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Literature for peptidase S14.003: peptidase Clp (type 3)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

(Topics flags: A Assay, S Structure, M Mutation, P Specificity, K Knockout, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Chen,W., Lander,G.C. and Yang,J.
    Cryo-EM structures of human ClpXP reveal mechanisms of assembly and proteolytic activation
    Nat Commun (2026) 17, 1064-1064. PubMed  Europe PubMed DOI  PMC  EPMC
  2. Miciaccia,M., Armenise,D., Baldelli,O.M., Liturri,A., Mammone,M., Graziano,G., Contino,M., Rizzo,F., Polosa,P.L., Bruni,F., Deligne,C., Broutier,L., Cavallaro,G., Fortuna,C.G., Tolomeo,A., Green,C., Bonifazi,A., Majaesic,E., Barghash,M.M., Lee,N.P.J., Houry,W.A., Gratteri,C., Talarico,C., Filieri,S., Micalizzi,G., Donnarumma,D., Dugo,P., Mondello,L., Sardanelli,A.M., Nazarian,J., Ferorelli,S., Perrone,M.G. and Scilimati,A.
    Dysregulation of human ClpP using small molecules with piperazine-based scaffold for diffuse intrinsic pontine glioma therapy validated by patient-derived tumor organoids
    Res Sq (2026) PubMed  Europe PubMed DOI  PMC  EPMC  I
    3. 2025
  3. Armenise,D., Baldelli,O.M., Liturri,A., Cavallaro,G., Fortuna,C.G., Ferorelli,S., Miciaccia,M., Perrone,M.G. and Scilimati,A.
    Mitochondrial Protease ClpP: Cancer Marker and Drug Target
    Pharmaceuticals (Basel) (2025) 18 PubMed  Europe PubMed DOI  PMC  EPMC
  4. Drizyte-Miller,K., Degan,S.E., Mouery,R.D., Amparo,A.M., Mouery,B.L., Chang,W.H., Yang,R., Nicewarner Pena,S.R., Baldelli,E., Klomp,J.A., Iwanowicz,E.J., Graves,L.M., Petricoin,E.F., Cox,A.D., Stalnecker,C.A., Bryant,K.L. and Der,C.J.
    Dordaviprone/ONC201 Activation of the ClpP Mitochondrial Protease Inhibits the Growth of KRAS-Mutant Pancreatic Cancer and Overcomes RAS Inhibitor Resistance
    bioRxiv (2025) PubMed  Europe PubMed DOI  PMC  EPMC  I
  5. Feng,Y., Goncalves,M.M., Jitkova,Y., Keszei,A.F.A., Yan,Y., Sarathy,C., St-Germain,J., Kenney,T.M.G., Tcheng,M., Trudel,V., Mancini,R.S., Upadhyay,R., Hurren,R., Gronda,M., Schultz,M., Soriano,K., Lees,K., Pomroy,N.C., Currie,S.Q.W., Prive,G.G., Reed,M.A., Yudin,A.K., Penn,L.Z., Arrowsmith,C.H., Raught,B., Mazhab-Jafari,M.T., Vahidi,S. and Schimmer,A.D.
    Serine phosphorylation facilitates protein degradation by the human mitochondrial ClpXP protease
    Proc Natl Acad Sci U S A (2025) 122, e2422447122-e2422447122. PubMed  Europe PubMed DOI  PMC  EPMC
  6. Goncalves,M.M., Uday,A.B., Forrester,T.J.B., Currie,S.Q.W., Kim,A.S., Feng,Y., Jitkova,Y., Velyvis,A., Harkness,R.W., Kimber,M.S., Schimmer,A.D., Zeytuni,N. and Vahidi,S.
    Mechanism of allosteric activation in human mitochondrial ClpP protease
    Proc Natl Acad Sci U S A (2025) 122, e2419881122-e2419881122. PubMed  Europe PubMed DOI  I
  7. Graves,L., Daglish,S., Canterbury,O., Graves,P., Carter,S., Beese,S., Hynek,M., Mouery,B., Mistreanu,A., Bhatt,A., Tellez,N., Butler,M., Aponte-Collazo,L., Fennell,E., Herring,L., Lyons,S., Mills,C., Ashamalla,H., Iwanowicz,E., Iv,J.M., Bear,J., Greer,Y. and Lipkowitz,S.
    Small Molecule Activators of the Mitochondrial Protease ClpP Induce Senescence in Triple-Negative Breast Cancer Cells and Sensitize Cells to the Bcl-2 Inhibitor Venetoclax
    Res Sq (2025) PubMed  Europe PubMed DOI  PMC  EPMC  I
  8. Liu,X., Gu,J., Liu,S., Huang,J., Li,L., Wang,F., He,S., Mi,Z., Zhang,Y., Wen,J., Gao,Q., Yang,H., Feng,Y., Luo,H., Zhai,X., Zhang,L., Zheng,Y., Luo,Y. and Niu,T.
    The mitochondrial protease ClpP is a promising target for multiple myeloma treatment
    Biochem Pharmacol (2025) 236, 116855-116855. PubMed  Europe PubMed DOI  I
  9. Perini,T., Zordan,P., Del Pizzo,R., Resnati,M., Viviani,L., Stefanoni,D., Cassina,L., Orfanelli,U.P., Trudu,M., Oliva,L., Lacidogna,D., Samur,M.K., Materozzi,M., Drago,D., Andolfo,A., Patrone,M., Degano,M., Boletta,A., Milan,E., Ciceri,F., Munshi,N.C., Bellone,M. and Cenci,S.
    The mitochondrial protease ClpP is a metabolic vulnerability and an immunogenic trigger against multiple myeloma
    Blood (2025) PubMed  Europe PubMed DOI
  10. Qin,L., Moreno Rueda,L.Y., Ray,U., Mahmud,I., Tan,L., Lorenzi,P.L., Liu,S., Lin,H.Y., Mery,D.E., Zhan,F., Shaughnessy,J.D., Jr., Yi,Q., Acevedo Calado,M.J., Wang,H., Manasanch,E.E., Lee,H.C., Patel,K.K., Kuiatse,I., Symer,D.E. and Orlowski,R.Z.
    Targeting Caseinolytic Mitochondrial Matrix Peptidase, a Novel Contributor to High-risk Behavior, in Multiple Myeloma
    Blood (2025) PubMed  Europe PubMed DOI
  11. Shu,Z., Zhang,J., Wu,Y., Yang,T. and Luo,Y.
    Recent advances in the design of small molecules targeting human ClpP
    Future Med Chem (2025) , 1-18. PubMed  Europe PubMed DOI
  12. Tang,R., Li,Q., Zhou,H., Li,Y., Li,T., Jiang,J., Chen,Z., Kong,L., Li,Y., Xiao,Y. and Sun,H.
    Design, Synthesis, and Biological Evaluation of Novel Activators of Human Caseinolytic Protease P with a Pyrazololactam Scaffold
    J Med Chem (2025) PubMed  Europe PubMed DOI
  13. Tserennadmid,B., Nam,M.K., Park,J.H., Rhim,H. and Kang,S.
    HAP/ClpP-mediated disaggregation and degradation of Mutant SOD1 aggregates: A potential therapeutic strategy for Amyotrophic lateral sclerosis (ALS)
    Biochem Biophys Res Commun (2025) 756, 151533-151533. PubMed  Europe PubMed DOI
  14. Turner,M., Harkness,R.W., Ripstein,Z.A., Huang,R. and Vahidi,S.
    Allosteric regulation of proteolytic machines unveiled by the synergy between cryo-EM and solution NMR spectroscopy
    Biochem J (2025) 483 PubMed  Europe PubMed DOI
  15. Wang,H., Liu,Y., Liu,J., Zhang,S., Li,X., Sun,L., Liu,F., Liu,Y. and Xiao,L.
    Mitochondrial protease ClpP deficiency protects against tubulointerstitial damage in diabetic kidney disease
    Int Immunopharmacol (2025) 166, 115641-115641. PubMed  Europe PubMed DOI  K
  16. Xu,Z., Pokushalov,D., Kabir,M., Lee,Y., Chattopadhyay,M., Jenkins,E.C., Choo,C., Kaniskan,H.U., Germain,D. and Jin,J.
    Targeting the Mitochondrial Protease ClpP for Anticancer Therapy
    J Med Chem (2025) PubMed  Europe PubMed DOI
    17. 2024
  17. Cao,J., Cao,F., Wang,C., Jiao,Z., You,Y., Wang,X. and Zhao,W.
    ONC206 targeting ClpP induces mitochondrial dysfunction and protective autophagy in hepatocellular carcinoma cells
    Neoplasia (2024) 55, 101015-101015. PubMed  Europe PubMed DOI  K  I
  18. Giarrizzo,M., LaComb,J.F., Patel,H.R., Reddy,R.G., Haley,J.D., Graves,L.M., Iwanowicz,E.J. and Bialkowska,A.B.
    TR-107, An Agonist of Caseinolytic Peptidase Proteolytic Subunit, Disrupts Mitochondrial Metabolism and Inhibits the Growth of Human Colorectal Cancer Cells
    Mol Cancer Ther (2024) 23, 1761-1778. PubMed  Europe PubMed DOI
  19. Jiang,J., Xie,G., Li,T., Ding,H., Tang,R., Luo,J., Li,Q., Lu,W., Xiao,Y. and Sun,H.
    Discovery of Dehydrogenated Imipridone Derivatives as Activators of Human Caseinolytic Protease P
    J Med Chem (2024) 67, 15328-15352. PubMed  Europe PubMed DOI  I
  20. Liu,S., Sui,J., Luo,B., Zhang,J., Xiang,X., Yang,T., Luo,Y. and Liu,J.
    Discovery of 5-(Piperidin-4-yl)-1,2,4-oxadiazole Derivatives as a New Class of Human Caseinolytic Protease P Agonists for the Treatment of Hepatocellular Carcinoma
    J Med Chem (2024) PubMed  Europe PubMed DOI  I
  21. Miciaccia,M., Rizzo,F., Centonze,A., Cavallaro,G., Contino,M., Armenise,D., Baldelli,O.M., Solidoro,R., Ferorelli,S., Scarcia,P., Agrimi,G., Zingales,V., Cimetta,E., Ronsisvalle,S., Sipala,F.M., Polosa,P.L., Fortuna,C.G., Perrone,M.G. and Scilimati,A.
    Harmaline to Human Mitochondrial Caseinolytic Serine Protease Activation for Pediatric Diffuse Intrinsic Pontine Glioma Treatment
    Pharmaceuticals (Basel) (2024) 17 PubMed  Europe PubMed DOI  PMC  EPMC  I
  22. Paredes,F., Williams,H.C., Liu,X., Holden,C., Bogan,B., Wang,Y., Crotty,K.M., Yeligar,S.M., Elorza,A.A., Lin,Z., Rezvan,A. and San Martin,A.
    The mitochondrial protease ClpP is a druggable target that controls VSMC phenotype by a SIRT1-dependent mechanism
    Redox Biol (2024) 73, 103203-103203. PubMed  Europe PubMed DOI  PMC  EPMC
  23. Zhang,J., Qiu,Z., Liu,S., Huang,J., Luo,B., Sui,J., Dai,Z., Xiang,X., Yang,T. and Luo,Y.
    Discovery of a Novel Series of Homo sapiens Caseinolytic Protease P Agonists for Colorectal Adenocarcinoma Treatment via ATF3-Dependent Integrated Stress Response
    J Med Chem (2024) 67, 2812-2836. PubMed  Europe PubMed DOI
    24. 2023
  24. Gonzalez-Paz,L., Lossada,C., Hurtado-Leon,M.L., Fernandez-Materan,F.V., Paz,J.L., Parvizi,S., Cardenas Castillo,R.E., Romero,F. and Alvarado,Y.J.
    Intrinsic Dynamics of the ClpXP Proteolytic Machine Using Elastic Network Models
    ACS Omega (2023) 8, 7302-7318. PubMed  Europe PubMed DOI  PMC  EPMC
  25. Guo,C., Xiao,Y., Gu,J., Zhao,P., Hu,Z., Zheng,J., Hua,R., Hai,Z., Su,J., Zhang,J.V., Yeung,W.S.B. and Wang,T.
    ClpP/ClpX deficiency impairs mitochondrial functions and mTORC1 signaling during spermatogenesis
    Commun Biol (2023) 6, 1012-1012. PubMed  Europe PubMed DOI  PMC  EPMC
  26. Zhang,R., Wang,P., Wei,B., Chen,L., Song,X., Pan,Y., Li,J., Gan,J., Zhang,T. and Yang,C.G.
    Assessment of the structure-activity relationship and antileukemic activity of diacylpyramide compounds as human ClpP agonists
    Eur J Med Chem (2023) 258, 115577-115577. PubMed  Europe PubMed DOI
    27. 2022
  27. Huang,J., Zhang,J., Luo,B., Qiao,W., Qiu,Z., Song,R., Dai,Z., Sui,J., Xu,X., Ruan,S., Li,C., Luo,Y. and Yang,T.
    Discovery of a Novel Series of Imipridone Compounds as Homo sapiens Caseinolytic Protease P Agonists with Potent Antitumor Activities In Vitro and In Vivo
    J Med Chem (2022) 65, 7629-7655. DOI
  28. Wang,P., Zhang,T., Wang,X., Xiao,H., Li,H., Zhou,L.L., Yang,T., Wei,B., Zhu,Z., Zhou,L., Yang,S., Lu,X., Zhang,Y., Huang,Y., Gan,J. and Yang,C.G.
    Aberrant human ClpP activation disturbs mitochondrial proteome homeostasis to suppress pancreatic ductal adenocarcinoma
    Cell Chem Biol (2022) 29, 1396-1408. PubMed  Europe PubMed DOI
  29. Zhang,J., Luo,B., Sui,J., Qiu,Z., Huang,J., Yang,T. and Luo,Y.
    IMP075 targeting ClpP for colon cancer therapy in vivo and in vitro
    Biochem Pharmacol (2022) 204, 115232-115232. PubMed  Europe PubMed DOI  K
    30. 2021
  30. Cormio,A., Sanguedolce,F., Pesce,V. and Musicco,C.
    Mitochondrial Caseinolytic Protease P: A Possible Novel Prognostic Marker and Therapeutic Target in Cancer
    Int J Mol Sci (2021) 22 PubMed  Europe PubMed DOI  PMC  EPMC  V
  31. Forli,F., Bruschini,L., Franciosi,B., Battini,R., Marinella,G., Berrettini,S. and Lazzerini,F.
    A Rare Case of Perrault Syndrome with Auditory Neuropathy Spectrum Disorder: Cochlear Implantation Treatment and Literature Review
    Audiol Res (2021) 11, 609-617. PubMed  Europe PubMed DOI  PMC  EPMC
  32. Kou,X., Ding,H., Li,L. and Chao,H.
    Caseinolytic protease P (CLPP) activated by ONC201 inhibits proliferation and promotes apoptosis in human epithelial ovarian cancer cells by inducing mitochondrial dysfunction
    Ann Transl Med (2021) 9, 1463-1463. PubMed  Europe PubMed DOI  PMC  EPMC
  33. Song,R., Yang,Y., Huang,J., Qiao,W., Luo,B., Ju,Y., Yang,T. and Luo,Y.
    Discovery of novel indolin-2-one compounds as potent inhibitors of HsClpP for cancer treatment
    Bioorg Chem (2021) 110, 104820-104820. PubMed  Europe PubMed DOI  I
    34. 2020
  34. Esencan,E., Jiang,Z., Wang,T., Zhang,M., Soylemez-Imamoglu,G. and Seli,E.
    Impaired mitochondrial stress response due to CLPP deletion is associated with altered mitochondrial dynamics and increased apoptosis in cumulus cells
    Reprod Sci (2020) 27, 621-630. PubMed  Europe PubMed DOI  K
  35. Esencan,E., Cozzolino,M., Imamoglu,G. and Seli,E.
    Mitochondrial Stress Response Gene Clpp Is Not Required for Granulosa Cell Function
    Antioxidants (Basel) (2020) 10 PubMed  Europe PubMed DOI  PMC  EPMC
  36. Jacques,S., van der Sloot,A.M., C Huard,C., Coulombe-Huntington,J., Tsao,S., Tollis,S., Bertomeu,T., Culp,E.J., Pallant,D., Cook,M.A., Bonneil,E., Thibault,P., Wright,G.D. and Tyers,M.
    Imipridone anticancer compounds ectopically activate the ClpP protease and represent a new scaffold for antibiotic development
    Genetics (2020) 214, 1103-1120. PubMed  Europe PubMed DOI
  37. Mirali,S. and Schimmer,A.D.
    The role of mitochondrial proteases in leukemic cells and leukemic stem cells
    Stem Cells Transl Med (2020) PubMed  Europe PubMed DOI
  38. Nouri,K., Feng,Y. and Schimmer,A.D.
    Mitochondrial ClpP serine protease-biological function and emerging target for cancer therapy
    Cell Death Dis (2020) 11, 841-841. PubMed  Europe PubMed DOI  PMC  EPMC  V
  39. Prabhu,V.V., Morrow,S., Rahman Kawakibi,A., Zhou,L., Ralff,M., Ray,J., Jhaveri,A., Ferrarini,I., Lee,Y., Parker,C., Zhang,Y., Borsuk,R., Chang,W.I., Honeyman,J.N., Tavora,F., Carneiro,B., Raufi,A., Huntington,K., Carlsen,L., Louie,A., Safran,H., Seyhan,A.A., Tarapore,R.S., Schalop,L., Stogniew,M., Allen,J.E., Oster,W. and El-Deiry,W.S.
    ONC201 and imipridones: Anti-cancer compounds with clinical efficacy
    Neoplasia (2020) 22, 725-744. PubMed  Europe PubMed DOI  PMC  EPMC
  40. Ripstein,Z.A., Vahidi,S., Houry,W.A., Rubinstein,J.L. and Kay,L.E.
    A processive rotary mechanism couples substrate unfolding and proteolysis in the ClpXP degradation machinery
    elife (2020) 9 PubMed  Europe PubMed DOI  S
  41. Sha,Z., Fishovitz,J., Wang,S., Chilakala,S., Xu,Y. and Lee,I.
    A selective fluorogenic peptide substrate for the human mitochondrial ATP-dependent protease complex ClpXP
    Chembiochem (2020) 21, 2037-2048. PubMed  Europe PubMed DOI  A  P  I
  42. Strack,P.R., Brodie,E.J., Zhan,H., Schuenemann,V.J., Valente,L.J., Saiyed,T., Lowth,B.R., Angley,L.M., Perugini,M.A., Zeth,K., Truscott,K.N. and Dougan,D.A.
    Polymerase delta-interacting protein 38 (PDIP38) modulates the stability and activity of the mitochondrial AAA+ protease CLPXP
    Commun Biol (2020) 3, 646-646. PubMed  Europe PubMed DOI  PMC  EPMC
    43. 2019
  43. Ishizawa,J., Zarabi,S.F., Davis,R.E., Halgas,O., Nii,T., Jitkova,Y., Zhao,R., St-Germain,J., Heese,L.E., Egan,G., Ruvolo,V.R., Barghout,S.H., Nishida,Y., Hurren,R., Ma,W., Gronda,M., Link,T., Wong,K., Mabanglo,M., Kojima,K., Borthakur,G., Maclean,N., Ma,M.C.J., Leber,A.B., Minden,M.D., Houry,W., Kantarjian,H., Stogniew,M., Raught,B., Pai,E.F., Schimmer,A.D. and Andreeff,M.
    Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality
    Cancer Cell (2019) 35, 721-737. PubMed  Europe PubMed DOI  PMC  EPMC
  44. Wong,K.S. and Houry,W.A.
    Chemical modulation of human mitochondrial ClpP: potential application in cancer therapeutics
    ACS Chem Biol (2019) 14, 2349-2360. PubMed  Europe PubMed DOI
    45. 2018
  45. Becker,C., Kukat,A., Szczepanowska,K., Hermans,S., Senft,K., Brandscheid,C.P., Maiti,P. and Trifunovic,A.
    CLPP deficiency protects against metabolic syndrome but hinders adaptive thermogenesis
    EMBO Rep (2018) 19, e45126.-e45126. PubMed  Europe PubMed DOI
  46. Bhaskaran,S., Pharaoh,G., Ranjit,R., Murphy,A., Matsuzaki,S., Nair,B.C., Forbes,B., Gispert,S., Auburger,G., Humphries,K.M., Kinter,M., Griffin,T.M. and Deepa,S.S.
    Loss of mitochondrial protease ClpP protects mice from diet-induced obesity and insulin resistance
    EMBO Rep (2018) 19, e45009-e45009. PubMed  Europe PubMed DOI  K
  47. Brodie,E.J., Zhan,H., Saiyed,T., Truscott,K.N. and Dougan,D.A.
    Perrault syndrome type 3 caused by diverse molecular defects in CLPP
    Sci Rep (2018) 8, 12862-12862. PubMed  Europe PubMed DOI  PMC  EPMC  M
  48. Dougan,D.A., Hantke,I. and Turgay,K.
    Dysregulating ClpP: from antibiotics to anticancer?
    Cell Chem Biol (2018) 25, 929-930. PubMed  Europe PubMed DOI
  49. Gronauer,T.F., Mandl,M.M., Lakemeyer,M., Hackl,M.W., Messner,M., Korotkov,V.S., Pachmayr,J. and Sieber,S.A.
    Design and synthesis of tailored human caseinolytic protease P inhibitors
    Chem Commun (Camb) (2018) 54, 9833-9836. PubMed  Europe PubMed DOI  I
  50. Stahl,M., Korotkov,V.S., Balogh,D., Kick,L.M., Gersch,M., Pahl,A., Kielkowski,P., Richter,K., Schneider,S. and Sieber,S.A.
    Selective activation of human caseinolytic protease P (ClpP)
    Angew Chem Int Ed Engl (2018) 57, 14602-14607. PubMed  Europe PubMed DOI
    51. 2016
  51. Gersch,M., Stahl,M., Poreba,M., Dahmen,M., Dziedzic,A., Drag,M. and Sieber,S.A.
    Barrel-shaped ClpP proteases display attenuated cleavage specificities
    ACS Chem Biol (2016) 11, 389-399. PubMed  Europe PubMed DOI  P
  52. Pryde,K.R., Taanman,J.W. and Schapira,A.H.
    A LON-ClpP proteolytic axis degrades complex I to extinguish ROS production in depolarized mitochondria
    Cell Rep (2016) 17, 2522-2531. PubMed  Europe PubMed DOI
    53. 2015
  53. Cole,A., Wang,Z., Coyaud,E., Voisin,V., Gronda,M., Jitkova,Y., Mattson,R., Hurren,R., Babovic,S., Maclean,N., Restall,I., Wang,X., Jeyaraju,D.V., Sukhai,M.A., Prabha,S., Bashir,S., Ramakrishnan,A., Leung,E., Qia,Y.H., Zhang,N., Combes,K.R., Ketela,T., Lin,F., Houry,W.A., Aman,A., Al-Awar,R., Zheng,W., Wienholds,E., Xu,C.J., Dick,J., Wang,J.C., Moffat,J., Minden,M.D., Eaves,C.J., Bader,G.D., Hao,Z., Kornblau,S.M., Raught,B. and Schimmer,A.D.
    Inhibition of the mitochondrial protease ClpP as a therapeutic strategy for human acute myeloid leukemia
    Cancer Cell (2015) 27, 864-876. PubMed  Europe PubMed DOI  PMC  EPMC  K
    54. 2013
  54. Jenkinson,E.M., Rehman,A.U., Walsh,T., Clayton-Smith,J., Lee,K., Morell,R.J., Drummond,M.C., Khan,S.N., Naeem,M.A., Rauf,B., Billington,N., Schultz,J.M., Urquhart,J.E., Lee,M.K., Berry,A., Hanley,N.A., Mehta,S., Cilliers,D., Clayton,P.E., Kingston,H., Smith,M.J., Warner,T.T., Black,G.C., Trump,D., Davis,J.R., Ahmad,W., Leal,S.M., Riazuddin,S., King,M.C., Friedman,T.B. and Newman,W.G.
    Perrault syndrome is caused by recessive mutations in CLPP, encoding a mitochondrial ATP-dependent chambered protease
    Am J Hum Genet (2013) 92, 605-613. PubMed  Europe PubMed DOI  PMC  EPMC  M
    55. 2005
  55. [YEAR:22-8-2005]Kang,S.G., Dimitrova,M.N., Ortega,J., Ginsburg,A. and Maurizi,M.R.
    Human mitochondrial ClpP is a stable heptamer that assembles into a tetradecamer in the presence of ClpX
    J Biol Chem (22-8-2005) 280, 35424-35432. PubMed  Europe PubMed DOI
    56. 2004
  56. Kang,S.G., Maurizi,M.R., Thompson,M., Mueser,T. and Ahvazi,B.
    Crystallography and mutagenesis point to an essential role for the N-terminus of human mitochondrial ClpP
    J Struct Biol (2004) 148, 338-352. PubMed  Europe PubMed DOI  S
    57. 2002
  57. [YEAR:7-6-2002]Kang,S.G., Ortega,J., Singh,S.K., Wang,N., Huang,N.N., Steven,A.C. and Maurizi,M.R.
    Functional proteolytic complexes of the human mitochondrial ATP-dependent protease, hClpXP
    J Biol Chem (7-6-2002) 277, 21095-21102. PubMed  Europe PubMed DOI
    58. 2000
  58. Andresen,B.S., Corydon,T.J., Wilsbech,M., Bross,P., Schroeder,L.D., Hindkjaer,T.F., Bolund,L. and Gregersen,N.
    Characterization of mouse Clpp protease cDNA, gene, and protein
    Mamm Genome (2000) 11, 275-280. PubMed  Europe PubMed DOI
  59. Corydon,T.J., Wilsbech,M., Jespersgaard,C., Andresen,B.S., Borglum,A.D., Pedersen,S., Bolund,L., Gregersen,N. and Bross,P.
    Human and mouse mitochondrial orthologs of bacterial ClpX
    Mamm Genome (2000) 11, 899-905. PubMed  Europe PubMed
    60. 1999
  60. [YEAR:1-10-1999]de Sagarra,M.R., Mayo,I., Marco,S., Rodriguez-Vilarino,S., Oliva,J., Carrascosa,J.L. and Casta n,J.G.
    Mitochondrial localization and oligomeric structure of HClpP, the human homologue of E. coli ClpP
    J Mol Biol (1-10-1999) 292, 819-825. PubMed  Europe PubMed DOI
  61. [YEAR:4-6-1999]Santagata,S., Bhattacharyya,D., Wang,F.H., Singha,N., Hodtsev,A. and Spanopoulou,E.
    Molecular cloning and characterization of a mouse homolog of bacterial ClpX, a novel mammalian class II member of the Hsp100/Clp chaperone family
    J Biol Chem (4-6-1999) 274, 16311-16319. PubMed  Europe PubMed DOI
    62. 1998
  62. [YEAR:1-4-1998]Corydon,T.J., Bross,P., Holst,H.U., Neve,S., Kristiansen,K., Gregersen,N. and Bolund,L.
    A human homologue of Escherichia coli ClpP caseinolytic protease: recombinant expression, intracellular processing and subcellular localization
    Biochem J (1-4-1998) 331, 309-316. PubMed  Europe PubMed  PMC  EPMC
    63. 1995
  63. Bross,P., Andresen,B.S., Knudsen,I., Kruse,T.A. and Gregersen,N.
    Human ClpP protease: CDNA sequence, tissue-specific expression and chromosomal assignment of the gene
    FEBS Lett (1995) 377, 249-252. PubMed  Europe PubMed DOI

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