Searches of the MEROPS database

Display Known Cleavages for a Protein

Please enter a UniProt accession (eg P05067):

Accession:

Sequence B2RPK0

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Peptide and protein substrates that are thought to be physiologically relevant are indicated by P. Peptide and protein substrates that are not physiologically relevant are indicated by N. How cleavage sites have been identified are indicated by the following evidence codes: NT = N-terminal sequencing, MS = mass spectroscopy, MU = mutation, CS = consensus sequence, LC = liquid chromatography. To see all annotated cleavages for a peptidase, click on the peptidase name.

Cleavage Site	Peptidase	Residue range	Cleavage type	Description	Evidence	Reference
1	unknown peptidase	1-211	P		NT	<%Agarwal et al., 2012[]%>
11	peptidyl-Lys metallopeptidase	1-211	N		MS
16	granzyme B (Homo sapiens-type)	2-211	N		MS	Van Damme et al., 2010
27	peptidyl-Lys metallopeptidase	1-211	N		MS
111	peptidyl-Lys metallopeptidase	1-211	N		MS
112	lysyl endopeptidase (bacteria)	1-211	N		MS
113	peptidyl-Lys metallopeptidase	1-211	N		MS
126	peptidyl-Lys metallopeptidase	1-211	N		MS
127	peptidyl-Lys metallopeptidase	1-211	N		MS
128	trypsin 1	1-211	N		MS	Schilling & Overall, 2008
130	cathepsin K	128-146	N		MS	Schilling & Overall, 2008
131	matrix metallopeptidase-2	128-146	N		MS	Schilling & Overall, 2008
131	glutamyl endopeptidase I	128-146	N		MS	Schilling & Overall, 2008
140	peptidyl-Lys metallopeptidase	1-211	N		MS
146	trypsin 1	1-211	N		MS	Schilling & Overall, 2008
147	trypsin 1	1-211	N		MS	Schilling & Overall, 2008