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Literature for peptidase S13.002: D-Ala-D-Ala carboxypeptidase (Actinomadura-type)

Summary Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Inhibitors

(Topics flags: S Structure, P Specificity, I Inhibitor, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2026
  1. Xu,X., Scholivet,A., Champ,S., Berge,M., Yeerkenjiang,Z., Desjardins,J., Denis,Y., Douzi,B., Byrne,D., Talla,E. and Latifi,A.
    Co-option of an ancestral peptidase controls developmental patterning in multicellular cyanobacteria
    iScience (2026) 29, 114265-114265. PubMed  Europe PubMed DOI  PMC  EPMC
    2. 2013
  2. Dzhekieva,L., Adediran,S.A., Herman,R., Kerff,F., Duez,C., Charlier,P., Sauvage,E. and Pratt,R.F.
    Inhibition of dd-peptidases by a specific trifluoroketone: crystal structure of a complex with the Actinomadura R39 dd-peptidase
    Biochemistry (2013) 52, 2128-2138. PubMed  Europe PubMed DOI  S  I
  3. Nemmara,V.V., Adediran,S.A., Dave,K., Duez,C. and Pratt,R.F.
    Dual substrate specificity of Bacillus subtilis PBP4a
    Biochemistry (2013) 52, 2627-2637. PubMed  Europe PubMed DOI  P
    4. 2012
  4. Pelto,R.B. and Pratt,R.F.
    Kinetics and stereochemistry of hydrolysis of an N-(phenylacetyl)-alpha-hydroxyglycine ester catalyzed by serine beta-lactamases and dd-peptidases
    Org Biomol Chem (2012) 10, 7356-7362. PubMed  Europe PubMed DOI  P
  5. Sauvage,E. and Frere,J.M.
    Actinomadura R39 D-Ala-D-Ala carboxypeptidase
    [ISSN:978-0-12-407742-3] (2012) 3, 3480-3484. DOI
  6. Sliwa,A., Dive,G. and Marchand-Brynaert,J.
    12- to 22-Membered bridged beta-lactams as potential penicillin-binding protein inhibitors
    Chem Asian J (2012) 7, 425-434. PubMed  Europe PubMed DOI  I
    7. 2011
  7. Adediran,S.A., Kumar,I., Nagarajan,R., Sauvage,E. and Pratt,R.F.
    Kinetics of reactions of the Actinomadura R39 dd-peptidase with specific substrates
    Biochemistry (2011) 50, 376-387. PubMed  Europe PubMed DOI
  8. Nemmara,V.V., Dzhekieva,L., Subarno Sarkar,K., Adediran,S.A., Duez,C., Nicholas,R.A. and Pratt,R.F.
    Substrate specificity of low-molecular mass bacterial dd-peptidases
    Biochemistry (2011) 50, 10091-10101. PubMed  Europe PubMed DOI  P
  9. Zervosen,A., Herman,R., Kerff,F., Herman,A., Bouillez,A., Prati,F., Pratt,R.F., Frere,J.M., Joris,B., Luxen,A., Charlier,P. and Sauvage,E.
    Unexpected tricovalent binding mode of boronic acids within the active site of a penicillin-binding protein
    J Am Chem Soc (2011) 133, 10839-10848. PubMed  Europe PubMed DOI  S  I
    10. 2010
  10. Dzhekieva,L., Rocaboy,M., Kerff,F., Charlier,P., Sauvage,E. and Pratt,R.F.
    Crystal structure of a complex between the Actinomadura R39 dd-peptidase and a peptidoglycan-mimetic boronate inhibitor: interpretation of a transition state analogue in terms of catalytic mechanism
    Biochemistry (2010) 49, 6411-6419. PubMed  Europe PubMed DOI  S  I
    11. 2009
  11. Inglis,S.R., Zervosen,A., Woon,E.C., Gerards,T., Teller,N., Fischer,D.S., Luxen,A. and Schofield,C.J.
    Synthesis and evaluation of 3-(dihydroxyboryl)benzoic acids as d,d-carboxypeptidase R39 inhibitors
    J Med Chem (2009) 52, 6097-6106. PubMed  Europe PubMed DOI  I
  12. Sauvage,E., Zervosen,A., Dive,G., Herman,R., Amoroso,A., Joris,B., Fonze,E., Pratt,R.F., Luxen,A., Charlier,P. and Kerff,F.
    Structural basis of the inhibition of class A beta-lactamases and penicillin-binding proteins by 6-beta-iodopenicillanate
    J Am Chem Soc (2009) 131, 15262-15269. PubMed  Europe PubMed DOI  S  I
    13. 2008
  13. Pratt,R.F.
    Substrate specificity of bacterial DD-peptidases (penicillin-binding proteins)
    Cell Mol Life Sci (2008) 65, 2138-2155. PubMed  Europe PubMed DOI  V  P
  14. Sauvage,E., Powell,A.J., Heilemann,J., Josephine,H.R., Charlier,P., Davies,C. and Pratt,R.F.
    Crystal structures of complexes of bacterial DD-peptidases with peptidoglycan-mimetic ligands: the substrate specificity puzzle
    J Mol Biol (2008) 381, 383-393. PubMed  Europe PubMed DOI  PMC  EPMC  S
    15. 2007
  15. Sauvage,E., Duez,C., Herman,R., Kerff,F., Petrella,S., Anderson,J.W., Adediran,S.A., Pratt,R.F., Frere,J.M. and Charlier,P.
    Crystal structure of the Bacillus subtilis penicillin-binding protein 4a, and its complex with a peptidoglycan mimetic peptide
    J Mol Biol (2007) 371, 528-539. PubMed  Europe PubMed DOI  S
    16. 2005
  16. [YEAR:29-6-2005]Sauvage,E., Herman,R., Petrella,S., Duez,C., Bouillenne,F., Frere,J.M. and Charlier,P.
    Crystal structure of the Actinomadura R39 DD-peptidase reveals new domains in penicillin-binding proteins
    J Biol Chem (29-6-2005) 280, 31249-31256. PubMed  Europe PubMed DOI  S
    17. 2004
  17. Frere,J.M.
    Actinomadura R39 D-Ala-D-Ala carboxypeptidase
    [ISSN:0-12-079610-4] (2004) 2, 1971-1973.  V
    18. 2003
  18. [YEAR:1-8-2003]Anderson,J.W., Adediran,S.A., Charlier,P., Nguyen-Disteche,M., Frere,J.M., Nicholas,R.A. and Pratt,R.F.
    On the substrate specificity of bacterial DD-peptidases: evidence from two series of peptidoglycan-mimetic peptides
    Biochem J (1-8-2003) 373, 949-955. PubMed  Europe PubMed DOI  PMC  EPMC
    19. 2001
  19. Duez,C., Vanhove,M., Gallet,X., Bouillenne,F., Docquier,J., Brans,A. and Frere,J.
    Purification and characterization of PBP4a, a new low-molecular-weight penicillin-binding protein from Bacillus subtilis
    J Bacteriol (2001) 183, 1595-1599. PubMed  Europe PubMed DOI  PMC  EPMC
    20. 1997
  20. Zhao,G.H., Duez,C., Lepage,S., Forceille,C., Rhazi,N., Klein,D., Ghuysen,J.M. and Frere,J.M.
    Site-directed mutagenesis of the Actinomadura R39 DD-peptidase
    Biochem J (1997) 327, 377-381. PubMed  Europe PubMed  PMC  EPMC
    21. 1995
  21. Damblon,C., Ledent,P., Zhao,G.H., Jamin,M., Dubus,A., Vanhove,M., Raquet,X., Christiaens,L. and Frere,J.M.
    Thiolester substrates of dd-peptidases and beta-lactamases
    Lett Pept Sci (1995) 2, 212-216. DOI
    22. 1992
  22. Granier,B., Duez,C., Lepage,S., Englebert,S., Dusart,J., Dideberg,O., Van Beeumen,J., Frere,J.M. and Ghuysen,J.M.
    Primary and predicted secondary structures of the Actinomadura R39 extracellular DD-peptidase, a penicillin-binding protein (PBP) related to the Escherichia coli PBP4
    Biochem J (1992) 282, 781-788. PubMed  Europe PubMed  PMC  EPMC
    23. 1986
  23. Morel,P., Guinand,M., Vacheron,M.J. and Michel,G.
    Biologically active glycopeptides from Actinomadura R 39. I. Continuous preparation of glycotri- and glyco-tetrapeptides with immobilized dd-carboxypeptidase from Streptomyces albus G
    Biotechnol Appl Biochem (1986) 8, 404-413.
    24. 1981
  24. Duez,C., Joris,B., Frere,J.M., Ghuysen,J.M. and Van Beeumen,J.
    The penicillin-binding site in the exocellular DD-carboxypeptidase-transpeptidase of Actinomadura R39
    Biochem J (1981) 193, 83-86. PubMed  Europe PubMed  PMC  EPMC
  25. Perkins,H.R., Frere,J.M. and Ghuysen,J.M.
    Synthetic peptide inhibitors of transpeptidation by the exocellular DD-carboxypeptidase-transpeptidase from Actinomadura R39
    FEBS Lett (1981) 123, 75-78. PubMed  Europe PubMed DOI  I
    26. 1974
  26. Frere,J.M., Ghuysen,J.M., Reynolds,P.E. and Moreno,R.
    Binding of beta-lactam antibiotics to the exocellular DD-carboxypeptidase-transpeptidase of Streptomyces R39
    Biochem J (1974) 143, 241-249. PubMed  Europe PubMed  PMC  EPMC
  27. Frere,J.M., Moreno,R. and Ghuysen,J.M.
    Molecular weight, amino acid composition and physicochemical properties of the exocellular DD-carboxypeptidase-transpeptidase of Streptomyces R39
    Biochem J (1974) 143, 233-240. PubMed  Europe PubMed  PMC  EPMC
    28. 1973
  28. [YEAR:27-3-1973]Ghuysen,J.M., Leyh-Bouille,M., Campbell,J.N., Moreno,R., Frere,J.M., Duez,C., Nieto,M. and Perkins,H.R.
    Structure of the wall peptidoglycan of Streptomyces R39 and the specificity profile of its exocellular DD-carboxypeptidase-transpeptidase for peptide acceptors
    Biochemistry (27-3-1973) 12, 1243-1251. PubMed  Europe PubMed

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