Literature for peptidase S14.003: peptidase Clp (type 3)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates

(Topics flags: A Assay, S Structure, M Mutation, P Specificity, K Knockout, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

2026

Chen,W., Lander,G.C. and Yang,J. Cryo-EM structures of human ClpXP reveal mechanisms of assembly and proteolytic activation Nat Commun (2026) 17, 1064-1064. PubMed Europe PubMed DOI PMC EPMC
Miciaccia,M., Armenise,D., Baldelli,O.M., Liturri,A., Mammone,M., Graziano,G., Contino,M., Rizzo,F., Polosa,P.L., Bruni,F., Deligne,C., Broutier,L., Cavallaro,G., Fortuna,C.G., Tolomeo,A., Green,C., Bonifazi,A., Majaesic,E., Barghash,M.M., Lee,N.P.J., Houry,W.A., Gratteri,C., Talarico,C., Filieri,S., Micalizzi,G., Donnarumma,D., Dugo,P., Mondello,L., Sardanelli,A.M., Nazarian,J., Ferorelli,S., Perrone,M.G. and Scilimati,A. Dysregulation of human ClpP using small molecules with piperazine-based scaffold for diffuse intrinsic pontine glioma therapy validated by patient-derived tumor organoids Res Sq (2026) PubMed Europe PubMed DOI PMC EPMC I

2025

Armenise,D., Baldelli,O.M., Liturri,A., Cavallaro,G., Fortuna,C.G., Ferorelli,S., Miciaccia,M., Perrone,M.G. and Scilimati,A. Mitochondrial Protease ClpP: Cancer Marker and Drug Target Pharmaceuticals (Basel) (2025) 18 PubMed Europe PubMed DOI PMC EPMC
Drizyte-Miller,K., Degan,S.E., Mouery,R.D., Amparo,A.M., Mouery,B.L., Chang,W.H., Yang,R., Nicewarner Pena,S.R., Baldelli,E., Klomp,J.A., Iwanowicz,E.J., Graves,L.M., Petricoin,E.F., Cox,A.D., Stalnecker,C.A., Bryant,K.L. and Der,C.J. Dordaviprone/ONC201 Activation of the ClpP Mitochondrial Protease Inhibits the Growth of KRAS-Mutant Pancreatic Cancer and Overcomes RAS Inhibitor Resistance bioRxiv (2025) PubMed Europe PubMed DOI PMC EPMC I
Feng,Y., Goncalves,M.M., Jitkova,Y., Keszei,A.F.A., Yan,Y., Sarathy,C., St-Germain,J., Kenney,T.M.G., Tcheng,M., Trudel,V., Mancini,R.S., Upadhyay,R., Hurren,R., Gronda,M., Schultz,M., Soriano,K., Lees,K., Pomroy,N.C., Currie,S.Q.W., Prive,G.G., Reed,M.A., Yudin,A.K., Penn,L.Z., Arrowsmith,C.H., Raught,B., Mazhab-Jafari,M.T., Vahidi,S. and Schimmer,A.D. Serine phosphorylation facilitates protein degradation by the human mitochondrial ClpXP protease Proc Natl Acad Sci U S A (2025) 122, e2422447122-e2422447122. PubMed Europe PubMed DOI PMC EPMC
Goncalves,M.M., Uday,A.B., Forrester,T.J.B., Currie,S.Q.W., Kim,A.S., Feng,Y., Jitkova,Y., Velyvis,A., Harkness,R.W., Kimber,M.S., Schimmer,A.D., Zeytuni,N. and Vahidi,S. Mechanism of allosteric activation in human mitochondrial ClpP protease Proc Natl Acad Sci U S A (2025) 122, e2419881122-e2419881122. PubMed Europe PubMed DOI I
Graves,L., Daglish,S., Canterbury,O., Graves,P., Carter,S., Beese,S., Hynek,M., Mouery,B., Mistreanu,A., Bhatt,A., Tellez,N., Butler,M., Aponte-Collazo,L., Fennell,E., Herring,L., Lyons,S., Mills,C., Ashamalla,H., Iwanowicz,E., Iv,J.M., Bear,J., Greer,Y. and Lipkowitz,S. Small Molecule Activators of the Mitochondrial Protease ClpP Induce Senescence in Triple-Negative Breast Cancer Cells and Sensitize Cells to the Bcl-2 Inhibitor Venetoclax Res Sq (2025) PubMed Europe PubMed DOI PMC EPMC I
Liu,X., Gu,J., Liu,S., Huang,J., Li,L., Wang,F., He,S., Mi,Z., Zhang,Y., Wen,J., Gao,Q., Yang,H., Feng,Y., Luo,H., Zhai,X., Zhang,L., Zheng,Y., Luo,Y. and Niu,T. The mitochondrial protease ClpP is a promising target for multiple myeloma treatment Biochem Pharmacol (2025) 236, 116855-116855. PubMed Europe PubMed DOI I
Perini,T., Zordan,P., Del Pizzo,R., Resnati,M., Viviani,L., Stefanoni,D., Cassina,L., Orfanelli,U.P., Trudu,M., Oliva,L., Lacidogna,D., Samur,M.K., Materozzi,M., Drago,D., Andolfo,A., Patrone,M., Degano,M., Boletta,A., Milan,E., Ciceri,F., Munshi,N.C., Bellone,M. and Cenci,S. The mitochondrial protease ClpP is a metabolic vulnerability and an immunogenic trigger against multiple myeloma Blood (2025) PubMed Europe PubMed DOI
Qin,L., Moreno Rueda,L.Y., Ray,U., Mahmud,I., Tan,L., Lorenzi,P.L., Liu,S., Lin,H.Y., Mery,D.E., Zhan,F., Shaughnessy,J.D., Jr., Yi,Q., Acevedo Calado,M.J., Wang,H., Manasanch,E.E., Lee,H.C., Patel,K.K., Kuiatse,I., Symer,D.E. and Orlowski,R.Z. Targeting Caseinolytic Mitochondrial Matrix Peptidase, a Novel Contributor to High-risk Behavior, in Multiple Myeloma Blood (2025) PubMed Europe PubMed DOI
Shu,Z., Zhang,J., Wu,Y., Yang,T. and Luo,Y. Recent advances in the design of small molecules targeting human ClpP Future Med Chem (2025) , 1-18. PubMed Europe PubMed DOI
Tang,R., Li,Q., Zhou,H., Li,Y., Li,T., Jiang,J., Chen,Z., Kong,L., Li,Y., Xiao,Y. and Sun,H. Design, Synthesis, and Biological Evaluation of Novel Activators of Human Caseinolytic Protease P with a Pyrazololactam Scaffold J Med Chem (2025) PubMed Europe PubMed DOI
Tserennadmid,B., Nam,M.K., Park,J.H., Rhim,H. and Kang,S. HAP/ClpP-mediated disaggregation and degradation of Mutant SOD1 aggregates: A potential therapeutic strategy for Amyotrophic lateral sclerosis (ALS) Biochem Biophys Res Commun (2025) 756, 151533-151533. PubMed Europe PubMed DOI
Turner,M., Harkness,R.W., Ripstein,Z.A., Huang,R. and Vahidi,S. Allosteric regulation of proteolytic machines unveiled by the synergy between cryo-EM and solution NMR spectroscopy Biochem J (2025) 483 PubMed Europe PubMed DOI
Wang,H., Liu,Y., Liu,J., Zhang,S., Li,X., Sun,L., Liu,F., Liu,Y. and Xiao,L. Mitochondrial protease ClpP deficiency protects against tubulointerstitial damage in diabetic kidney disease Int Immunopharmacol (2025) 166, 115641-115641. PubMed Europe PubMed DOI K
Xu,Z., Pokushalov,D., Kabir,M., Lee,Y., Chattopadhyay,M., Jenkins,E.C., Choo,C., Kaniskan,H.U., Germain,D. and Jin,J. Targeting the Mitochondrial Protease ClpP for Anticancer Therapy J Med Chem (2025) PubMed Europe PubMed DOI

2024

Cao,J., Cao,F., Wang,C., Jiao,Z., You,Y., Wang,X. and Zhao,W. ONC206 targeting ClpP induces mitochondrial dysfunction and protective autophagy in hepatocellular carcinoma cells Neoplasia (2024) 55, 101015-101015. PubMed Europe PubMed DOI K I
Giarrizzo,M., LaComb,J.F., Patel,H.R., Reddy,R.G., Haley,J.D., Graves,L.M., Iwanowicz,E.J. and Bialkowska,A.B. TR-107, An Agonist of Caseinolytic Peptidase Proteolytic Subunit, Disrupts Mitochondrial Metabolism and Inhibits the Growth of Human Colorectal Cancer Cells Mol Cancer Ther (2024) 23, 1761-1778. PubMed Europe PubMed DOI
Jiang,J., Xie,G., Li,T., Ding,H., Tang,R., Luo,J., Li,Q., Lu,W., Xiao,Y. and Sun,H. Discovery of Dehydrogenated Imipridone Derivatives as Activators of Human Caseinolytic Protease P J Med Chem (2024) 67, 15328-15352. PubMed Europe PubMed DOI I
Liu,S., Sui,J., Luo,B., Zhang,J., Xiang,X., Yang,T., Luo,Y. and Liu,J. Discovery of 5-(Piperidin-4-yl)-1,2,4-oxadiazole Derivatives as a New Class of Human Caseinolytic Protease P Agonists for the Treatment of Hepatocellular Carcinoma J Med Chem (2024) PubMed Europe PubMed DOI I
Miciaccia,M., Rizzo,F., Centonze,A., Cavallaro,G., Contino,M., Armenise,D., Baldelli,O.M., Solidoro,R., Ferorelli,S., Scarcia,P., Agrimi,G., Zingales,V., Cimetta,E., Ronsisvalle,S., Sipala,F.M., Polosa,P.L., Fortuna,C.G., Perrone,M.G. and Scilimati,A. Harmaline to Human Mitochondrial Caseinolytic Serine Protease Activation for Pediatric Diffuse Intrinsic Pontine Glioma Treatment Pharmaceuticals (Basel) (2024) 17 PubMed Europe PubMed DOI PMC EPMC I
Paredes,F., Williams,H.C., Liu,X., Holden,C., Bogan,B., Wang,Y., Crotty,K.M., Yeligar,S.M., Elorza,A.A., Lin,Z., Rezvan,A. and San Martin,A. The mitochondrial protease ClpP is a druggable target that controls VSMC phenotype by a SIRT1-dependent mechanism Redox Biol (2024) 73, 103203-103203. PubMed Europe PubMed DOI PMC EPMC
Zhang,J., Qiu,Z., Liu,S., Huang,J., Luo,B., Sui,J., Dai,Z., Xiang,X., Yang,T. and Luo,Y. Discovery of a Novel Series of Homo sapiens Caseinolytic Protease P Agonists for Colorectal Adenocarcinoma Treatment via ATF3-Dependent Integrated Stress Response J Med Chem (2024) 67, 2812-2836. PubMed Europe PubMed DOI

2023

Gonzalez-Paz,L., Lossada,C., Hurtado-Leon,M.L., Fernandez-Materan,F.V., Paz,J.L., Parvizi,S., Cardenas Castillo,R.E., Romero,F. and Alvarado,Y.J. Intrinsic Dynamics of the ClpXP Proteolytic Machine Using Elastic Network Models ACS Omega (2023) 8, 7302-7318. PubMed Europe PubMed DOI PMC EPMC
Guo,C., Xiao,Y., Gu,J., Zhao,P., Hu,Z., Zheng,J., Hua,R., Hai,Z., Su,J., Zhang,J.V., Yeung,W.S.B. and Wang,T. ClpP/ClpX deficiency impairs mitochondrial functions and mTORC1 signaling during spermatogenesis Commun Biol (2023) 6, 1012-1012. PubMed Europe PubMed DOI PMC EPMC
Zhang,R., Wang,P., Wei,B., Chen,L., Song,X., Pan,Y., Li,J., Gan,J., Zhang,T. and Yang,C.G. Assessment of the structure-activity relationship and antileukemic activity of diacylpyramide compounds as human ClpP agonists Eur J Med Chem (2023) 258, 115577-115577. PubMed Europe PubMed DOI

2022

Huang,J., Zhang,J., Luo,B., Qiao,W., Qiu,Z., Song,R., Dai,Z., Sui,J., Xu,X., Ruan,S., Li,C., Luo,Y. and Yang,T. Discovery of a Novel Series of Imipridone Compounds as Homo sapiens Caseinolytic Protease P Agonists with Potent Antitumor Activities In Vitro and In Vivo J Med Chem (2022) 65, 7629-7655. DOI
Wang,P., Zhang,T., Wang,X., Xiao,H., Li,H., Zhou,L.L., Yang,T., Wei,B., Zhu,Z., Zhou,L., Yang,S., Lu,X., Zhang,Y., Huang,Y., Gan,J. and Yang,C.G. Aberrant human ClpP activation disturbs mitochondrial proteome homeostasis to suppress pancreatic ductal adenocarcinoma Cell Chem Biol (2022) 29, 1396-1408. PubMed Europe PubMed DOI
Zhang,J., Luo,B., Sui,J., Qiu,Z., Huang,J., Yang,T. and Luo,Y. IMP075 targeting ClpP for colon cancer therapy in vivo and in vitro Biochem Pharmacol (2022) 204, 115232-115232. PubMed Europe PubMed DOI K

2021

Cormio,A., Sanguedolce,F., Pesce,V. and Musicco,C. Mitochondrial Caseinolytic Protease P: A Possible Novel Prognostic Marker and Therapeutic Target in Cancer Int J Mol Sci (2021) 22 PubMed Europe PubMed DOI PMC EPMC V
Forli,F., Bruschini,L., Franciosi,B., Battini,R., Marinella,G., Berrettini,S. and Lazzerini,F. A Rare Case of Perrault Syndrome with Auditory Neuropathy Spectrum Disorder: Cochlear Implantation Treatment and Literature Review Audiol Res (2021) 11, 609-617. PubMed Europe PubMed DOI PMC EPMC
Kou,X., Ding,H., Li,L. and Chao,H. Caseinolytic protease P (CLPP) activated by ONC201 inhibits proliferation and promotes apoptosis in human epithelial ovarian cancer cells by inducing mitochondrial dysfunction Ann Transl Med (2021) 9, 1463-1463. PubMed Europe PubMed DOI PMC EPMC
Song,R., Yang,Y., Huang,J., Qiao,W., Luo,B., Ju,Y., Yang,T. and Luo,Y. Discovery of novel indolin-2-one compounds as potent inhibitors of HsClpP for cancer treatment Bioorg Chem (2021) 110, 104820-104820. PubMed Europe PubMed DOI I

2020

Esencan,E., Jiang,Z., Wang,T., Zhang,M., Soylemez-Imamoglu,G. and Seli,E. Impaired mitochondrial stress response due to CLPP deletion is associated with altered mitochondrial dynamics and increased apoptosis in cumulus cells Reprod Sci (2020) 27, 621-630. PubMed Europe PubMed DOI K
Esencan,E., Cozzolino,M., Imamoglu,G. and Seli,E. Mitochondrial Stress Response Gene Clpp Is Not Required for Granulosa Cell Function Antioxidants (Basel) (2020) 10 PubMed Europe PubMed DOI PMC EPMC
Jacques,S., van der Sloot,A.M., C Huard,C., Coulombe-Huntington,J., Tsao,S., Tollis,S., Bertomeu,T., Culp,E.J., Pallant,D., Cook,M.A., Bonneil,E., Thibault,P., Wright,G.D. and Tyers,M. Imipridone anticancer compounds ectopically activate the ClpP protease and represent a new scaffold for antibiotic development Genetics (2020) 214, 1103-1120. PubMed Europe PubMed DOI
Mirali,S. and Schimmer,A.D. The role of mitochondrial proteases in leukemic cells and leukemic stem cells Stem Cells Transl Med (2020) PubMed Europe PubMed DOI
Nouri,K., Feng,Y. and Schimmer,A.D. Mitochondrial ClpP serine protease-biological function and emerging target for cancer therapy Cell Death Dis (2020) 11, 841-841. PubMed Europe PubMed DOI PMC EPMC V
Prabhu,V.V., Morrow,S., Rahman Kawakibi,A., Zhou,L., Ralff,M., Ray,J., Jhaveri,A., Ferrarini,I., Lee,Y., Parker,C., Zhang,Y., Borsuk,R., Chang,W.I., Honeyman,J.N., Tavora,F., Carneiro,B., Raufi,A., Huntington,K., Carlsen,L., Louie,A., Safran,H., Seyhan,A.A., Tarapore,R.S., Schalop,L., Stogniew,M., Allen,J.E., Oster,W. and El-Deiry,W.S. ONC201 and imipridones: Anti-cancer compounds with clinical efficacy Neoplasia (2020) 22, 725-744. PubMed Europe PubMed DOI PMC EPMC
Ripstein,Z.A., Vahidi,S., Houry,W.A., Rubinstein,J.L. and Kay,L.E. A processive rotary mechanism couples substrate unfolding and proteolysis in the ClpXP degradation machinery elife (2020) 9 PubMed Europe PubMed DOI S
Sha,Z., Fishovitz,J., Wang,S., Chilakala,S., Xu,Y. and Lee,I. A selective fluorogenic peptide substrate for the human mitochondrial ATP-dependent protease complex ClpXP Chembiochem (2020) 21, 2037-2048. PubMed Europe PubMed DOI A P I
Strack,P.R., Brodie,E.J., Zhan,H., Schuenemann,V.J., Valente,L.J., Saiyed,T., Lowth,B.R., Angley,L.M., Perugini,M.A., Zeth,K., Truscott,K.N. and Dougan,D.A. Polymerase delta-interacting protein 38 (PDIP38) modulates the stability and activity of the mitochondrial AAA+ protease CLPXP Commun Biol (2020) 3, 646-646. PubMed Europe PubMed DOI PMC EPMC

2019

Ishizawa,J., Zarabi,S.F., Davis,R.E., Halgas,O., Nii,T., Jitkova,Y., Zhao,R., St-Germain,J., Heese,L.E., Egan,G., Ruvolo,V.R., Barghout,S.H., Nishida,Y., Hurren,R., Ma,W., Gronda,M., Link,T., Wong,K., Mabanglo,M., Kojima,K., Borthakur,G., Maclean,N., Ma,M.C.J., Leber,A.B., Minden,M.D., Houry,W., Kantarjian,H., Stogniew,M., Raught,B., Pai,E.F., Schimmer,A.D. and Andreeff,M. Mitochondrial ClpP-Mediated Proteolysis Induces Selective Cancer Cell Lethality Cancer Cell (2019) 35, 721-737. PubMed Europe PubMed DOI PMC EPMC
Wong,K.S. and Houry,W.A. Chemical modulation of human mitochondrial ClpP: potential application in cancer therapeutics ACS Chem Biol (2019) 14, 2349-2360. PubMed Europe PubMed DOI

2018

Becker,C., Kukat,A., Szczepanowska,K., Hermans,S., Senft,K., Brandscheid,C.P., Maiti,P. and Trifunovic,A. CLPP deficiency protects against metabolic syndrome but hinders adaptive thermogenesis EMBO Rep (2018) 19, e45126.-e45126. PubMed Europe PubMed DOI
Bhaskaran,S., Pharaoh,G., Ranjit,R., Murphy,A., Matsuzaki,S., Nair,B.C., Forbes,B., Gispert,S., Auburger,G., Humphries,K.M., Kinter,M., Griffin,T.M. and Deepa,S.S. Loss of mitochondrial protease ClpP protects mice from diet-induced obesity and insulin resistance EMBO Rep (2018) 19, e45009-e45009. PubMed Europe PubMed DOI K
Brodie,E.J., Zhan,H., Saiyed,T., Truscott,K.N. and Dougan,D.A. Perrault syndrome type 3 caused by diverse molecular defects in CLPP Sci Rep (2018) 8, 12862-12862. PubMed Europe PubMed DOI PMC EPMC M
Dougan,D.A., Hantke,I. and Turgay,K. Dysregulating ClpP: from antibiotics to anticancer? Cell Chem Biol (2018) 25, 929-930. PubMed Europe PubMed DOI
Gronauer,T.F., Mandl,M.M., Lakemeyer,M., Hackl,M.W., Messner,M., Korotkov,V.S., Pachmayr,J. and Sieber,S.A. Design and synthesis of tailored human caseinolytic protease P inhibitors Chem Commun (Camb) (2018) 54, 9833-9836. PubMed Europe PubMed DOI I
Stahl,M., Korotkov,V.S., Balogh,D., Kick,L.M., Gersch,M., Pahl,A., Kielkowski,P., Richter,K., Schneider,S. and Sieber,S.A. Selective activation of human caseinolytic protease P (ClpP) Angew Chem Int Ed Engl (2018) 57, 14602-14607. PubMed Europe PubMed DOI

2016

Gersch,M., Stahl,M., Poreba,M., Dahmen,M., Dziedzic,A., Drag,M. and Sieber,S.A. Barrel-shaped ClpP proteases display attenuated cleavage specificities ACS Chem Biol (2016) 11, 389-399. PubMed Europe PubMed DOI P
Pryde,K.R., Taanman,J.W. and Schapira,A.H. A LON-ClpP proteolytic axis degrades complex I to extinguish ROS production in depolarized mitochondria Cell Rep (2016) 17, 2522-2531. PubMed Europe PubMed DOI

2015

Cole,A., Wang,Z., Coyaud,E., Voisin,V., Gronda,M., Jitkova,Y., Mattson,R., Hurren,R., Babovic,S., Maclean,N., Restall,I., Wang,X., Jeyaraju,D.V., Sukhai,M.A., Prabha,S., Bashir,S., Ramakrishnan,A., Leung,E., Qia,Y.H., Zhang,N., Combes,K.R., Ketela,T., Lin,F., Houry,W.A., Aman,A., Al-Awar,R., Zheng,W., Wienholds,E., Xu,C.J., Dick,J., Wang,J.C., Moffat,J., Minden,M.D., Eaves,C.J., Bader,G.D., Hao,Z., Kornblau,S.M., Raught,B. and Schimmer,A.D. Inhibition of the mitochondrial protease ClpP as a therapeutic strategy for human acute myeloid leukemia Cancer Cell (2015) 27, 864-876. PubMed Europe PubMed DOI PMC EPMC K

2013

Jenkinson,E.M., Rehman,A.U., Walsh,T., Clayton-Smith,J., Lee,K., Morell,R.J., Drummond,M.C., Khan,S.N., Naeem,M.A., Rauf,B., Billington,N., Schultz,J.M., Urquhart,J.E., Lee,M.K., Berry,A., Hanley,N.A., Mehta,S., Cilliers,D., Clayton,P.E., Kingston,H., Smith,M.J., Warner,T.T., Black,G.C., Trump,D., Davis,J.R., Ahmad,W., Leal,S.M., Riazuddin,S., King,M.C., Friedman,T.B. and Newman,W.G. Perrault syndrome is caused by recessive mutations in CLPP, encoding a mitochondrial ATP-dependent chambered protease Am J Hum Genet (2013) 92, 605-613. PubMed Europe PubMed DOI PMC EPMC M

2005

[YEAR:22-8-2005]Kang,S.G., Dimitrova,M.N., Ortega,J., Ginsburg,A. and Maurizi,M.R. Human mitochondrial ClpP is a stable heptamer that assembles into a tetradecamer in the presence of ClpX J Biol Chem (22-8-2005) 280, 35424-35432. PubMed Europe PubMed DOI

2004

Kang,S.G., Maurizi,M.R., Thompson,M., Mueser,T. and Ahvazi,B. Crystallography and mutagenesis point to an essential role for the N-terminus of human mitochondrial ClpP J Struct Biol (2004) 148, 338-352. PubMed Europe PubMed DOI S

2002

[YEAR:7-6-2002]Kang,S.G., Ortega,J., Singh,S.K., Wang,N., Huang,N.N., Steven,A.C. and Maurizi,M.R. Functional proteolytic complexes of the human mitochondrial ATP-dependent protease, hClpXP J Biol Chem (7-6-2002) 277, 21095-21102. PubMed Europe PubMed DOI

2000

Andresen,B.S., Corydon,T.J., Wilsbech,M., Bross,P., Schroeder,L.D., Hindkjaer,T.F., Bolund,L. and Gregersen,N. Characterization of mouse Clpp protease cDNA, gene, and protein Mamm Genome (2000) 11, 275-280. PubMed Europe PubMed DOI
Corydon,T.J., Wilsbech,M., Jespersgaard,C., Andresen,B.S., Borglum,A.D., Pedersen,S., Bolund,L., Gregersen,N. and Bross,P. Human and mouse mitochondrial orthologs of bacterial ClpX Mamm Genome (2000) 11, 899-905. PubMed Europe PubMed

1999

[YEAR:1-10-1999]de Sagarra,M.R., Mayo,I., Marco,S., Rodriguez-Vilarino,S., Oliva,J., Carrascosa,J.L. and Casta n,J.G. Mitochondrial localization and oligomeric structure of HClpP, the human homologue of E. coli ClpP J Mol Biol (1-10-1999) 292, 819-825. PubMed Europe PubMed DOI
[YEAR:4-6-1999]Santagata,S., Bhattacharyya,D., Wang,F.H., Singha,N., Hodtsev,A. and Spanopoulou,E. Molecular cloning and characterization of a mouse homolog of bacterial ClpX, a novel mammalian class II member of the Hsp100/Clp chaperone family J Biol Chem (4-6-1999) 274, 16311-16319. PubMed Europe PubMed DOI

1998

[YEAR:1-4-1998]Corydon,T.J., Bross,P., Holst,H.U., Neve,S., Kristiansen,K., Gregersen,N. and Bolund,L. A human homologue of Escherichia coli ClpP caseinolytic protease: recombinant expression, intracellular processing and subcellular localization Biochem J (1-4-1998) 331, 309-316. PubMed Europe PubMed PMC EPMC

1995

Bross,P., Andresen,B.S., Knudsen,I., Kruse,T.A. and Gregersen,N. Human ClpP protease: CDNA sequence, tissue-specific expression and chromosomal assignment of the gene FEBS Lett (1995) 377, 249-252. PubMed Europe PubMed DOI