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Literature for peptidase S41.001: C-terminal processing peptidase-1

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: A Assay, P Specificity, I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Gonzalez,L.J., Hita,F.J., Pontoriero,L., Pierattelli,R., Binolfi,A. and Vila,A.J.
    Periplasmic protein quality control at atomic level in live cells
    Nat Commun (2025) 16, 8366-8366. PubMed  Europe PubMed DOI  PMC  EPMC
  2. Park,S., Jeon,W.J., Lee,Y., Lim,C.L., Lee,E., Oh,H.B., Lee,G.S., Kwon,O.H., Ryu,B., Cho,Y.J., Kim,C.S., Yoon,S.I., Chung,J.M. and Cho,H.
    A periplasmic protein modulates the proteolysis of peptidoglycan hydrolases to maintain cell wall homeostasis in Escherichia coli
    Proc Natl Acad Sci U S A (2025) 122, e2418854122-e2418854122. PubMed  Europe PubMed DOI
    3. 2024
  3. Sommerfield,A.G., Wang,M., Mamana,J. and Darwin,A.J.
    In vivo and in vitro analysis of the role of the Prc protease in inducing mucoidy in Pseudomonas aeruginosa
    bioRxiv (2024) PubMed  Europe PubMed DOI  PMC  EPMC
  4. Sommerfield,A.G., Wang,M., Mamana,J. and Darwin,A.J.
    In vivo and in vitro analyses of the role of the Prc protease in inducing mucoidy in Pseudomonas aeruginosa
    J Bacteriol (2024) , e0022224-e0022224. PubMed  Europe PubMed DOI
    5. 2023
  5. Gonzalez,L.J., Bahr,G., Gonzalez,M.M., Bonomo,R.A. and Vila,A.J.
    In-cell kinetic stability is an essential trait in metallo-beta-lactamase evolution
    Nat Chem Biol (2023) 19, 1116-1126. PubMed  Europe PubMed DOI
  6. Swoboda,A.R., Wood,N.A., Saery,E.A., Fisher,D.J. and Ouellette,S.P.
    The Periplasmic Tail-Specific Protease, Tsp, Is Essential for Secondary Differentiation in Chlamydia trachomatis
    J Bacteriol (2023) 205, e0009923-e0009923. PubMed  Europe PubMed DOI  PMC  EPMC  K
    7. 2022
  7. Jeon,W.J. and Cho,H.
    A Cell Wall Hydrolase MepH Is Negatively Regulated by Proteolysis Involving Prc and NlpI in Escherichia coli
    Front Microbiol (2022) 13, 878049-878049. PubMed  Europe PubMed DOI  PMC  EPMC
  8. Lopez-Escarpa,D., Castanheira,S. and Garcia-del Portillo,F.
    OmpR and Prc contribute to switch the Salmonella morphogenetic program in response to phagosome cues
    Mol Microbiol (2022) 118, 477-493. PubMed  Europe PubMed DOI  PMC  EPMC
    9. 2021
  9. Chakraborty,D. and Darwin,A.J.
    Direct and indirect interactions promote complexes of the lipoprotein LbcA, the CtpA protease and its substrates, and other cell wall proteins in Pseudomonas aeruginosa
    J Bacteriol (2021) , JB0039321-JB0039321. PubMed  Europe PubMed DOI
    10. 2020
  10. Huang,W.C., Lin,C.Y., Hashimoto,M., Wu,J.J., Wang,M.C., Lin,W.H., Chen,C.S. and Teng,C.H.
    The role of the bacterial protease Prc in the uropathogenesis of extraintestinal pathogenic Escherichia coli
    J Biomed Sci (2020) 27, 14-14. PubMed  Europe PubMed DOI  PMC  EPMC
  11. Jun,D., Idem,U. and Dahms,T.E.S.
    Altered Envelope Structure and Nanomechanical Properties of a C-Terminal Protease A-Deficient Rhizobium leguminosarum
    Microorganisms (2020) 8 PubMed  Europe PubMed DOI  PMC  EPMC
  12. Roy,R., You,R.I., Lin,M.D. and Lin,N.T.
    Mutation of the carboxy-terminal processing protease in Acinetobacter baumannii affects motility, leads to loss of membrane integrity, and reduces virulence
    Pathogens (2020) 9 PubMed  Europe PubMed DOI
    13. 2018
  13. Delgado,C., Florez,L., Lollett,I., Lopez,C., Kangeyan,S., Kumari,H., Stylianou,M., Smiddy,R.J., Schneper,L., Sautter,R.T., Szatmari,G. and Mathee,K.
    Pseudomonas aeruginosa regulated intramembrane proteolysis (RIP): protease MucP can overcome mutations in the AlgO periplasmic protease to restore alginate production in nonmucoid revertants
    J Bacteriol (2018) 200, e00215-18-e00215-18. PubMed  Europe PubMed DOI
  14. Srivastava,D., Seo,J., Rimal,B., Kim,S.J., Zhen,S. and Darwin,A.J.
    A proteolytic complex targets multiple cell wall hydrolases in Pseudomonas aeruginosa
    MBio (2018) 9 PubMed  Europe PubMed DOI  PMC  EPMC
    15. 2017
  15. Su,M.Y., Som,N., Wu,C.Y., Su,S.C., Kuo,Y.T., Ke,L.C., Ho,M.R., Tzeng,S.R., Teng,C.H., Mengin-Lecreulx,D., Reddy,M. and Chang,C.I.
    Structural basis of adaptor-mediated protein degradation by the tail-specific PDZ-protease Prc
    Nat Commun (2017) 8, 1516-1516. PubMed  Europe PubMed DOI  PMC  EPMC
    16. 2015
  16. Kohlmann,F., Shima,K., Hilgenfeld,R., Solbach,W., Rupp,J. and Hansen,G.
    Structural basis of the proteolytic and chaperone activity of Chlamydia trachomatis CT441
    J Bacteriol (2015) 197, 211-218. PubMed  Europe PubMed DOI
  17. Kohlmann,F., Shima,K., Rupp,J., Solbach,W., Hilgenfeld,R. and Hansen,G.
    Production, crystallization and X-ray diffraction analysis of the protease CT441 from Chlamydia trachomatis
    Acta Crystallogr F Struct Biol Commun (2015) 71, 1454-1458. PubMed  Europe PubMed DOI
  18. Singh,S.K., Parveen,S., saiSree,L. and Reddy,M.
    Regulated proteolysis of a cross-link-specific peptidoglycan hydrolase contributes to bacterial morphogenesis
    Proc Natl Acad Sci U S A (2015) 112, 10956-10961. PubMed  Europe PubMed DOI
  19. Teoh,W.P., Matson,J.S. and DiRita,V.J.
    Regulated intramembrane proteolysis of the virulence activator TcpP in Vibrio cholerae is initiated by the tail-specific protease (Tsp)
    Mol Microbiol (2015) 97, 822-831. PubMed  Europe PubMed DOI
    20. 2014
  20. Bastiaansen,K.C., Ibanez,A., Ramos,J.L., Bitter,W. and Llamas,M.A.
    The Prc and RseP proteases control bacterial cell-surface signalling activity
    Environ Microbiol (2014) 16, 2433-2443. PubMed  Europe PubMed DOI
    21. 2013
  21. Seo,J. and Darwin,A.J.
    The Pseudomonas aeruginosa periplasmic protease CtpA can affect systems that impact its ability to mount both acute and chronic infections
    Infect Immun (2013) 81, 4561-4570. PubMed  Europe PubMed DOI
    22. 2012
  22. Keiler,K.C.
    Tsp protease
    [ISSN:978-0-12-407742-3] (2012) 3, 3605-3607. DOI
  23. Sautter,R., Ramos,D., Schneper,L., Ciofu,O., Wassermann,T., Koh,C.L., Heydorn,A., Hentzer,M., Hoiby,N., Kharazmi,A., Molin,S., Devries,C.A., Ohman,D.E. and Mathee,K.
    A complex multilevel attack on Pseudomonas aeruginosa algT/U expression and AlgT/U activity results in the loss of alginate production
    Gene (2012) 498, 242-253. PubMed  Europe PubMed DOI
  24. Wang,C.Y., Wang,S.W., Huang,W.C., Kim,K.S., Chang,N.S., Wang,Y.H., Wu,M.H. and Teng,C.H.
    Prc contributes to Escherichia coli evasion of classical complement-mediated serum killing
    Infect Immun (2012) 80, 3399-3409. PubMed  Europe PubMed DOI
  25. Weski,J., Meltzer,M., Spaan,L., Monig,T., Oeljeklaus,J., Hauske,P., Vouilleme,L., Volkmer,R., Boisguerin,P., Boyd,D., Huber,R., Kaiser,M. and Ehrmann,M.
    Chemical Biology Approaches Reveal Conserved Features of a C-Terminal Processing PDZ Protease
    Chembiochem (2012) 13, 402-408. PubMed  Europe PubMed DOI  I
    26. 2011
  26. Hoge,R., Laschinski,M., Jaeger,K.E., Wilhelm,S. and Rosenau,F.
    The subcellular localization of a C-terminal processing protease in Pseudomonas aeruginosa
    FEMS Microbiol Lett (2011) 316, 23-30. PubMed  Europe PubMed DOI
  27. Zhong,G.
    Chlamydia trachomatis secretion of proteases for manipulating host signaling pathways
    Front Microbiol (2011) 2, 14-14. PubMed  Europe PubMed DOI  PMC  EPMC
    28. 2010
  28. Borth,N., Massier,J., Franke,C., Sachse,K., Saluz,H.P. and Hanel,F.
    Chlamydial protease CT441 interacts with SRAP1 co-activator of estrogen receptor alpha and partially alleviates its co-activation activity
    J Steroid Biochem Mol Biol (2010) 119, 89-95. PubMed  Europe PubMed DOI
    29. 2007
  29. Lad,S.P., Li,J., da Silva Correia,J., Pan,Q., Gadwal,S., Ulevitch,R.J. and Li,E.
    Cleavage of p65/RelA of the NF-kappaB pathway by Chlamydia
    Proc Natl Acad Sci U S A (2007) 104, 2933-2938. PubMed  Europe PubMed DOI  PMC  EPMC
  30. Lad,S.P., Yang,G., Scott,D.A., Wang,G., Nair,P., Mathison,J., Reddy,V.S. and Li,E.
    Chlamydial CT441 is a PDZ domain-containing tail-specific protease that interferes with the NF-kappaB pathway of immune response
    J Bacteriol (2007) 189, 6619-6625. PubMed  Europe PubMed DOI  PMC  EPMC
    31. 2005
  31. Reiling,S.A., Jansen,J.A., Henley,B.J., Singh,S., Chattin,C., Chandler,M. and Rowen,D.W.
    Prc protease promotes mucoidy in mucA mutants of Pseudomonas aeruginosa
    Microbiology (Reading) (2005) 151, 2251-2261. PubMed  Europe PubMed DOI
    32. 2004
  32. Keiler,K.C. and Sauer,R.T.
    Tsp protease
    [ISSN:0-12-079610-4] (2004) 2, 2027-2028.  V
  33. Tadokoro,A., Hayashi,H., Kishimoto,T., Makino,Y., Fujisaki,S. and Nishimura,Y.
    Interaction of the Escherichia coli lipoprotein NlpI with periplasmic Prc (Tsp) protease
    J Biochem (2004) 135, 185-191. PubMed  Europe PubMed DOI
    34. 2002
  34. [YEAR:18-10-2002]Spiers,A., Lamb,H.K., Cocklin,S., Wheeler,K.A., Budworth,J., Dodds,A.L., Pallen,M.J., Maskell,D.J., Charles,I.G. and Hawkins,A.R.
    PDZ domains facilitate binding of high temperature requirement protease A (HtrA) and tail-specific protease (Tsp) to heterologous substrates through recognition of the small stable RNA A (ssrA)-encoded peptide
    J Biol Chem (18-10-2002) 277, 39443-39449. PubMed  Europe PubMed DOI
    35. 2000
  35. [YEAR:21-3-2000]Beebe,K.D., Shin,J., Peng,J., Chaudhury,C., Khera,J. and Pei,D.
    Substrate recognition through a PDZ domain in tail-specific protease
    Biochemistry (21-3-2000) 39, 3149-3155. PubMed  Europe PubMed DOI
    36. 1998
  36. [YEAR:1-10-1998]Beebe,K.D. and Pei,D.
    A continuous fluorimetric assay for tail-specific protease
    Anal Biochem (1-10-1998) 263, 51-56. PubMed  Europe PubMed DOI  A  P
    37. 1997
  37. Ponting,C.P.
    Evidence for PDZ domains in bacteria, yeast, and plants
    Protein Sci (1997) 6, 464-468. PubMed  Europe PubMed DOI  PMC  EPMC
    38. 1996
  38. Bass,S., Gu,Q.M. and Christen,A.
    Multicopy suppressors of prc mutant Escherichia coli include two HtrA (DegP) protease homologs (HhoAB), DksA, and a truncated RlpA
    J Bacteriol (1996) 178, 1154-1161. PubMed  Europe PubMed
  39. Jentsch,S.
    When proteins receive deadly messages at birth
    Science (1996) 271, 955-956. PubMed  Europe PubMed DOI
  40. [YEAR:16-2-1996]Keiler,K.C., Waller,P.R. and Sauer,R.T.
    Role of a peptide tagging system in degradation of proteins synthesized from damaged messenger RNA
    Science (16-2-1996) 271, 990-993. PubMed  Europe PubMed
  41. Keiler,K.C. and Sauer,R.T.
    Sequence determinants of C-terminal substrate recognition by the Tsp protease
    J Biol Chem (1996) 271, 2589-2593. PubMed  Europe PubMed DOI
    42. 1995
  42. Keiler,K.C. and Sauer,R.T.
    Identification of active site residues of the Tsp protease
    J Biol Chem (1995) 270, 28864-28868. PubMed  Europe PubMed DOI
  43. Keiler,K.C., Silber,K.R., Downard,K.M., Papayannopoulos,I.A., Biemann,K. and Sauer,R.T.
    C-terminal specific protein degradation: activity and substrate specificity of the Tsp protease
    Protein Sci (1995) 4, 1507-1515. PubMed  Europe PubMed DOI  PMC  EPMC
    44. 1994
  44. Silber,K.R. and Sauer,R.T.
    Deletion of the prc (tsp) gene provides evidence for additional tail-specific proteolytic activity in Escherichia coli K-12
    Mol Gen Genet (1994) 242, 237-240. PubMed  Europe PubMed
    45. 1992
  45. Silber,K.R., Keiler,K.C. and Sauer,R.T.
    Tsp: a tail-specific protease that selectively degrades proteins with nonpolar C termini
    Proc Natl Acad Sci U S A (1992) 89, 295-299. PubMed  Europe PubMed  PMC  EPMC
    46. 1991
  46. Hara,H., Yamamoto,Y., Higashitani,A., Suzuki,H. and Nishimura,Y.
    Cloning, mapping, and characterization of the Escherichia coli prc gene, which is involved in C-terminal processing of penicillin-binding protein 3
    J Bacteriol (1991) 173, 4799-4813. PubMed  Europe PubMed  PMC  EPMC
    47. 1990
  47. Parsell,D.A., Silber,K.R. and Sauer,R.T.
    Carboxy-terminal determinants of intracellular protein degradation
    Genes Dev (1990) 4, 277-286. PubMed  Europe PubMed
    48. 1989
  48. Nagasawa,H., Sakagami,Y., Suzuki,A., Suzuki,H., Hara,H. and Hirota,Y.
    Determination of the cleavage site involved in C-terminal processing of penicillin-binding protein 3 of Escherichia coli
    J Bacteriol (1989) 171, 5890-5893. PubMed  Europe PubMed  PMC  EPMC
    49. 1988
  49. Park,J.H., Lee,Y.S., Chung,C.H. and Goldberg,A.L.
    Purification and characterization of protease Re, a cytoplasmic endoprotease in Escherichia coli
    J Bacteriol (1988) 170, 921-926. PubMed  Europe PubMed  PMC  EPMC

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