Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence O43776

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-548	P		NT	<%Agarwal et al., 2012[]%>
32	matrix metallopeptidase-2	23-51	N		MS	Schilling & Overall, 2008
51	glutamyl endopeptidase I	2-548	N		MS	Schilling & Overall, 2008
223	granzyme B (Homo sapiens-type)	2-548	N		MS	Van Damme et al., 2010
275	cathepsin L	264-286	N		MS	Biniossek et al., 2011
367	trypsin 1	2-548	N		MS	Schilling & Overall, 2008
385	trypsin 1	2-548	N		MS	Schilling & Overall, 2008
429	granzyme B (Homo sapiens-type)	2-548	N		MS	Van Damme et al., 2010
478	trypsin 1	2-548	N		MS	Schilling & Overall, 2008
490	trypsin 1	2-548	N		MS	Schilling & Overall, 2008