Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase S41.001: C-terminal processing peptidase-1

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: A Assay, P Specificity, I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2025
  1. Park,S., Jeon,W.J., Lee,Y., Lim,C.L., Lee,E., Oh,H.B., Lee,G.S., Kwon,O.H., Ryu,B., Cho,Y.J., Kim,C.S., Yoon,S.I., Chung,J.M. and Cho,H.
    A periplasmic protein modulates the proteolysis of peptidoglycan hydrolases to maintain cell wall homeostasis in Escherichia coli
    Proc Natl Acad Sci U S A122, e2418854122-e2418854122. PubMed  Europe PubMed DOI
    2. 2024
  2. Sommerfield,A.G., Wang,M., Mamana,J. and Darwin,A.J.
    In vivo and in vitro analysis of the role of the Prc protease in inducing mucoidy in Pseudomonas aeruginosa
    bioRxiv PubMed  Europe PubMed DOI
    3. 2023
  3. Gonzalez,L.J., Bahr,G., Gonzalez,M.M., Bonomo,R.A. and Vila,A.J.
    In-cell kinetic stability is an essential trait in metallo-beta-lactamase evolution
    Nat Chem Biol19, 1116-1126. PubMed  Europe PubMed DOI
  4. Swoboda,A.R., Wood,N.A., Saery,E.A., Fisher,D.J. and Ouellette,S.P.
    The Periplasmic Tail-Specific Protease, Tsp, Is Essential for Secondary Differentiation in Chlamydia trachomatis
    J Bacteriol205, e0009923-e0009923. PubMed  Europe PubMed DOI  K
    5. 2022
  5. Jeon,W.J. and Cho,H.
    A Cell Wall Hydrolase MepH Is Negatively Regulated by Proteolysis Involving Prc and NlpI in Escherichia coli
    Front Microbiol13, 878049-878049. PubMed  Europe PubMed DOI
  6. Lopez-Escarpa,D., Castanheira,S. and Garcia-del Portillo,F.
    OmpR and Prc contribute to switch the Salmonella morphogenetic program in response to phagosome cues
    Mol Microbiol118, 477-493. PubMed  Europe PubMed DOI
    7. 2021
  7. Chakraborty,D. and Darwin,A.J.
    Direct and indirect interactions promote complexes of the lipoprotein LbcA, the CtpA protease and its substrates, and other cell wall proteins in Pseudomonas aeruginosa
    J BacteriolJB0039321-JB0039321. PubMed  Europe PubMed DOI
    8. 2020
  8. Huang,W.C., Lin,C.Y., Hashimoto,M., Wu,J.J., Wang,M.C., Lin,W.H., Chen,C.S. and Teng,C.H.
    The role of the bacterial protease Prc in the uropathogenesis of extraintestinal pathogenic Escherichia coli
    J Biomed Sci27, 14-14. PubMed  Europe PubMed DOI
  9. Jun,D., Idem,U. and Dahms,T.E.S.
    Altered Envelope Structure and Nanomechanical Properties of a C-Terminal Protease A-Deficient Rhizobium leguminosarum
    Microorganisms8, PubMed  Europe PubMed DOI
  10. Roy,R., You,R.I., Lin,M.D. and Lin,N.T.
    Mutation of the carboxy-terminal processing protease in Acinetobacter baumannii affects motility, leads to loss of membrane integrity, and reduces virulence
    Pathogens9, PubMed  Europe PubMed DOI
    11. 2018
  11. Delgado,C., Florez,L., Lollett,I., Lopez,C., Kangeyan,S., Kumari,H., Stylianou,M., Smiddy,R.J., Schneper,L., Sautter,R.T., Szatmari,G. and Mathee,K.
    Pseudomonas aeruginosa regulated intramembrane proteolysis (RIP): protease MucP can overcome mutations in the AlgO periplasmic protease to restore alginate production in nonmucoid revertants
    J Bacteriol200, e00215-18-e00215-18. PubMed  Europe PubMed DOI
  12. Srivastava,D., Seo,J., Rimal,B., Kim,S.J., Zhen,S. and Darwin,A.J.
    A proteolytic complex targets multiple cell wall hydrolases in Pseudomonas aeruginosa
    MBio9, PubMed  Europe PubMed DOI
    13. 2017
  13. Su,M.Y., Som,N., Wu,C.Y., Su,S.C., Kuo,Y.T., Ke,L.C., Ho,M.R., Tzeng,S.R., Teng,C.H., Mengin-Lecreulx,D., Reddy,M. and Chang,C.I.
    Structural basis of adaptor-mediated protein degradation by the tail-specific PDZ-protease Prc
    Nat Commun8, 1516-1516. PubMed  Europe PubMed DOI
    14. 2015
  14. Kohlmann,F., Shima,K., Rupp,J., Solbach,W., Hilgenfeld,R. and Hansen,G.
    Production, crystallization and X-ray diffraction analysis of the protease CT441 from Chlamydia trachomatis
    Acta Crystallogr F Struct Biol Commun71, 1454-1458. PubMed  Europe PubMed DOI
  15. Kohlmann,F., Shima,K., Hilgenfeld,R., Solbach,W., Rupp,J. and Hansen,G.
    Structural basis of the proteolytic and chaperone activity of Chlamydia trachomatis CT441
    J Bacteriol197, 211-218. PubMed  Europe PubMed DOI
  16. Singh,S.K., Parveen,S., saiSree,L. and Reddy,M.
    Regulated proteolysis of a cross-link-specific peptidoglycan hydrolase contributes to bacterial morphogenesis
    Proc Natl Acad Sci U S A112, 10956-10961. PubMed  Europe PubMed DOI
  17. Teoh,W.P., Matson,J.S. and DiRita,V.J.
    Regulated intramembrane proteolysis of the virulence activator TcpP in Vibrio cholerae is initiated by the tail-specific protease (Tsp)
    Mol Microbiol97, 822-831. PubMed  Europe PubMed DOI
    18. 2014
  18. Bastiaansen,K.C., Ibanez,A., Ramos,J.L., Bitter,W. and Llamas,M.A.
    The Prc and RseP proteases control bacterial cell-surface signalling activity
    Environ Microbiol16, 2433-2443. PubMed  Europe PubMed DOI
    19. 2013
  19. Seo,J. and Darwin,A.J.
    The Pseudomonas aeruginosa periplasmic protease CtpA can affect systems that impact its ability to mount both acute and chronic infections
    Infect Immun81, 4561-4570. PubMed  Europe PubMed DOI
    20. 2012
  20. Keiler,K.C.
    Tsp protease
    [ISSN:978-0-12-407742-3]3, 3605-3607. DOI
  21. Sautter,R., Ramos,D., Schneper,L., Ciofu,O., Wassermann,T., Koh,C.L., Heydorn,A., Hentzer,M., Hoiby,N., Kharazmi,A., Molin,S., Devries,C.A., Ohman,D.E. and Mathee,K.
    A complex multilevel attack on Pseudomonas aeruginosa algT/U expression and AlgT/U activity results in the loss of alginate production
    Gene498, 242-253. PubMed  Europe PubMed DOI
  22. Wang,C.Y., Wang,S.W., Huang,W.C., Kim,K.S., Chang,N.S., Wang,Y.H., Wu,M.H. and Teng,C.H.
    Prc contributes to Escherichia coli evasion of classical complement-mediated serum killing
    Infect Immun80, 3399-3409. PubMed  Europe PubMed DOI
  23. Weski,J., Meltzer,M., Spaan,L., Monig,T., Oeljeklaus,J., Hauske,P., Vouilleme,L., Volkmer,R., Boisguerin,P., Boyd,D., Huber,R., Kaiser,M. and Ehrmann,M.
    Chemical Biology Approaches Reveal Conserved Features of a C-Terminal Processing PDZ Protease
    Chembiochem13, 402-408. PubMed  Europe PubMed DOI  I
    24. 2011
  24. Hoge,R., Laschinski,M., Jaeger,K.E., Wilhelm,S. and Rosenau,F.
    The subcellular localization of a C-terminal processing protease in Pseudomonas aeruginosa
    FEMS Microbiol Lett316, 23-30. PubMed  Europe PubMed DOI
  25. Zhong,G.
    Chlamydia trachomatis secretion of proteases for manipulating host signaling pathways
    Front Microbiol2, 14-14. PubMed  Europe PubMed DOI
    26. 2010
  26. Borth,N., Massier,J., Franke,C., Sachse,K., Saluz,H.P. and Hanel,F.
    Chlamydial protease CT441 interacts with SRAP1 co-activator of estrogen receptor alpha and partially alleviates its co-activation activity
    J Steroid Biochem Mol Biol119, 89-95. PubMed  Europe PubMed DOI
    27. 2007
  27. Lad,S.P., Yang,G., Scott,D.A., Wang,G., Nair,P., Mathison,J., Reddy,V.S. and Li,E.
    Chlamydial CT441 is a PDZ domain-containing tail-specific protease that interferes with the NF-kappaB pathway of immune response
    J Bacteriol189, 6619-6625. PubMed  Europe PubMed DOI
  28. Lad,S.P., Li,J., da Silva Correia,J., Pan,Q., Gadwal,S., Ulevitch,R.J. and Li,E.
    Cleavage of p65/RelA of the NF-kappaB pathway by Chlamydia
    Proc Natl Acad Sci U S A104, 2933-2938. PubMed  Europe PubMed DOI
    29. 2005
  29. Reiling,S.A., Jansen,J.A., Henley,B.J., Singh,S., Chattin,C., Chandler,M. and Rowen,D.W.
    Prc protease promotes mucoidy in mucA mutants of Pseudomonas aeruginosa
    Microbiology (Reading)151, 2251-2261. PubMed  Europe PubMed DOI
    30. 2004
  30. Keiler,K.C. and Sauer,R.T.
    Tsp protease
    [ISSN:0-12-079610-4]2, 2027-2028.  V
  31. Tadokoro,A., Hayashi,H., Kishimoto,T., Makino,Y., Fujisaki,S. and Nishimura,Y.
    Interaction of the Escherichia coli lipoprotein NlpI with periplasmic Prc (Tsp) protease
    J Biochem135, 185-191. PubMed  Europe PubMed DOI
    32. 2002
  32. [YEAR:18-10-2002]Spiers,A., Lamb,H.K., Cocklin,S., Wheeler,K.A., Budworth,J., Dodds,A.L., Pallen,M.J., Maskell,D.J., Charles,I.G. and Hawkins,A.R.
    PDZ domains facilitate binding of high temperature requirement protease A (HtrA) and tail-specific protease (Tsp) to heterologous substrates through recognition of the small stable RNA A (ssrA)-encoded peptide
    J Biol Chem277, 39443-39449. PubMed  Europe PubMed DOI
    33. 2000
  33. [YEAR:21-3-2000]Beebe,K.D., Shin,J., Peng,J., Chaudhury,C., Khera,J. and Pei,D.
    Substrate recognition through a PDZ domain in tail-specific protease
    Biochemistry39, 3149-3155. PubMed  Europe PubMed DOI
    34. 1998
  34. [YEAR:1-10-1998]Beebe,K.D. and Pei,D.
    A continuous fluorimetric assay for tail-specific protease
    Anal Biochem263, 51-56. PubMed  Europe PubMed DOI  A  P
    35. 1997
  35. Ponting,C.P.
    Evidence for PDZ domains in bacteria, yeast, and plants
    Protein Sci6, 464-468. PubMed  Europe PubMed DOI
    36. 1996
  36. Bass,S., Gu,Q.M. and Christen,A.
    Multicopy suppressors of prc mutant Escherichia coli include two HtrA (DegP) protease homologs (HhoAB), DksA, and a truncated RlpA
    J Bacteriol178, 1154-1161. PubMed  Europe PubMed
  37. Jentsch,S.
    When proteins receive deadly messages at birth
    Science271, 955-956. PubMed  Europe PubMed DOI
  38. Keiler,K.C. and Sauer,R.T.
    Sequence determinants of C-terminal substrate recognition by the Tsp protease
    J Biol Chem271, 2589-2593. PubMed  Europe PubMed DOI
  39. [YEAR:16-2-1996]Keiler,K.C., Waller,P.R. and Sauer,R.T.
    Role of a peptide tagging system in degradation of proteins synthesized from damaged messenger RNA
    Science271, 990-993. PubMed  Europe PubMed
    40. 1995
  40. Keiler,K.C., Silber,K.R., Downard,K.M., Papayannopoulos,I.A., Biemann,K. and Sauer,R.T.
    C-terminal specific protein degradation: activity and substrate specificity of the Tsp protease
    Protein Sci4, 1507-1515. PubMed  Europe PubMed DOI
  41. Keiler,K.C. and Sauer,R.T.
    Identification of active site residues of the Tsp protease
    J Biol Chem270, 28864-28868. PubMed  Europe PubMed DOI
    42. 1994
  42. Silber,K.R. and Sauer,R.T.
    Deletion of the prc (tsp) gene provides evidence for additional tail-specific proteolytic activity in Escherichia coli K-12
    Mol Gen Genet242, 237-240. PubMed  Europe PubMed
    43. 1992
  43. Silber,K.R., Keiler,K.C. and Sauer,R.T.
    Tsp: a tail-specific protease that selectively degrades proteins with nonpolar C termini
    Proc Natl Acad Sci U S A89, 295-299. PubMed  Europe PubMed
    44. 1991
  44. Hara,H., Yamamoto,Y., Higashitani,A., Suzuki,H. and Nishimura,Y.
    Cloning, mapping, and characterization of the Escherichia coli prc gene, which is involved in C-terminal processing of penicillin-binding protein 3
    J Bacteriol173, 4799-4813. PubMed  Europe PubMed
    45. 1990
  45. Parsell,D.A., Silber,K.R. and Sauer,R.T.
    Carboxy-terminal determinants of intracellular protein degradation
    Genes Dev4, 277-286. PubMed  Europe PubMed
    46. 1989
  46. Nagasawa,H., Sakagami,Y., Suzuki,A., Suzuki,H., Hara,H. and Hirota,Y.
    Determination of the cleavage site involved in C-terminal processing of penicillin-binding protein 3 of Escherichia coli
    J Bacteriol171, 5890-5893. PubMed  Europe PubMed
    47. 1988
  47. Park,J.H., Lee,Y.S., Chung,C.H. and Goldberg,A.L.
    Purification and characterization of protease Re, a cytoplasmic endoprotease in Escherichia coli
    J Bacteriol170, 921-926. PubMed  Europe PubMed

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2025 EBI
Terms of use