Merops Switch to
Inhibitors

Peptidase

Family Clan SEARCHES BLAST
MEROPS SUBMISSIONS

Other
information

Literature for peptidase S21.001: assemblin

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors Pharma

(Topics flags: S Structure, P Specificity, I Inhibitor, E Expression, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2023
  1. Pachota,M., Grzywa,R., Iwanejko,J., Synowiec,A., Iwan,D., Kaminska,K., Skorenski,M., Bielecka,E., Szczubialka,K., Nowakowska,M., Mackereth,C.D., Wojaczynska,E., Sienczyk,M. and Pyrc,K.
    Novel inhibitors of HSV-1 protease effective in vitro and in vivo
    Antiviral Res (2023) 213, 105604-105604. PubMed  Europe PubMed DOI  I
    2. 2016
  2. Szilvay,A.-M., Sarria,S.V., Mannelqvist,M., Aasland,R. and Furnes,C.
    Proteolytic activity assayed by subcellular localization switching of a substrate
    Biochem Biophys Rep (2016) 8, 23-28. PubMed  Europe PubMed DOI
    3. 2015
  3. Mello,J.F., Botelho,N.C., Souza,A.M., Oliveira,R., Brito,M.A., Abrahim-Vieira Bde,A., Sodero,A.C., Castro,H.C., Cabral,L.M., Miceli,L.A. and Rodrigues,C.R.
    Computational studies of benzoxazinone derivatives as antiviral agents against herpes virus type 1 protease
    Molecules (2015) 20, 10689-10704. PubMed  Europe PubMed DOI  I
  4. Zuhlsdorf,M., Werten,S., Klupp,B.G., Palm,G.J., Mettenleiter,T.C. and Hinrichs,W.
    Dimerization-induced allosteric changes of the oxyanion-hole loop activate the pseudorabies virus assemblin pUL26N, a herpesvirus serine protease
    PLoS Pathog (2015) 11, e1005045-e1005045. PubMed  Europe PubMed DOI
    5. 2014
  5. Skorenski,M. and Sienczyk,M.
    Anti-herpesvirus agents: a patent and literature review (2003 to present)
    Expert Opin Ther Pat (2014) 24, 925-941. PubMed  Europe PubMed DOI  I
    6. 2012
  6. Shahian,T. and Craik,C.S.
    Kaposi's sarcoma virus assemblin (herpesvirus 8-type assemblin)
    [ISSN:978-0-12-407742-3] (2012) 3, 3545-3550. DOI  V
    7. 2007
  7. Laurent,S., Blondeau,C., Belghazi,M., Remy,S., Esnault,E., Rasschaert,P. and Rasschaert,D.
    Sequential autoprocessing of Marek's disease herpesvirus protease differs from that of other herpesviruses
    J Virol (2007) 81, 6117-6121. PubMed  Europe PubMed DOI  PMC  EPMC  P
    8. 2004
  8. Darke,P.L.
    Herpesvirus assemblin
    [ISSN:0-12-079610-4] (2004) 2, 2009-2011.  V
    9. 2002
  9. Tong,L.
    Viral proteases
    Chem Rev (2002) 102, 4609-4626. PubMed  Europe PubMed DOI  V
    10. 2001
  10. Sheaffer,A.K., Newcomb,W.W., Gao,M., Yu,D., Weller,S.K., Brown,J.C. and Tenney,D.J.
    Herpes simplex virus DNA cleavage and packaging proteins associate with the procapsid prior to its maturation
    J Virol (2001) 75, 687-698. PubMed  Europe PubMed DOI  PMC  EPMC
    11. 2000
  11. Newcomb,W.W., Trus,B.L., Cheng,N., Steven,A.C., Sheaffer,A.K., Tenney,D.J., Weller,S.K. and Brown,J.C.
    Isolation of herpes simplex virus procapsids from cells infected with a protease-deficient mutant virus
    J Virol (2000) 74, 1663-1673. PubMed  Europe PubMed DOI  PMC  EPMC
  12. Sheaffer,A.K., Newcomb,W.W., Brown,J.C., Gao,M., Weller,S.K. and Tenney,D.J.
    Evidence for controlled incorporation of herpes simplex virus type 1 UL26 protease into capsids
    J Virol (2000) 74, 6838-6848. PubMed  Europe PubMed DOI  PMC  EPMC
  13. Waxman,L. and Darke,P.L.
    The herpesvirus proteases as targets for antiviral chemotherapy
    Antivir Chem Chemother (2000) 11, 1-22. PubMed  Europe PubMed
    14. 1997
  14. Apeler,H., Gottschalk,U., Guntermann,D., Hansen,J., Massen,J., Schmidt,E., Schneider,K.H., Schneidereit,M. and Rubsamen-Waigmann,H.
    Expression of natural and synthetic genes encoding herpes simplex virus 1 protease in Escherichia coli and purification of the protein
    Eur J Biochem (1997) 247, 890-895. PubMed  Europe PubMed  E
  15. Hall,M.R. and Gibson,W.
    Assemblin homolog of herpes simplex virus type 1 retains proteolytic activity when expressed as a recombinant two-chain enzyme
    Virology (1997) 227, 160-167. PubMed  Europe PubMed DOI
  16. Hippenmeyer,P.J., Rankin,A.M., Luckow,V.A. and Neises,G.R.
    Protease-deficient herpes simplex virus protects mice from lethal herpesvirus infection
    J Virol (1997) 71, 988-995. PubMed  Europe PubMed  PMC  EPMC
  17. Holwerda,B.C.
    Herpesvirus proteases: Targets for novel antiviral drugs
    Antiviral Res (1997) 35, 1-21. PubMed  Europe PubMed DOI
  18. [YEAR:18-11-1997]Hoog,S.S., Smith,W.W., Qiu,X., Janson,C.A., Hellmig,B., McQueney,M.S., O'Donnell,K., O'Shannessy,D., DiLella,A.G., Debouck,C. and Abdel-Meguid,S.S.
    Active site cavity of herpesvirus proteases revealed by the crystal structure of herpes simplex virus protease/inhibitor complex
    Biochemistry (18-11-1997) 36, 14023-14029. PubMed  Europe PubMed DOI  S  I
  19. Jarvest,R.L., Connor,S.C., Gorniak,J.G., Jennings,L.J., Serafinowska,H.T. and West,A.
    Potent selective thienoxazinone inhibitors of herpes proteases
    Bioorg Med Chem Lett (1997) 7, 1733-1738.  I
  20. Register,R.B. and Shafer,J.A.
    Alterations in catalytic activity and virus maturation produced by mutation of the conserved histidine residues of herpes simplex virus type 1 protease
    J Virol (1997) 71, 8572-8581. PubMed  Europe PubMed  PMC  EPMC
  21. Robertson,B.J., McCann,P.J., III, Matusick-Kumar,L., Preston,V.G. and Gao,M.
    Na, an autoproteolytic product of the herpes simplex virus type 1 protease, can functionally substitute for the assembly protein ICP35
    J Virol (1997) 71, 1683-1687. PubMed  Europe PubMed  PMC  EPMC
  22. Schmidt,U. and Darke,P.L.
    Dimerization and activation of the herpes simplex virus type 1 protease
    J Biol Chem (1997) 272, 7732-7735. PubMed  Europe PubMed DOI
    23. 1995
  23. Gibson,W., Welch,A.R. and Hall,M.R.T.
    Assemblin, a herpes virus serine maturational proteinase and new molecular target for antivirals
    Perspect Drug Discov Des (1995) 2, 413-426. DOI  V
  24. Roizman,B. and Sears,A.
    Herpes simplex viruses and their replication
     (1995) 3, 2231-2295.
  25. Steffy,K.R., Schoen,S. and Chen,C.M.
    Nucleotide sequence of the herpes simplex virus type 2 gene encoding the protease and capsid protein ICP35
    J Gen Virol (1995) 76, 1069-1072. PubMed  Europe PubMed
    26. 1994
  26. [YEAR:29-4-1994]DiIanni,C.L., Stevens,J.T., Bolgar,M., O'Boyle,D.R., Weinheimer,S.P. and Colonno,R.J.
    Identification of the serine residue at the active site of the herpes simplex virus type 1 protease
    J Biol Chem (29-4-1994) 269, 12672-12676. PubMed  Europe PubMed  I
  27. Gao,M., Matusick-Kumar,L., Hurlburt,W., DiTusa,S.F., Newcomb,W.W., Brown,J.C., McCann,P.J., III, Deckman,I. and Colonno,R.J.
    The protease of herpes simplex virus type 1 is essential for functional capsid formation and viral growth
    J Virol (1994) 68, 3702-3712. PubMed  Europe PubMed  PMC  EPMC
    28. 1993
  28. DiIanni,C.L., Drier,D.A., Deckman,I.C., McCann,P.J., III, Liu,F., Roizman,B., Colonno,R.J. and Cordingley,M.G.
    Identification of the herpes simplex virus-1 protease cleavage sites by direct sequence analysis of autoproteolytic cleavage products
    J Biol Chem (1993) 268, 2048-2051. PubMed  Europe PubMed  P
  29. DiIanni,C.L., Mapelli,C., Drier,D.A., Tsao,J., Natarajan,S., Riexinger,D., Festin,S.M., Bolgar,M., Yamanaka,G. and Weinheimer,S.P.
    In vitro activity of the herpes simplex virus type 1 protease with peptide substrates
    J Biol Chem (1993) 268, 25449-25454. PubMed  Europe PubMed  P  I
  30. Weinheimer,S.P., McCann,P.J., III, O'Boyle,D.R., Stevens,J.T., Boyd,B.A., Drier,D.A., Yamanaka,G.A., DiIanni,C.L., Deckman,I.C. and Cordingley,M.G.
    Autoproteolysis of herpes simplex virus type 1 protease releases an active catalytic domain found in intermediate capsid particles
    J Virol (1993) 67, 5813-5822. PubMed  Europe PubMed  PMC  EPMC
    31. 1992
  31. Preston,V.G., Rixon,F.J., McDougall,I.M., McGregor,M. and al Kobaisi,M.F.
    Processing of the herpes simplex virus assembly protein ICP35 near its carboxy terminal end requires the product of the whole of the UL26 reading frame
    Virology (1992) 186, 87-98. PubMed  Europe PubMed DOI
    32. 1991
  32. Liu,F.Y. and Roizman,B.
    The herpes simplex virus 1 gene encoding a protease also contains within its coding domain the gene encoding the more abundant substrate
    J Virol (1991) 65, 5149-5156. PubMed  Europe PubMed  PMC  EPMC
  33. Welch,A.R., Woods,A.S., McNally,L.M., Cotter,R.J. and Gibson,W.
    A herpesvirus maturational proteinase, assemblin: identification of its gene, putative active site domain, and cleavage site
    Proc Natl Acad Sci U S A (1991) 88, 10792-10796. PubMed  Europe PubMed  PMC  EPMC

feedback
Page created 8-September-2023

EMBL-EBI logo

© 2026 EBI
Terms of use