeptidase-2	895-912	N		MS	Schilling & Overall, 2008
912	glutamyl endopeptidase I	1-1220	N		MS	Schilling & Overall, 2008
940	trypsin 1	1-1220	N		MS	Schilling & Overall, 2008
952	trypsin 1	1-1220	N		MS	Schilling & Overall, 2008
999	trypsin 1	1-1220	N		MS	Schilling & Overall, 2008
1015	trypsin 1	1-1220	N		MS	Schilling & Overall, 2008
1043	trypsin 1	1-1220	N		MS	Schilling & Overall, 2008
1055	trypsin 1	1-1220	N		MS	Schilling & Overall, 2008