Literature for peptidase S09.003: dipeptidyl-peptidase IV (eukaryote)

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Structure Literature Substrates Pharma

(Topics flags: S Structure, A Assay, T Target, P Specificity, K Knockout, E Expression, V Review, M Mutation, I Inhibitor, L Localization. To select only the references relevant to a single topic, click the link above. See explanation.)

2025

Shen,C., Oh,H.R., Park,Y.R., Oh,S. and Park,J.H.
Soluble DPP4 promotes hepatocyte lipid accumulation via SOX2-SCD1 signaling and counteracts DPP4 inhibition
Biochem Biophys Res Commun756, 151521-151521. PubMed Europe PubMed DOI K
Shieh,T.M., Lin,N.C., Shen,Y.W., Lan,W.C. and Shih,Y.H.
Epithelium-derived exosomal dipeptidyl peptidase-4 involved in arecoline-induced oral submucous fibrosis
Biochim Biophys Acta Mol Basis Dis167683-167683. PubMed Europe PubMed DOI

2024

Bayanati,M., Ismail Mahboubi Rabbani,M., Sirous Kabiri,S., Mir,B., Rezaee,E. and Tabatabai,S.A.
Dipeptidyl Peptidase-4 Inhibitors: A Systematic Review of Structure-Activity Relationship Studies
Iran J Pharm Res23, e151581-e151581. PubMed Europe PubMed DOI V
Chayah,M., Luque-Gonzalez,A., Gomez-Perez,V., Salagre,D., Al-Shdaifat,A., Campos,J.M., Conejo-Garcia,A. and Agil,A.
Synthesis and Anti-Diabetic Activity of an 8-Purine Derivative as a Novel DPP-4 Inhibitor in Obese Diabetic Zucker Rats
Drug Des Devel Ther18, 1133-1141. PubMed Europe PubMed DOI I
Chen,J., Ji,H., Luo,J., Zhang,D. and Liu,S.
Two novel angiotensin-converting enzyme (ACE) and dipeptidyl peptidase IV (DPP-IV) inhibiting peptides from tilapia (Oreochromis mossambicus) skin and their molecular docking mechanism
J Food Sci89, 3603-3617. PubMed Europe PubMed DOI I
Cui,C., Cao,F., Kong,I.I., Wu,Q., Li,F., Li,H. and Liu,D.
A model-informed approach to accelerate the clinical development of cofrogliptin (HSK7653), a novel ultralong-acting dipeptidyl peptidase-4 inhibitor
Diabetes Obes Metab26, 592-601. PubMed Europe PubMed DOI I
Gheonea,T.C., Surlin,P., Nicolae,F.M., Gheorghe,D.N., Popescu,D.M. and Rogoveanu,I.
Dipeptidyl-Peptidase-4 and Glucagon-like-Peptide-1, a Link in the Connection between Periodontitis and Diabetes Mellitus-What Do We Know So Far?-A Scoping Review
J Clin Med13, PubMed Europe PubMed DOI
Gnoth,K., Bar,J.W., Rosche,F., Rahfeld,J.U. and Demuth,H.U.
Contribution of amino acids in the active site of dipeptidyl peptidase 4 to the catalytic action of the enzyme
PLoS ONE19, e0289239-e0289239. PubMed Europe PubMed DOI
Guo,X., Feng,H., Cai,L., Zheng,J. and Li,Y.
DPP-IV as a potential candidate in anti-obesity and obesity-related diseases treatment
Biomed Pharmacother180, 117464-117464. PubMed Europe PubMed DOI
Ingle,H., Molleston,J.M., Hall,P.D., Bui,D., Wang,L., Foster,L., Antia,A., Ding,S., Lee,S., Fremont,D.H. and Baldridge,M.T.
The neonatal Fc receptor and DPP4 are human astrovirus receptors
Nat Microbiol9, 3321-3331. PubMed Europe PubMed DOI
Janin,Y.L.
On the origins of SARS-CoV-2 main protease inhibitors
RSC Med Chem15, 81-118. PubMed Europe PubMed DOI V I
Li,X., Zhang,Z., Jiang,W., Ju,Y., Guo,W. and Huang,Z.
Dipeptidyl Peptidase 4 (DPP4) Exacerbates Osteoarthritis Progression in an Enzyme-Independent Manner
Adv Sci (Weinh)e2410525-e2410525. PubMed Europe PubMed DOI
Liu,M., Zeng,J., Zhang,W., Lei,J., Li,S., Zhou,J., Cheng,D. and He,L.
Fabrication of a Near-Infrared-Emissive Probe for Detecting Dipeptidyl Peptidase 4 in the Liver of Diabetic Mice and Clinical Serum
Anal Chem PubMed Europe PubMed DOI
Liu,Y., Zhao,W., Jiang,Y., Xing,S. and Li,W.
Study on the Mechanism of Interaction between Dipeptidyl Peptidase 4 and Inhibitory Peptides Based on Gaussian Accelerated Molecular Dynamic Simulation
Int J Mol Sci25, PubMed Europe PubMed DOI
Lu,P., Dai,S.M., Zhou,H., Wang,F., Dong,W.R. and Jiang,J.H.
Xanthene-based near-infrared chromophores for high-contrast fluorescence and photoacoustic imaging of dipeptidyl peptidase 4
Chem Sci15, 2221-2228. PubMed Europe PubMed DOI
Masyita,A., Firdayani,F., Listiana,S. and Besari,A.Y.
Emodin derivatives as novel potent DPP-4 inhibitors: Design, synthesis, and in vitro evaluation
Biochem Biophys Res Commun735, 150867-150867. PubMed Europe PubMed DOI I
Nag,S., Mandal,S., Mukherjee,O., Majumdar,T., Mukhopadhyay,S. and Kundu,R.
Vildagliptin inhibits high fat and fetuin-A mediated DPP-4 expression, intracellular lipid accumulation and improves insulin secretory defects in pancreatic beta cells
Biochim Biophys Acta Mol Basis Dis1870, 167047-167047. PubMed Europe PubMed DOI K I
Shamim,S., Alam,O., Jha,M., Nazar,S., Mathur,V., Ali,S., Iliyas,A., Chandra,K., Jamil Ahmed,S.M.A., Naim,M.J. and Parveen,B.
Triazole scaffold-based DPP-IV Inhibitors for the management of Type-II Diabetes Mellitus: Insight into Molecular Docking and SAR
Curr Top Med Chem PubMed Europe PubMed DOI V I
Shao,S., Zhang,N., Specht,G.P., You,S., Song,L., Fu,Q., Huang,D., You,H., Shu,J., Domissy,A., Li,S., Nguyen-Tran,V., Joseph,S.B., Chatterjee,A.K., Chen,J.J., Schultz,P.G. and Bollong,M.J.
Pharmacological expansion of type 2 alveolar epithelial cells promotes regenerative lower airway repair
Proc Natl Acad Sci U S A121, e2400077121-e2400077121. PubMed Europe PubMed DOI
Sivaraman,S.A. and Sabareesh,V.
An Update on Dipeptidyl Peptidase-IV Inhibiting Peptides
Curr Protein Pept Sci25, 267-285. PubMed Europe PubMed DOI V
Vorstandlechner,V. and Mildner,M.
Much More Than Just Diabetes: The Pivotal Role of Dipeptidyl-Peptidase 4 in Skin Fibrosis
J Invest Dermatol144, 2341-2343. PubMed Europe PubMed DOI
Zhang,J., Zhu,Y.D., Li,C.Q., Fan,Y.M., Huo,H., Sun,C.G., Zhou,J., Sun,L., Qian,X.K. and Zou,L.W.
A sensitive fluorescence assay of serum dipeptidyl peptidase IV activity to predict the suitability of its inhibitors in patients with type 2 diabetes mellitus
J Pharm Biomed Anal249, 116382-116382. PubMed Europe PubMed DOI

2023

Cambier,S., Beretta,F., Portner,N., Metzemaekers,M., de Carvalho,A.C., Martens,E., Kaes,J., Aelbrecht,C., Jacobs,C., Van Mol,P., Wauters,E., Meersseman,P., Hermans,G., Marques,R.E., Vanaudenaerde,B., Vos,R., Wauters,J., Gouwy,M. and Proost,P.
Proteolytic inactivation of CXCL12 in the lungs and circulation of COVID-19 patients
Cell Mol Life Sci80, 234-234. PubMed Europe PubMed DOI I
Castle,A.R., Kang,S.G., Eskandari-Sedighi,G., Wohlgemuth,S., Nguyen,M.A., Drucker,D.J., Mulvihill,E.E. and Westaway,D.
Beta-endoproteolysis of the cellular prion protein by dipeptidyl peptidase-4 and fibroblast activation protein
Proc Natl Acad Sci U S A120, e2209815120-e2209815120. PubMed Europe PubMed DOI
Chen,Y.H., Zhang,X., Chou,C.H., Hsueh,M.F., Attarian,D., Li,Y.J. and Kraus,V.B.
Association of Dipeptidylpeptidase 4 (CD26) With Chondrocyte Senescence and Radiographic Progression in Knee Osteoarthritis
Arthritis Rheumatol75, 1120-1131. PubMed Europe PubMed DOI
Fadzeyeva,E., Locatelli,C.A.A., Trzaskalski,N.A., Nguyen,M.A., Capozzi,M.E., Vulesevic,B., Morrow,N.M., Ghorbani,P., Hanson,A.A., Lorenzen-Schmidt,I., Doyle,M.A., Seymour,R., Varin,E.M., Fullerton,M.D., Campbell,J.E. and Mulvihill,E.E.
Pancreas-derived DPP4 is not essential for glucose homeostasis under metabolic stress
iScience26, 106748-106748. PubMed Europe PubMed DOI
Gonzatti,M.B., Junior,J.E.M., Rocha,A.J., de Oliveira,J.S., Evangelista,A.J.J., Fonseca,F.M.P., Ceccatto,V.M., de Oliveira,A.C. and da Cruz Freire,J.E.
Mechanism of molecular interaction of sitagliptin with human DPP(4) enzyme - New Insights
Adv Med Sci68, 402-408. PubMed Europe PubMed DOI I
Guan,C., Luo,J., Li,S., Tan,Z.L., Wang,Y., Chen,H., Yamamoto,N., Zhang,C., Lu,Y., Chen,J. and Xing,X.H.
Exploration of DPP-IV Inhibitory Peptide Design Rules Assisted by the Deep Learning Pipeline That Identifies the Restriction Enzyme Cutting Site
ACS Omega8, 39662-39672. PubMed Europe PubMed DOI
Li,J., Ma,M., Li,J., Xu,L., Song,D., Ma,P. and Fei,Q.
Visualizing Dipeptidyl Peptidase-IV with an Advanced Non-pi-Conjugated Fluorescent Probe for Early Thyroid Disease Diagnosis
Anal Chem95, 17577-17585. PubMed Europe PubMed DOI
Li,Q., Deng,X., Xu,Y.J. and Dong,L.
Development of Long-Acting Dipeptidyl Peptidase-4 Inhibitors: Structural Evolution and Long-Acting Determinants
J Med Chem66, 11593-11631. PubMed Europe PubMed DOI

2022

Alves,E.S., Tonet-Furioso,A.C., Alves,V.P., Moraes,C.F., Perez,D.I.V., Bastos,I.M.D., Cordova,C. and Nobrega,O.T.
A haplotype in the dipeptidyl peptidase 4 gene impacts glycemic-related traits of Brazilian older adults
Braz J Med Biol Res55, e12148-e12148. PubMed Europe PubMed DOI
Benramdane,S., De Loose,J., Beyens,O., Van Rymenant,Y., Vliegen,G., Augustyns,K., De Winter,H., De Meester,I. and Van der Veken,P.
Vildagliptin-Derived Dipeptidyl Peptidase 9 (DPP9) Inhibitors: Identification of a DPP8/9-Specific Lead
ChemMedChem17, e202200097-e202200097. PubMed Europe PubMed DOI I
Bernstein,H.G., Keilhoff,G., Dobrowolny,H. and Steiner,J.
The many facets of CD26/dipeptidyl peptidase 4 and its inhibitors in disorders of the CNS - a critical overview
Rev Neurosci34, 1-24. PubMed Europe PubMed DOI V
Bhargave,A., Devi,K., Ahmad,I., Yadav,A. and Gupta,R.
Genetic variation in DPP-IV gene linked to predisposition of T2DM: A case control study
J Diabetes Metab Disord21, 1709-1716. PubMed Europe PubMed DOI
Huang,J., Liu,X., Wei,Y., Li,X., Gao,S., Dong,L., Rao,X. and Zhong,J.
Emerging Role of Dipeptidyl Peptidase-4 in Autoimmune Disease
Front Immunol13, 830863-830863. PubMed Europe PubMed DOI V
Maslov,I.O., Zinevich,T.V., Kirichenko,O.G., Trukhan,M.V., Shorshnev,S.V., Tuaeva,N.O., Gureev,M.A., Dahlen,A.D., Porozov,Y.B., Schioth,H.B. and Trukhan,V.M.
Design, Synthesis and Biological Evaluation of Neogliptin, a Novel 2-Azabicyclo[2.2.1]heptane-Based Inhibitor of Dipeptidyl Peptidase-4 (DPP-4)
Pharmaceuticals (Basel)15, PubMed Europe PubMed DOI I
Masui,S., Yonezawa,A., Yokoyama,K., Iwamoto,N., Shimada,T., Onishi,A., Onizawa,H., Fujii,T., Murakami,K., Murata,K., Tanaka,M., Nakagawa,S., Hira,D., Itohara,K., Imai,S., Nakagawa,T., Hayakari,M., Matsuda,S., Morinobu,A., Terada,T. and Matsubara,K.
N-terminus of Etanercept is Proteolytically Processed by Dipeptidyl Peptidase-4
Pharm Res39, 2541-2554. PubMed Europe PubMed DOI
Pan,J., Zhang,Q., Zhang,C., Yang,W., Liu,H., Lv,Z., Liu,J. and Jiao,Z.
Inhibition of Dipeptidyl Peptidase-4 by Flavonoids: Structure-Activity Relationship, Kinetics and Interaction Mechanism
Front Nutr9, 892426-892426. PubMed Europe PubMed DOI I
Sebastian-Martin,A., Sanchez,B.G., Mora-Rodriguez,J.M., Bort,A. and Diaz-Laviada,I.
Role of Dipeptidyl Peptidase-4 (DPP4) on COVID-19 Physiopathology
Biomedicines10, PubMed Europe PubMed DOI V
Shatizadeh Malekshahi,S., Yavarian,J. and Shafiei-Jandaghi,N.Z.
Usage of peptidases by SARS-CoV-2 and several human coronaviruses as receptors: A mysterious story
Biotechnol Appl Biochem69, 124-128. PubMed Europe PubMed DOI
Yang,Q., Fu,B., Luo,D., Wang,H., Cao,H., Chen,X., Tian,L. and Yu,X.
The Multiple Biological Functions of Dipeptidyl Peptidase-4 in Bone Metabolism
Front Endocrinol (Lausanne)13, 856954-856954. PubMed Europe PubMed DOI V

2021

Alkin,N., Dunaevsky,Y., Elpidina,E., Beljakova,G., Tereshchenkova,V., Filippova,I. and Belozersky,M.
Proline-Specific Fungal Peptidases: Genomic Analysis and Identification of Secreted DPP4 in Alkaliphilic and Alkalitolerant Fungi
J Fungi (Basel)7, PubMed Europe PubMed DOI
Arshia, Fayyaz,S., Shaikh,M., Khan,K.M. and Choudhary,M.I.
Anti-glycemic potential of benzophenone thio/semicarbazone derivatives: synthesis, enzyme inhibition and ligand docking studies
J Biomol Struct Dyn1-12. PubMed Europe PubMed DOI I
Bardaweel,S.K., Hajjo,R. and Sabbah,D.A.
Sitagliptin: a potential drug for the treatment of COVID-19?
Acta Pharm71, 175-184. PubMed Europe PubMed DOI I
Beumer,J., Geurts,M.H., Lamers,M.M., Puschhof,J., Zhang,J., van der Vaart,J., Mykytyn,A.Z., Breugem,T.I., Riesebosch,S., Schipper,D., van den Doel,P.B., de Lau,W., Pleguezuelos-Manzano,C., Busslinger,G., Haagmans,B.L. and Clevers,H.
A CRISPR/Cas9 genetically engineered organoid biobank reveals essential host factors for coronaviruses
Nat Commun12, 5498-5498. PubMed Europe PubMed DOI
Cameron,K., Rozano,L., Falasca,M. and Mancera,R.L.
Does the SARS-CoV-2 Spike Protein Receptor Binding Domain Interact Effectively with the DPP4 (CD26) Receptor? A Molecular Docking Study
Int J Mol Sci22, PubMed Europe PubMed DOI
Cao,W., Chen,X., Chin,Y., Zheng,J., Lim,P.E., Xue,C. and Tang,Q.
Identification of curcumin as a potential alpha-glucosidase and dipeptidyl-peptidase 4 inhibitor: Molecular docking study, in vitro and in vivo biological evaluation
J Food Biocheme13686-e13686. PubMed Europe PubMed DOI I
Choudhary,S., Sreenivasulu,K., Mitra,P., Misra,S. and Sharma,P.
Role of Genetic Variants and Gene Expression in the Susceptibility and Severity of COVID-19
Ann Lab Med41, 129-138. PubMed Europe PubMed DOI
Francis,P. and Chakraborty,K.
Clathriketal, a new tricyclic spiroketal compound from marine sponge Clathria prolifera attenuates serine exopeptidase dipeptidyl peptidase-IV
Nat Prod Res1-9. PubMed Europe PubMed DOI I
Herz,C.T., Brix,J.M., Ludvik,B., Schernthaner,G. and Schernthaner,G.H.
Decrease of dipeptidyl peptidase 4 activity is associated with weight loss after bariatric surgery
Obes Surg PubMed Europe PubMed DOI
Hu,X., Chen,S., Xie,C., Li,Z., Wu,Z. and You,Z.
DPP4 gene silencing inhibits proliferation and epithelial-mesenchymal transition of papillary thyroid carcinoma cells through suppression of the MAPK pathway
J Endocrinol Invest PubMed Europe PubMed DOI K
Iwanaga,T. and Nio-Kobayashi,J.
Cellular expression of CD26/dipeptidyl peptidase IV
Biomed Res42, 229-237. PubMed Europe PubMed DOI V
Lau,S.K.P., Fan,R.Y.Y., Zhu,L., Li,K.S.M., Wong,A.C.P., Luk,H.K.H., Wong,E.Y.M., Lam,C.S.F., Lo,G.C.S., Fung,J., He,Z., Fok,F.C.H., Au-Yeung,R.K.H., Zhang,L., Kok,K.H., Yuen,K.Y. and Woo,P.C.Y.
Isolation of MERS-related coronavirus from lesser bamboo bats that uses DPP4 and infects human-DPP4-transgenic mice
Nat Commun12, 216-216. PubMed Europe PubMed DOI
Li,T.T., Peng,C., Wang,J.Q., Xu,Z.J., Su,M.B., Li,J., Zhu,W.L. and Li,J.Y.
Distal mutation V486M disrupts the catalytic activity of DPP4 by affecting the flap of the propeller domain
Acta Pharmacol Sin PubMed Europe PubMed DOI
Love,K.M. and Liu,Z.
DPP4 Activity, Hyperinsulinemia and Atherosclerosis
J Clin Endocrinol Metab PubMed Europe PubMed DOI V
Lugowska,A., Baydakova,G., Ilyushkina,A., Zakharova,E., Mierzewska,H., Szymanska,K., Wierzba,J., Kubalska,J., Graban,A., Kmiec,T., Perkowska-Sumila,B., Tylki-Szymanska,A. and Bednarska-Makaruk,M.
Elevated Dipeptidyl Peptidase IV (DPP-IV) Activity in Plasma from Patients with Various Lysosomal Diseases
Diagnostics (Basel)11, PubMed Europe PubMed DOI
Ngetich,E., Lapolla,P., Chandrashekar,A., Handa,A. and Lee,R.
The role of dipeptidyl peptidase-IV in abdominal aortic aneurysm pathogenesis: A systematic review
Vasc Med1358863X211034574-1358863X21358863X. PubMed Europe PubMed DOI
Pan,K., Ohnuma,K., Morimoto,C. and Dang,N.H.
CD26/Dipeptidyl Peptidase IV and Its Multiple Biological Functions
Cureus13, e13495-e13495. PubMed Europe PubMed DOI V
Scheen,A.J.
DPP-4 inhibition and COVID-19: From initial concerns to recent expectations
Diabetes Metab47, 101213-101213. PubMed Europe PubMed DOI
Schmiedl,A., Wagener,I., Jungen,M., von Horsten,S. and Stephan,M.
Lung development and immune status under chronic LPS exposure in rat pups with and without CD26/DPP4 deficiency
Cell Tissue Res PubMed Europe PubMed DOI
Singh,A.K., Yadav,D., Sharma,N. and Jin,J.O.
Dipeptidyl Peptidase (DPP)-IV Inhibitors with Antioxidant Potential Isolated from Natural Sources: A Novel Approach for the Management of Diabetes
Pharmaceuticals (Basel)14, PubMed Europe PubMed DOI V
Tomovic,K., Ilic,B.S. and Smelcerovic,A.
Structure-Activity Relationship Analysis of Cocrystallized Gliptin-like Pyrrolidine, Trifluorophenyl, and Pyrimidine-2,4-Dione Dipeptidyl Peptidase-4 Inhibitors
J Med Chem64, 9639-9648. PubMed Europe PubMed DOI
Torrecillas-Baena,B., Galvez-Moreno,M.A., Quesada-Gomez,J.M., Dorado,G. and Casado-Diaz,A.
Influence of Dipeptidyl Peptidase-4 (DPP4) on Mesenchymal Stem-Cell (MSC) Biology: Implications for Regenerative Medicine - Review
Stem Cell Rev Rep PubMed Europe PubMed DOI V
Vorstandlechner,V., Laggner,M., Copic,D., Klas,K., Direder,M., Chen,Y., Golabi,B., Haslik,W., Radtke,C., Tschachler,E., Hotzenecker,K., Ankersmit,H.J. and Mildner,M.
The serine proteases dipeptidyl-peptidase 4 and urokinase are key molecules in human and mouse scar formation
Nat Commun12, 6242-6242. PubMed Europe PubMed DOI
Wang,J., Zhang,L., Qu,Y., Yang,Y., Cao,T., Cao,Y., Iqbal,A., Qin,W. and Liu,Y.
Long-Wavelength Ratiometric Fluorescent Probe for the Early Diagnosis of Diabetes
Anal Chem93, 11461-11469. PubMed Europe PubMed DOI
Yang,X., Zhu,Y., Shi,Q., Zhao,X., Huang,Y., Yao,F., Zhang,Y. and Wang,Z.
Dipeptidyl peptidase IV is required for endometrial carcinoma cell proliferation and tumorigenesis via the IL-6/STAT3 pathway
J Obstet Gynaecol Res47, 2449-2459. PubMed Europe PubMed DOI
Yazbeck,R., Jaenisch,S.E. and Abbott,C.A.
Dipeptidyl peptidase 4 inhibitors: Applications in innate immunity?
Biochem Pharmacol188, 114517-114517. PubMed Europe PubMed DOI V
Yeh,K.C., Yeh,T.K., Huang,C.Y., Hu,C.B., Wang,M.H., Huang,Y.W., Chou,L.H., Ho,H.H., Song,J.S., Hsu,T., Jiaang,W.T., Chao,Y.S. and Chen,C.T.
DBPR108, a novel dipeptidyl peptidase-4 inhibitor with antihyperglycemic activity
Life Sci278, 119574-119574. PubMed Europe PubMed DOI I
Yoshihara,M., Mizutani,S., Kato,Y., Matsumoto,K., Mizutani,E., Mizutani,H., Fujimoto,H., Osuka,S. and Kajiyama,H.
Recent Insights into Human Endometrial Peptidases in Blastocyst Implantation via Shedding of Microvesicles
Int J Mol Sci22, PubMed Europe PubMed DOI
Zhang,T., Tong,X., Zhang,S., Wang,D., Wang,L., Wang,Q. and Fan,H.
The Roles of Dipeptidyl Peptidase 4 (DPP4) and DPP4 Inhibitors in Different Lung Diseases: New Evidence
Front Pharmacol12, 731453-731453. PubMed Europe PubMed DOI V

2020

Abdel Motaal,A., Salem,H.H., Almaghaslah,D., Alsayari,A., Bin Muhsinah,A., Alfaifi,M.Y., Elbehairi,S.E.I., Shati,A.A. and El-Askary,H.
Flavonol Glycosides: In Vitro Inhibition of DPPIV, Aldose Reductase and Combating Oxidative Stress are Potential Mechanisms for Mediating the Antidiabetic Activity of Cleome droserifolia
Molecules25, PubMed Europe PubMed DOI I
Ahmad,I., Arifianti,A.E., Sakti,A.S., Saputri,F.C. and Mun'im,A.
Simultaneous Natural Deep Eutectic Solvent-Based Ultrasonic-Assisted Extraction of Bioactive Compounds of Cinnamon Bark and Sappan Wood as a Dipeptidyl Peptidase IV Inhibitor
Molecules25, PubMed Europe PubMed DOI I
Alsamghan,A.S., Alwabli,A.S., Abadi,M., Alsaleem,S.A., Anbari,D.M., Alomari,A.S., Alzahrani,O., Alam,Q. and Tarique,M.
From sequence analysis of DPP-4 to molecular docking based searching of its inhibitors
Bioinformation16, 444-451. PubMed Europe PubMed DOI
Araki,M., Kanegawa,N., Iwata,H., Sagae,Y., Ito,K., Masuda,K. and Okuno,Y.
Hydrophobic interactions at subsite S1' of human dipeptidyl peptidase IV contribute significantly to the inhibitory effect of tripeptides
Heliyon6, e04227-e04227. PubMed Europe PubMed DOI
Asiabi,P., Dolmans,M.M., Ambroise,J., Camboni,A. and Amorim,C.A.
In vitro differentiation of theca cells from ovarian cells isolated from postmenopausal women
Hum Reprod35, 2793-2807. PubMed Europe PubMed DOI
Baggio,L.L., Varin,E.M., Koehler,J.A., Cao,X., Lokhnygina,Y., Stevens,S.R., Holman,R.R. and Drucker,D.J.
Plasma levels of DPP4 activity and sDPP4 are dissociated from inflammation in mice and humans
Nat Commun11, 3766-3766. PubMed Europe PubMed DOI I
Balazki,P., Schaller,S., Eissing,T. and Lehr,T.
A Physiologically-Based Quantitative Systems Pharmacology Model of the Incretin Hormones GLP-1 and GIP and the DPP4 Inhibitor Sitagliptin
CPT Pharmacometrics Syst Pharmacol9, 353-362. PubMed Europe PubMed DOI I
Barchetta,I., Ceccarelli,V., Cimini,F.A., Barone,E., Sentinelli,F., Coluzzi,M., Chiappetta,C., Bertoccini,L., Tramutola,A., Labbadia,G., Di Cristofano,C., Silecchia,G., Leonetti,F. and Cavallo,M.G.
Circulating dipeptidyl peptidase-4 is independently associated with the presence and severity of NAFLD/NASH in individuals with and without obesity and metabolic disease
J Endocrinol Invest PubMed Europe PubMed DOI
Bindu,B., Vijayalakshmi,S. and Manikandan,A.
Synthesis and discovery of triazolo-pyridazine-6-yl-substituted piperazines as effective anti-diabetic drugs; evaluated over dipeptidyl peptidase-4 inhibition mechanism and insulinotropic activities
Eur J Med Chem187, 111912-111912. PubMed Europe PubMed DOI I
Carr,R.D. and Solomon,A.
Inhibitors of dipeptidyl peptidase-4 as therapeutic agents for individuals with type 2 diabetes: a 25-year journey
Diabet Med PubMed Europe PubMed DOI I
Charoenkwan,P., Kanthawong,S., Nantasenamat,C., Hasan,M.M. and Shoombuatong,W.
iDPPIV-SCM: A Sequence-Based Predictor for Identifying and Analyzing Dipeptidyl Peptidase IV (DPP-IV) Inhibitory Peptides Using a Scoring Card Method
J Proteome Res19, 4125-4136. PubMed Europe PubMed DOI
Chen,L., Zhang,X., Zhang,L. and Zheng,D.
Effect of Saxagliptin, a Dipeptidyl Peptidase 4 Inhibitor, on Non-Alcoholic Fatty Liver Disease
Diabetes Metab Syndr Obes13, 3507-3518. PubMed Europe PubMed DOI I
Deacon,C.F.
Dipeptidyl peptidase 4 inhibitors in the treatment of type 2 diabetes mellitus
Nat Rev Endocrinol16, 642-653. PubMed Europe PubMed DOI V
Devarakonda,C.K.V., Meredith,E., Ghosh,M. and Shapiro,L.H.
Coronavirus Receptors as Immune Modulators
J Immunol PubMed Europe PubMed DOI V
Du,H., Wang,D.W. and Chen,C.
The potential effects of DPP-4 inhibitors on cardiovascular system in COVID-19 patients
J Cell Mol Med PubMed Europe PubMed DOI
Du,J., Fu,L., Ji,F., Wang,C., Liu,S. and Qiu,X.
FosB recruits KAT5 to potentiate the growth and metastasis of papillary thyroid cancer in a DPP4-dependent manner
Life Sci259, 118374-118374. PubMed Europe PubMed DOI K
Dunaevsky,Y.E., Tereshchenkova,V.F., Oppert,B., Belozersky,M.A., Filippova,I.Y. and Elpidina,E.N.
Human proline specific peptidases: a comprehensive analysis
Biochim Biophys Acta Gen Subj1864, 129636-129636. PubMed Europe PubMed DOI V
Franco,R., Lillo,A., Rivas-Santisteban,R., Rodriguez-Perez,A.I., Reyes-Resina,I., Labandeira-Garcia,J.L. and Navarro,G.
Functional Complexes of Angiotensin-Converting Enzyme 2 and Renin-Angiotensin System Receptors: Expression in Adult but Not Fetal Lung Tissue
Int J Mol Sci21, PubMed Europe PubMed DOI
Gomaa,S.H., Abaza,M.M., Elattar,H.A., Amin,G.A. and Elshahawy,D.M.
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Guan,G.Y., Wei,N., Song,T., Zhao,C., Sun,Y., Pan,R.X., Zhang,L.L., Xu,Y.Y., Dai,Y.M. and Han,H.
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Maremanda,K.P., Sundar,I.K., Li,D. and Rahman,I.
Age-dependent assessment of genes involved in cellular senescence, telomere and mitochondrial pathways in human lung tissue of smokers, COPD and IPF: Associations with SARS-CoV-2 COVID-19 ACE2-TMPRSS2-Furin-DPP4 axis
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Melo,F.J., Pinto-Lopes,P., Estevinho,M.M. and Magro,F.
The Role of Dipeptidyl Peptidase 4 as a Therapeutic Target and Serum Biomarker in Inflammatory Bowel Disease: A Systematic Review
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Mendez,L.R., Arrebola,Y., Valdes-Tresanco,M.E., Diaz-Guevara,L., Bergado,G., Sanchez,B., Charli,J.L. and Alonso,I.P.
Bestatin and bacitracin inhibit porcine kidney cortex dipeptidyl peptidase IV activity and reduce human melanoma MeWo cell viability
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Moffitt,L.R., Bilandzic,M., Wilson,A.L., Chen,Y., Gorrell,M.D., Oehler,M.K., Plebanski,M. and Stephens,A.N.
Hypoxia Regulates DPP4 Expression, Proteolytic Inactivation, and Shedding from Ovarian Cancer Cells
Int J Mol Sci21, PubMed Europe PubMed DOI
Mozafari,N., Azadi,S., Mehdi-Alamdarlou,S., Ashrafi,H. and Azadi,A.
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Nicotera,R., Casarella,A., Longhitano,E., Bolignano,D., Andreucci,M., De Sarro,G., Cernaro,V., Russo,E. and Coppolino,G.
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Pantaleao,S.Q., Philot,E.A., de Oliveira Almeida,M., Lima,A.N., de Sairre,M.I., Scott,A.L. and Honorio,K.M.
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Patel,P.M., Jones,V.A., Kridin,K. and Amber,K.T.
The role of Dipeptidyl Peptidase-4 in cutaneous disease
Exp Dermatol PubMed Europe PubMed DOI V
Raha,A.A., Chakraborty,S., Henderson,J., Mukaetova-Ladinska,E., Zaman,S., Trowsdale,J. and Raha-Chowdhury,R.
Investigation of CD26, a potential SARS-CoV-2 receptor, as a biomarker of age and pathology
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Sun,Z.G., Li,Z.N. and Zhu,H.L.
The Research Progress of DPP-4 Inhibitors
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Tomovic,K., Ilic,B.S., Smelcerovic,Z., Miljkovic,M., Yancheva,D., Kojic,M., Mavrova,A.T., Kocic,G. and Smelcerovic,A.
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Valencia,I., Peiro,C., Lorenzo,O., Sanchez-Ferrer,C.F., Eckel,J. and Romacho,T.
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Wicik,Z., Eyileten,C., Jakubik,D., Simoes,S.N., Martins,D.C., Jr., Pavao,R., Siller-Matula,J.M. and Postula,M.
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Wong,C.K.H., Man,K.K.C., Chan,E.W.Y., Wu,T., Tse,E.T.Y., Wong,I.C.K. and Lam,C.L.K.
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Xi,C.R., Di Fazio,A., Nadvi,N.A., Patel,K., Xiang,M.S.W., Zhang,H.E., Deshpande,C., Low,J.K.K., Wang,X.T., Chen,Y., McMillan,C.L.D., Isaacs,A., Osborne,B., Vieira de Ribeiro,A.J., McCaughan,G.W., Mackay,J.P., Church,W.B. and Gorrell,M.D.
A Novel Purification Procedure for Active Recombinant Human DPP4 and the Inability of DPP4 to Bind SARS-CoV-2
Molecules25, PubMed Europe PubMed DOI
Yamamoto,K., Ohnishi,S., Mizushima,T., Kodaira,J., Ono,M., Hatanaka,Y., Hatanaka,K.C., Kuriki,Y., Kamiya,M., Ehira,N., Shinada,K., Takahashi,H., Shimizu,Y., Urano,Y. and Sakamoto,N.
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Yip,H.K., Lee,M.S., Li,Y.C., Shao,P.L., Chiang,J.Y., Sung,P.H., Yang,C.H. and Chen,K.H.
Dipeptidyl Peptidase-4 deficiency effectively protects the brain and neurological function in rodent after acute Hemorrhagic Stroke
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Yoon,H., Cho,S.H., Seo,Y.R., Yu,K.S., Park,S.S. and Song,M.J.
Optimization and validation of a fluorogenic dipeptidyl peptidase 4 enzymatic assay in human plasma
Anal Biochem612, 113952-113952. PubMed Europe PubMed DOI I
Zeng,S., Dou,W., Li,M., Zhou,Y., Guo,J., Zhao,N., Huang,H., Zhou,Q., Hu,W., Ma,Y., Zhao,X. and Xie,H.
Discovery of an Orally Active and Long-Acting DPP-IV Inhibitor through Property-Based Optimization with an in Silico Biotransformation Prediction Tool
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Zhao,Y., Zou,J., Song,Y., Peng,J., Wang,Y. and Bi,Y.
A novel label-free fluorescence assay for dipeptidyl peptidase 4 activity detection based on supramolecular self-assembly
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2019

Ahren,B.
DPP-4 Inhibition and the path to clinical proof
Front Endocrinol (Lausanne)10, 376-376. PubMed Europe PubMed DOI I
De,S., Banerjee,S., Kumar,S.K.A. and Paira,P.
Critical role of dipeptidyl peptidase IV: a therapeutic target for diabetes and cancer
Mini Rev Med Chem19, 88-97. PubMed Europe PubMed DOI I
Deng,X., Wang,N., Meng,L., Zhou,S., Huang,J., Xing,J., He,L., Jiang,W. and Li,Q.
Optimization of the benzamide fragment targeting the S2' site leads to potent dipeptidyl peptidase-IV inhibitors
Bioorg Chem103366-103366. PubMed Europe PubMed DOI I
Divya,K., Vivek,H.K., Priya,B.S. and Nanjunda Swamy,S.
Rapid detection of DPP-IV activity in porcine serum: a fluorospectrometric assay
Anal Biochem113557-113557. PubMed Europe PubMed DOI A
Elmansi,A.M., Awad,M.E., Eisa,N.H., Kondrikov,D., Hussein,K.A., Aguilar-Perez,A., Herberg,S., Periyasamy-Thandavan,S., Fulzele,S., Hamrick,M.W., McGee-Lawrence,M.E., Isales,C.M., Volkman,B.F. and Hill,W.D.
What doesn't kill you makes you stranger: dipeptidyl peptidase-4 (CD26) proteolysis differentially modulates the activity of many peptide hormones and cytokines generating novel cryptic bioactive ligands
Pharmacol Ther198, 90-108. PubMed Europe PubMed DOI V
Gou,Z.P., Wang,Z.L., Liang,X.F., Zheng,L., Wang,Y. and Feng,P.
Single-dose escalation study of yogliptin in healthy Chinese volunteers
Eur J Pharm Sci136, 104950-104950. PubMed Europe PubMed DOI I
Gupta,S. and Sen,U.
More than just an enzyme: dipeptidyl peptidase-4 (DPP-4) and its association with diabetic kidney remodelling
Pharmacol Res147, 104391-104391. PubMed Europe PubMed DOI
Hollande,C., Boussier,J., Ziai,J., Nozawa,T., Bondet,V., Phung,W., Lu,B., Duffy,D., Paradis,V., Mallet,V., Eberl,G., Sandoval,W., Schartner,J.M., Pol,S., Barreira da Silva,R. and Albert,M.L.
Inhibition of the dipeptidyl peptidase DPP4 (CD26) reveals IL-33-dependent eosinophil-mediated control of tumor growth
Nat Immunol20, 257-264. PubMed Europe PubMed DOI I
Huang,F., Ning,M., Wang,K., Liu,J., Guan,W., Leng,Y. and Shen,J.
Discovery of highly polar beta-homophenylalanine derivatives as nonsystemic intestine-targeted dipeptidyl peptidase IV inhibitors
J Med Chem62, 10919-10925. PubMed Europe PubMed DOI I
Kong,F., Pang,X., Zhao,J., Deng,P., Zheng,M., Zhong,D. and Chen,X.
Hydrolytic metabolism of cyanopyrrolidine DPP-4 inhibitors mediated by dipeptidyl peptidases
Drug Metab Dispos47, 238-248. PubMed Europe PubMed DOI I
Lu,Y., Lu,P., Wang,Y., Fang,X., Wu,J. and Wang,X.
A novel dipeptidyl peptidase IV inhibitory tea peptide improves pancreatic beta-cell function and reduces alpha-cell proliferation in streptozotocin-induced diabetic mice
Int J Mol Sci20, PubMed Europe PubMed DOI I
Mishra,A., Cross,M., Hofmann,A., Coster,M.J., Karim,A. and Sattar,A.
Identification of a novel scaffold for inhibition of dipeptidyl peptidase-4
J Comput Biol26, 1470-1486. PubMed Europe PubMed DOI I
Mohanty,I.R., Borde,M., Kumar C,S. and Maheshwari,U.
Dipeptidyl peptidase IV inhibitory activity of Terminalia arjuna attributes to its cardioprotective effects in experimental diabetes: in silico, in vitro and in vivo analyses
Phytomedicine57, 158-165. PubMed Europe PubMed DOI I
Nieto-Fontarigo,J.J., Gonzalez-Barcala,F.J., San Jose,E., Arias,P., Nogueira,M. and Salgado,F.J.
CD26 and asthma: a comprehensive review
Clin Rev Allergy Immunol56, 139-160. PubMed Europe PubMed DOI
Ogasawara,A., Kamiya,M., Sakamoto,K., Kuriki,Y., Fujita,K., Komatsu,T., Ueno,T., Hanaoka,K., Onoyama,H., Abe,H., Tsuji,Y., Fujishiro,M., Koike,K., Fukayama,M., Seto,Y. and Urano,Y.
Red fluorescence probe targeted to dipeptidylpeptidase-IV for highly sensitive detection of esophageal cancer
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Sesti,G., Avogaro,A., Belcastro,S., Bonora,B.M., Croci,M., Daniele,G., Dauriz,M., Dotta,F., Formichi,C., Frontoni,S., Invitti,C., Orsi,E., Picconi,F., Resi,V., Bonora,E. and Purrello,F.
Ten years of experience with DPP-4 inhibitors for the treatment of type 2 diabetes mellitus
Acta Diabetol56, 605-617. PubMed Europe PubMed DOI I
Sharma,S., Srivastava,S., Shrivastava,A., Malik,R., Almalki,F., Saifullah,K., Alam,M.M., Shaqiquzzaman,M., Ali,S. and Akhter,M.
Mining of potential dipeptidyl peptidase-IV inhibitors as anti-diabetic agents using integrated in silico approaches
J Biomol Struct Dyn1-13. PubMed Europe PubMed DOI I
Syam,Y.M., El-Karim,S.S.A., Nasr,T., Elseginy,S.A., Anwar,M.M., Kamel,M.M. and Ali,H.F.
Design, synthesis and biological evaluation of spiro cyclohexane-1,2-quinazoline derivatives as potent dipeptidyl peptidase IV inhibitors
Mini Rev Med Chem19, 250-269. PubMed Europe PubMed DOI I
Tomovic,K., Ilic,B.S., Miljkovic,M., Dimov,S., Yancheva,D., Kojic,M., Mavrova,A.T., Kocic,G. and Smelcerovic,A.
Benzo[4,5]thieno[2,3-d]pyrimidine phthalimide derivative, one of the rare noncompetitive inhibitors of dipeptidyl peptidase-4
Arch Pharm (Weinheim)e1900238-e1900238. PubMed Europe PubMed DOI I
Varin,E.M., Mulvihill,E.E., Beaudry,J.L., Pujadas,G., Fuchs,S., Tanti,J.F., Fazio,S., Kaur,K., Cao,X., Baggio,L.L., Matthews,D., Campbell,J.E. and Drucker,D.J.
Circulating levels of soluble dipeptidyl peptidase-4 are dissociated from inflammation and induced by enzymatic DPP4 inhibition
Cell Metab29, 320-334. PubMed Europe PubMed DOI
Yang,F., Takagaki,Y., Yoshitomi,Y., Ikeda,T., Li,J., Kitada,M., Kumagai,A., Kawakita,E., Shi,S., Kanasaki,K. and Koya,D.
Inhibition of dipeptidyl peptidase-4 accelerates epithelial-mesenchymal transition and breast cancer metastasis via the CXCL12/CXCR4/mTOR axis
Cancer Res79, 735-746. PubMed Europe PubMed DOI I
Yazbeck,R., Jaenisch,S., Squire,M., Abbott,C.A., Parkinson-Lawrence,E., Brooks,D.A. and Butler,R.N.
Development of a (13)C stable isotope assay for dipeptidyl peptidase-4 enzyme activity a new breath test for dipeptidyl peptidase activity
Sci Rep9, 4906-4906. PubMed Europe PubMed DOI A
Zhao,X., Zhang,K., Daniel,P., Wisbrun,N., Fuchs,H. and Fan,H.
Delayed allogeneic skin graft rejection in CD26-deficient mice
Cell Mol Immunol16, 557-567. PubMed Europe PubMed DOI K

2018

Abd El-Karim,S.S., Anwar,M.M., Syam,Y.M., Nael,M.A., Ali,H.F. and Motaleb,M.A.
Rational design and synthesis of new tetralin-sulfonamide derivatives as potent anti-diabetics and DPP-4 inhibitors: 2D & 3D QSAR, in vivo radiolabeling and bio distribution studies
Bioorg Chem81, 481-493. PubMed Europe PubMed DOI I
Casrouge,A., Sauer,A.V., Barreira da Silva,R., Tejera-Alhambra,M., Sanchez-Ramon,S., ICAReB, Cancrini,C., Ingersoll,M.A., Aiuti,A. and Albert,M.L.
Lymphocytes are a major source of circulating soluble dipeptidyl peptidase 4
Clin Exp Immunol194, 166-179. PubMed Europe PubMed DOI
Cheng,A.C., Doherty,E.M., Johnstone,S., DiMauro,E.F., Dao,J., Luthra,A., Ye,J., Tang,J., Nixey,T., Min,X., Tagari,P., Miranda,L.P. and Wang,Z.
Structure-guided discovery of dual-recognition chemibodies
Sci Rep8, 7570-7570. PubMed Europe PubMed DOI
Deacon,C.F.
Peptide degradation and the role of DPP-4 inhibitors in the treatment of type 2 diabetes
Peptides100, 150-157. PubMed Europe PubMed DOI I
Deacon,C.F.
A review of dipeptidyl peptidase-4 inhibitors. Hot topics from randomized controlled trials
Diabetes Obes Metab20 Suppl 1, 34-46. PubMed Europe PubMed DOI I
Fan,C., Wu,X., Liu,Q., Li,Q., Liu,S., Lu,J., Yang,Y., Cao,Y., Huang,W., Liang,C., Ying,T., Jiang,S. and Wang,Y.
A human DPP4-knockin mouse's susceptibility to infection by authentic and pseudotyped MERS-CoV
Viruses10, PubMed Europe PubMed DOI
Gupta,A., Jacobson,G.A., Burgess,J.R., Jelinek,H.F., Nichols,D.S., Narkowicz,C.K. and Al-Aubaidy,H.A.
Citrus bioflavonoids dipeptidyl peptidase-4 inhibition compared with gliptin antidiabetic medications
Biochem Biophys Res Commun503, 21-25. PubMed Europe PubMed DOI I
Kalhotra,P., Chittepu,V.C.S.R., Osorio-Revilla,G. and Gallardo-Velazquez,T.
Structure(-)activity relationship and molecular docking of natural product library reveal chrysin as a novel dipeptidyl peptidase-4 (DPP-4) inhibitor: an integrated in silico and in vitro study
Molecules23, PubMed Europe PubMed DOI I
Kato,E., Kawakami,K. and Kawabata,J.
Macrocarpal C isolated from Eucalyptus globulus inhibits dipeptidyl peptidase 4 in an aggregated form
J Enzyme Inhib Med Chem33, 106-109. PubMed Europe PubMed DOI I
Khalaf,R.A., Sabbah,D., Al-Shalabi,E., Al-Sheikh,I., Albadawi,G. and Abu Sheikha,G.
Synthesis, structural characterization and docking studies of sulfamoyl-phenyl acid esters as dipeptidyl peptidase-IV inhibitors
Curr Comput Aided Drug Des14, 142-151. PubMed Europe PubMed DOI I
Kuranov,S.O., Tsypysheva,I.P., Khvostov,M.V., Zainullina,L.F., Borisevich,S.S., Vakhitova,Y.V., Luzina,O.A. and Salakhutdinov,N.F.
Synthesis and evaluation of camphor and cytisine-based cyanopyrrolidines as DPP-IV inhibitors for the treatment of type 2 diabetes mellitus
Bioorg Med Chem26, 4402-4409. PubMed Europe PubMed DOI I
Li,N., Wang,L.J., Jiang,B., Li,X.Q., Guo,C.L., Guo,S.J. and Shi,D.Y.
Recent progress of the development of dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes mellitus
Eur J Med Chem151, 145-157. PubMed Europe PubMed DOI I
Li,N., Wang,L.J., Jiang,B., Guo,S.J., Li,X.Q., Chen,X.C., Luo,J., Li,C., Wang,Y. and Shi,D.Y.
Design, synthesis and biological evaluation of novel pyrimidinedione derivatives as DPP-4 inhibitors
Bioorg Med Chem Lett28, 2131-2135. PubMed Europe PubMed DOI I
Liu,T., Ning,J., Wang,B., Dong,B., Li,S., Tian,X., Yu,Z., Peng,Y., Wang,C., Zhao,X., Huo,X., Sun,C., Cui,J., Feng,L. and Ma,X.
Activatable near-infrared fluorescent probe for dipeptidyl peptidase IV and its bioimaging applications in living cells and animals
Anal Chem90, 3965-3973. PubMed Europe PubMed DOI L
Luippold,G., Mark,M., Klein,T., Amann,K. and Daniel,C.
Differences in kidney-specific DPP-4 inhibition by linagliptin and sitagliptin
Diabetes Res Clin Pract143, 199-203. PubMed Europe PubMed DOI I
Ohnuma,K., Hatano,R., Komiya,E., Otsuka,H., Itoh,T., Iwao,N., Kaneko,Y., Yamada,T., Dang,N.H. and Morimoto,C.
A novel role for CD26/dipeptidyl peptidase IV as a therapeutic target
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Ojeda-Montes,M.J., Gimeno,A., Tomas-Hernandez,S., Cereto-Massague,A., Beltran-Debon,R., Valls,C., Mulero,M., Pujadas,G. and Garcia-Vallve,S.
Activity and selectivity cliffs for DPP-IV inhibitors: lessons we can learn from SAR studies and their application to virtual screening
Med Res Rev38, 1874-1915. PubMed Europe PubMed DOI S I
Olivares,M., Schuppel,V., Hassan,A.M., Beaumont,M., Neyrinck,A.M., Bindels,L.B., Benitez-Paez,A., Sanz,Y., Haller,D., Holzer,P. and Delzenne,N.M.
The potential role of the dipeptidyl peptidase-4-like activity from the gut microbiota on the host health
Front Microbiol9, 1900-1900. PubMed Europe PubMed DOI
Pantaleao,S.Q., Philot,E.A., de Resende-Lara,P.T., Lima,A.N., Perahia,D., Miteva,M.A., Scott,A.L. and Honorio,K.M.
Structural dynamics of DPP-4 and its influence on the projection of bioactive ligands
Molecules23, PubMed Europe PubMed DOI
Park,D.S., Kim,K., Jang,M. and Choi,S.C.
Role of dipeptidyl peptidase-4 as a potentiator of activin/nodal signaling pathway
BMB Rep51, 636-641. PubMed Europe PubMed
Patil,R.B., Barbosa,E.G., Sangshetti,J.N., Zambre,V.P. and Sawant,S.D.
Structural insights of dipeptidyl peptidase-IV inhibitors through molecular dynamics-guided receptor-dependent 4D-QSAR studies
Mol Divers22, 575-583. PubMed Europe PubMed DOI I
Rohilla,A., Gupta,T., Pathak,A., Akhtar,M.J., Haider,M.R., Haider,K. and Shahar Yar,M.
Emergence of promising novel DPP-4 inhibitory heterocycles as anti-diabetic agents: a review
Arch Pharm (Weinheim)e1800127-e1800127. PubMed Europe PubMed DOI I
Salaga,M., Binienda,A., Draczkowski,P., Kosson,P., Kordek,R., Jozwiak,K. and Fichna,J.
Novel peptide inhibitor of dipeptidyl peptidase IV (Tyr-Pro-D-Ala-NH2) with anti-inflammatory activity in the mouse models of colitis
Peptides108, 34-45. PubMed Europe PubMed DOI I
Svarcbahs,R., Julku,U.H., Norrbacka,S. and Myohanen,T.T.
Removal of prolyl oligopeptidase reduces alpha-synuclein toxicity in cells and in vivo
Sci Rep8, 1552-1552. PubMed Europe PubMed DOI K
Turdu,G., Gao,H., Jiang,Y. and Kabas,M.
Plant dipeptidyl peptidase-IV inhibitors as antidiabetic agents: a brief review
Future Med Chem10, 1229-1239. PubMed Europe PubMed DOI I
Wang,X., Zheng,P., Huang,G., Yang,L. and Zhou,Z.
Dipeptidyl peptidase-4(DPP-4) inhibitors: promising new agents for autoimmune diabetes
Clin Exp Med18, 473-480. PubMed Europe PubMed DOI I
Xing,J., Gong,Q., Zhang,R., Sun,S., Zou,R. and Wu,A.
A novel non-enzymatic hydrolytic probe for dipeptidyl peptidase IV specific recognition and imaging
Chem Commun (Camb)54, 8773-8776. PubMed Europe PubMed DOI A
Yang,L., Han,W., Luo,Y., Hu,X., Xu,Y., Li,H., Hu,C., Huang,D., Ma,J., Yang,Y., Chen,Q., Li,Y., Zhang,J., Xia,H., Chen,Z., Wang,H., Ran,D. and Yang,J.
Adapentpronitrile, a new dipeptidyl peptidase-IV inhibitor, ameliorates diabetic neuronal injury through inhibiting mitochondria-related oxidative stress and apoptosis
Front Cell Neurosci12, 214-214. PubMed Europe PubMed DOI I

2017

Akoumianakis,I. and Antoniades,C.
Dipeptidyl peptidase IV inhibitors as novel regulators of vascular disease
Vascul Pharmacol96-98, 1-4. PubMed Europe PubMed DOI T
Aldewachi,H.S., Woodroofe,N., Turega,S. and Gardiner,P.H.E.
Optimization of gold nanoparticle-based real-time colorimetric assay of dipeptidyl peptidase IV activity
Talanta169, 13-19. PubMed Europe PubMed DOI A
Ali,Z., Akhtar,M.J., Haider,M.R., Khan,A.A., Siddiqui,A.A. and Yar,M.S.
Design and synthesis of quinazoline-3,4-(4H)-diamine endowed with thiazoline moiety as new class for DPP-4 and DPPH inhibitor
Bioorg Chem71, 181-191. PubMed Europe PubMed DOI I
Angevin,E., Isambert,N., Trillet-Lenoir,V., You,B., Alexandre,J., Zalcman,G., Vielh,P., Farace,F., Valleix,F., Podoll,T., Kuramochi,Y., Miyashita,I., Hosono,O., Dang,N.H., Ohnuma,K., Yamada,T., Kaneko,Y. and Morimoto,C.
First-in-human phase 1 of YS110, a monoclonal antibody directed against CD26 in advanced CD26-expressing cancers
Br J Cancer116, 1126-1134. PubMed Europe PubMed DOI
Antonyan,A., Schlenzig,D., Schilling,S., Naumann,M., Sharoyan,S., Mardanyan,S. and Demuth,H.U.
Concerted action of dipeptidyl peptidase IV and glutaminyl cyclase results in formation of pyroglutamate-modified amyloid peptides in vitro
Neurochem Int113, 112-119. PubMed Europe PubMed DOI
Bohm,A., Wagner,R., Machicao,F., Holst,J.J., Gallwitz,B., Stefan,N., Fritsche,A., Haring,H.U. and Staiger,H.
DPP4 gene variation affects GLP-1 secretion, insulin secretion, and glucose tolerance in humans with high body adiposity
PLoS ONE12, e0181880-e0181880. PubMed Europe PubMed DOI M
Chandra,S., Pandey,J., Tamrakar,A.K. and Siddiqi,M.I.
SVMDLF: a novel R-based web application for prediction of dipeptidyl peptidase 4 inhibitors
Chem Biol Drug Des90, 1173-1183. PubMed Europe PubMed DOI I
Deng,X., Han,L., Zhou,J., Zhang,H. and Li,Q.
Discovery of triazole-based uracil derivatives bearing amide moieties as novel dipeptidyl peptidase-IV inhibitors
Bioorg Chem75, 357-367. PubMed Europe PubMed DOI I
Herlihy,S.E., Tang,Y., Phillips,J.E. and Gomer,R.H.
Functional similarities between the Dictyostelium protein AprA and the human protein dipeptidyl-peptidase IV
Protein Sci26, 578-585. PubMed Europe PubMed DOI
Huan,Y., Jiang,Q., Li,G., Bai,G., Zhou,T., Liu,S., Li,C., Liu,Q., Sun,S., Yang,M., Guo,N., Wang,X., Wang,S., Liu,Y., Wang,G., Huang,H. and Shen,Z.
The dual DPP4 inhibitor and GPR119 agonist HBK001 regulates glycemic control and beta cell function ex and in vivo
Sci Rep7, 4351-4351. PubMed Europe PubMed DOI I
Jackson,E.K.
Context-dependent effects of dipeptidyl peptidase 4 inhibitors
Curr Opin Nephrol Hypertens26, 83-90. PubMed Europe PubMed DOI I
Jain,M.R., Joharapurkar,A.A., Kshirsagar,S.G., Patel,V.J., Bahekar,R.H., Patel,H.V., Jadav,P.A., Patel,P.R. and Desai,R.C.
ZY15557 a novel long acting inhibitor of dipeptidyl peptidase-4 for the treatment of Type 2 diabetes mellitus
Br J Pharmacol174, 2346-2357. PubMed Europe PubMed DOI I
Janssens,R., Mortier,A., Boff,D., Ruytinx,P., Gouwy,M., Vantilt,B., Larsen,O., Daugvilaite,V., Rosenkilde,M.M., Parmentier,M., Noppen,S., Liekens,S., Van Damme,J., Struyf,S., Teixeira,M.M., Amaral,F.A. and Proost,P.
Truncation of CXCL12 by CD26 reduces its CXC chemokine receptor 4- and atypical chemokine receptor 3-dependent activity on endothelial cells and lymphocytes
Biochem Pharmacol132, 92-101. PubMed Europe PubMed DOI
Kim,K.M., Noh,J.H., Bodogai,M., Martindale,J.L., Yang,X., Indig,F.E., Basu,S.K., Ohnuma,K., Morimoto,C., Johnson,P.F., Biragyn,A., Abdelmohsen,K. and Gorospe,M.
Identification of senescent cell surface targetable protein DPP4
Genes Dev31, 1529-1534. PubMed Europe PubMed DOI
Lei,Y., Hu,L., Yang,G., Piao,L., Jin,M. and Cheng,X.
Dipeptidyl peptidase-IV inhibition for the treatment of cardiovascular disease - recent insights focusing on angiogenesis and neovascularization
Circ J81, 770-776. PubMed Europe PubMed DOI I
Maezaki,H., Tawada,M., Yamashita,T., Banno,Y., Miyamoto,Y., Yamamoto,Y., Ikedo,K., Kosaka,T., Tsubotani,S., Tani,A., Asakawa,T., Suzuki,N. and Oi,S.
Design of potent dipeptidyl peptidase IV (DPP-4) inhibitors by employing a strategy to form a salt bridge with Lys554
Bioorg Med Chem Lett27, 3565-3571. PubMed Europe PubMed DOI I
Ogawa,F., Takeda,M., Miyanaga,K., Tani,K., Yamazawa,R., Ito,K., Tarui,A., Sato,K. and Omote,M.
Development of a fluorogenic small substrate for dipeptidyl peptidase-4
Beilstein J Org Chem13, 2690-2697. PubMed Europe PubMed DOI A
Patel,B.D., Bhadada,S.V. and Ghate,M.D.
Design, synthesis and anti-diabetic activity of triazolotriazine derivatives as dipeptidyl peptidase-4 (DPP-4) inhibitors
Bioorg Chem72, 345-358. PubMed Europe PubMed DOI I
Rozano,L., Abdullah Zawawi,M.R., Ahmad,M.A. and Jaganath,I.B.
Computational analysis of Gynura bicolor bioactive compounds as dipeptidyl peptidase-IV inhibitor
Adv Bioinformatics2017, 5124165-5124165. PubMed Europe PubMed DOI I
Salaga,M., Mokrowiecka,A., Zielinska,M., Malecka-Panas,E., Kordek,R., Kamysz,E. and Fichna,J.
New peptide inhibitor of dipeptidyl peptidase IV, EMDB-1 extends the half-life of GLP-2 and attenuates colitis in mice after topical administration
J Pharmacol Exp Ther363, 92-103. PubMed Europe PubMed DOI I
Sato,A. and Ogita,H.
Pathophysiological implications of dipeptidyl peptidases
Curr Protein Pept Sci18, 843-849. PubMed Europe PubMed DOI
Sharma,M.C., Jain,S. and Sharma,R.
In silico screening for identification of pyrrolidine derivatives dipeptidyl peptidase-IV inhibitors using COMFA, CoMSIA, HQSAR and docking studies
In Silico Pharmacol5, 13-13. PubMed Europe PubMed DOI I
Uchida,T., Wakasugi,M., Kitamura,T., Yamamoto,T., Asakura,M., Fujiwara,R., Itoh,T., Fujii,H. and Hirono,S.
Exploration of DPP-IV inhibitors with a novel scaffold by multistep in silico screening
J Mol Graph Model79, 254-263. PubMed Europe PubMed DOI I
Wang,Z., Jiang,J., Hu,P. and Zhao,Q.
Development and validation of a UPLC-MS/MS method for simultaneous determination of fotagliptin and its two major metabolites in human plasma and urine
Bioanalysis9, 381-393. PubMed Europe PubMed I
Zou,L.W., Wang,P., Qian,X.K., Feng,L., Yu,Y., Wang,D.D., Jin,Q., Hou,J., Liu,Z.H., Ge,G.B. and Yang,L.
A highly specific ratiometric two-photon fluorescent probe to detect dipeptidyl peptidase IV in plasma and living systems
Biosens Bioelectron90, 283-289. PubMed Europe PubMed DOI A

2016

An update on the 'gliptins'
Drug Ther Bull54, 138-141. PubMed Europe PubMed DOI V I
Akinboye,E.S., Brennen,W.N., Rosen,D.M., Bakare,O. and Denmeade,S.R.
Iterative design of emetine-based prodrug targeting fibroblast activation protein (FAP) and dipeptidyl peptidase IV DPPIV using a tandem enzymatic activation strategy
Prostate76, 703-714. PubMed Europe PubMed DOI
Amini,Z., Fatemi,M.H. and Gharaghani,S.
Hybrid docking-QSAR studies of DPP-IV inhibition activities of a series of aminomethyl-piperidones
Comput Biol Chem64, 335-345. PubMed Europe PubMed DOI I
Arulmozhiraja,S., Matsuo,N., Ishitsubo,E., Okazaki,S., Shimano,H. and Tokiwa,H.
Comparative binding analysis of dipeptidyl peptidase IV (DPP-4) with antidiabetic drugs - an ab initio fragment molecular orbital study
PLoS ONE11, e0166275-e0166275. PubMed Europe PubMed DOI I
Cox,J.M., Chu,H.D., Kuethe,J.T., Gao,Y.D., Scapin,G., Eiermann,G., He,H., Li,X., Lyons,K.A., Metzger,J., Petrov,A., Wu,J.K., Xu,S., Sinha-Roy,R., Weber,A.E. and Biftu,T.
The discovery of novel 5,6,5- and 5,5,6-tricyclic pyrrolidines as potent and selective DPP-4 inhibitors
Bioorg Med Chem Lett26, 2622-2626. PubMed Europe PubMed DOI I
de Almeida Salles,T., Zogbi,C., de Lima,T.M., de Godoi Carneiro,C., Garcez,A.T., Barbeiro,H.V., Antonio,E.L., Dos Santos,L., da Costa Pereira,A., Tucci,P.J., de Paula Faria,D., Soriano,F.G. and Girardi,A.C.
The contributions of dipeptidyl peptidase IV to inflammation in heart failure
Am J Physiol Heart Circ Physiol310, H1760-H1772. PubMed Europe PubMed DOI I
Deacon,C.F. and Lebovitz,H.E.
Comparative review of dipeptidyl peptidase-4 inhibitors and sulphonylureas
Diabetes Obes Metab18, 333-347. PubMed Europe PubMed DOI I
Decalf,J., Tarbell,K.V., Casrouge,A., Price,J.D., Linder,G., Mottez,E., Sultanik,P., Mallet,V., Pol,S., Duffy,D. and Albert,M.L.
Inhibition of DPP4 activity in humans establishes its in vivo role in CXCL10 post-translational modification: prospective placebo-controlled clinical studies
EMBO Mol Med8, 679-683. PubMed Europe PubMed DOI I
Glorie,L., D'Haese,P.C. and Verhulst,A.
Boning up on DPP4, DPP4 substrates, and DPP4-adipokine interactions: logical reasoning and known facts about bone related effects of DPP4 inhibitors
Bone92, 37-49. PubMed Europe PubMed DOI V
Gonzalez,R. and Unniappan,S.
Mass spectrometry-assisted confirmation of the inability of dipeptidyl peptidase-4 to cleave goldfish peptide YY(1-36) and the lack of anorexigenic effects of peptide YY(3-36) in goldfish (Carassius auratus)
Fish Physiol Biochem42, 831-844. PubMed Europe PubMed DOI
Grimshaw,C.E., Jennings,A., Kamran,R., Ueno,H., Nishigaki,N., Kosaka,T., Tani,A., Sano,H., Kinugawa,Y., Koumura,E., Shi,L. and Takeuchi,K.
Trelagliptin (SYR-472, Zafatek), novel once-weekly treatment for type 2 diabetes, inhibits dipeptidyl peptidase-4 (DPP-4) via a non-covalent mechanism
PLoS ONE11, e0157509-e0157509. PubMed Europe PubMed DOI I
Ikeda,J., Kimoto,N., Kitayama,T. and Kunori,S.
Cardiac DPP-4 inhibition by saxagliptin ameliorates isoproterenol-induced myocardial remodeling and cardiac diastolic dysfunction in rats
J Pharmacol Sci132, 65-70. PubMed Europe PubMed DOI I
Kato,E., Uenishi,Y., Inagaki,Y., Kurokawa,M. and Kawabata,J.
Isolation of rugosin A, B and related compounds as dipeptidyl peptidase-IV inhibitors from rose bud extract powder
Biosci Biotechnol Biochem80, 2087-2092. PubMed Europe PubMed DOI I
Li,S., Xu,H., Cui,S., Wu,F., Zhang,Y., Su,M., Gong,Y., Qiu,S., Jiao,Q., Qin,C., Shan,J., Zhang,M., Wang,J., Yin,Q., Xu,M., Liu,X., Wang,R., Zhu,L., Li,J., Xu,Y., Jiang,H., Zhao,Z., Li,J. and Li,H.
Discovery and rational design of natural-product-derived 2-phenyl-3,4-dihydro-2h-benzo[f]chromen-3-amine analogs as novel and potent dipeptidyl peptidase 4 (DPP-4) inhibitors for the treatment of type 2 diabetes
J Med Chem59, 6772-6790. PubMed Europe PubMed DOI I
Nojima,H., Kanou,K., Terashi,G., Takeda-Shitaka,M., Inoue,G., Atsuda,K., Itoh,C., Iguchi,C. and Matsubara,H.
Comprehensive analysis of the co-structures of dipeptidyl peptidase IV and its inhibitor
BMC Struct Biol16, 11-11. PubMed Europe PubMed DOI S I
Onoyama,H., Kamiya,M., Kuriki,Y., Komatsu,T., Abe,H., Tsuji,Y., Yagi,K., Yamagata,Y., Aikou,S., Nishida,M., Mori,K., Yamashita,H., Fujishiro,M., Nomura,S., Shimizu,N., Fukayama,M., Koike,K., Urano,Y. and Seto,Y.
Rapid and sensitive detection of early esophageal squamous cell carcinoma with fluorescence probe targeting dipeptidylpeptidase IV
Sci Rep6, 26399-26399. PubMed Europe PubMed DOI L
Pissarnitski,D.A., Zhao,Z., Cole,D., Wu,W.L., Domalski,M., Clader,J.W., Scapin,G., Voigt,J., Soriano,A., Kelly,T., Powles,M.A., Yao,Z. and Burnett,D.A.
Scaffold-hopping from xanthines to tricyclic guanines: a case study of dipeptidyl peptidase 4 (DPP4) inhibitors
Bioorg Med Chem24, 5534-5545. PubMed Europe PubMed DOI I
Ran,Y., Pei,H., Shao,M. and Chen,L.
Synthesis, biological evaluation, and molecular docking of (R)-2-((8-(3-aminopiperidin-1-yl)-3-methyl-7-(3-methylbut-2-en-1-yl)-26-dioxo-2367-tetrahydro-1H-purin-1-yl)methyl)benzonitrile as dipeptidyl peptidase IV inhibitors
Chem Biol Drug Des87, 290-295. PubMed Europe PubMed DOI I
Remm,F., Franz,W.M. and Brenner,C.
Gliptins and their target dipeptidyl peptidase 4: implications for the treatment of vascular disease
Eur Heart J Cardiovasc Pharmacother2, 185-193. PubMed Europe PubMed DOI I
Schnapp,G., Klein,T., Hoevels,Y., Bakker,R.A. and Nar,H.
Comparative analysis of binding kinetics and thermodynamics of dipeptidyl peptidase-4 inhibitors and their relationship to structure
J Med Chem59, 7466-7477. PubMed Europe PubMed DOI I
Shi,S., Kanasaki,K. and Koya,D.
Linagliptin but not Sitagliptin inhibited transforming growth factor-beta2-induced endothelial DPP-4 activity and the endothelial-mesenchymal transition
Biochem Biophys Res Commun471, 184-190. PubMed Europe PubMed DOI I
Suman,R.K., Mohanty,I.R., Maheshwari,U., Borde,M.K. and Deshmukh,Y.A.
Natural dipeptidyl peptidase-IV inhibitor mangiferin mitigates diabetes- and metabolic syndrome-induced changes in experimental rats
Diabetes Metab Syndr Obes9, 261-272. PubMed Europe PubMed DOI
van Doremalen,N., Miazgowicz,K.L. and Munster,V.J.
Mapping the specific amino acid residues that make hamster DPP4 functional as a receptor for Middle East Respiratory Syndrome coronavirus
J Virol90, 5499-5502. PubMed Europe PubMed DOI
Wagner,L., Kaestner,F., Wolf,R., Stiller,H., Heiser,U., Manhart,S., Hoffmann,T., Rahfeld,J.U., Demuth,H.U., Rothermundt,M. and von Horsten,S.
Identifying neuropeptide Y (NPY) as the main stress-related substrate of dipeptidyl peptidase 4 (DPP4) in blood circulation
Neuropeptides57, 21-34. PubMed Europe PubMed DOI
Wagner,L., Klemann,C., Stephan,M. and von Horsten,S.
Unravelling the immunological roles of dipeptidyl peptidase 4 (DPP4) activity and/or structure homologue (DASH) proteins
Clin Exp Immunol184, 265-283. PubMed Europe PubMed DOI
Wang,Y., Wu,X., Cheng,Y. and Zhao,X.
A fluorescent switchable AIE probe for selective imaging of dipeptidyl peptidase-4 in vitro and in vivo and its application in screening DPP-4 inhibitors
Chem Commun (Camb)52, 3478-3481. PubMed Europe PubMed DOI L
Wong,P.F., Gall,M.G., Bachovchin,W.W., McCaughan,G.W., Keane,F.M. and Gorrell,M.D.
Neuropeptide Y is a physiological substrate of fibroblast activation protein: enzyme kinetics in blood plasma and expression of Y2R and Y5R in human liver cirrhosis and hepatocellular carcinoma
Peptides75, 80-95. PubMed Europe PubMed DOI
Wu,W.L., Hao,J., Domalski,M., Burnett,D.A., Pissarnitski,D., Zhao,Z., Stamford,A., Scapin,G., Gao,Y.D., Soriano,A., Kelly,T.M., Yao,Z., Powles,M.A., Chen,S., Mei,H. and Hwa,J.
Discovery of novel tricyclic heterocycles as potent and selective DPP-4 inhibitors for the treatment of type 2 diabetes
ACS Med Chem Lett7, 498-501. PubMed Europe PubMed DOI I
Zhong,J., Kankanala,S. and Rajagopalan,S.
Dipeptidyl peptidase-4 inhibition: insights from the bench and recent clinical studies
Curr Opin Lipidol27, 484-492. PubMed Europe PubMed DOI I

2015

Asakura,M., Fujii,H., Atsuda,K., Itoh,T. and Fujiwara,R.
Dipeptidyl peptidase-4 greatly contributes to the hydrolysis of vildagliptin in human liver
Drug Metab Dispos43, 477-484. PubMed Europe PubMed DOI I
Barreira da Silva,R., Laird,M.E., Yatim,N., Fiette,L., Ingersoll,M.A. and Albert,M.L.
Dipeptidylpeptidase 4 inhibition enhances lymphocyte trafficking, improving both naturally occurring tumor immunity and immunotherapy
Nat Immunol16, 850-858. PubMed Europe PubMed DOI I
Block,H., Maertens,B., Spriestersbach,A., Kubicek,J. and Schafer,F.
Proteolytic affinity tag cleavage
Methods Enzymol559, 71-97. PubMed Europe PubMed DOI
Costante,R., Stefanucci,A., Carradori,S., Novellino,E. and Mollica,A.
DPP-4 inhibitors: a patent review (2012 - 2014)
Expert Opin Ther Pat25, 209-236. PubMed Europe PubMed DOI V I
Gao,Y., Zhang,Y., Zhu,J., Li,B., Li,Z., Zhu,W., Shi,J., Jia,Q. and Li,Y.
Recent progress in natural products as DPP-4 inhibitors
Future Med Chem7, 1079-1089. PubMed Europe PubMed DOI I
Gilibili,R.R., Bhamidipati,R.K., Mullangi,R. and Srinivas,N.R.
Retrospective and prospective human intravenous and oral pharmacokinetic projection of dipeptidyl peptidase-IV inhibitors using simple allometric principles - case studies of ABT-279, ABT-341, alogliptin, carmegliptin, sitagliptin and vildagliptin
J Pharm Pharm Sci18, 434-448. PubMed Europe PubMed I
Jain,M.R., Joharapurkar,A.A., Bahekar,R.H., Patel,H., Jadav,P., Kshirsagar,S.G., Patel,V.J., Patel,K.N., Ramanathan,V.K., Patel,P.R. and Desai,R.C.
Pharmacological characterization of ZYDPLA1, a novel long-acting dipeptidyl peptidase-4 inhibitor
J Diabetes7, 708-717. PubMed Europe PubMed DOI I
Jiang,T., Zhou,Y., Chen,Z., Sun,P., Zhu,J., Zhang,Q., Wang,Z., Shao,Q., Jiang,X., Li,B., Chen,K., Jiang,H., Wang,H., Zhu,W. and Shen,J.
Design, synthesis, and pharmacological evaluation of fused beta-homophenylalanine derivatives as potent DPP-4 inhibitors
ACS Med Chem Lett6, 602-606. PubMed Europe PubMed DOI I
Jiang,T., Zhou,Y., Zhu,J., Chen,Z., Sun,P., Zhang,Q., Wang,Z., Shao,Q., Jiang,X., Li,B., Wang,H., Zhu,W. and Shen,J.
Design, synthesis, and pharmacological evaluation of highly potent and selective dipeptidyl peptidase-4 inhibitors
Arch Pharm (Weinheim)348, 399-407. PubMed Europe PubMed DOI I
Kushwaha,R.N., Srivastava,R., Mishra,A., Rawat,A.K., Srivastava,A.K., Haq,W. and Katti,S.B.
Design, synthesis, biological screening, and molecular docking studies of piperazine-derived constrained inhibitors of DPP-IV for the treatment of type 2 diabetes
Chem Biol Drug Des85, 439-446. PubMed Europe PubMed DOI I
Lacroix,I.M. and Li-Chan,E.C.
Comparison of the susceptibility of porcine and human dipeptidyl-peptidase IV to inhibition by protein-derived peptides
Peptides69, 19-25. PubMed Europe PubMed DOI I
Lan,V.T.T., Ito,K., Ohno,M., Motoyama,T., Ito,S. and Kawarasaki,Y.
Analyzing a dipeptide library to identify human dipeptidyl peptidase IV inhibitor
Food Chem175, 66-73. PubMed Europe PubMed DOI I
McKeage,K.
Trelagliptin: first global approval
Drugs75, 1161-1164. PubMed Europe PubMed DOI I
Mo,D.W., Dong,S., Sun,H., Chen,J.S., Pang,J.X., Xi,B.M. and Chen,W.H.
Synthesis and potent inhibitory activities of carboxybenzyl-substituted 8-(3-(R)-aminopiperidin-1-yl)-7-(2-chloro/cyanobenzyl)-3-methyl-3,7-dihydro-purine-2,6-diones as dipeptidyl peptidase IV (DPP-IV) inhibitors
Bioorg Med Chem Lett25, 1872-1875. PubMed Europe PubMed DOI I
Morikawa,T., Ninomiya,K., Akaki,J., Kakihara,N., Kuramoto,H., Matsumoto,Y., Hayakawa,T., Muraoka,O., Wang,L.B., Wu,L.J., Nakamura,S., Yoshikawa,M. and Matsuda,H.
Dipeptidyl peptidase-IV inhibitory activity of dimeric dihydrochalcone glycosides from flowers of Helichrysum arenarium
J Nat Med69, 494-506. PubMed Europe PubMed DOI I
Ohno,M., Ito,K., Lan,V.T., Kusubata,M., Tometsuka,C., Koyama,Y.I., Motoyama,T., Ito,S. and Kawarasaki,Y.
Synergistic inhibition of human dipeptidyl peptidase IV by combinations of peptides
Peptides69, 115-117. PubMed Europe PubMed DOI I
Panchapakesan,U. and Pollock,C.
The role of dipeptidyl peptidase-4 inhibitors in diabetic kidney disease
Front Immunol6, 443-443. PubMed Europe PubMed DOI I
Patel,B.D. and Ghate,M.D.
3D-QSAR studies of dipeptidyl peptidase-4 inhibitors using various alignment methods
Med Chem Res24, 1060-1069. DOI I
Patil,S., Sharma,R. and Abhishek,A.
Comparative study to predict dipeptidyl peptidase IV inhibitory activity of beta-amino amide scaffold
Indian J Pharm Sci77, 142-150. PubMed Europe PubMed I
Ran,Y., Pei,H., Xie,C., Ma,L., Wu,Y., Lei,K., Shao,M., Tang,M., Xiang,M., Peng,A., Wei,Y. and Chen,L.
Scaffold-based design of xanthine as highly potent inhibitors of DPP-IV for improving glucose homeostasis in DIO mice
Mol Divers19, 333-346. PubMed Europe PubMed DOI I
Ren,H., Zhuo,X., Su,H., Li,X., Tang,H., Jin,Y., Zhao,Q. and Wang,S.
Synthesis and evaluation of novel xanthone derivatives as potent dipeptidyl peptidase-4 inhibitors
Asian J Chem27, 2079-2081. DOI I
Salles,T.A., Santos,L.D., Barauna,V.G. and Girardi,A.C.
Potential role of dipeptidyl peptidase IV in the pathophysiology of heart failure
Int J Mol Sci16, 4226-4249. PubMed Europe PubMed DOI
Scheen,A.J.
A review of gliptins for 2014
Expert Opin Pharmacother16, 43-62. PubMed Europe PubMed DOI V I
Schwehm,C., Li,J., Song,H., Hu,X., Kellam,B. and Stocks,M.J.
Synthesis of new DPP-4 inhibitors based on a novel tricyclic scaffold
ACS Med Chem Lett6, 324-328. PubMed Europe PubMed DOI I
Shoombuatong,W., Prachayasittikul,V., Anuwongcharoen,N., Songtawee,N., Monnor,T., Prachayasittikul,S., Prachayasittikul,V. and Nantasenamat,C.
Navigating the chemical space of dipeptidyl peptidase-4 inhibitors
Drug Des Devel Ther9, 4515-4549. PubMed Europe PubMed DOI I
Smelcerovic,A., Miljkovic,F., Kolarevic,A., Lazarevic,J., Djordjevic,A., Kocic,G. and Anderluh,M.
An overview of recent dipeptidyl peptidase-IV inhibitors: linking their structure and physico-chemical properties with SAR, pharmacokinetics and toxicity
Curr Top Med Chem15, 2342-2372. PubMed Europe PubMed V I
Srivastava,J.K., Dubey,P., Singh,S., Bhat,H.R., Kumawat,M.K. and Singh,U.P.
Discovery of novel 1,3,5-triazine-thiazolidine-2,4-diones as dipeptidyl peptidase-4 inhibitors with antibacterial activity targeting the S1 pocket for the treatment of type 2 diabetes
RSC Adv5, 14095-14102. DOI I
Velazquez,S., De Castro,S., Diez-Torrubia,A., Balzarini,J. and Camarasa,M.J.
Dipeptidyl-peptidase IV (DPP IV/CD26)-activated prodrugs: a successful strategy for improving water solubility and oral bioavailability
Curr Med Chem22, 1041-1054. PubMed Europe PubMed
Verma,S.K., Sharma,S.K. and Thareja,S.
Docking study of novel pyrrolidine derivatives as potential dipeptidyl peptidase-IV (DPP-IV) inhibitors
Lett Drug Des Discov12, 284-291. I
Watanabe,Y.S., Yasuda,Y., Kojima,Y., Okada,S., Motoyama,T., Takahashi,R. and Oka,M.
Anagliptin, a potent dipeptidyl peptidase IV inhibitor: its single-crystal structure and enzyme interactions
J Enzyme Inhib Med Chem30, 981-988. PubMed Europe PubMed DOI S I
Zhang,J., Liu,Y., Lv,J., Cao,Y. and Li,G.
Dipeptidyl peptidase-IV activity assay and inhibitor screening using a gold nanoparticle-modified gold electrode with an immobilized enzyme substrate
Mikrochim Acta182, 281-288. DOI A
Zhong,J. and Rajagopalan,S.
Dipeptidyl peptidase-4 regulation of SDF-1/CXCR4 axis: implications for cardiovascular disease
Front Immunol6, 477-477. PubMed Europe PubMed DOI V
Zhong,J., Maiseyeu,A., Davis,S.N. and Rajagopalan,S.
DPP4 in cardiometabolic disease: recent insights from the laboratory and clinical trials of DPP4 inhibition
Circ Res116, 1491-1504. PubMed Europe PubMed DOI I

2014

Al-Balas,Q.A., Sowaileh,M.F., Hassan,M.A., Qandil,A.M., Alzoubi,K.H., Mhaidat,N.M., Almaaytah,A.M. and Khabour,O.F.
Novel N-substituted aminobenzamide scaffold derivatives targeting the dipeptidyl peptidase-IV enzyme
Drug Des Devel Ther8, 129-163. PubMed Europe PubMed DOI I
Arrebola,Y.M., Gomez,H., Valiente,P.A., Chavez,M.D.L.A. and Pascual,I.
Dipeptidyl peptidase IV and its implication in cancer
Biotecnol Apl31, 93-110.
Biftu,T., Sinha-Roy,R., Chen,P., Qian,X., Feng,D., Kuethe,J.T., Scapin,G., Gao,Y.D., Yan,Y., Krueger,D., Bak,A., Eiermann,G., He,J., Cox,J., Hicks,J., Lyons,K., He,H., Salituro,G., Tong,S., Patel,S., Doss,G., Petrov,A., Wu,J., Xu,S.S., Sewall,C., Zhang,X., Zhang,B., Thornberry,N.A. and Weber,A.E.
Omarigliptin (MK-3102): a novel long-acting DPP-4 inhibitor for once-weekly treatment of type 2 diabetes
J Med Chem57, 3205-3212. PubMed Europe PubMed DOI I
Chakraborty,C., Hsu,M.J. and Agoramoorthy,G.
Understanding the molecular dynamics of type-2 diabetes drug target DPP-4 and its interaction with sitagliptin and inhibitor diprotin-A
Cell Biochem Biophys70, 907-922. PubMed Europe PubMed DOI I
Chua,S., Lee,F.Y., Tsai,T.H., Sheu,J.J., Leu,S., Sun,C.K., Chen,Y.L., Chang,H.W., Chai,H.T., Liu,C.F., Lu,H.I. and Yip,H.K.
Inhibition of dipeptidyl peptidase-IV enzyme activity protects against myocardial ischemia-reperfusion injury in rats
J Transl Med12, 357-357. PubMed Europe PubMed DOI I
Dahan,A., Wolk,O., Yang,P., Mittal,S., Wu,Z., Landowski,C.P. and Amidon,G.L.
Dipeptidyl peptidase IV as a potential target for selective prodrug activation and chemotherapeutic action in cancers
Mol Pharm11, 4385-4394. PubMed Europe PubMed DOI
Fujimoto,N., Ohnuma,K., Aoe,K., Hosono,O., Yamada,T., Kishimoto,T. and Morimoto,C.
Clinical significance of soluble CD26 in malignant pleural mesothelioma
PLoS ONE9, e115647-e115647. PubMed Europe PubMed DOI
Hatanaka,T., Kawakami,K. and Uraji,M.
Inhibitory effect of collagen-derived tripeptides on dipeptidylpeptidase-IV activity
J Enzyme Inhib Med Chem29, 823-828. PubMed Europe PubMed DOI I
Inagaki,N., Onouchi,H., Sano,H., Funao,N., Kuroda,S. and Kaku,K.
SYR-472, a novel once-weekly dipeptidyl peptidase-4 (DPP-4) inhibitor, in type 2 diabetes mellitus: a phase 2, randomised, double-blind, placebo-controlled trial
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Janardhan,S. and Sastry,G.N.
Dipeptidyl peptidase IV inhibitors: a new paradigm in type 2 diabetes treatment
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Design, synthesis and biological evaluation of hetero-aromatic moieties substituted pyrrole-2-carbonitrile derivatives as dipeptidyl peptidase IV inhibitors
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Design, synthesis and biological evaluation of 4-fluoropyrrolidine-2-carbonitrile and octahydrocyclopenta[b]pyrrole-2-carbonitrile derivatives as dipeptidyl peptidase IV inhibitors
Eur J Med Chem86, 242-256. PubMed Europe PubMed DOI I
Juillerat-Jeanneret,L.
Dipeptidyl peptidase IV and its inhibitors: therapeutics for type 2 diabetes and what else?
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Kim,N.H., Yu,T. and Lee,D.H.
The nonglycemic actions of dipeptidyl peptidase-4 inhibitors
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Kim,Y., Kim,U., Kim,I.S., Lee,S.H., Lee,J., Kim,D.H. and Yoo,H.H.
Absorption, distribution, metabolism and excretion of gemigliptin, a novel dipeptidyl peptidase IV inhibitor, in rats
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DPP4 Deficiency preserved cardiac function in abdominal aortic banding rats
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Sixteen-years of clinically relevant dipeptidyl peptidase-IV (DPP-IV) inhibitors for treatment of type-2 diabetes: a perspective
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Investigating the contributions of residues to dipeptidyl peptidase-IV inhibitor binding by molecular dynamics simulation
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Population pharmacokinetic analysis of dutogliptin, a selective dipeptidyl peptidase-4 inhibitor
Clin Pharmacol Drug Dev3, 297-304. PubMed Europe PubMed DOI I
Mohandas,R., Sautina,L., Beem,E., Schuler,A., Chan,W.Y., Domsic,J., McKenna,R., Johnson,R.J. and Segal,M.S.
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Pharmacology, physiology, and mechanisms of action of dipeptidyl peptidase-4 inhibitors
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Namoto,K., Sirockin,F., Ostermann,N., Gessier,F., Flohr,S., Sedrani,R., Gerhartz,B., Trappe,J., Hassiepen,U., Duttaroy,A., Ferreira,S., Sutton,J.M., Clark,D.E., Fenton,G., Beswick,M. and Baeschlin,D.K.
Discovery of C-(1-aryl-cyclohexyl)-methylamines as selective, orally available inhibitors of dipeptidyl peptidase IV
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Nedosugova,L.V., Petunina,N.A. and Galstyan,K.O.
Initial investigation of efficacy and safety of a new dipeptidyl peptidase-4 inhibitor, gosogliptin, for type 2 diabetes in Russia
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An in silico model to predict the potential of dietary proteins as sources of dipeptidyl peptidase IV (DPP-IV) inhibitory peptides
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Patil,S. and Sharma,R.
3D QSAR study and designing of novel prolinenitriles derivatives as dipeptidyl peptidase IV inhibitor
Curr Trends Biotechnol Pharm8, 254-263. I
Peng,C.H., Yang,Y.S., Chan,K.C., Wang,C.J., Chen,M.L. and Huang,C.N.
Hibiscus sabdariffa polyphenols alleviate insulin resistance and renal epithelial to mesenchymal transition: a novel action mechanism mediated by type 4 dipeptidyl peptidase
J Agric Food Chem62, 9736-9743. PubMed Europe PubMed DOI I
Rizzo,M.R., Barbieri,M., Boccardi,V., Angellotti,E., Marfella,R. and Paolisso,G.
Dipeptidyl peptidase-4 inhibitors have protective effect on cognitive impairment in aged diabetic patients with mild cognitive impairment
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Shedding of dipeptidyl peptidase 4 is mediated by metalloproteases and up-regulated by hypoxia in human adipocytes and smooth muscle cells
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Sawant,S.D., Nerkar,A.G., Velapure,A.V. and Pawar,N.D.
Design, synthesis, QSAR studies and in vitro evaluation of novel triazolopiperazine based B-Amino amides as dipeptidyl peptidase-IV (DPP-IV) inhibitors: Part-I
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Shu,C., Ge,H., Song,M., Chen,J.H., Zhou,H., Qi,Q., Wang,F., Ma,X., Yang,X., Zhang,G., Ding,Y., Zhou,D., Peng,P., Shih,C.K., Xu,J. and Wu,F.
Discovery of imigliptin, a novel selective DPP-4 inhibitor for the treatment of type 2 diabetes
ACS Med Chem Lett5, 921-926. PubMed Europe PubMed DOI I
Singh,A.K.
Dipeptidyl peptidase-4 inhibitors: novel mechanism of actions
Indian J Endocrinol Metab18, 753-759. PubMed Europe PubMed DOI I
Song,W., Wang,Y., Wang,N., Wang,D., Guo,J., Fu,L. and Shi,X.
Identification of residues on human receptor DPP4 critical for MERS-CoV binding and entry
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Tanwar,O., Tanwar,L., Shaquiquzzaman,M., Alam,M.M. and Akhter,M.
Structure based virtual screening of MDPI database: discovery of structurally diverse and novel DPP-IV inhibitors
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Tanwar,O., Deora,G.S., Tanwar,L., Kumar,G., Janardhan,S., Alam,M.M., Shaquiquzzaman,M. and Akhter,M.
Novel hydrazine derivatives as selective DPP-IV inhibitors: findings from virtual screening and validation through molecular dynamics simulations
J Mol Model20, 2118-2118. PubMed Europe PubMed DOI I
Ustun-Aytekin,O., Gurhan,I.D., Ohura,K., Imai,T. and Ongen,G.
Monitoring of the effects of transfection with baculovirus on Sf9 cell line and expression of human dipeptidyl peptidase IV
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Wang,S., Su,M., Wang,J., Li,Z., Zhang,L., Ji,X., Li,J., Li,J. and Liu,H.
(R)-3-Amino-1-((3aS,7aS)-octahydro-1H-indol-1-yl)-4-(2,4,5-trifluorophenyl)butan-1-one derivatives as potent inhibitors of dipeptidyl peptidase-4: design, synthesis, biological evaluation, and molecular modeling
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Wang,S.C., Zeng,L.L., Ding,Y.Y., Zeng,S.G., Song,H.R., Hu,W.H. and Xie,H.
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Xiao,P.-F., Guo,R., Huang,S.-Q., Cui,H.-J., Ye,S. and Zhang,Z.
Discovery of dipeptidyl peptidase IV (DPP4) inhibitors based on a novel indole scaffold
Chin Chem Lett209, 1509-1519. DOI I
Xing,J., Li,Q., Zhang,S., Liu,H., Zhao,L., Cheng,H., Zhang,Y., Zhou,J. and Zhang,H.
Identification of dipeptidyl peptidase IV inhibitors: virtual screening, synthesis and biological evaluation
Chem Biol Drug Des84, 364-377. PubMed Europe PubMed DOI I
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Emerging roles of dipeptidyl peptidase 4 inhibitors: anti-inflammatory and immunomodulatory effect and its application in diabetes mellitus
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Dipeptidyl peptidase-4 inhibitors: Multitarget drugs, not only antidiabetes drugs
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2013

Almasri,I.M., Taha,M.O. and Mohammad,M.K.
New leads for DPP IV inhibition: structure-based pharmacophore mapping and virtual screening study
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Aroor,A., McKarns,S., Nistala,R., Demarco,V., Gardner,M., Garcia-Touza,M., Whaley-Connell,A. and Sowers,J.R.
DPP-4 inhibitors as therapeutic modulators of immune cell function and associated cardiovascular and renal insulin resistance in obesity and diabetes
Cardiorenal Med3, 48-56. PubMed Europe PubMed DOI I
Ben-Shlomo,S., Zvibel,I., Rabinowich,L., Goldiner,I., Shlomai,A., Santo,E.M., Halpern,Z., Oren,R. and Fishman,S.
Dipeptidyl peptidase 4-deficient rats have improved bile secretory function in high fat diet-induced steatosis
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Biftu,T., Qian,X., Chen,P., Feng,D., Scapin,G., Gao,Y.D., Cox,J., Sinha Roy,R., Eiermann,G., He,H., Lyons,K., Salituro,G., Patel,S., Petrov,A., Xu,F., Xu,S.S., Zhang,B., Caldwell,C., Wu,J.K., Lyons,K. and Weber,A.E.
Novel tetrahydropyran analogs as dipeptidyl peptidase IV inhibitors: Profile of clinical candidate (2R,3S,5R)-2- (2,5-difluorophenyl)-5-(4,6-dihydropyrrolo [3,4-c]pyrazol-5-(1H)-yl)tetrahydro-2H-pyran-3-amine (23) [corrected]
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Cahn,A. and Raz,I.
Emerging gliptins for type 2 diabetes
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Czechtizky,W., Dedio,J., Desai,B., Dixon,K., Farrant,E., Feng,Q., Morgan,T., Parry,D.M., Ramjee,M.K., Selway,C.N., Schmidt,T., Tarver,G.J. and Wright,A.G.
Integrated synthesis and testing of substituted xanthine based DPP4 inhibitors: application to drug discovery
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Dos Santos,L., Salles,T.A., Arruda-Junior,D.F., Campos,L.C., Pereira,A.C., Barreto,A.L., Antonio,E.L., Mansur,A.J., Tucci,P.J., Krieger,J.E. and Girardi,A.C.
Circulating dipeptidyl peptidase IV activity correlates with cardiac dysfunction in human and experimental heart failure
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Fan,J., Johnson,M.H., Lila,M.A., Yousef,G. and de Mejia,E.G.
Berry and citrus phenolic compounds inhibit dipeptidyl peptidase IV: implications in diabetes management
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Furuta,S., Smart,C., Hackett,A., Benning,R. and Warrington,S.
Pharmacokinetics and metabolism of [14C]anagliptin, a novel dipeptidyl peptidase-4 inhibitor, in humans
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Furuta,S., Tamura,M., Hirooka,H., Mizuno,Y., Miyoshi,M. and Furuta,Y.
Pharmacokinetic disposition of anagliptin, a novel dipeptidyl peptidase-4 inhibitor, in rats and dogs
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Gomez,H., Chappe,M., Valiente,P.A., Pons,T., de Los Angeles Chavez,M., Charli,J.-L. and Pascual,I.
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Haverslag,R.T., de Groot,D., Grundmann,S., Meder,B., Goumans,M.J., Pasterkamp,G., Hoefer,I.E. and de Kleijn,D.P.
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A general method for making peptide therapeutics resistant to serine protease degradation: application to dipeptidyl peptidase IV substrates
J Med Chem56, 8339-8351. PubMed Europe PubMed DOI I
Hikida,A., Ito,K., Motoyama,T., Kato,R. and Kawarasaki,Y.
Systematic analysis of a dipeptide library for inhibitor development using human dipeptidyl peptidase IV produced by a Saccharomyces cerevisiae expression system
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Itou,M., Kawaguchi,T., Taniguchi,E. and Sata,M.
Dipeptidyl peptidase-4: A key player in chronic liver disease
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Khalaf,R.A., Sheikha,G.A., Al-Sha'er,M. and Taha,M.
Design, synthesis and biological evaluation of N4-sulfonamido-succinamic, phthalamic, acrylic and benzoyl acetic acid derivatives as potential DPP IV inhibitors
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Khurana,S., Margamuljana,L., Joseph,C., Schouteden,S., Buckley,S.M. and Verfaillie,C.M.
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Kim,S.H., Lee,S.H. and Yim,H.J.
Gemigliptin, a novel dipeptidyl peptidase 4 inhibitor: first new anti-diabetic drug in the history of Korean pharmaceutical industry
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Lin,K., Cai,Z., Wang,F., Zhang,W. and Zhou,W.
Synthesis and biological evaluation of xanthine derivatives on dipeptidyl peptidase 4
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Liu,Y., Si,M., Tang,L., Shangguan,S., Wu,H., Li,J., Wu,P., Ma,X., Liu,T. and Hu,Y.
Synthesis and biological evaluation of novel benzyl-substituted (S)-phenylalanine derivatives as potent dipeptidyl peptidase 4 inhibitors
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Liu,Y., Wu,Y., Wu,H., Tang,L., Wu,P., Liu,T. and Hu,Y.
Design, synthesis, biological evaluation, and docking studies of (S)-phenylalanine derivatives with a 2-cyanopyrrolidine moiety as potent dipeptidyl peptidase 4 inhibitors
Chem Biol Drug Des82, 140-146. PubMed Europe PubMed DOI I
Liu,Y., Jiang,C., Wu,H., Wu,P., Si,M., Hu,Y. and Liu,T.
Design, synthesis and biological evaluation of novel imidazolone derivatives as dipeptidyl peptidase 4 inhibitors
Med Chem9, 938-946. PubMed Europe PubMed DOI I
Lu,G., Hu,Y., Wang,Q., Qi,J., Gao,F., Li,Y., Zhang,Y., Zhang,W., Yuan,Y., Bao,J., Zhang,B., Shi,Y., Yan,J. and Gao,G.F.
Molecular basis of binding between novel human coronavirus MERS-CoV and its receptor CD26
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Meng,X.-G., Cai,Z.-Y. and Zhou,W.-C.
Dipeptidyl peptidase 4 inhibitors: Research advances
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A comparative study of the binding modes of recently launched dipeptidyl peptidase IV inhibitors in the active site
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Nongonierma,A.B. and FitzGerald,R.J.
Inhibition of dipeptidyl peptidase IV (DPP-IV) by tryptophan containing dipeptides
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Ou,X., O'Leary,H.A. and Broxmeyer,H.E.
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Computational studies on structurally diverse dipeptidyl peptidase IV inhibitors: an approach for new antidiabetic drug development
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DPP-4 inhibitors improve cognition and brain mitochondrial function of insulin-resistant rats
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Poplawski,S.E., Lai,J.H., Li,Y., Jin,Z., Liu,Y., Wu,W., Wu,Y., Zhou,Y., Sudmeier,J.L., Sanford,D.G. and Bachovchin,W.W.
Identification of selective and potent inhibitors of fibroblast activation protein and prolyl oligopeptidase
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Sharma,M., Gupta,M., Singh,D., Kumar,M. and Kaur,P.
Synthesis, evaluation and molecular docking of prolyl-fluoropyrrolidine derivatives as dipeptidyl peptidase IV inhibitors
Chem Biol Drug Des82, 156-166. PubMed Europe PubMed DOI I
Sharma,M., Singh,D. and Gupta,M.
Synthesis and evaluation of thiouracil derivatives as dipeptidyl peptidase IV inhibitors
Chem Biol Drug Des81, 257-264. PubMed Europe PubMed DOI I
Sharoyan,S., Antonyan,A., Mardanyan,S., Harutyunyan,H., Movsisyan,N., Hovnanyan,N. and Hovnanyan,K.
Interaction of dipeptydil peptidase IV with amyloid peptides
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Tang,J., Majeti,J., Sudom,A., Xiong,Y., Lu,M., Liu,Q., Higbee,J., Zhang,Y., Wang,Y., Wang,W., Cao,P., Xia,Z., Johnstone,S., Min,X., Yang,X., Shao,H., Yu,T., Sharkov,N., Walker,N., Tu,H., Shen,W. and Wang,Z.
An inhibitory antibody against dipeptidyl peptidase IV improves glucose tolerance in vivo
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Tatosian,D.A., Guo,Y., Schaeffer,A.K., Gaibu,N., Popa,S., Stoch,A., Langdon,R.B. and Kauh,E.A.
Dipeptidyl Peptidase-4 Inhibition in Patients with Type 2 Diabetes Treated with Saxagliptin, Sitagliptin, or Vildagliptin
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Wang,J., Feng,Y., Ji,X., Deng,G., Leng,Y. and Liu,H.
Synthesis and biological evaluation of pyrrolidine-2-carbonitrile and 4-fluoropyrrolidine-2-carbonitrile derivatives as dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes
Bioorg Med Chem21, 7418-7429. PubMed Europe PubMed DOI I
Wang,N., Shi,X., Jiang,L., Zhang,S., Wang,D., Tong,P., Guo,D., Fu,L., Cui,Y., Liu,X., Arledge,K.C., Chen,Y.H., Zhang,L. and Wang,X.
Structure of MERS-CoV spike receptor-binding domain complexed with human receptor DPP4
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Wang,X., Li,Y., Gui,X.-R. and Cheng,X.-C.
Progress in dipeptidyl peptidase-4 and its inhibitors
Chin Pharm J (China)48, 1789-1796. DOI I
Wang,X.M., Yang,Y.J. and Wu,Y.J.
The emerging role of dipeptidyl peptidase-4 inhibitors in cardiovascular protection: current position and perspectives
Cardiovasc Drugs Ther27, 297-307. PubMed Europe PubMed DOI I
Xie,H., Zeng,L., Zeng,S., Lu,X., Zhao,X., Zhang,G., Tu,Z., Xu,H., Yang,L., Zhang,X., Wang,S. and Hu,W.
Highly potent dipeptidyl peptidase IV inhibitors derived from alogliptin through pharmacophore hybridization and lead optimization
Eur J Med Chem68, 312-320. PubMed Europe PubMed DOI I
Zeng,S., Xie,H., Zeng,L.L., Lu,X., Zhao,X., Zhang,G.C., Tu,Z.C., Xu,H.J., Yang,L., Zhang,X.Q. and Hu,W.
Discovery of potent dipeptidyl peptidase IV inhibitors through pharmacophore hybridization and hit-to-lead optimization
Bioorg Med Chem21, 1749-1755. PubMed Europe PubMed DOI I
Zhang,L., Su,M., Li,J., Ji,X., Wang,J., Li,Z., Li,J. and Liu,H.
Design, synthesis, structure-activity relationships, and docking studies of 1-(gamma-1,2,3-triazol substituted prolyl)-(S)-3,3-difluoropyrrolidines as a novel series of potent and selective dipeptidyl peptidase-4 inhibitors
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Zhao,G., Kwon,C., Wang,A., Robertson,J.G., Marcinkeviciene,J., Parker,R.A., Kirby,M.S. and Hamann,L.G.
Substituted piperidinyl glycinyl 2-cyano-4,5-methano pyrrolidines as potent and stable dipeptidyl peptidase IV inhibitors
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An emerging role of dipeptidyl peptidase 4 (DPP4) beyond glucose control: potential implications in cardiovascular disease
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Zhu,L., Li,Y., Qiu,L., Su,M., Wang,X., Xia,C., Qu,Y., Li,J., Li,J., Xiong,B. and Shen,J.
Design and synthesis of 4-(2,4,5-trifluorophenyl)butane-1,3-diamines as dipeptidyl peptidase IV inhibitors
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2012

Aghili,N., Devaney,J.M., Alderman,L.O., Zukowska,Z., Epstein,S.E. and Burnett,M.S.
Polymorphisms in dipeptidyl peptidase IV gene are associated with the risk of myocardial infarction in patients with atherosclerosis
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Davis,J.A., Kumar,P.S., Singh,S., Surender,A., Roy,S., Khanna,V., Sethi,S., Pal,C., Sharma,L., Benjamin,B., Mittra,S., Sattigeri,J. and Bansal,V.S.
Biological evaluation of RBx-0128, a potent and selective dipeptidyl peptidase-IV inhibitor in type 2 diabetes genetic model
Indian J Pharmacol44, 759-764. PubMed Europe PubMed DOI I
De,S. and Banerjee,S.
Structure based design of few substituted piperidones as dipeptidyl peptidase inhibitors
Int J Pharmcy Pharm Sci4, 163-170. I
Derosa,G. and Maffioli,P.
Dipeptidyl peptidase-4 inhibitors: 3 years of experience
Diabetes Technol Ther14, 350-364. PubMed Europe PubMed DOI I
Detel,D., Pugel,E.P., Pucar,L.B., Buljevic,S. and Varljen,J.
Development and resolution of colitis in mice with target deletion of dipeptidyl peptidase IV
Exp Physiol97, 486-496. PubMed Europe PubMed DOI K
Diez-Torrubia,A., Cabrera,S., Lambeir,A.M., Balzarini,J., Camarasa,M.J. and Velazquez,S.
Dipeptidyl peptidase IV (DPPIV/CD26)-based prodrugs of hydroxy-containing drugs
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Fan,H., Tansi,F.L., Weihofen,W.A., Bottcher,C., Hu,J., Martinez,J., Saenger,W. and Reutter,W.
Molecular mechanism and structural basis of interactions of dipeptidyl peptidase IV with adenosine deaminase and human immunodeficiency virus type-1 transcription transactivator
Eur J Cell Biol91, 265-273. PubMed Europe PubMed DOI
Fukuda-Tsuru,S., Anabuki,J., Abe,Y., Yoshida,K. and Ishii,S.
A novel, potent, and long-lasting dipeptidyl peptidase-4 inhibitor, teneligliptin, improves postprandial hyperglycemia and dyslipidemia after single and repeated administrations
Eur J Pharmacol696, 194-202. PubMed Europe PubMed DOI I
Gibbs,J.P., Fredrickson,J., Barbee,T., Correa,I., Smith,B., Lin,S.L. and Gibbs,M.A.
Quantitative model of the relationship between dipeptidyl peptidase-4 (DPP-4) inhibition and response: meta-analysis of alogliptin, saxagliptin, sitagliptin, and vildagliptin efficacy results
J Clin Pharmacol52, 1494-1505. PubMed Europe PubMed DOI I
Guasch,L., Ojeda,M.J., Gonzalez-Abuin,N., Sala,E., Cereto-Massague,A., Mulero,M., Valls,C., Pinent,M., Ardevol,A., Garcia-Vallve,S. and Pujadas,G.
Identification of novel human dipeptidyl peptidase-IV inhibitors of natural origin (part I): virtual screening and activity assays
PLoS ONE7, e44971-e44971. PubMed Europe PubMed DOI I
Guasch,L., Sala,E., Ojeda,M.J., Valls,C., Blade,C., Mulero,M., Blay,M., Ardevol,A., Garcia-Vallve,S. and Pujadas,G.
Identification of novel human dipeptidyl peptidase-IV inhibitors of natural origin (part II): in silico prediction in antidiabetic extracts
PLoS ONE7, e44972-e44972. PubMed Europe PubMed DOI I
Ikuma,Y., Hochigai,H., Kimura,H., Nunami,N., Kobayashi,T., Uchiyama,K., Furuta,Y., Sakai,M., Horiguchi,M., Masui,Y., Okazaki,K., Sato,Y. and Nakahira,H.
Discovery of 3H-imidazo[4,5-c]quinolin-4(5H)-ones as potent and selective dipeptidyl peptidase IV (DPP-4) inhibitors
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Jadav,P., Bahekar,R., Shah,S.R., Patel,D., Joharapurkar,A., Shah,K., Bhardwaj,S., Patel,K., Patel,K., Chopade,R., Shaikh,M., Sairam,K.V.V.M. and Jain,M.
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CD26/DPP-4 inhibition recruits regenerative stem cells via stromal cell-derived factor-1 and beneficially influences ischaemia-reperfusion injury in mouse lung transplantation
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Kim,H.J., Kwak,W.Y., Min,J.P., Sung,S.Y., Kim,H.D., Kim,M.K., Kim,H.S., Park,K.J., Son,M.H., Kim,S.H. and Lee,B.J.
Dipeptidyl peptidase-4 inhibitor with beta-amino amide scaffold: synthesis, SAR and biological evaluation
Bioorg Med Chem Lett22, 5545-5549. PubMed Europe PubMed DOI I
Lam,B., Zhang,Z., Stafford,J.A., Skene,R.J., Shi,L. and Gwaltney,S.L.
Structure-based design of pyridopyrimidinediones as dipeptidyl peptidase IV inhibitors
Bioorg Med Chem Lett22, 6628-6631. PubMed Europe PubMed DOI I
Lasserson,D. and Mant,J.
The role of dipeptidyl peptidase-4 inhibitors
BMJ344, e1213-e1213. PubMed Europe PubMed DOI I
Li,C., Lu,W., Lu,C., Xiao,W., Shen,X., Huang,J., Liu,G. and Tang,Y.
Identification of diverse dipeptidyl peptidase IV inhibitors via structure-based virtual screening
J Mol Model18, 4033-4042. PubMed Europe PubMed DOI I
Liu,W., Yan,M., Liu,Y., McLeish,K.R., Coleman,W.G., Jr. and Rodgers,G.P.
Olfactomedin 4 inhibits cathepsin C-mediated protease activities, thereby modulating neutrophil killing of Staphylococcus aureus and Escherichia coli in mice
J Immunol189, 2460-2467. PubMed Europe PubMed DOI
Liu,X., Zhang,L.N., Feng,Y., Zhang,L., Qu,H., Cao,G.Q. and Leng,Y.
Acute and chronic administration of SHR117887, a novel and specific dipeptidyl peptidase-4 inhibitor, improves metabolic control in diabetic rodent models
Acta Pharmacol Sin33, 1013-1022. PubMed Europe PubMed DOI I
Liu,Y., Hu,Y. and Liu,T.
Recent advances in non-peptidomimetic dipeptidyl peptidase 4 inhibitors: medicinal chemistry and preclinical aspects
Curr Med Chem19, 3982-3999. PubMed Europe PubMed DOI V I
Marchetti,C., Di Carlo,A., Facchiano,F., Senatore,C., De Cristofaro,R., Luzi,A., Federici,M., Romani,M., Napolitano,M., Capogrossi,M.C. and Germani,A.
High mobility group box 1 is a novel substrate of dipeptidyl peptidase-IV
Diabetologia55, 236-244. PubMed Europe PubMed DOI P
Matheeussen,V., Lambeir,A.M., Jungraithmayr,W., Gomez,N., Mc Entee,K., Van der Veken,P., Scharpe,S. and De Meester,I.
Method comparison of dipeptidyl peptidase IV activity assays and their application in biological samples containing reversible inhibitors
Clin Chim Acta413, 456-462. PubMed Europe PubMed DOI A
Misumi,Y. and Ikehara,Y.
Dipeptidyl-peptidase IV
[ISSN:978-0-12-407742-3]3, 3374-3379. DOI
Monami,M., Lamanna,C., Desideri,C.M. and Mannucci,E.
DPP-4 Inhibitors and lipids: systematic review and meta-analysis
Adv Ther29, 14-25. PubMed Europe PubMed DOI I
Nitta,A., Fujii,H., Sakami,S., Satoh,M., Nakaki,J., Satoh,S., Kumagai,H. and Kawai,H.
Novel series of 3-amino-N-(4-aryl-1,1-dioxothian-4-yl)butanamides as potent and selective dipeptidyl peptidase IV inhibitors
Bioorg Med Chem Lett22, 7036-7040. PubMed Europe PubMed DOI I
Pilla,E., Moller,U., Sauer,G., Mattiroli,F., Melchior,F. and Geiss-Friedlander,R.
A novel SUMO1-specific interacting motif in dipeptidyl peptidase 9 (DPP9) that is important for enzymatic regulation
J Biol Chem287, 44320-44329. PubMed Europe PubMed DOI
Sharma,M., Gupta,M., Singh,D., Kumar,M. and Kaur,P.
Synthesis, evaluation and molecular docking of thiazolopyrimidine derivatives as dipeptidyl peptidase IV inhibitors
Chem Biol Drug Des80, 918-928. PubMed Europe PubMed DOI I
Song,J.S., Lee,K.R., Kwon,H.J., Rhee,S.D., Kim,M.S., Choi,S.H., Lee,S.H., Song,I.S., Ahn,J.H., Ahn,S.H. and Bae,M.A.
Pharmacokinetics and pharmacodynamics of KR-66223, a novel DPP-4 inhibitor
Drug Metab Pharmacokinet27, 216-222. PubMed Europe PubMed DOI I
Wu,D., Jin,F., Lu,W., Zhu,J., Li,C., Wang,W., Tang,Y., Jiang,H., Huang,J., Liu,G. and Li,J.
Synthesis, structure-activity relationship, and pharmacophore modeling studies of pyrazole-3-carbohydrazone derivatives as dipeptidyl peptidase IV inhibitors
Chem Biol Drug Des79, 897-906. PubMed Europe PubMed DOI I
Wu,W., Liu,Y., Milo,L.J., Jr., Shu,Y., Zhao,P., Li,Y., Woznica,I., Yu,G., Sanford,D.G., Zhou,Y., Poplawski,S.E., Connolly,B.A., Sudmeier,J.L., Bachovchin,W.W. and Lai,J.H.
4-Substituted boro-proline dipeptides: synthesis, characterization, and dipeptidyl peptidase IV, 8, and 9 activities
Bioorg Med Chem Lett22, 5536-5540. PubMed Europe PubMed DOI I
Xie,H., Zeng,L., Zeng,S., Lu,X., Zhang,G., Zhao,X., Cheng,N., Tu,Z., Li,Z., Xu,H., Yang,L., Zhang,X., Huang,M., Zhao,J. and Hu,W.
Novel pyrrolopyrimidine analogues as potent dipeptidyl peptidase IV inhibitors based on pharmacokinetic property-driven optimization
Eur J Med Chem52, 205-212. PubMed Europe PubMed DOI I
Yoshida,T., Akahoshi,F., Sakashita,H., Kitajima,H., Nakamura,M., Sonda,S., Takeuchi,M., Tanaka,Y., Ueda,N., Sekiguchi,S., Ishige,T., Shima,K., Nabeno,M., Abe,Y., Anabuki,J., Soejima,A., Yoshida,K., Takashina,Y., Ishii,S., Kiuchi,S., Fukuda,S., Tsutsumiuchi,R., Kosaka,K., Murozono,T., Nakamaru,Y., Utsumi,H., Masutomi,N., Kishida,H., Miyaguchi,I. and Hayashi,Y.
Discovery and preclinical profile of teneligliptin (3-[(2S,4S)-4-[4-(3-methyl-1-phenyl-1H-pyrazol-5-yl)piperazin-1-yl]pyrrolidin-2-ylcarbonyl]thiazolidine): a highly potent, selective, long-lasting and orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
Bioorg Med Chem20, 5705-5719. PubMed Europe PubMed DOI I
Yoshida,T., Akahoshi,F., Sakashita,H., Sonda,S., Takeuchi,M., Tanaka,Y., Nabeno,M., Kishida,H., Miyaguchi,I. and Hayashi,Y.
Fused bicyclic heteroarylpiperazine-substituted l-prolylthiazolidines as highly potent DPP-4 inhibitors lacking the electrophilic nitrile group
Bioorg Med Chem20, 5033-5041. PubMed Europe PubMed DOI S I
Zhang,X., Wang,J., Su,M., Li,Z., Li,J., Li,J. and Liu,H.
Discovering novel alpha-aminoacyl-containing proline derivatives with potent and selective inhibitory activity against dipeptidyl peptidase IV: design, synthesis, biological evaluation, and molecular modeling
Chem Biol Drug Des80, 843-852. PubMed Europe PubMed DOI I

2011

Ahn,H.J., Kim,K.B., Liu,K.H., Shin,J.G., Ahn,J.H., Kim,M.S., Bae,M.A. and Song,I.S.
In vitro metabolism and transport of the new dipeptidyl peptidase 4 inhibitors, KR66222 and KR66223
Xenobiotica41, 445-455. PubMed Europe PubMed DOI I
Ahren,B.
Inhibition of dipeptidyl peptidase-4 (DPP-4): a target to treat type 2 diabetes
Curr Enzyme Inhib7, 205-217. DOI I
Andrews,K.M., Beebe,D.A., Benbow,J.W., Boyer,D.A., Doran,S.D., Hui,Y., Liu,S., McPherson,R.K., Neagu,C., Parker,J.C., Piotrowski,D.W., Schneider,S.R., Treadway,J.L., Vanvolkenberg,M.A. and Zembrowski,W.J.
1-((3S,4S)-4-Amino-1-(4-substituted-1,3,5-triazin-2-yl) pyrrolidin-3-yl)-5,5-difluoropiperidin-2-one inhibitors of DPP-4 for the treatment of type 2 diabetes
Bioorg Med Chem Lett21, 1810-1814. PubMed Europe PubMed DOI I
Ansorge,S., Nordhoff,K., Bank,U., Heimburg,A., Julius,H., Breyer,D., Thielitz,A., Reinhold,D. and Tager,M.
Novel aspects of cellular action of dipeptidyl peptidase IV/CD26
Biol Chem392, 153-168. PubMed Europe PubMed DOI
Banno,Y., Miyamoto,Y., Sasaki,M., Oi,S., Asakawa,T., Kataoka,O., Takeuchi,K., Suzuki,N., Ikedo,K., Kosaka,T., Tsubotani,S., Tani,A., Funami,M., Tawada,M., Yamamoto,Y., Aertgeerts,K., Yano,J. and Maezaki,H.
Identification of 3-aminomethyl-1,2-dihydro-4-phenyl-1-isoquinolones: a new class of potent, selective, and orally active non-peptide dipeptidyl peptidase IV inhibitors that form a unique interaction with Lys554
Bioorg Med Chem19, 4953-4970. PubMed Europe PubMed DOI S I
Cao,G.Y., Li,X.C., Zhao,N., Liu,Q. and Hu,X.
Dipeptidyl peptidase IV inhibitors for the treatment of type 2 diabetes
Chin J New Drugs20, 497-502. I
Chen,S.J. and Jiaang,W.T.
Current advances and therapeutic potential of agents targeting dipeptidyl peptidases-IV, -II, 8/9 and fibroblast activation protein
Curr Top Med Chem11, 1447-1463. PubMed Europe PubMed DOI I
Cho,J.M., Jang,H.W., Cheon,H., Jeong,Y.T., Kim,D.H., Lim,Y.M., Choi,S.H., Yang,E.K., Shin,C.Y., Son,M.H., Kim,S.H., Kim,H.J. and Lee,M.S.
A novel dipeptidyl peptidase IV inhibitor DA-1229 ameliorates streptozotocin-induced diabetes by increasing beta-cell replication and neogenesis
Diabetes Res Clin Pract91, 72-79. PubMed Europe PubMed DOI I
Deng,J., Peng,L., Zhang,G., Lan,X., Li,C., Chen,F., Zhou,Y., Lin,Z., Chen,L., Dai,R., Xu,H., Yang,L., Zhang,X. and Hu,W.
The highly potent and selective dipeptidyl peptidase IV inhibitors bearing a thienopyrimidine scaffold effectively treat type 2 diabetes
Eur J Med Chem46, 71-76. PubMed Europe PubMed DOI I
Huber,B.C., Brunner,S., Segeth,A., Nathan,P., Fischer,R., Zaruba,M.M., Vallaster,M., Theiss,H.D., David,R., Gerbitz,A. and Franz,W.M.
Parathyroid hormone is a DPP-IV inhibitor and increases SDF-1-driven homing of CXCR4(+) stem cells into the ischaemic heart
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Kato,N., Oka,M., Murase,T., Yoshida,M., Sakairi,M., Yakufu,M., Yamashita,S., Yasuda,Y., Yoshikawa,A., Hayashi,Y., Shirai,M., Mizuno,Y., Takeuchi,M., Makino,M., Takeda,M. and Kakigami,T.
Synthesis and pharmacological characterization of potent, selective, and orally bioavailable isoindoline class dipeptidyl peptidase IV inhibitors
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Kato,N., Oka,M., Murase,T., Yoshida,M., Sakairi,M., Yamashita,S., Yasuda,Y., Yoshikawa,A., Hayashi,Y., Makino,M., Takeda,M., Mirensha,Y. and Kakigami,T.
Discovery and pharmacological characterization of N-[2-({2-[(2S)-2-cyanopyrrolidin-1-yl]-2-oxoethyl}amino)-2-methylpropyl]-2-methylpyrazolo[1,5-a]pyrimidine-6-carboxamide hydrochloride (anagliptin hydrochloride salt) as a potent and selective DPP-IV inhibitor
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Kidd,S., Bueso-Ramos,C., Jagan,S., Paganessi,L.A., Boggio,L.N., Fung,H.C., Gregory,S.A. and Christopherson,K.W.
In Vivo expansion of the megakaryocyte progenitor cell population in adult CD26-deficient mice
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Kim,H.J., Kwak,W.Y., Min,J.P., Lee,J.Y., Yoon,T.H., Kim,H.D., Shin,C.Y., Kim,M.K., Choi,S.H., Kim,H.S., Yang,E.K., Cheong,Y.H., Chae,Y.N., Park,K.J., Jang,J.M., Choi,S.J., Son,M.H., Kim,S.H., Yoo,M. and Lee,B.J.
Discovery of DA-1229: A potent, long acting dipeptidyl peptidase-4 inhibitor for the treatment of type 2 diabetes
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Ku,H.C., Chen,W.P. and Su,M.J.
DPP4 deficiency preserves cardiac function via GLP-1 signaling in rats subjected to myocardial ischemia/reperfusion
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Kuhn-Wache,K., Bar,J.W., Hoffmann,T., Wolf,R., Rahfeld,J.U. and Demuth,H.U.
Selective inhibition of dipeptidyl peptidase 4 by targeting a substrate-specific secondary binding site
Biol Chem392, 223-231. PubMed Europe PubMed DOI P I
Li,C., Shen,J., Li,W., Lu,C., Liu,G. and Tang,Y.
Possible ligand release pathway of dipeptidyl peptidase IV investigated by molecular dynamics simulations
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Maezaki,H., Banno,Y., Miyamoto,Y., Moritou,Y., Asakawa,T., Kataoka,O., Takeuchi,K., Suzuki,N., Ikedo,K., Kosaka,T., Sasaki,M., Tsubotani,S., Tani,A., Funami,M., Yamamoto,Y., Tawada,M., Aertgeerts,K., Yano,J. and Oi,S.
Discovery of potent, selective, and orally bioavailable quinoline-based dipeptidyl peptidase IV inhibitors targeting Lys554
Bioorg Med Chem19, 4482-4498. PubMed Europe PubMed DOI I
Matteucci,E. and Giampietro,O.
Dipeptidyl peptidase-4 inhibition: linking chemical properties to clinical safety
Curr Med Chem18, 4753-4760. PubMed Europe PubMed DOI I
Mendieta,L., Tarrago,T. and Giralt,E.
Recent patents of dipeptidyl peptidase IV inhibitors
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Miyamoto,Y., Banno,Y., Yamashita,T., Fujimoto,T., Oi,S., Moritoh,Y., Asakawa,T., Kataoka,O., Yashiro,H., Takeuchi,K., Suzuki,N., Ikedo,K., Kosaka,T., Tsubotani,S., Tani,A., Sasaki,M., Funami,M., Amano,M., Yamamoto,Y., Aertgeerts,K., Yano,J. and Maezaki,H.
Discovery of a 3-pyridylacetic acid derivative (TAK-100) as a potent, selective and orally active dipeptidyl peptidase IV (DPP-4) inhibitor
J Med Chem54, 831-850. PubMed Europe PubMed DOI I
Miyamoto,Y., Banno,Y., Yamashita,T., Fujimoto,T., Oi,S., Moritoh,Y., Asakawa,T., Kataoka,O., Takeuchi,K., Suzuki,N., Ikedo,K., Kosaka,T., Tsubotani,S., Tani,A., Funami,M., Amano,M., Yamamoto,Y., Aertgeerts,K., Yano,J. and Maezaki,H.
Design and synthesis of 3-pyridylacetamide derivatives as dipeptidyl peptidase IV (DPP-4) inhibitors targeting a bidentate interaction with Arg125
Bioorg Med Chem19, 172-185. PubMed Europe PubMed DOI I
Motoshima,K., Sugita,K., Hashimoto,Y. and Ishikawa,M.
Non-competitive and selective dipeptidyl peptidase IV inhibitors with phenethylphenylphthalimide skeleton derived from thalidomide-related alpha-glucosidase inhibitors and liver X receptor antagonists
Bioorg Med Chem Lett21, 3041-3045. PubMed Europe PubMed DOI I
Murugesan,V., Sethi,N., Prabhakar,Y.S. and Katti,S.B.
CoMFA and CoMSIA of diverse pyrrolidine analogues as dipeptidyl peptidase IV inhibitors: active site requirements
Mol Divers15, 457-466. PubMed Europe PubMed DOI I
Nishio,Y., Kimura,H., Sawada,N., Sugaru,E., Horiguchi,M., Ono,M., Furuta,Y., Sakai,M., Masui,Y., Otani,M., Hashizuka,T., Honda,Y., Deguchi,J., Nakagawa,T. and Nakahira,H.
2-({6-[(3R)-3-amino-3-methylpiperidine-1-yl]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-5H-pyrrolo[3,2-d]pyrimidine-5-yl}methyl)-4-fluorobenzonitrile (DSR-12727): A potent, orally active dipeptidyl peptidase IV inhibitor without mechanism-based inactivation of CYP3A
Bioorg Med Chem19, 5490-5499. PubMed Europe PubMed DOI I
Ohnuma,K., Hosono,O., Dang,N.H. and Morimoto,C.
Dipeptidyl peptidase in autoimmune pathophysiology
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Paliwal,S., Seth,D., Yadav,D., Yadav,R. and Paliwal,S.
Development of a robust QSAR model to predict the affinity of pyrrolidine analogs for dipeptidyl peptidase IV (DPP- IV)
J Enzyme Inhib Med Chem26, 129-140. PubMed Europe PubMed DOI I
Park,W.S., Kang,S.K., Jun,M.A., Shin,M.S., Kim,K.Y., Rhee,S.D., Bae,M.A., Kim,M.S., Kim,K.R., Kang,N.S., Yoo,S.E., Lee,J.O., Song,D.H., Silinski,P., Schneider,S.E., Ahn,J.H. and Kim,S.S.
Discovery of beta-aminoacyl containing thiazolidine derivatives as potent and selective dipeptidyl peptidase IV inhibitors
Bioorg Med Chem Lett21, 1366-1370. PubMed Europe PubMed DOI I
Pascual,I., Gomez,H., Pons,T., Chappe,M., Vargas,M.A., Valdes,G., Lopez,A., Saroyan,A., Charli,J.L. and de Los Angeles Chavez,M.
Effect of divalent cations on the porcine kidney cortex membrane-bound form of dipeptidyl peptidase IV
Int J Biochem Cell Biol43, 363-371. PubMed Europe PubMed DOI
Shah,Z., Kampfrath,T., Deiuliis,J.A., Zhong,J., Pineda,C., Ying,Z., Xu,X., Lu,B., Moffatt-Bruce,S., Durairaj,R., Sun,Q., Mihai,G., Maiseyeu,A. and Rajagopalan,S.
Long-term dipeptidyl-peptidase 4 inhibition reduces atherosclerosis and inflammation via effects on monocyte recruitment and chemotaxis
Circulation124, 2338-2349. PubMed Europe PubMed DOI I
Shan,Z., Peng,M., Fan,H., Lu,Q., Lu,P., Zhao,C. and Chen,Y.
Discovery of potent dipeptidyl peptidase IV inhibitors derived from beta-aminoamides bearing substituted [1,2,3]-triazolopiperidines for the treatment of type 2 diabetes
Bioorg Med Chem Lett21, 1731-1735. PubMed Europe PubMed DOI I
Singh,S., Roy,S., Sethi,S., Benjamin,B., Sundaram,S., Khanna,V., Kandalkar,S.R., Pal,C., Kant,R., Patra,A.K., Rayasam,G., Mittra,S., Saini,K.S., Paliwal,J., Chugh,A., Ahmed,S., Sattigeri,J., Cliff,I., Ray,A., Bansal,V.S., Bhatnagar,P.K. and Davis,J.A.
RBx-0597, a potent, selective and slow-binding inhibitor of dipeptidyl peptidase-IV for the treatment of type 2 diabetes
Eur J Pharmacol652, 157-163. PubMed Europe PubMed DOI I
Tajima,A., Yamamoto,K., Kozakai,A., Okumura-Kitajima,L., Mita,Y., Kitano,K., Jingu,S. and Nakaike,S.
(2S,4S)-4-Fluoro-1-{[(2-hydroxy-1,1-dimethylethyl)amino]acetyl}-pyrrolidine-2-carbonitrile monobenzenesulfonate (TS-021) is a selective and reversible dipeptidyl peptidase IV inhibitor
Eur J Pharmacol655, 99-107. PubMed Europe PubMed DOI I
Tang,H.K., Chen,K.C., Liou,G.G., Cheng,S.C., Chien,C.H., Tang,H.Y., Huang,L.H., Chang,H.P., Chou,C.Y. and Chen,X.
Role of a propeller loop in the quaternary structure and enzymatic activity of prolyl dipeptidases DPP-IV and DPP9
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Wagner,L., Wermann,M., Rosche,F., Rahfeld,J.U., Hoffmann,T. and Demuth,H.U.
Isolation of dipeptidyl peptidase IV (DP 4) isoforms from porcine kidney by preparative isoelectric focusing to improve crystallization
Biol Chem392, 665-677. PubMed Europe PubMed DOI
Yang,W., Xia,W., Mao,J., Xu,D., Chen,J., Feng,S., Wang,J., Li,H., Theisen,C.F., Petersen,J.M., Thorolfsson,M., Rasmussen,H.B., Junker,F., Boel,E. and Su,J.
High level expression, purification and activation of human dipeptidyl peptidase I from mammalian cells
Protein Expr Purif76, 59-64. PubMed Europe PubMed DOI E
Zhang,Z., Wallace,M.B., Feng,J., Stafford,J.A., Skene,R.J., Shi,L., Lee,B., Aertgeerts,K., Jennings,A., Xu,R., Kassel,D.B., Kaldor,S.W., Navre,M., Webb,D.R. and Gwaltney,S.L.
Design and synthesis of pyrimidinone and pyrimidinedione inhibitors of dipeptidyl peptidase IV
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2010

Boehringer,M., Fischer,H., Hennig,M., Hunziker,D., Huwyler,J., Kuhn,B., Loeffler,B.M., Luebbers,T., Mattei,P., Narquizian,R., Sebokova,E., Sprecher,U. and Wessel,H.P.
Aryl- and heteroaryl-substituted aminobenzo[a]quinolizines as dipeptidyl peptidase IV inhibitors
Bioorg Med Chem Lett20, 1106-1108. PubMed Europe PubMed DOI I
Brigance,R.P., Meng,W., Fura,A., Harrity,T., Wang,A., Zahler,R., Kirby,M.S. and Hamann,L.G.
Synthesis and SAR of azolopyrimidines as potent and selective dipeptidyl peptidase-4 (DPP4) inhibitors for type 2 diabetes
Bioorg Med Chem Lett20, 4395-4398. PubMed Europe PubMed DOI I
Cho,T.P., Long,Y.F., Gang,L.Z., Yang,W., Jun,L.H., Yuan,S.G., Hong,F.J., Lin,W., Liang,G.D., Lei,Z., Jing,L.J., Shen,G.A., Hong,S.G., Dan,W., Ying,F., Ke,Y.P., Ying,L., Jun,F. and Tai,M.X.
Synthesis and biological evaluation of azobicyclo[3.3.0] octane derivatives as dipeptidyl peptidase 4 inhibitors for the treatment of type 2 diabetes
Bioorg Med Chem Lett20, 3565-3568. PubMed Europe PubMed DOI I
Cho,T.P., Gang,L.Z., Long,Y.F., Yang,W., Qian,W., Lei,Z., Jing,L.J., Ying,F., Ke,Y.P., Ying,L. and Jun,F.
Synthesis and biological evaluation of bicyclo[3.3.0] octane derivatives as dipeptidyl peptidase 4 inhibitors for the treatment of type 2 diabetes
Bioorg Med Chem Lett20, 3521-3525. PubMed Europe PubMed DOI I
Chung,K.M., Cheng,J.H., Suen,C.S., Huang,C.H., Tsai,C.H., Huang,L.H., Chen,Y.R., Wang,A.H., Jiaang,W.T., Hwang,M.J. and Chen,X.
The dimeric transmembrane domain of prolyl dipeptidase DPP-IV contributes to its quaternary structure and enzymatic activities
Protein Sci19, 1627-1638. PubMed Europe PubMed DOI
Deacon,C.F. and Holst,J.J.
Linagliptin, a xanthine-based dipeptidyl peptidase-4 inhibitor with an unusual profile for the treatment of type 2 diabetes
Expert Opin Investig Drugs19, 133-140. PubMed Europe PubMed DOI I
Furuta,Y., Horiguchi,M., Sugaru,E., Ono-Kishino,M., Otani,M., Sakai,M., Masui,Y., Tsuchida,A., Sato,Y., Takubo,K., Hochigai,H., Kimura,H., Nakahira,H., Nakagawa,T. and Taiji,M.
Chronic administration of DSP-7238, a novel, potent, specific and substrate-selective DPP IV inhibitor, improves glycaemic control and beta-cell damage in diabetic mice
Diabetes Obes Metab12, 421-430. PubMed Europe PubMed DOI I
Haddley,K.
Dutogliptin tartrate: dipeptidyl peptidase 4 inhibitor treatment of diabetes
Drugs Future35, 529-535. DOI I
Han,B., Huan,Y., Lin,Z.Y., Li,P., Shen,Z.F., Yin,D.L. and Huang,H.H.
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Yao Xue Xue Bao45, 1379-1384. PubMed Europe PubMed I
Jang,S., Chung,T.Y., Shin,J., Lin,K.L., Tzen,J.T. and Li,F.Y.
Docking study of the precursor peptide of mastoparan onto its putative processing enzyme, dipeptidyl peptidase IV: a revisit to molecular ticketing
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Jiang,Y.K.
Molecular docking and 3D-QSAR studies on beta-phenylalanine derivatives as dipeptidyl peptidase IV inhibitors
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Johnson,K.M.
Dutogliptin, a dipeptidyl peptidase-4 inhibitor for the treatment of type 2 diabetes mellitus
Curr Opin Investig Drugs11, 455-463. PubMed Europe PubMed I
Kawaguchi,M., Okabe,T., Terai,T., Hanaoka,K., Kojima,H., Minegishi,I. and Nagano,T.
A time-resolved fluorescence probe for dipeptidyl peptidase 4 and its application in inhibitor screening
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Kichik,N., Tarrago,T. and Giralt,E.
Simultaneous (19)F NMR screening of prolyl oligopeptidase and dipeptidyl peptidase IV inhibitors
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Kirby,M., Yu,D.M., O'Connor,S. and Gorrell,M.D.
Inhibitor selectivity in the clinical application of dipeptidyl peptidase-4 inhibition
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Lin,C.T., Tang,H.Y., Han,Y.S., Liu,H.P., Huang,S.F., Chien,C.H., Shyy,J., Chiu,J.J. and Chen,X.
Downregulation of signaling-active IGF-1 by dipeptidyl peptidase IV (DPP-IV)
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Peptidomics of the prolyl peptidases
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Mattei,P., Boehringer,M., Di Giorgio,P., Fischer,H., Hennig,M., Huwyler,J., Kocer,B., Kuhn,B., Loeffler,B.M., Macdonald,A., Narquizian,R., Rauber,E., Sebokova,E. and Sprecher,U.
Discovery of carmegliptin: a potent and long-acting dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
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2008

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ASP4,000, a novel, selective, dipeptidyl peptidase 4 inhibitor with antihyperglycemic activity
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Thomas,L., Eckhardt,M., Langkopf,E., Tadayyon,M., Himmelsbach,F. and Mark,M.
(R)-8-(3-Amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione (BI 1356), a novel xanthine-based dipeptidyl peptidase 4 inhibitor, has a superior potency and longer duration of action compared with other dipeptidyl peptidase-4 inhibitors
J Pharmacol Exp Ther325, 175-182. PubMed Europe PubMed DOI I
Tsai,H.J., Chou,S.Y., Chuang,S.H., Chen,C.C. and Hsu,F.L.
D-420720, a novel orally active sulfonamide compound dipeptidyl peptidase IV inhibitor: structure and activity relationship of arylsulfonamide to dipeptidyl peptidase IV inhibition
Drug Dev Res69, 514-519. DOI I
Venkatesham,A., Krishna,D.R. and Reddy,Y.N.
Dipeptidyl peptidase-IV (DPP-IV) inhibitory activity of metformin
Pharmacologyonline2, 372-378. I
Wallace,M.B., Feng,J., Zhang,Z., Skene,R.J., Shi,L., Caster,C.L., Kassel,D.B., Xu,R. and Gwaltney,S.L.
Structure-based design and synthesis of benzimidazole derivatives as dipeptidyl peptidase IV inhibitors
Bioorg Med Chem Lett18, 2362-2367. PubMed Europe PubMed DOI I
Wang,Y., Serradell,N., Rosa,E. and Bolos,J.
Alogliptin benzoate. Dipeptidyl-peptidase IV (DPP IV) inhibitor treatment of type 2 diabetes
Drugs Future33, 7-12. DOI I
Wani,J.H., John-Kalarickal,J. and Fonseca,V.A.
Dipeptidyl peptidase-4 as a new target of action for type 2 diabetes mellitus: a systematic review
Cardiol Clin26, 639-648. PubMed Europe PubMed DOI V I

2007

Ahn,J.H., Shin,M.S., Jun,M.A., Jung,S.H., Kang,S.K., Kim,K.R., Rhee,S.D., Kang,N.S., Kim,S.Y., Sohn,S.K., Kim,S.G., Jin,M.S., Lee,J.O., Cheon,H.G. and Kim,S.S.
Synthesis, biological evaluation and structural determination of beta-aminoacyl-containing cyclic hydrazine derivatives as dipeptidyl peptidase IV (DPP-IV) inhibitors
Bioorg Med Chem Lett17, 2622-2628. PubMed Europe PubMed DOI I
Backes,B.J., Longenecker,K., Hamilton,G.L., Stewart,K., Lai,C., Kopecka,H., von Geldern,T.W., Madar,D.J., Pei,Z., Lubben,T.H., Zinker,B.A., Tian,Z., Ballaron,S.J., Stashko,M.A., Mika,A.K., Beno,D.W., Kempf-Grote,A.J., Black-Schaefer,C., Sham,H.L. and Trevillyan,J.M.
Pyrrolidine-constrained phenethylamines: the design of potent, selective, and pharmacologically efficacious dipeptidyl peptidase IV (DPP4) inhibitors from a lead-like screening hit
Bioorg Med Chem Lett17, 2005-2012. PubMed Europe PubMed DOI I
Biftu,T., Scapin,G., Singh,S., Feng,D., Becker,J.W., Eiermann,G., He,H., Lyons,K., Patel,S., Petrov,A., Sinha-Roy,R., Zhang,B., Wu,J., Zhang,X., Doss,G.A., Thornberry,N.A. and Weber,A.E.
Rational design of a novel, potent, and orally bioavailable cyclohexylamine DPP-4 inhibitor by application of molecular modeling and X-ray crystallography of sitagliptin
Bioorg Med Chem Lett17, 3384-3387. PubMed Europe PubMed DOI S I
Biftu,T., Feng,D., Qian,X., Liang,G.B., Kieczykowski,G., Eiermann,G., He,H., Leiting,B., Lyons,K., Petrov,A., Sinha-Roy,R., Zhang,B., Scapin,G., Patel,S., Gao,Y.D., Singh,S., Wu,J., Zhang,X., Thornberry,N.A. and Weber,A.E.
(3R)-4-[(3R)-3-Amino-4-(2,4,5-trifluorophenyl)butanoyl]-3-(2,2,2-trifluoro ethyl)-1,4-diazepan-2-one, a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
Bioorg Med Chem Lett17, 49-52. PubMed Europe PubMed DOI I
Campbell,R.K.
Rationale for dipeptidyl peptidase 4 inhibitors: a new class of oral agents for the treatment of type 2 diabetes mellitus
Ann Pharmacother41, 51-60. PubMed Europe PubMed DOI V I
Chahal,H. and Chowdhury,T.A.
Gliptins: a new class of oral hypoglycaemic agent
QJM100, 671-677. PubMed Europe PubMed DOI I
Chen,P., Caldwell,C.G., Mathvink,R.J., Leiting,B., Marsilio,F., Patel,R.A., Wu,J.K., He,H., Lyons,K.A., Thornberry,N.A. and Weber,A.E.
Imidazopiperidine amides as dipeptidyl peptidase IV inhibitors for the treatment of diabetes
Bioorg Med Chem Lett17, 5853-5857. PubMed Europe PubMed DOI I
Corbett,J.W., Dirico,K., Song,W., Boscoe,B.P., Doran,S.D., Boyer,D., Qiu,X., Ammirati,M., VanVolkenburg,M.A., McPherson,R.K., Parker,J.C. and Cox,E.D.
Design and synthesis of potent amido- and benzyl-substituted cis-3-amino-4-(2-cyanopyrrolidide)pyrrolidinyl DPP-IV inhibitors
Bioorg Med Chem Lett17, 6707-6713. PubMed Europe PubMed DOI S I
Cox,J.M., Harper,B., Mastracchio,A., Leiting,B., Sinha Roy,R., Patel,R.A., Wu,J.K., Lyons,K.A., He,H., Xu,S., Zhu,B., Thornberry,N.A., Weber,A.E. and Edmondson,S.D.
Discovery of 3-aminopiperidines as potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitors
Bioorg Med Chem Lett17, 4579-4583. PubMed Europe PubMed DOI I
Davoodi,J., Kelly,J., Gendron,N.H. and MacKenzie,A.E.
The Simpson-Golabi-Behmel syndrome causative glypican-3, binds to and inhibits the dipeptidyl peptidase activity of CD26
Proteomics7, 2300-2310. PubMed Europe PubMed DOI
Deacon,C.F.
Dipeptidyl peptidase 4 inhibition with sitagliptin: a new therapy for Type 2 diabetes
Expert Opin Investig Drugs16, 533-545. PubMed Europe PubMed DOI I
Duffy,J.L., Kirk,B.A., Wang,L., Eiermann,G.J., He,H., Leiting,B., Lyons,K.A., Patel,R.A., Patel,S.B., Petrov,A., Scapin,G., Wu,J.K., Thornberry,N.A. and Weber,A.E.
4-Aminophenylalanine and 4-aminocyclohexylalanine derivatives as potent, selective, and orally bioavailable inhibitors of dipeptidyl peptidase IV
Bioorg Med Chem Lett17, 2879-2885. PubMed Europe PubMed DOI S I
Duffy,N.A., Green,B.D., Irwin,N., Gault,V.A., McKillop,A.M., O'Harte,F.P. and Flatt,P.R.
Effects of antidiabetic drugs on dipeptidyl peptidase IV activity: nateglinide is an inhibitor of DPP IV and augments the antidiabetic activity of glucagon-like peptide-1
Eur J Pharmacol568, 278-286. PubMed Europe PubMed DOI I
Eckhardt,M., Langkopf,E., Mark,M., Tadayyon,M., Thomas,L., Nar,H., Pfrengle,W., Guth,B., Lotz,R., Sieger,P., Fuchs,H. and Himmelsbach,F.
8-(3-(R)-Aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin -2-ylmethyl)-3,7-dihydropurine-2,6-dione (BI 1356), a highly potent, selective, long-acting, and orally bioavailable DPP-4 inhibitor for the treatment of type 2 diabetes
J Med Chem50, 6450-6453. PubMed Europe PubMed DOI S I
Epstein,B.J.
Drug evaluation: PSN-9301, a short-acting inhibitor of dipeptidyl peptidase IV
Curr Opin Investig Drugs8, 331-337. PubMed Europe PubMed I
Ferraris,D., Belyakov,S., Li,W., Oliver,E., Ko,Y.S., Calvin,D., Lautar,S., Thomas,B. and Rojas,C.
Azetidine-based inhibitors of dipeptidyl peptidase IV (DPP IV)
Curr Top Med Chem7, 597-608. PubMed Europe PubMed DOI I
Frerker,N., Wagner,L., Wolf,R., Heiser,U., Hoffmann,T., Rahfeld,J.U., Schade,J., Karl,T., Naim,H.Y., Alfalah,M., Demuth,H.U. and von Horsten,S.
Neuropeptide Y (NPY) cleaving enzymes: structural and functional homologues of dipeptidyl peptidase 4
Peptides28, 257-268. PubMed Europe PubMed DOI
Garcia-Aparicio,C., Diez-Torrubia,A., Balzarini,J., Lambeir,A.M., Velazquez,S. and Camarasa,M.J.
Efficient conversion of tetrapeptide-based TSAO prodrugs to the parent drug by dipeptidyl-peptidase IV (DPPIV/CD26)
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He,Y.L., Sabo,R., Campestrini,J., Wang,Y., Ligueros-Saylan,M., Lasseter,K.C., Dilzer,S.C., Howard,D. and Dole,W.P.
The influence of hepatic impairment on the pharmacokinetics of the dipeptidyl peptidase IV (DPP-4) inhibitor vildagliptin
Eur J Clin Pharmacol63, 677-686. PubMed Europe PubMed DOI I
Hiramatsu,H., Kyono,K., Yamamoto,A., Saeki,K., Shima,H., Sugiyama,S., Inaka,K. and Shimizu,R.
Crystal structures of human dipeptidyl peptidase IV in its apo and diprotin B-complexed forms
Acta Biochim Biophys Sin (Shanghai)39, 335-343. PubMed Europe PubMed DOI S I
Idris,I. and Donnelly,R.
Dipeptidyl peptidase-IV inhibitors: a major new class of oral antidiabetic drug
Diabetes Obes Metab9, 153-165. PubMed Europe PubMed DOI I
Jackson,E.K., Zhang,M., Liu,W. and Mi,Z.
Inhibition of renal dipeptidyl peptidase IV enhances peptide YY1-36-induced potentiation of angiotensin II-mediated renal vasoconstriction in spontaneously hypertensive rats
J Pharmacol Exp Ther323, 431-437. PubMed Europe PubMed DOI
Kaelin,D.E., Smenton,A.L., Eiermann,G.J., He,H., Leiting,B., Lyons,K.A., Patel,R.A., Patel,S.B., Petrov,A., Scapin,G., Wu,J.K., Thornberry,N.A., Weber,A.E. and Duffy,J.L.
4-Arylcyclohexylalanine analogs as potent, selective, and orally active inhibitors of dipeptidyl peptidase IV
Bioorg Med Chem Lett17, 5806-5811. PubMed Europe PubMed DOI I
Kondo,T., Nekado,T., Sugimoto,I., Ochi,K., Takai,S., Kinoshita,A., Tajima,Y., Yamamoto,S., Kawabata,K., Nakai,H. and Toda,M.
Design and synthesis of new potent dipeptidyl peptidase IV inhibitors with enhanced ex vivo duration
Bioorg Med Chem15, 2631-2650. PubMed Europe PubMed DOI I
Kondo,T., Sugimoto,I., Nekado,T., Ochi,K., Ohtani,T., Tajima,Y., Yamamoto,S., Kawabata,K., Nakai,H. and Toda,M.
Design and synthesis of long-acting inhibitors of dipeptidyl peptidase IV
Bioorg Med Chem15, 2715-2735. PubMed Europe PubMed DOI I
Koo,K.D., Kim,M.J., Kim,S., Kim,K.H., Hong,S.Y., Hur,G.C., Yim,H.J., Kim,G.T., Han,H.O., Kwon,O.H., Kwon,T.S., Koh,J.S. and Lee,C.S.
Synthesis, SAR, and X-ray structure of novel potent DPPIV inhibitors: oxadiazolyl ketones
Bioorg Med Chem Lett17, 4167-4172. PubMed Europe PubMed DOI S I
Kowalchick,J.E., Leiting,B., Pryor,K.D., Marsilio,F., Wu,J.K., He,H., Lyons,K.A., Eiermann,G.J., Petrov,A., Scapin,G., Patel,R.A., Thornberry,N.A., Weber,A.E. and Kim,D.
Design, synthesis, and biological evaluation of triazolopiperazine-based beta-amino amides as potent, orally active dipeptidyl peptidase IV (DPP-4) inhibitors
Bioorg Med Chem Lett17, 5934-5939. PubMed Europe PubMed DOI S I
Kuhn,B., Hennig,M. and Mattei,P.
Molecular recognition of ligands in dipeptidyl peptidase IV
Curr Top Med Chem7, 609-619. PubMed Europe PubMed DOI V
Lai,J.H., Wu,W., Zhou,Y., Maw,H.H., Liu,Y., Milo,L.J., Jr., Poplawski,S.E., Henry,G.D., Sudmeier,J.L., Sanford,D.G. and Bachovchin,W.W.
Synthesis and characterization of constrained peptidomimetic dipeptidyl peptidase IV inhibitors: amino-lactam boroalanines
J Med Chem50, 2391-2398. PubMed Europe PubMed DOI I
Lai,K.S., Ho,N.H., Cheng,J.D. and Tung,C.H.
Selective fluorescence probes for dipeptidyl peptidase activity - fibroblast activation protein and dipeptidyl peptidase IV
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Liang,G.B., Qian,X., Feng,D., Biftu,T., Eiermann,G., He,H., Leiting,B., Lyons,K., Petrov,A., Sinha-Roy,R., Zhang,B., Wu,J., Zhang,X., Thornberry,N.A. and Weber,A.E.
Optimization of 1,4-diazepan-2-one containing dipeptidyl peptidase IV inhibitors for the treatment of type 2 diabetes
Bioorg Med Chem Lett17, 1903-1907. PubMed Europe PubMed DOI I
Lubbers,T., Bohringer,M., Gobbi,L., Hennig,M., Hunziker,D., Kuhn,B., Loffler,B., Mattei,P., Narquizian,R., Peters,J.U., Ruff,Y., Wessel,H.P. and Wyss,P.
1,3-Disubstituted 4-aminopiperidines as useful tools in the optimization of the 2-aminobenzo[a]quinolizine dipeptidyl peptidase IV inhibitors
Bioorg Med Chem Lett17, 2966-2970. PubMed Europe PubMed DOI I
Maes,M.B., Scharpe,S. and De Meester,I.
Dipeptidyl peptidase II (DPPII), a review
Clin Chim Acta380, 31-49. PubMed Europe PubMed DOI V
O'Farrell,A.M., Van Vliet,A., Abou Farha,K., Cherrington,J.M., Campbell,D.A., Li,X., Hanway,D., Li,J. and Guler,H.P.
Pharmacokinetic and pharmacodynamic assessments of the dipeptidyl peptidase-4 inhibitor PHX1149: double-blind, placebo-controlled, single- and multiple-dose studies in healthy subjects
Clin Ther29, 1692-1705. PubMed Europe PubMed DOI I
Oefner,C., Pierau,S., Schulz,H. and Dale,G.E.
Structural studies of a bifunctional inhibitor of neprilysin and DPP-IV
Acta Crystallogr D Biol Crystallogr63, 975-981. PubMed Europe PubMed DOI S I
Panina,G.
The DPP-4 inhibitor vildagliptin: robust glycaemic control in type 2 diabetes and beyond
Diabetes Obes Metab9 Suppl 1, 32-39. PubMed Europe PubMed DOI I
Pei,Z., Li,X., von Geldern,T.W., Longenecker,K., Pireh,D., Stewart,K.D., Backes,B.J., Lai,C., Lubben,T.H., Ballaron,S.J., Beno,D.W., Kempf-Grote,A.J., Sham,H.L. and Trevillyan,J.M.
Discovery and structure-activity relationships of piperidinone- and piperidine-constrained phenethylamines as novel, potent, and selective dipeptidyl peptidase IV inhibitors
J Med Chem50, 1983-1987. PubMed Europe PubMed DOI I
Peters,J.U.
11 Years of cyanopyrrolidines as DPP-IV inhibitors
Curr Top Med Chem7, 579-595. PubMed Europe PubMed DOI I
Pissurlenkar,R.R., Shaikh,M.S. and Coutinho,E.C.
3D-QSAR studies of dipeptidyl peptidase IV inhibitors using a docking based alignment
J Mol Model13, 1047-1071. PubMed Europe PubMed DOI I
Reinhold,D., Biton,A., Goihl,A., Pieper,S., Lendeckel,U., Faust,J., Neubert,K., Bank,U., Tager,M., Ansorge,S. and Brocke,S.
Dual inhibition of dipeptidyl peptidase IV and aminopeptidase N suppresses inflammatory immune responses
Ann N Y Acad Sci1110, 402-409. PubMed Europe PubMed DOI
Rosenstock,J. and Zinman,B.
Dipeptidyl peptidase-4 inhibitors and the management of type 2 diabetes mellitus
Curr Opin Endocrinol Diabetes Obes14, 98-107. PubMed Europe PubMed DOI I
Ruth,D.M., Buckley,S.J., O'Connor,B.F. and O'Fagain,C.
Solvent and thermal stability, and pH kinetics, of proline-specific dipeptidyl peptidase IV-like enzyme from bovine serum
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Sakashita,H., Akahoshi,F., Yoshida,T., Kitajima,H., Hayashi,Y., Ishii,S., Takashina,Y., Tsutsumiuchi,R. and Ono,S.
Lead optimization of [(S)-gamma-(arylamino)prolyl]thiazolidine focused on gamma-substituent: indoline compounds as potent DPP-IV inhibitors
Bioorg Med Chem15, 641-655. PubMed Europe PubMed DOI I
Scott,R., Wu,M., Sanchez,M. and Stein,P.
Efficacy and tolerability of the dipeptidyl peptidase-4 inhibitor sitagliptin as monotherapy over 12 weeks in patients with type 2 diabetes
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Sebokova,E., Christ,A.D., Boehringer,M. and Mizrahi,J.
Dipeptidyl peptidase IV inhibitors: the next generation of new promising therapies for the management of type 2 diabetes
Curr Top Med Chem7, 547-555. PubMed Europe PubMed DOI V I
Sheehan,S.M., Mest,H.J., Watson,B.M., Klimkowski,V.J., Timm,D.E., Cauvin,A., Parsons,S.H., Shi,Q., Canada,E.J., Wiley,M.R., Ruehter,G., Evers,B., Petersen,S., Blaszczak,L.C., Pulley,S.R., Margolis,B.J., Wishart,G.N., Renson,B., Hankotius,D., Mohr,M., Zechel,J.C., Michael Kalbfleisch,J., Dingess-Hammond,E.A., Boelke,A. and Weichert,A.G.
Discovery of non-covalent dipeptidyl peptidase IV inhibitors which induce a conformational change in the active site
Bioorg Med Chem Lett17, 1765-1768. PubMed Europe PubMed DOI S I
Simpkins,L.M., Bolton,S., Pi,Z., Sutton,J.C., Kwon,C., Zhao,G., Magnin,D.R., Augeri,D.J., Gungor,T., Rotella,D.P., Sun,Z., Liu,Y., Slusarchyk,W.S., Marcinkeviciene,J., Robertson,J.G., Wang,A., Robl,J.A., Atwal,K.S., Zahler,R.L., Parker,R.A., Kirby,M.S. and Hamann,L.G.
Potent non-nitrile dipeptidic dipeptidyl peptidase IV inhibitors
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Thielitz,A., Reinhold,D., Vetter,R., Bank,U., Helmuth,M., Hartig,R., Wrenger,S., Wiswedel,I., Lendeckel,U., Kahne,T., Neubert,K., Faust,J., Zouboulis,C.C., Ansorge,S. and Gollnick,H.
Inhibitors of dipeptidyl peptidase IV and aminopeptidase N target major pathogenetic steps in acne initiation
J Invest Dermatol127, 1042-1051. PubMed Europe PubMed DOI T I
Thompson,M.A., Ohnuma,K., Abe,M., Morimoto,C. and Dang,N.H.
CD26/dipeptidyl peptidase IV as a novel therapeutic target for cancer and immune disorders
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Thornberry,N.A. and Weber,A.E.
Discovery of JANUVIA (Sitagliptin), a selective dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
Curr Top Med Chem7, 557-568. PubMed Europe PubMed DOI I
Tran,T., Quan,C., Edosada,C.Y., Mayeda,M., Wiesmann,C., Sutherlin,D. and Wolf,B.B.
Synthesis and structure-activity relationship of N-acyl-Gly-, N-acyl-Sar- and N-blocked-boroPro inhibitors of FAP, DPP4, and POP
Bioorg Med Chem Lett17, 1438-1442. PubMed Europe PubMed DOI I
Wright,S.W., Ammirati,M.J., Andrews,K.M., Brodeur,A.M., Danley,D.E., Doran,S.D., Lillquist,J.S., Liu,S., McClure,L.D., McPherson,R.K., Olson,T.V., Orena,S.J., Parker,J.C., Rocke,B.N., Soeller,W.C., Soglia,C.B., Treadway,J.L., VanVolkenburg,M.A., Zhao,Z. and Cox,E.D.
(3R,4S)-4-(2,4,5-Trifluorophenyl)-pyrrolidin-3-ylamine inhibitors of dipeptidyl peptidase IV: synthesis, in vitro, in vivo, and X-ray crystallographic characterization
Bioorg Med Chem Lett17, 5638-5642. PubMed Europe PubMed DOI I
Yoshida,T., Sakashita,H., Akahoshi,F. and Hayashi,Y.
[(S)-gamma-(4-Aryl-1-piperazinyl)-l-prolyl]thiazolidines as a novel series of highly potent and long-lasting DPP-IV inhibitors
Bioorg Med Chem Lett17, 2618-2621. PubMed Europe PubMed DOI I
Zeng,J., Liu,G., Tang,Y. and Jiang,H.
3D-QSAR studies on fluoropyrrolidine amides as dipeptidyl peptidase IV inhibitors by CoMFA and CoMSIA
J Mol Model13, 993-1000. PubMed Europe PubMed DOI I

2006

[YEAR:20-12-2006]Bank,U., Heimburg,A., Helmuth,M., Stefin,S., Lendeckel,U., Reinhold,D., Faust,J., Fuchs,P., Sens,B., Neubert,K., Tager,M. and Ansorge,S.
Triggering endogenous immunosuppressive mechanisms by combined targeting of dipeptidyl peptidase IV (DPIV/CD26) and aminopeptidase N (APN/ CD13) - a novel approach for the treatment of inflammatory bowel disease
Int Immunopharmacol6, 1925-1934. PubMed Europe PubMed DOI I
Barnett,A.
DPP-4 inhibitors and their potential role in the management of type 2 diabetes
Int J Clin Pract60, 1454-1470. PubMed Europe PubMed DOI V I
Bjelke,J.R., Kanstrup,A.B. and Rasmussen,H.B.
Selectivity among dipeptidyl peptidases of the S9b family
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[YEAR:27-10-2006]Brandt,I., Lambeir,A.M., Ketelslegers,J.M., Vanderheyden,M., Scharpe,S. and De Meester,I.
Dipeptidyl-peptidase IV converts intact B-type natriuretic peptide into its des-SerPro form
Clin Chem52, 82-87. PubMed Europe PubMed DOI I
Edmondson,S.D., Mastracchio,A., Mathvink,R.J., He,J., Harper,B., Park,Y.J., Beconi,M., Di Salvo,J., Eiermann,G.J., He,H., Leiting,B., Leone,J.F., Levorse,D.A., Lyons,K., Patel,R.A., Patel,S.B., Petrov,A., Scapin,G., Shang,J., Roy,R.S., Smith,A., Wu,J.K., Xu,S., Zhu,B., Thornberry,N.A. and Weber,A.E.
(2S,3S)-3-Amino-4-(3,3-difluoropyrrolidin-1-yl)-N,N-dimethyl-4-oxo-2-(4-[1 ,2,4]triazolo[1,5-a]- pyridin-6-ylphenyl)butanamide: a selective alpha-amino amide dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
J Med Chem49, 3614-3627. PubMed Europe PubMed DOI I
[YEAR:22-6-2006]Emanuele,E., Minoretti,P., Martinelli,V., Pesenti,S., Olivieri,V., Aldeghi,A. and Politi,P.
Circulating levels of soluble CD26 are associated with phobic anxiety in women
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Synthesis, kinetic evaluation, and utilization of a biotinylated dipeptide proline diphenyl phosphonate for the disclosure of dipeptidyl peptidase IV-like serine proteases
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[YEAR:6-6-2006]Gilmore,B.F., Lynas,J.F., Scott,C.J., McGoohan,C., Martin,L. and Walker,B.
Dipeptide proline diphenyl phosphonates are potent, irreversible inhibitors of seprase (FAPalpha)
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Green,B.D., Flatt,P.R. and Bailey,C.J.
Inhibition of dipeptidylpeptidase IV activity as a therapy of Type 2 diabetes
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[YEAR:27-7-2006]Green,B.D., Irwin,N., Duffy,N.A., Gault,V.A., O'Harte,F.P. and Flatt,P.R.
Inhibition of dipeptidyl peptidase-IV activity by metformin enhances the antidiabetic effects of glucagon-like peptide-1
Eur J Pharmacol547, 192-199. PubMed Europe PubMed DOI I
[YEAR:7-9-2006]Guieu,R., Fenouillet,E., Devaux,C., Fajloun,Z., Carrega,L., Sabatier,J.M., Sauze,N. and Marguet,D.
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Development of a dual fluorogenic and chromogenic dipeptidyl peptidase IV substrate
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Glucagon-like peptide-1: from extract to agent. The Claude Bernard Lecture, 2005
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Mechanism of Gly-Pro-pNA cleavage catalyzed by dipeptidyl peptidase-IV and its inhibition by saxagliptin (BMS-477118)
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[YEAR:27-9-2006]Kurukulasuriya,R., Rohde,J.J., Szczepankiewicz,B.G., Basha,F., Lai,C., Jae,H.S., Winn,M., Stewart,K.D., Longenecker,K.L., Lubben,T.W., Ballaron,S.J., Sham,H.L. and von Geldern,T.W.
Xanthine mimetics as potent dipeptidyl peptidase IV inhibitors
Bioorg Med Chem Lett16, 6226-6230. PubMed Europe PubMed DOI I
[YEAR:20-6-2006]Longenecker,K.L., Stewart,K.D., Madar,D.J., Jakob,C.G., Fry,E.H., Wilk,S., Lin,C.W., Ballaron,S.J., Stashko,M.A., Lubben,T.H., Yong,H., Pireh,D., Pei,Z., Basha,F., Wiedeman,P.E., von Geldern,T.W., Trevillyan,J.M. and Stoll,V.S.
Crystal structures of DPP-IV (CD26) from rat kidney exhibit flexible accommodation of peptidase-selective inhibitors
Biochemistry45, 7474-7482. PubMed Europe PubMed DOI S I
[YEAR:19-10-2006]Madar,D.J., Kopecka,H., Pireh,D., Yong,H., Pei,Z., Li,X., Wiedeman,P.E., Djuric,S.W., von Geldern,T.W., Fickes,M.G., Bhagavatula,L., McDermott,T., Wittenberger,S., Richards,S.J., Longenecker,K.L., Stewart,K.D., Lubben,T.H., Ballaron,S.J., Stashko,M.A., Long,M.A., Wells,H., Zinker,B.A., Mika,A.K., Beno,D.W., Kempf-Grote,A.J., Polakowski,J., Segreti,J., Reinhart,G.A., Fryer,R.M., Sham,H.L. and Trevillyan,J.M.
Discovery of 2-[4-{{2-(2S,5R)-2-cyano-5-ethynyl-1-pyrrolidinyl]-2-oxoethyl]amino]- 4-methyl-1-piperidinyl]-4-pyridinecarboxylic acid (ABT-279): a very potent, selective, effective, and well-tolerated inhibitor of dipeptidyl peptidase-IV, useful for the treatment of diabetes
J Med Chem49, 6416-6420. PubMed Europe PubMed DOI I
[YEAR:19-12-2006]Magnin,D.R., Taunk,P.C., Robertson,J.G., Wang,A., Marcinkeviciene,J., Kirby,M.S. and Hamann,L.G.
Seco-prolinenitrile inhibitors of dipeptidyl peptidase IV define minimal pharmacophore requirements at P1
Bioorg Med Chem Lett16, 1731-1734. PubMed Europe PubMed DOI I
Masur,K., Schwartz,F., Entschladen,F., Niggemann,B. and Zaenker,K.S.
DPPIV inhibitors extend GLP-2 mediated tumour promoting effects on intestinal cancer cells
Regul Pept137, 147-155. PubMed Europe PubMed DOI I
Mu,J., Woods,J., Zhou,Y.P., Roy,R.S., Li,Z., Zycband,E., Feng,Y., Zhu,L., Li,C., Howard,A.D., Moller,D.E., Thornberry,N.A. and Zhang,B.B.
Chronic inhibition of dipeptidyl peptidase-4 with a sitagliptin analog preserves pancreatic beta-cell mass and function in a rodent model of type 2 diabetes
Diabetes55, 1695-1704. PubMed Europe PubMed DOI I
Nordhoff,S., Cerezo-Galvez,S., Feurer,A., Hill,O., Matassa,V.G., Metz,G., Rummey,C., Thiemann,M. and Edwards,P.J.
The reversed binding of beta-phenethylamine inhibitors of DPP-IV: X-ray structures and properties of novel fragment and elaborated inhibitors
Bioorg Med Chem Lett16, 1744-1748. PubMed Europe PubMed DOI S I
[YEAR:6-6-2006]Ogawa,Y., Mamura,Y., Murayama,N. and Yanoshita,R.
Characterization and cDNA cloning of dipeptidyl peptidase IV from the venom of Gloydius blomhoffi brevicaudus
Comp Biochem Physiol B Biochem Mol Biol145, 35-42. PubMed Europe PubMed DOI
[YEAR:24-8-2006]Pei,Z., Li,X., Longenecker,K., von Geldern,T.W., Wiedeman,P.E., Lubben,T.H., Zinker,B.A., Stewart,K., Ballaron,S.J., Stashko,M.A., Mika,A.K., Beno,D.W., Long,M., Wells,H., Kempf-Grote,A.J., Madar,D.J., McDermott,T.S., Bhagavatula,L., Fickes,M.G., Pireh,D., Solomon,L.R., Lake,M.R., Edalji,R., Fry,E.H., Sham,H.L. and Trevillyan,J.M.
Discovery, structure-activity relationship, and pharmacological evaluation of (5-substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as potent dipeptidyl peptidase IV inhibitors
J Med Chem49, 5387-5387. PubMed Europe PubMed DOI I
[YEAR:15-6-2006]Pei,Z., Li,X., Longenecker,K., von Geldern,T.W., Wiedeman,P.E., Lubben,T.H., Zinker,B.A., Stewart,K., Ballaron,S.J., Stashko,M.A., Mika,A.K., Beno,D.W., Long,M., Wells,H., Kempf-Grote,A.J., Madar,D.J., McDermott,T.S., Bhagavatula,L., Fickes,M.G., Pireh,D., Solomon,L.R., Lake,M.R., Edalji,R., Fry,E.H., Sham,H.L. and Trevillyan,J.M.
Discovery, structure-activity relationship, and pharmacological evaluation of (5-substituted-pyrrolidinyl-2-carbonyl)-2-cyanopyrrolidines as potent dipeptidyl peptidase IV inhibitors
J Med Chem49, 3520-3535. PubMed Europe PubMed DOI I
[YEAR:2-11-2006]Pei,Z., Li,X., von Geldern,T.W., Madar,D.J., Longenecker,K., Yong,H., Lubben,T.H., Stewart,K.D., Zinker,B.A., Backes,B.J., Judd,A.S., Mulhern,M., Ballaron,S.J., Stashko,M.A., Mika,A.K., Beno,D.W., Reinhart,G.A., Fryer,R.M., Preusser,L.C., Kempf-Grote,A.J., Sham,H.L. and Trevillyan,J.M.
Discovery of ((4R,5S)-5-Amino-4-(2,4,5- trifluorophenyl)cyclohex-1-enyl)-(3- (trifluoromethyl)-5,6-dihydro- [1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methanone (ABT-341), a highly potent, selective, orally efficacious, and safe dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
J Med Chem49, 6439-6442. PubMed Europe PubMed DOI I
[YEAR:14-10-2006]Qiao,L., Baumann,C.A., Crysler,C.S., Ninan,N.S., Abad,M.C., Spurlino,J.C., DesJarlais,R.L., Kervinen,J., Neeper,M.P., Bayoumy,S.S., Williams,R., Deckman,I.C., Dasgupta,M., Reed,R.L., Huebert,N.D., Tomczuk,B.E. and Moriarty,K.J.
Discovery, SAR, and X-ray structure of novel biaryl-based dipeptidyl peptidase IV inhibitors
Bioorg Med Chem Lett16, 123-128. PubMed Europe PubMed DOI I
Rosenstock,J., Brazg,R., Andryuk,P.J., Lu,K. and Stein,P.
Efficacy and safety of the dipeptidyl peptidase-4 inhibitor sitagliptin added to ongoing pioglitazone therapy in patients with type 2 diabetes: a 24-week, multicenter, randomized, double-blind, placebo-controlled, parallel-group study
Clin Ther28, 1556-1568. PubMed Europe PubMed DOI I
[YEAR:3-2-2006]Sakashita,H., Akahoshi,F., Kitajima,H., Tsutsumiuchi,R. and Hayashi,Y.
[(S)-gamma-(Arylamino)prolyl]thiazolidine compounds as a novel series of potent and stable DPP-IV inhibitors
Bioorg Med Chem14, 3662-3671. PubMed Europe PubMed DOI I
Schlesselman,L.S.
Vildagliptin: A dipeptidyl peptidase-IV inhibitor for the treatment of type 2 diabetes
Formulary41, 494-500. I
[YEAR:31-3-2006]Tsai,T.Y., Coumar,M.S., Hsu,T., Hsieh,H.P., Chien,C.H., Chen,C.T., Chang,C.N., Lo,Y.K., Wu,S.H., Huang,C.Y., Huang,Y.W., Wang,M.H., Wu,H.Y., Lee,H.J., Chen,X., Chao,Y.S. and Jiaang,W.T.
Substituted pyrrolidine-2,4-dicarboxylic acid amides as potent dipeptidyl peptidase IV inhibitors
Bioorg Med Chem Lett16, 3268-3272. PubMed Europe PubMed DOI I
[YEAR:12-1-2006]Tsu,H., Chen,X., Chen,C.T., Lee,S.J., Chang,C.N., Kao,K.H., Coumar,M.S., Yeh,Y.T., Chien,C.H., Wang,H.S., Lin,K.T., Chang,Y.Y., Wu,S.H., Chen,Y.S., Lu,I.L., Wu,S.Y., Tsai,T.Y., Chen,W.C., Hsieh,H.P., Chao,Y.S. and Jiaang,W.T.
2-[3-[2-[(2S)-2-Cyano-1-pyrrolidinyl]-2-oxoethylamino]-3-methyl-1-oxobutyl ]- 1,2,3,4-tetrahydroisoquinoline: a potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV
J Med Chem49, 373-380. PubMed Europe PubMed DOI I
[YEAR:1-6-2006]Wright,S.W., Ammirati,M.J., Andrews,K.M., Brodeur,A.M., Danley,D.E., Doran,S.D., Lillquist,J.S., McClure,L.D., McPherson,R.K., Orena,S.J., Parker,J.C., Polivkova,J., Qiu,X., Soeller,W.C., Soglia,C.B., Treadway,J.L., VanVolkenburg,M.A., Wang,H., Wilder,D.C. and Olson,T.V.
cis-2,5-Dicyanopyrrolidine inhibitors of dipeptidyl peptidase IV: synthesis and in vitro, in vivo, and X-ray crystallographic characterization
J Med Chem49, 3068-3076. PubMed Europe PubMed DOI S I
[YEAR:16-8-2006]Xu,J., Wei,L., Mathvink,R.J., Edmondson,S.D., Eiermann,G.J., He,H., Leone,J.F., Leiting,B., Lyons,K.A., Marsilio,F., Patel,R.A., Patel,S.B., Petrov,A., Scapin,G., Wu,J.K., Thornberry,N.A. and Weber,A.E.
Discovery of potent, selective, and orally bioavailable oxadiazole-based dipeptidyl peptidase IV inhibitors
Bioorg Med Chem Lett16, 5373-5377. PubMed Europe PubMed DOI I
[YEAR:2-12-2006]Xu,J., Wei,L., Mathvink,R., Edmondson,S.D., Mastracchio,A., Eiermann,G.J., He,H., Leone,J.F., Leiting,B., Lyons,K.A., Marsilio,F., Patel,R.A., Petrov,A., Wu,J.K., Thornberry,N.A. and Weber,A.E.
Discovery of potent, selective, and orally bioavailable pyridone-based dipeptidyl peptidase-4 inhibitors
Bioorg Med Chem Lett16, 1346-1349. PubMed Europe PubMed DOI I
[YEAR:15-9-2006]Yamazaki,K., Yasuda,N., Inoue,T., Nagakura,T., Kira,K., Shinoda,M., Saeki,T. and Tanaka,I.
7-But-2-ynyl-9-(6-methoxy-pyridin-3-yl)-6-piperazin-1-yl-7,9-dihydro-purin -8-one is a novel competitive and selective inhibitor of dipeptidyl peptidase IV with an antihyperglycemic activity
J Pharmacol Exp Ther319, 1253-1257. PubMed Europe PubMed DOI I
[YEAR:16-8-2006]Yasuda,N., Nagakura,T., Inoue,T., Yamazaki,K., Katsutani,N., Takenaka,O., Clark,R., Matsuura,F., Emori,E., Yoshikawa,S., Kira,K., Ikuta,H., Okada,T., Saeki,T., Asano,O. and Tanaka,I.
E3024, 3-but-2-ynyl-5-methyl-2-piperazin-1-yl-3,5-dihydro-4H-imidazo[4,5-d]pyrida zin-4-one tosylate, is a novel, selective and competitive dipeptidyl peptidase-IV inhibitor
Eur J Pharmacol548, 181-187. PubMed Europe PubMed DOI I
Zhai,W., Cardell,M., De Meester,I., Augustyns,K., Hillinger,S., Inci,I., Arni,S., Jungraithmayr,W., Scharpe,S., Weder,W. and Korom,S.
Ischemia/reperfusion injury: the role of CD26/dipeptidyl-peptidase-IV-inhibition in lung transplantation
Transplant Proc38, 3369-3371. PubMed Europe PubMed DOI I

2005

[YEAR:1-2-2005]Abe,M., Akiyama,T., Umezawa,Y., Yamamoto,K., Nagai,M., Yamazaki,H., Ichikawa,Y. and Muraoka,Y.
Synthesis and biological activity of sulphostin analogues, novel dipeptidyl peptidase IV inhibitors
Bioorg Med Chem13, 785-797. PubMed Europe PubMed DOI I
Ahn,J.H., Jung,S.H., Kim,J.A., Song,S.B., Kwon,S.J., Kim,K.R., Rhee,S.D., Park,S.D., Lee,J.M., Kim,S.S. and Cheon,H.G.
Pyrazolidine derivatives with heteroaryl urea as dipeptidyl peptidase IV inhibitors
Chem Pharm Bull (Tokyo)53, 1048-1050. PubMed Europe PubMed DOI I
[YEAR:1-3-2005]Ahn,J.H., Kim,J.A., Kim,H.M., Kwon,H.M., Huh,S.C., Rhee,S.D., Kim,K.R., Yang,S.D., Park,S.D., Lee,J.M., Kim,S.S. and Cheon,H.G.
Synthesis and evaluation of pyrazolidine derivatives as dipeptidyl peptidase IV (DP-IV) inhibitors
Bioorg Med Chem Lett15, 1337-1340. PubMed Europe PubMed DOI I
Ahren,B., Pacini,G., Foley,J.E. and Schweizer,A.
Improved meal-related beta-cell function and insulin sensitivity by the dipeptidyl peptidase-IV inhibitor vildagliptin in metformin-treated patients with type 2 diabetes over 1year
Diabetes Care28, 1936-1940. PubMed Europe PubMed DOI I
[YEAR:2-5-2005]Ashton,W.T., Sisco,R.M., Dong,H., Lyons,K.A., He,H., Doss,G.A., Leiting,B., Patel,R.A., Wu,J.K., Marsilio,F., Thornberry,N.A. and Weber,A.E.
Dipeptidyl peptidase IV inhibitors derived from beta-aminoacylpiperidines bearing a fused thiazole, oxazole, isoxazole, or pyrazole
Bioorg Med Chem Lett15, 2253-2258. PubMed Europe PubMed DOI I
[YEAR:28-7-2005]Augeri,D.J., Robl,J.A., Betebenner,D.A., Magnin,D.R., Khanna,A., Robertson,J.G., Wang,A., Simpkins,L.M., Taunk,P., Huang,Q., Han,S.P., Abboa-Offei,B., Cap,M., Xin,L., Tao,L., Tozzo,E., Welzel,G.E., Egan,D.M., Marcinkeviciene,J., Chang,S.Y., Biller,S.A., Kirby,M.S., Parker,R.A. and Hamann,L.G.
Discovery and preclinical profile of saxagliptin (BMS-477118): a highly potent, long-acting, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
J Med Chem48, 5025-5037. PubMed Europe PubMed DOI I
Augustyns,K., Van der Veken,P., Senten,K. and Haemers,A.
The therapeutic potential of inhibitors of dipeptidyl peptidase IV (DPP IV) and related proline-specific dipeptidyl aminopeptidases
Curr Med Chem12, 971-998. PubMed Europe PubMed DOI I
[YEAR:1-7-2005]Brandt,I., Joossens,J., Chen,X., Maes,M.B., Scharpe,S., De Meester,I. and Lambeir,A.M.
Inhibition of dipeptidyl-peptidase IV catalyzed peptide truncation by Vildagliptin ((2S)-{[(3-hydroxyadamantan-1-yl)amino]acetyl}-pyrrolidine-2-carbonitrile)
Biochem Pharmacol70, 134-143. PubMed Europe PubMed DOI I
[YEAR:18-7-2005]Burkey,B.F., Li,X., Bolognese,L., Balkan,B., Mone,M., Russell,M., Hughes,T.E. and Wang,P.R.
Acute and chronic effects of the incretin enhancer vildagliptin in insulin-resistant rats
J Pharmacol Exp Ther315, 688-695. PubMed Europe PubMed DOI I
Deacon,C.F.
MK-431 (Merck)
Curr Opin Investig Drugs6, 419-426. PubMed Europe PubMed I
Demuth,H.U., McIntosh,C.H. and Pederson,R.A.
Type 2 diabetes - therapy with dipeptidyl peptidase IV inhibitors
Biochim Biophys Acta Proteins Proteom1751, 33-44. PubMed Europe PubMed DOI I
[YEAR:15-6-2005]Edmondson,S.D., Mastracchio,A., Duffy,J.L., Eiermann,G.J., He,H., Ita,I., Leiting,B., Leone,J.F., Lyons,K.A., Makarewicz,A.M., Patel,R.A., Petrov,A., Wu,J.K., Thornberry,N.A. and Weber,A.E.
Discovery of potent and selective orally bioavailable beta-substituted phenylalanine derived dipeptidyl peptidase IV inhibitors
Bioorg Med Chem Lett15, 3048-3052. PubMed Europe PubMed DOI I
[YEAR:7-3-2005]Geier,M.S., Tenikoff,D., Yazbeck,R., McCaughan,G.W., Abbott,C.A. and Howarth,G.S.
Development and resolution of experimental colitis in mice with targeted deletion of dipeptidyl peptidase IV
J Cell Physiol204, 687-692. PubMed Europe PubMed DOI
[YEAR:8-12-2005]Gorrell,M.D.
Dipeptidyl peptidase IV and related enzymes in cell biology and liver disorders
Clin Sci (Lond)108, 277-292. PubMed Europe PubMed DOI V
Herman,G.A., Stevens,C., Van Dyck,K., Bergman,A., Yi,B., De Smet,M., Snyder,K., Hilliard,D., Tanen,M., Tanaka,W., Wang,A.Q., Zeng,W., Musson,D., Winchell,G., Davies,M.J., Ramael,S., Gottesdiener,K.M. and Wagner,J.A.
Pharmacokinetics and pharmacodynamics of sitagliptin, an inhibitor of dipeptidyl peptidase IV, in healthy subjects: results from two randomized, double-blind, placebo-controlled studies with single oral doses
Clin Pharmacol Ther78, 675-688. PubMed Europe PubMed DOI I
[YEAR:25-6-2005]Hsiung,H.M., Smiley,D.L., Zhang,X.Y., Zhang,L., Yan,L.Z., Craft,L., Heiman,M.L. and Smith,D.P.
Potent peptide agonists for human melanocortin 3 and 4 receptors derived from enzymatic cleavages of human beta-MSH(5-22) by dipeptidyl peptidase I and dipeptidyl peptidase IV
Peptides26, 1988-1996. PubMed Europe PubMed DOI
Hu,Y., Ma,L., Wu,M., Wong,M.S., Li,B., Corral,S., Yu,Z., Nomanbhoy,T., Alemayehu,S., Fuller,S.R., Rosenblum,J.S., Rozenkrants,N., Minimo,L.C., Ripka,W.C., Szardenings,A.K., Kozarich,J.W. and Shreder,K.R.
Synthesis and structure-activity relationship of N-alkyl Gly-boro-Pro inhibitors of DPP4, FAP, and DPP7
Bioorg Med Chem Lett15, 4239-4242. PubMed Europe PubMed DOI I
[YEAR:19-8-2005]Hulin,B., Cabral,S., Lopaze,M.G., Van Volkenburg,M.A., Andrews,K.M. and Parker,J.C.
New fluorinated pyrrolidine and azetidine amides as dipeptidyl peptidase IV inhibitors
Bioorg Med Chem Lett15, 4770-4773. PubMed Europe PubMed DOI I
Hunziker,D., Hennig,M. and Peters,J.U.
Inhibitors of dipeptidyl peptidase IV - recent advances and structural views
Curr Top Med Chem5, 1623-1637. PubMed Europe PubMed DOI V I
[YEAR:28-1-2005]Islam,M.S., Rahman,S.A., Mirzaei,Z. and Islam,K.B.
Engineered beta-cells secreting dipeptidyl peptidase IV-resistant glucagon-like peptide-1 show enhanced glucose-responsiveness
Life Sci76, 1239-1248. PubMed Europe PubMed DOI
Kikkawa,F., Kajiyama,H., Shibata,K., Ino,K., Nomura,S. and Mizutani,S.
Dipeptidyl peptidase IV in tumor progression
Biochim Biophys Acta Proteins Proteom1751, 45-51. PubMed Europe PubMed DOI
[YEAR:13-1-2005]Kim,D., Wang,L., Beconi,M., Eiermann,G.J., Fisher,M.H., He,H., Hickey,G.J., Kowalchick,J.E., Leiting,B., Lyons,K., Marsilio,F., McCann,M.E., Patel,R.A., Petrov,A., Scapin,G., Patel,S.B., Roy,R.S., Wu,J.K., Wyvratt,M.J., Zhang,B.B., Zhu,L., Thornberry,N.A. and Weber,A.E.
(2R)-4-Oxo-4-[3-(trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-a]pyrazin -7(8H)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine: a potent, orally active dipeptidyl peptidase IV inhibitor for the treatment of type 2 diabetes
J Med Chem48, 141-151. PubMed Europe PubMed DOI I
[YEAR:25-7-2005]Kim,K.R., Rhee,S.D., Kim,H.Y., Jung,W.H., Yang,S.D., Kim,S.S., Ahn,J.H. and Cheon,H.G.
KR-62436, 6-{2-[2-(5-cyano-4,5-dihydropyrazol-1-yl)-2-oxoethylamino]ethylamino}nicotinonitrile, is a novel dipeptidyl peptidase-IV (DPP-IV) inhibitor with anti-hyperglycemic activity
Eur J Pharmacol518, 63-70. PubMed Europe PubMed DOI I
[YEAR:15-4-2005]Kopcho,L.M., Kim,Y.B., Wang,A., Liu,M.A., Kirby,M.S. and Marcinkeviciene,J.
Probing prime substrate binding sites of human dipeptidyl peptidase-IV using competitive substrate approach
Arch Biochem Biophys436, 367-376. PubMed Europe PubMed DOI P
Lankas,G.R., Leiting,B., Roy,R.S., Eiermann,G.J., Beconi,M.G., Biftu,T., Chan,C.C., Edmondson,S., Feeney,W.P., He,H., Ippolito,D.E., Kim,D., Lyons,K.A., Ok,H.O., Patel,R.A., Petrov,A.N., Pryor,K.A., Qian,X., Reigle,L., Woods,A., Wu,J.K., Zaller,D., Zhang,X., Zhu,L., Weber,A.E. and Thornberry,N.A.
Dipeptidyl peptidase IV inhibition for the treatment of type 2 diabetes: potential importance of selectivity over dipeptidyl peptidases 8 and 9
Diabetes54, 2988-2994. PubMed Europe PubMed DOI I
[YEAR:27-5-2005]Lautar,S.L., Rojas,C., Slusher,B.S., Wozniak,K.M., Wu,Y., Thomas,A.G., Waldon,D., Li,W., Ferraris,D. and Belyakov,S.
DPP IV inhibitor blocks mescaline-induced scratching and amphetamine-induced hyperactivity in mice
Brain Res1048, 177-184. PubMed Europe PubMed DOI I
Lindsay,J.R., Duffy,N.A., McKillop,A.M., Ardill,J., O'Harte,F.P., Flatt,P.R. and Bell,P.M.
Inhibition of dipeptidyl peptidase IV activity by oral metformin in Type 2 diabetes
Diabet Med22, 654-657. PubMed Europe PubMed DOI
[YEAR:1-7-2005]Lu,I.L., Lee,S.J., Tsu,H., Wu,S.Y., Kao,K.H., Chien,C.H., Chang,Y.Y., Chen,Y.S., Cheng,J.H., Chang,C.N., Chen,T.W., Chang,S.P., Chen,X. and Jiaang,W.T.
Glutamic acid analogues as potent dipeptidyl peptidase IV and 8 inhibitors
Bioorg Med Chem Lett15, 3271-3275. PubMed Europe PubMed DOI I
[YEAR:10-5-2005]Mari,A., Sallas,W.M., He,Y.L., Watson,C., Ligueros-Saylan,M., Dunning,B.E., Deacon,C.F., Holst,J.J. and Foley,J.E.
Vildagliptin, a dipeptidyl peptidase-IV inhibitor, improves model-assessed beta-cell function in patients with type 2 diabetes
J Clin Endocrinol Metab90, 4888-4894. PubMed Europe PubMed DOI I
[YEAR:16-3-2005]Mest,H.J. and Mentlein,R.
Dipeptidyl peptidase inhibitors as new drugs for the treatment of type 2 diabetes
Diabetologia48, 616-620. PubMed Europe PubMed DOI
Monod,M., Lechenne,B., Jousson,O., Grand,D., Zaugg,C., Stocklin,R. and Grouzmann,E.
Aminopeptidases and dipeptidyl-peptidases secreted by the dermatophyte Trichophyton rubrum
Microbiology (Reading)151, 145-155. PubMed Europe PubMed DOI
Nauck,M.A. and El-Ouaghlidi,A.
The therapeutic actions of DPP-IV inhibition are not mediated by glucagon-like peptide-1
Diabetologia48, 608-611. PubMed Europe PubMed DOI
[YEAR:15-5-2005]Nielsen,L.L.
Incretin mimetics and DPP-IV inhibitors for the treatment of type 2 diabetes
Drug Discov Today10, 703-710. PubMed Europe PubMed DOI I
[YEAR:16-7-2005]Plamboeck,A., Holst,J.J., Carr,R.D. and Deacon,C.F.
Neutral endopeptidase 24.11 and dipeptidyl peptidase IV are both mediators of the degradation of glucagon-like peptide 1 in the anaesthetised pig
Diabetologia48, 1882-1890. PubMed Europe PubMed DOI
Rigolet,P., Xi,X.G., Rety,S. and Chich,J.F.
The structural comparison of the bacterial PepX and human DPP-IV reveals sites for the design of inhibitors of PepX activity
FEBS J272, 2050-2059. PubMed Europe PubMed DOI
Ristic,S., Byiers,S., Foley,J. and Holmes,D.
Improved glycaemic control with dipeptidyl peptidase-4 inhibition in patients with type 2 diabetes: vildagliptin (LAF237) dose response
Diabetes Obes Metab7, 692-698. PubMed Europe PubMed DOI I
Sorbera,L.A. and Castaner,J.
MK-0431 - agent for type 2 diabetes dipeptidyl-peptidase IV (CD26) inhibitor
Drugs Future30, 337-343. I
Wargent,E., Stocker,C., Augstein,P., Heinke,P., Meyer,A., Hoffmann,T., Subramanian,A., Sennitt,M.V., Demuth,H.U., Arch,J.R. and Cawthorne,M.A.
Improvement of glucose tolerance in Zucker diabetic fatty rats by long-term treatment with the dipeptidyl peptidase inhibitor P32/98: comparison with and combination with rosiglitazone
Diabetes Obes Metab7, 170-181. PubMed Europe PubMed DOI I
[YEAR:28-1-2005]Weihofen,W.A., Liu,J., Reutter,W., Saenger,W. and Fan,H.
Crystal structures of HIV-1 Tat-derived nonapeptides Tat-(1-9) and Trp2-Tat-(1-9) bound to the active site of dipeptidyl-peptidase IV (CD26)
J Biol Chem280, 14911-14917. PubMed Europe PubMed DOI S
[YEAR:16-5-2005]Xu,J., Wei,L., Mathvink,R., He,J., Park,Y.J., He,H., Leiting,B., Lyons,K.A., Marsilio,F., Patel,R.A., Wu,J.K., Thornberry,N.A. and Weber,A.E.
Discovery of potent and selective phenylalanine based dipeptidyl peptidase IV inhibitors
Bioorg Med Chem Lett15, 2533-2536. PubMed Europe PubMed DOI I
[YEAR:14-10-2005]Xu,S., Zhu,B., Teffera,Y., Pan,D.E., Caldwell,C.G., Doss,G., Stearns,R.A., Evans,D.C. and Beconi,M.G.
Metabolic activation of fluoropyrrolidine dipeptidyl peptidase-IV inhibitors by rat liver microsomes
Drug Metab Dispos33, 121-130. PubMed Europe PubMed DOI I
[YEAR:18-7-2005]Zhao,G., Taunk,P.C., Magnin,D.R., Simpkins,L.M., Robl,J.A., Wang,A., Robertson,J.G., Marcinkeviciene,J., Sitkoff,D.F., Parker,R.A., Kirby,M.S. and Hamann,L.G.
Diprolyl nitriles as potent dipeptidyl peptidase IV inhibitors
Bioorg Med Chem Lett15, 3992-3995. PubMed Europe PubMed DOI I

2004

Abe,M., Akiyama,T., Nakamura,H., Kojima,F., Harada,S. and Muraoka,Y.
First synthesis and determination of the absolute configuration of sulphostin, a novel inhibitor of dipeptidyl peptidase IV
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[YEAR:1-8-2004]Adams,S., Miller,G.T., Jesson,M.I., Watanabe,T., Jones,B. and Wallner,B.P.
PT-100, a small molecule dipeptidyl peptidase inhibitor, has potent antitumor effects and augments antibody-mediated cytotoxicity via a novel immune mechanism
Cancer Res64, 5471-5480. PubMed Europe PubMed DOI I
Aertgeerts,K., Ye,S., Shi,L., Prasad,S.G., Witmer,D., Chi,E., Sang,B.C., Wijnands,R.A., Webb,D.R. and Swanson,R.V.
N-linked glycosylation of dipeptidyl peptidase IV (CD26): effects on enzyme activity, homodimer formation, and adenosine deaminase binding
Protein Sci13, 145-154. PubMed Europe PubMed DOI
Aertgeerts,K., Ye,S., Tennant,M.G., Kraus,M.L., Rogers,J., Sang,B.C., Skene,R.J., Webb,D.R. and Prasad,G.S.
Crystal structure of human dipeptidyl peptidase IV in complex with a decapeptide reveals details on substrate specificity and tetrahedral intermediate formation
Protein Sci13, 412-421. PubMed Europe PubMed DOI S
[YEAR:6-9-2004]Ahn,J.H., Kim,H.M., Jung,S.H., Kang,S.K., Kim,K.R., Rhee,S.D., Yang,S.D., Cheon,H.G. and Kim,S.S.
Synthesis and DP-IV inhibition of cyano-pyrazoline derivatives as potent anti-diabetic agents
Bioorg Med Chem Lett14, 4461-4465. PubMed Europe PubMed DOI
Ahren,B. and Schmitz,O.
GLP-1 receptor agonists and DPP-4 inhibitors in the treatment of type 2 diabetes
Horm Metab Res36, 867-876. PubMed Europe PubMed DOI V
Ahren,B., Gomis,R., Standl,E., Mills,D. and Schweizer,A.
Twelve- and 52-week efficacy of the dipeptidyl peptidase IV inhibitor LAF237 in metformin-treated patients with type 2 diabetes
Diabetes Care27, 2874-2880. PubMed Europe PubMed DOI I
Ahren,B., Landin-Olsson,M., Jansson,P.A., Svensson,M., Holmes,D. and Schweizer,A.
Inhibition of dipeptidyl peptidase-4 reduces glycemia, sustains insulin levels, and reduces glucagon levels in type 2 diabetes
J Clin Endocrinol Metab89, 2078-2084. PubMed Europe PubMed DOI I
Aytac,U. and Dang,N.H.
CD26/dipeptidyl peptidase IV: a regulator of immune function and a potential molecular target for therapy
Curr Drug Targets Immune Endocr Metabol Disord4, 11-18. PubMed Europe PubMed DOI
[YEAR:2-6-2004]Bjelke,J.R., Christensen,J., Branner,S., Wagtmann,N., Olsen,C., Kanstrup,A.B. and Rasmussen,H.B.
Tyrosine 547 constitutes an essential part of the catalytic mechanism of dipeptidyl peptidase IV
J Biol Chem279, 34691-34697. PubMed Europe PubMed DOI I
[YEAR:20-9-2004]Brockunier,L.L., He,J., Colwell,L.F., Jr., Habulihaz,B., He,H., Leiting,B., Lyons,K.A., Marsilio,F., Patel,R.A., Teffera,Y., Wu,J.K., Thornberry,N.A., Weber,A.E. and Parmee,E.R.
Substituted piperazines as novel dipeptidyl peptidase IV inhibitors
Bioorg Med Chem Lett14, 4763-4766. PubMed Europe PubMed DOI I
[YEAR:17-5-2004]Cheon,H.G., Lee,C.M., Kim,B.T. and Hwang,K.J.
Lead discovery of quinoxalinediones as an inhibitor of dipeptidyl peptidase-IV (DPP-IV) by high-throughput screening
Bioorg Med Chem Lett14, 2661-2664. PubMed Europe PubMed DOI I
Chien,C.H., Huang,L.H., Chou,C.Y., Chen,Y.S., Han,Y.S., Chang,G.G., Liang,P.H. and Chen,X.
One site mutation disrupts dimer formation in human DPP-IV proteins
J Biol Chem279, 52338-52345. PubMed Europe PubMed DOI
Deacon,C.F., Ahren,B. and Holst,J.J.
Inhibitors of dipeptidyl peptidase IV: a novel approach for the prevention and treatment of Type 2 diabetes?
Expert Opin Investig Drugs13, 1091-1102. PubMed Europe PubMed DOI I
Dikov,A., Dimitrova,M., Krieg,R. and Halbhuber,K.J.
New fluorescent method for the histochemical detection of dipeptidyl peptidase IV using glycyl-L-prolyl-2-anthraquinonyl hydrazide as substrate
Cell Mol Biol (Noisy-le-grand)50, OL553-OL558. PubMed Europe PubMed
[YEAR:18-10-2004]Edmondson,S.D., Mastracchio,A., Beconi,M., Colwell,L.F., Jr., Habulihaz,B., He,H., Kumar,S., Leiting,B., Lyons,K.A., Mao,A., Marsilio,F., Patel,R.A., Wu,J.K., Zhu,L., Thornberry,N.A., Weber,A.E. and Parmee,E.R.
Potent and selective proline derived dipeptidyl peptidase IV inhibitors
Bioorg Med Chem Lett14, 5151-5155. PubMed Europe PubMed DOI I
[YEAR:15-11-2004]Ferraris,D., Ko,Y.S., Calvin,D., Chiou,T., Lautar,S., Thomas,B., Wozniak,K., Rojas,C., Kalish,V. and Belyakov,S.
Ketopyrrolidines and ketoazetidines as potent dipeptidyl peptidase IV (DPP IV) inhibitors
Bioorg Med Chem Lett14, 5579-5583. PubMed Europe PubMed DOI I
[YEAR:1-12-2004]Fukushima,H., Hiratate,A., Takahashi,M., Saito,M., Munetomo,E., Kitano,K., Saito,H., Takaoka,Y. and Yamamoto,K.
Synthesis and structure-activity relationships of potent 3- or 4-substituted-2-cyanopyrrolidine dipeptidyl peptidase IV inhibitors
Bioorg Med Chem12, 6053-6061. PubMed Europe PubMed DOI I
[YEAR:22-6-2004]Girardi,A.C., Knauf,F., Demuth,H.U. and Aronson,P.S.
Role of dipeptidyl peptidase IV in regulating activity of Na+/H+ exchanger isoform NHE3 in proximal tubule cells
Am J Physiol Cell Physiol287, C1238-C1245. PubMed Europe PubMed DOI I
Hiramatsu,H., Yamamoto,A., Kyono,K., Higashiyama,Y., Fukushima,C., Shima,H., Sugiyama,S., Inaka,K. and Shimizu,R.
The crystal structure of human dipeptidyl peptidase IV (DPPIV) complex with diprotin A
Biol Chem385, 561-564. PubMed Europe PubMed DOI S
[YEAR:9-1-2004]Ludwig,K., Fan,H., Dobers,J., Berger,M., Reutter,W. and Bottcher,C.
3D structure of the CD26-ADA complex obtained by cryo-EM and single particle analysis
Biochem Biophys Res Commun313, 223-229. PubMed Europe PubMed DOI S
[YEAR:6-5-2004]Magnin,D.R., Robl,J.A., Sulsky,R.B., Augeri,D.J., Huang,Y., Simpkins,L.M., Taunk,P.C., Betebenner,D.A., Robertson,J.G., Abboa-Offei,B.E., Wang,A., Cap,M., Xin,L., Tao,L., Sitkoff,D.F., Malley,M.F., Gougoutas,J.Z., Khanna,A., Huang,Q., Han,S.P., Parker,R.A. and Hamann,L.G.
Synthesis of novel potent dipeptidyl peptidase IV inhibitors with enhanced chemical stability: interplay between the N-terminal amino acid alkyl side chain and the cyclopropyl group of alpha-aminoacyl-l-cis-4,5-methanoprolinenitrile-based inhibitors
J Med Chem47, 2587-2598. PubMed Europe PubMed DOI I
McIntyre,J.A. and Castaner,J.
Talabostat. Oncolytic, hematopoietic agent, dipeptidyl-peptidase IV (CD26) inhibitor, fibroblast activation protein inhibitor
Drugs Future29, 882-886. I
McIntyre,J.A. and Castaner,J.
Vildagliptin. Agent for type 2 diabetes, dipeptidyl-peptidase IV inhibitor
Drugs Future29, 887-891. I
Misumi,Y. and Ikehara,Y.
Dipeptidyl-peptidase IV
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[YEAR:5-1-2004]Parmee,E.R., He,J., Mastracchio,A., Edmondson,S.D., Colwell,L., Eiermann,G., Feeney,W.P., Habulihaz,B., He,H., Kilburn,R., Leiting,B., Lyons,K., Marsilio,F., Patel,R.A., Petrov,A., Di Salvo,J., Wu,J.K., Thornberry,N.A. and Weber,A.E.
4-amino cyclohexylglycine analogues as potent dipeptidyl peptidase IV inhibitors
Bioorg Med Chem Lett14, 43-46. PubMed Europe PubMed DOI I
[YEAR:22-3-2004]Peters,J.U., Weber,S., Kritter,S., Weiss,P., Wallier,A., Boehringer,M., Hennig,M., Kuhn,B. and Loeffler,B.M.
Aminomethylpyrimidines as novel DPP-IV inhibitors: a 10(5)-fold activity increase by optimization of aromatic substituents
Bioorg Med Chem Lett14, 1491-1493. PubMed Europe PubMed DOI I
Pro,B. and Dang,N.H.
CD26/dipeptidyl peptidase IV and its role in cancer
Histol Histopathol19, 1345-1351. PubMed Europe PubMed
[YEAR:28-11-2004]Takasaki,K., Takada,H., Nakajima,T., Ueno,K., Ushiki,J. and Higo,K.
Involvement of the active metabolites in the inhibitory activity of K579 on rat plasma dipeptidyl peptidase IV
Eur J Pharmacol505, 237-241. PubMed Europe PubMed DOI I
[YEAR:23-2-2004]Takasaki,K., Iwase,M., Nakajima,T., Ueno,K., Nomoto,Y., Nakanishi,S. and Higo,K.
K579, a slow-binding inhibitor of dipeptidyl peptidase IV, is a long-acting hypoglycemic agent
Eur J Pharmacol486, 335-342. PubMed Europe PubMed DOI I
[YEAR:22-6-2004]Weihofen,W.A., Liu,J., Reutter,W., Saenger,W. and Fan,H.
Crystal structure of CD26/dipeptidyl-peptidase IV in complex with adenosine deaminase reveals a highly amphiphilic interface
J Biol Chem279, 43330-43335. PubMed Europe PubMed DOI S
[YEAR:20-9-2004]Xu,J., Ok,H.O., Gonzalez,E.J., Colwell,L.F., Jr., Habulihaz,B., He,H., Leiting,B., Lyons,K.A., Marsilio,F., Patel,R.A., Wu,J.K., Thornberry,N.A., Weber,A.E. and Parmee,E.R.
Discovery of potent and selective beta-homophenylalanine based dipeptidyl peptidase IV inhibitors
Bioorg Med Chem Lett14, 4759-4762. PubMed Europe PubMed DOI I

2003

Bar,J., Weber,A., Hoffmann,T., Stork,J., Wermann,M., Wagner,L., Aust,S., Gerhartz,B. and Demuth,H.U.
Characterisation of human dipeptidyl peptidase IV expressed in Pichia pastoris. A structural and mechanistic comparison between the recombinant human and the purified porcine enzyme
Biol Chem384, 1553-1563. PubMed Europe PubMed DOI E
Beconi,M.G., Mao,A., Liu,D.Q., Kochansky,C., Pereira,T., Raab,C., Pearson,P. and Lee Chiu,S.H.
Metabolism and pharmacokinetics of a dipeptidyl peptidase IV inhibitor in rats, dogs, and monkeys with selective carbamoyl glucuronidation of the primary amine in dogs
Drug Metab Dispos31, 1269-1277. PubMed Europe PubMed DOI I
Boonacker,E. and Van Noorden,C.J.
The multifunctional or moonlighting protein CD26/DPPIV
Eur J Cell Biol82, 53-73. PubMed Europe PubMed DOI
[YEAR:15-6-2003]Christopherson,K.W., Cooper,S. and Broxmeyer,H.E.
Cell surface peptidase CD26/DPPIV mediates G-CSF mobilization of mouse progenitor cells
Blood101, 4680-4686. PubMed Europe PubMed DOI
[YEAR:27-5-2003]Conarello,S.L., Li,Z., Ronan,J., Roy,R.S., Zhu,L., Jiang,G., Liu,F., Woods,J., Zycband,E., Moller,D.E., Thornberry,N.A. and Zhang,B.B.
Mice lacking dipeptidyl peptidase IV are protected against obesity and insulin resistance
Proc Natl Acad Sci U S A100, 6825-6830. PubMed Europe PubMed DOI K
[YEAR:29-4-2003]Engel,M., Hoffmann,T., Wagner,L., Wermann,M., Heiser,U., Kiefersauer,R., Huber,R., Bode,W., Demuth,H.U. and Brandstetter,H.
The crystal structure of dipeptidyl peptidase IV (CD26) reveals its functional regulation and enzymatic mechanism
Proc Natl Acad Sci U S A100, 5063-5068. PubMed Europe PubMed DOI S
[YEAR:30-5-2003]Gabrilovac,J., Abramic,M., Uzarevic,B., Andreis,A. and Poljak,L.
Dipeptidyl peptidase IV (DPPIV) enzyme activity on immature T-cell line R1.1 is down-regulated by dynorphin-A(1-17) as a non-substrate inhibitor
Life Sci73, 151-166. PubMed Europe PubMed DOI I
[YEAR:21-3-2003]Hiramatsu,H., Kyono,K., Higashiyama,Y., Fukushima,C., Shima,H., Sugiyama,S., Inaka,K., Yamamoto,A. and Shimizu,R.
The structure and function of human dipeptidyl peptidase IV, possessing a unique eight-bladed beta-propeller fold
Biochem Biophys Res Commun302, 849-854. PubMed Europe PubMed DOI S
[YEAR:1-5-2003]Kajiyama,H., Kikkawa,F., Khin,E., Shibata,K., Ino,K. and Mizutani,S.
Dipeptidyl peptidase IV overexpression induces up-regulation of E-cadherin and tissue inhibitors of matrix metalloproteinases, resulting in decreased invasive potential in ovarian carcinoma cells
Cancer Res63, 2278-2283. PubMed Europe PubMed
Karl,T., Hoffmann,T., Pabst,R. and von Horsten,S.
Extreme reduction of dipeptidyl peptidase IV activity in F344 rat substrains is associated with various behavioral differences
Physiol Behav80, 123-134. PubMed Europe PubMed DOI M
[YEAR:15-9-2003]Karl,T., Chwalisz,W.T., Wedekind,D., Hedrich,H.J., Hoffmann,T., Jacobs,R., Pabst,R. and von Horsten,S.
Localization, transmission, spontaneous mutations, and variation of function of the Dpp4 (dipeptidyl-peptidase IV; CD26) gene in rats
Regul Pept115, 81-90. PubMed Europe PubMed DOI
Kholova,I., Ludvikova,M., Ryska,A., Topolcan,O., Pikner,R., Pecen,L., Cap,J. and Holubec,L., Jr.
Diagnostic role of markers dipeptidyl peptidase IV and thyroid peroxidase in thyroid tumors
Anticancer Res23, 871-875. PubMed Europe PubMed
Lambeir,A.M., Durinx,C., Scharpe,S. and De Meester,I.
Dipeptidyl-peptidase IV from bench to bedside: an update on structural properties, functions, and clinical aspects of the enzyme DPP IV
Crit Rev Clin Lab Sci40, 209-294. PubMed Europe PubMed DOI
[YEAR:15-4-2003]Leiting,B., Pryor,K.D., Wu,J.K., Marsilio,F., Patel,R.A., Craik,C.S., Ellman,J.A., Cummings,R.T. and Thornberry,N.A.
Catalytic properties and inhibition of proline-specific dipeptidyl peptidases II, IV and VII
Biochem J371, 525-532. PubMed Europe PubMed DOI P
Lorey,S., Stockel-Maschek,A., Faust,J., Brandt,W., Stiebitz,B., Gorrell,M.D., Kahne,T., Mrestani-Klaus,C., Wrenger,S., Reinhold,D., Ansorge,S. and Neubert,K.
Different modes of dipeptidyl peptidase IV (CD26) inhibition by oligopeptides derived from the N-terminus of HIV-1 Tat indicate at least two inhibitor binding sites
Eur J Biochem270, 2147-2156. PubMed Europe PubMed DOI I
[YEAR:25-4-2003]Ludwig,K., Yan,S., Fan,H., Reutter,W. and Bottcher,C.
The 3D structure of rat DPPIV/CD26 as obtained by cryo-TEM and single particle analysis
Biochem Biophys Res Commun304, 73-77. PubMed Europe PubMed DOI S
Nagakura,T., Yasuda,N., Yamazaki,K., Ikuta,H. and Tanaka,I.
Enteroinsular axis of db/db mice and efficacy of dipeptidyl peptidase IV inhibition
Metabolism52, 81-86. PubMed Europe PubMed DOI
Oefner,C., D'arcy,A., Mac Sweeney,A., Pierau,S., Gardiner,R. and Dale,G.E.
High-resolution structure of human apo dipeptidyl peptidase IV/CD26 and its complex with 1-[([2-[(5-iodopyridin-2-yl)amino]-ethyl]amino)-acetyl]-2-cyano-(S)-pyrrol idine
Acta Crystallogr D Biol Crystallogr59, 1206-1212. PubMed Europe PubMed DOI S I
Pospisilik,J.A., Martin,J., Doty,T., Ehses,J.A., Pamir,N., Lynn,F.C., Piteau,S., Demuth,H.U., McIntosh,C.H. and Pederson,R.A.
Dipeptidyl peptidase IV inhibitor treatment stimulates beta-cell survival and islet neogenesis in streptozotocin-induced diabetic rats
Diabetes52, 741-750. PubMed Europe PubMed DOI I
Rasmussen,H.B., Branner,S., Wiberg,F.C. and Wagtmann,N.
Crystal structure of human dipeptidyl peptidase IV/CD26 in complex with a substrate analog
Nat Struct Biol10, 19-25. PubMed Europe PubMed DOI S
[YEAR:15-8-2003]Sakurada,C., Sakurada,S., Hayashi,T., Katsuyama,S., Tan-No,K. and Sakurada,T.
Degradation of endomorphin-2 at the supraspinal level in mice is initiated by dipeptidyl peptidase IV: an in vitro and in vivo study
Biochem Pharmacol66, 653-661. PubMed Europe PubMed DOI
Thoma,R., Loffler,B., Stihle,M., Huber,W., Ruf,A. and Hennig,M.
Structural basis of proline-specific exopeptidase activity as observed in human dipeptidyl peptidase-IV
Structure11, 947-959. PubMed Europe PubMed DOI S
[YEAR:19-6-2003]Villhauer,E.B., Brinkman,J.A., Naderi,G.B., Burkey,B.F., Dunning,B.E., Prasad,K., Mangold,B.L., Russell,M.E. and Hughes,T.E.
1-[[(3-hydroxy-1-adamantyl)amino]acetyl]-2-cyano-(S)-pyrrolidine: a potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitor with antihyperglycemic properties
J Med Chem46, 2774-2789. PubMed Europe PubMed DOI I
Williams,Y.N., Baba,H., Hayashi,S., Ikai,H., Sugita,T., Tanaka,S., Miyasaka,N. and Kubota,T.
Dipeptidyl peptidase IV on activated T cells as a target molecule for therapy of rheumatoid arthritis
Clin Exp Immunol131, 68-74. PubMed Europe PubMed DOI
[YEAR:20-6-2003]Zhu,L., Tamvakopoulos,C., Xie,D., Dragovic,J., Shen,X., Fenyk-Melody,J.E., Schmidt,K., Bagchi,A., Griffin,P.R., Thornberry,N.A. and Sinha Roy,R.
The role of dipeptidyl peptidase IV in the cleavage of glucagon family peptides: in vivo metabolism of pituitary adenylate cyclase activating polypeptide-(1-38)
J Biol Chem278, 22418-22423. PubMed Europe PubMed DOI

2002

Ahren,B., Simonsson,E., Larsson,H., Landin-Olsson,M., Torgeirsson,H., Jansson,P.A., Sandqvist,M., Bavenholm,P., Efendic,S., Eriksson,J.W., Dickinson,S. and Holmes,D.
Inhibition of dipeptidyl peptidase IV improves metabolic control over a 4-week study period in type 2 diabetes
Diabetes Care25, 869-875. PubMed Europe PubMed DOI I
[YEAR:22-3-2002]Alfalah,M., Jacob,R. and Naim,H.Y.
Intestinal dipeptidyl peptidase IV is efficiently sorted to the apical membrane through the concerted action of N- and O-glycans as well as association with lipid microdomains
J Biol Chem277, 10683-10690. PubMed Europe PubMed DOI
Christopherson,K.W., Hangoc,G. and Broxmeyer,H.E.
Cell surface peptidase CD26/dipeptidylpeptidase IV regulates CXCL12/stromal cell-derived factor-1 alpha-mediated chemotaxis of human cord blood CD34+ progenitor cells
J Immunol169, 7000-7008. PubMed Europe PubMed
Deacon,C.F., Wamberg,S., Bie,P., Hughes,T.E. and Holst,J.J.
Preservation of active incretin hormones by inhibition of dipeptidyl peptidase IV suppresses meal-induced incretin secretion in dogs
J Endocrinol172, 355-362. PubMed Europe PubMed DOI I
Dobers,J., Zimmermann-Kordmann,M., Leddermann,M., Schewe,T., Reutter,W. and Fan,H.
Expression, purification, and characterization of human dipeptidyl peptidase IV/CD26 in Sf9 insect cells
Protein Expr Purif25, 527-532. PubMed Europe PubMed DOI E
Ikushima,H., Munakata,Y., Iwata,S., Ohnuma,K., Kobayashi,S., Dang,N.H. and Morimoto,C.
Soluble CD26/dipeptidyl peptidase IV enhances transendothelial migration via its interaction with mannose 6-phosphate/insulin-like growth factor II receptor
Cell Immunol215, 106-110. PubMed Europe PubMed DOI
[YEAR:15-12-2002]Lambeir,A.M., Proost,P., Scharpe,S. and De Meester,I.
A kinetic study of glucagon-like peptide-1 and glucagon-like peptide-2 truncation by dipeptidyl peptidase IV, in vitro
Biochem Pharmacol64, 1753-1756. PubMed Europe PubMed DOI
[YEAR:6-9-2002]Lorey,S., Faust,J., Mrestani-Klaus,C., Kahne,T., Ansorge,S., Neubert,K. and Buhling,F.
Transcellular proteolysis demonstrated by novel cell surface-associated substrates of dipeptidyl peptidase IV (CD26)
J Biol Chem277, 33170-33177. PubMed Europe PubMed DOI
Ludwig,A., Schiemann,F., Mentlein,R., Lindner,B. and Brandt,E.
Dipeptidyl peptidase IV (CD26) on T cells cleaves the CXC chemokine CXCL11 (I-TAC) and abolishes the stimulating but not the desensitizing potential of the chemokine
J Leukoc Biol72, 183-191. PubMed Europe PubMed
Mitani,H., Takimoto,M. and Kimura,M.
Dipeptidyl peptidase IV inhibitor NVP-DPP728 ameliorates early insulin response and glucose tolerance in aged rats but not in aged Fischer 344 rats lacking its enzyme activity
Jpn J Pharmacol88, 451-458. PubMed Europe PubMed DOI I
Pospisilik,J.A., Stafford,S.G., Demuth,H.U., Brownsey,R., Parkhouse,W., Finegood,D.T., McIntosh,C.H. and Pederson,R.A.
Long-term treatment with the dipeptidyl peptidase IV inhibitor P32/98 causes sustained improvements in glucose tolerance, insulin sensitivity, hyperinsulinemia, and beta-cell glucose responsiveness in VDF (fa/fa) Zucker rats
Diabetes51, 943-950. PubMed Europe PubMed I
Pospisilik,J.A., Stafford,S.G., Demuth,H.U., McIntosh,C.H. and Pederson,R.A.
Long-term treatment with dipeptidyl peptidase IV inhibitor improves hepatic and peripheral insulin sensitivity in the VDF Zucker rat: a euglycemic-hyperinsulinemic clamp study
Diabetes51, 2677-2683. PubMed Europe PubMed I
Reimer,M.K., Holst,J.J. and Ahren,B.
Long-term inhibition of dipeptidyl peptidase IV improves glucose tolerance and preserves islet function in mice
Eur J Endocrinol146, 717-727. PubMed Europe PubMed I
[YEAR:31-5-2002]Richard,E., Alam,S.M., Arredondo-Vega,F.X., Patel,D.D. and Hershfield,M.S.
Clustered charged amino acids of human adenosine deaminase comprise a functional epitope for binding the adenosine deaminase complexing Protein CD26/Dipeptidyl Peptidase IV
J Biol Chem277, 19720-19726. PubMed Europe PubMed DOI
Shinosaki,T., Kobayashi,T., Kimura,K. and Kurihara,H.
Involvement of dipeptidyl peptidase IV in immune complex-mediated glomerulonephritis
Lab Invest82, 505-513. PubMed Europe PubMed
Sudre,B., Broqua,P., White,R.B., Ashworth,D., Evans,D.M., Haigh,R., Junien,J.L. and Aubert,M.L.
Chronic inhibition of circulating dipeptidyl peptidase IV by FE 999011 delays the occurrence of diabetes in male zucker diabetic fatty rats
Diabetes51, 1461-1469. PubMed Europe PubMed I
[YEAR:6-6-2002]Villhauer,E.B., Brinkman,J.A., Naderi,G.B., Dunning,B.E., Mangold,B.L., Mone,M.D., Russell,M.E., Weldon,S.C. and Hughes,T.E.
1-[2-[(5-Cyanopyridin-2-yl)amino]ethylamino]acetyl-2-(S)-pyrrolidinecarbonitrile: a potent, selective, and orally bioavailable dipeptidyl peptidase IV inhibitor with antihyperglycemic properties
J Med Chem45, 2362-2365. PubMed Europe PubMed DOI I

2001

Akiyama,T., Abe,M., Harada,S., Kojima,F., Sawa,R., Takahashi,Y., Naganawa,H., Homma,Y., Hamada,M., Yamaguchi,A., Aoyagi,T., Muraoka,Y. and Takeuchi,T.
Sulphostin, a potent inhibitor for dipeptidyl peptidase IV from Streptomyces sp. MK251-43F3
J Antibiot (Tokyo)54, 744-746. PubMed Europe PubMed I
Deacon,C.F., Danielson,P., Klarskov,L., Olesen,M. and Holst,J.J.
Dipeptidyl peptidase IV inhibition reduces the degradation and clearance of GIP and potentiates its insulinotropic and antihyperglycemic effects in anesthetized pigs
Diabetes50, 1588-1597. PubMed Europe PubMed
[YEAR:15-4-2001]Gonzalez-Gronow,M., Grenett,H.E., Weber,M.R., Gawdi,G. and Pizzo,S.V.
Interaction of plasminogen with dipeptidyl peptidase IV initiates a signal transduction mechanism which regulates expression of matrix metalloproteinase-9 by prostate cancer cells
Biochem J355, 397-407. PubMed Europe PubMed DOI
Gorrell,M.D., Gysbers,V. and McCaughan,G.W.
CD26: a multifunctional integral membrane and secreted protein of activated lymphocytes
Scand J Immunol54, 249-264. PubMed Europe PubMed DOI
Hass,G.M., Meyer,J.L., Newitt,R.A., Labuda,T., Brown,L., Aebersold,R. and Vessella,R.L.
Identification of the target of monoclonal antibody A6H as dipeptidyl peptidase IV/CD26 by LC MS\MS
Hybridoma20, 231-236. PubMed Europe PubMed DOI
Hildebrandt,M., Arck,P.C., Kruber,S., Demuth,H.U., Reutter,W. and Klapp,B.F.
Inhibition of dipeptidyl peptidase IV (DP IV, CD26) activity abrogates stress-induced, cytokine-mediated murine abortions
Scand J Immunol53, 449-454. PubMed Europe PubMed DOI I
[YEAR:10-8-2001]Lambeir,A.M., Proost,P., Durinx,C., Bal,G., Senten,K., Augustyns,K., Scharpe,S., Van Damme,J. and De Meester,I.
Kinetic investigation of chemokine truncation by CD26/dipeptidyl peptidase IV reveals a striking selectivity within the chemokine family
J Biol Chem276, 29839-29845. PubMed Europe PubMed DOI
[YEAR:2-11-2001]Lambeir,A.M., Durinx,C., Proost,P., Van Damme,J., Scharpe,S. and De Meester,I.
Kinetic study of the processing by dipeptidyl-peptidase IV/CD26 of neuropeptides involved in pancreatic insulin secretion
FEBS Lett507, 327-330. PubMed Europe PubMed DOI
[YEAR:8-6-2001]Nagakura,T., Yasuda,N., Yamazaki,K., Ikuta,H., Yoshikawa,S., Asano,O. and Tanaka,I.
Improved glucose tolerance via enhanced glucose-dependent insulin secretion in dipeptidyl peptidase IV-deficient Fischer rats
Biochem Biophys Res Commun284, 501-506. PubMed Europe PubMed DOI
[YEAR:12-1-2001]Pospisilik,J.A., Hinke,S.A., Pederson,R.A., Hoffmann,T., Rosche,F., Schlenzig,D., Glund,K., Heiser,U., McIntosh,C.H. and Demuth,H.
Metabolism of glucagon by dipeptidyl peptidase IV (CD26)
Regul Pept96, 133-141. PubMed Europe PubMed DOI I
Sentandreu,M.A. and Toldra,F.
Dipeptidyl peptidase IV from porcine skeletal muscle: purification and biochemical properties
Food Chem75, 159-168.
[YEAR:1-2-2001]Steinbrecher,A., Reinhold,D., Quigley,L., Gado,A., Tresser,N., Izikson,L., Born,I., Faust,J., Neubert,K., Martin,R., Ansorge,S. and Brocke,S.
Targeting dipeptidyl peptidase IV (CD26) suppresses autoimmune encephalomyelitis and up-regulates TGF-beta1 secretion in vivo
J Immunol166, 2041-2048. PubMed Europe PubMed I

2000

Dobers,J., Grams,S., Reutter,W. and Fan,H.
Roles of cysteines in rat dipeptidyl peptidase IV/CD26 in processing and proteolytic activity
Eur J Biochem267, 5093-5100. PubMed Europe PubMed DOI
[YEAR:2-4-2000]Erickson,R.H., Lai,R.S. and Kim,Y.S.
Role of hepatocyte nuclear factor 1alpha and 1beta in the transcriptional regulation of human dipeptidyl peptidase IV during differentiation of Caco-2 cells
Biochem Biophys Res Commun270, 235-239. PubMed Europe PubMed DOI
Gorrell,M.D., Abbott,C.A., Kahne,T., Levy,M.T., Church,W.B. and McCaughan,G.W.
Relating structure to function in the beta-propeller domain of dipeptidyl peptidase IV. Point mutations that influence adenosine deaminase binding, antibody binding and enzyme activity
Adv Exp Med Biol477, 89-95. PubMed Europe PubMed DOI
Hildebrandt,M., Reutter,W., Arck,P., Rose,M. and Klapp,B.F.
A guardian angel: the involvement of dipeptidyl peptidase IV in psychoneuroendocrine function, nutrition and immune defence
Clin Sci (Lond)99, 93-104. PubMed Europe PubMed
[YEAR:11-2-2000]Hinke,S.A., Pospisilik,J.A., Demuth,H.U., Mannhart,S., Kuhn-Wache,K., Hoffmann,T., Nishimura,E., Pederson,R.A. and McIntosh,C.H.
Dipeptidyl peptidase IV (DPIV/CD26) degradation of glucagon. Characterization of glucagon degradation products and DPIV-resistant analogs
J Biol Chem275, 3827-3834. PubMed Europe PubMed DOI
[YEAR:6-6-2000]Marguet,D., Baggio,L., Kobayashi,T., Bernard,A.M., Pierres,M., Nielsen,P.F., Ribel,U., Watanabe,T., Drucker,D.J. and Wagtmann,N.
Enhanced insulin secretion and improved glucose tolerance in mice lacking CD26
Proc Natl Acad Sci U S A97, 6874-6879. PubMed Europe PubMed DOI K
Pethiyagoda,C.L., Welch,D.R. and Fleming,T.P.
Dipeptidyl peptidase IV (DPPIV) inhibits cellular invasion of melanoma cells
Clin Exp Metastasis18, 391-400. PubMed Europe PubMed DOI
[YEAR:6-11-2000]Richard,E., Arredondo-Vega,F.X., Santisteban,I., Kelly,S.J., Patel,D.D. and Hershfield,M.S.
The binding site of human adenosine deaminase for CD26/Dipeptidyl peptidase IV: the Arg142Gln mutation impairs binding to cd26 but does not cause immune deficiency
J Exp Med192, 1223-1236. PubMed Europe PubMed DOI
Stockel-Maschek,A., Stiebitz,B., Born,I., Faust,J., Mogelin,W. and Neubert,K.
Potent inhibitors of dipeptidyl peptidase IV and their mechanisms of inhibition
Adv Exp Med Biol477, 117-123. PubMed Europe PubMed DOI I
[YEAR:15-6-2000]Stockel-Maschek,A., Mrestani-Klaus,C., Stiebitz,B., Demuth,H. and Neubert,K.
Thioxo amino acid pyrrolidides and thiazolidides: new inhibitors of proline specific peptidases
Biochim Biophys Acta1479, 15-31. PubMed Europe PubMed DOI I
[YEAR:21-1-2000]Wrenger,S., Kahne,T., Bohuon,C., Weglohner,W., Ansorge,S. and Reinhold,D.
Amino-terminal truncation of procalcitonin, a marker for systemic bacterial infections, by dipeptidyl peptidase IV (DP IV)
FEBS Lett466, 155-159. PubMed Europe PubMed DOI
[YEAR:21-7-2000]Wrenger,S., Faust,J., Mrestani-Klaus,C., Fengler,A., Stockel-Maschek,A., Lorey,S., Kahne,T., Brandt,W., Neubert,K., Ansorge,S. and Reinhold,D.
Down-regulation of T cell activation following inhibition of dipeptidyl peptidase IV/CD26 by the N-terminal part of the thromboxane A2 receptor
J Biol Chem275, 22180-22186. PubMed Europe PubMed

1999

Abbott,C.A., McCaughan,G.W., Levy,M.T., Church,W.B. and Gorrell,M.D.
Binding to human dipeptidyl peptidase IV by adenosine deaminase and antibodies that inhibit ligand binding involves overlapping, discontinuous sites on a predicted beta propeller domain
Eur J Biochem266, 798-810. PubMed Europe PubMed DOI
Augustyns,K., Bal,G., Thonus,G., Belyaev,A., Zhang,X.M., Bollaert,W., Lambeir,A.M., Durinx,C., Goossens,F. and Haemers,A.
The unique properties of dipeptidyl-peptidase IV (DPP IV/CD26) and the therapeutic potential of DPP IV inhibitors
Curr Med Chem6, 311-327. PubMed Europe PubMed I
Belyaev,A., Zhang,X., Augustyns,K., Lambeir,A.M., De Meester,I., Vedernikova,I., Scharpe,S. and Haemers,A.
Structure-activity relationship of diaryl phosphonate esters as potent irreversible dipeptidyl peptidase IV inhibitors
J Med Chem42, 1041-1052. PubMed Europe PubMed DOI I
Cheng,H.C., Abdel-Ghany,M., Zhang,S. and Pauli,B.U.
Is the Fischer 344/CRJ rat a protein-knock-out model for dipeptidyl peptidase IV-mediated lung metastasis of breast cancer?
Clin Exp Metastasis17, 609-615. PubMed Europe PubMed DOI K
[YEAR:15-2-1999]Erickson,R.H., Gum,J.R., Lotterman,C.D., Hicks,J.W., Lai,R.S. and Kim,Y.S.
Regulation of the gene for human dipeptidyl peptidase IV by hepatocyte nuclear factor 1alpha
Biochem J338, 91-97. PubMed Europe PubMed DOI
Gilmartin,L. and O'Cuinn,G.
Dipeptidyl aminopeptidase IV and aminopeptidase P, two proline specific enzymes from the cytoplasm of guinea-pig brain: their role in metabolism of peptides containing consecutive prolines
Neurosci Res34, 1-11. PubMed Europe PubMed DOI
Grondin,G., Hooper,N.M. and LeBel,D.
Specific localization of membrane dipeptidase and dipeptidyl peptidase IV in secretion granules of two different pancreatic islet cells
J Histochem Cytochem47, 489-498. PubMed Europe PubMed
[YEAR:7-9-1999]Hughes,T.E., Mone,M.D., Russell,M.E., Weldon,S.C. and Villhauer,E.B.
NVP-DPP728 (1-[[[2-[(5-cyanopyridin-2-yl) amino]ethyl] amino] acetyl]-2-cyano-(S)-pyrrolidine), a slow-binding inhibitor of dipeptidyl peptidase IV
Biochemistry38, 11597-11603. PubMed Europe PubMed DOI I
Siegel,E.G., Scharf,G., Gallwitz,B., Mentlein,R., Morys-Wortmann,C., Folsch,U.R. and Schmidt,W.E.
Comparison of the effect of native glucagon-like peptide 1 and dipeptidyl peptidase IV-resistant analogues on insulin release from rat pancreatic islets
Eur J Clin Invest29, 610-614. PubMed Europe PubMed DOI
Wagner,L., Naude,R.J., Oelofsen,W., Naganuma,T. and Muramoto,K.
Isolation and partial characterization of dipeptidyl peptidase IV from ostrich kidney
Enzyme Microb Technol25, 576-583.

1998

Ben-Shooshan,I. and Parola,A.H.
The CP-I subunit of adenosine deaminase complexing protein from calf kidney is identical to human, mouse, and rat dipeptidyl peptidase IV
Comp Biochem Physiol B Biochem Mol Biol119, 289-292. PubMed Europe PubMed DOI
Holst,J.J. and Deacon,C.F.
Inhibition of the activity of dipeptidyl-peptidase IV as a treatment for type 2 diabetes
Diabetes47, 1663-1670. PubMed Europe PubMed DOI
Iwaki-Egawa,S., Watanabe,Y., Kikuya,Y. and Fujimoto,Y.
Dipeptidyl peptidase IV from human serum: purification, characterization, and N-terminal amino acid sequence
J Biochem124, 428-433. PubMed Europe PubMed
[YEAR:15-6-1998]Niedermeyer,J., Enenkel,B., Park,J.E., Lenter,M., Rettig,W.J., Damm,K. and Schnapp,A.
Mouse fibroblast-activation protein - conserved Fap gene organization and biochemical function as a serine protease
Eur J Biochem254, 650-654. PubMed Europe PubMed DOI

1997

Brandt,W.
A molecular model of the active site of dipeptidyl peptidase IV. Explanation of the substrate specificity and interaction with inhibitors
Adv Exp Med Biol421, 171-178. PubMed Europe PubMed
Van Noorden,C.J., Boonacker,E., Bissell,E.R., Meijer,A.J., van Marle,J. and Smith,R.E.
Ala-Pro-Cresyl violet, a synthetic fluorogenic substrate for the analysis of kinetic parameters of dipeptidyl peptidase IV (CD26) in individual living rat hepatocytes
Anal Biochem252, 71-77. PubMed Europe PubMed DOI A

1996

Mentzel,S., Dijkman,H.B., van Son,J.P., Koene,R.A. and Assmann,K.J.
Organ distribution of aminopeptidase A and dipeptidyl peptidase IV in normal mice
J Histochem Cytochem44, 445-461. PubMed Europe PubMed
Pederson,R.A., Kieffer,T.J., Pauly,R., Kofod,H., Kwong,J. and McIntosh,C.H.
The enteroinsular axis in dipeptidyl peptidase IV-negative rats
Metabolism45, 1335-1341. PubMed Europe PubMed DOI K
Shibuya-Saruta,H., Kasahara,Y. and Hashimoto,Y.
Human serum dipeptidyl peptidase IV (DPPIV) and its unique properties
J Clin Lab Anal10, 435-440. PubMed Europe PubMed DOI I

1995

Bohm,S.K., Gum,J.R., Jr., Erickson,R.H., Hicks,J.W. and Kim,Y.S.
Human dipeptidyl peptidase IV gene promoter: tissue-specific regulation from a TATA-less GC-rich sequence characteristic of a housekeeping gene promoter
Biochem J311, 835-843. PubMed Europe PubMed
Borloo,M., Augustyns,K., Belyaev,A., De Meester,I., Lambeir,A.M., Goossens,F., Bollaert,W., Rajan,P., Scharpe,S. and Haemers,A.
Synthesis and evaluation of azaproline peptides as potential inhibitors of dipeptidyl peptidase IV and prolyl oligopeptidase
Lett Pept Sci2, 198-202. DOI I
Iwaki-Egawa,S., Watanabe,Y. and Fujimoto,Y.
Is CD26/dipeptidyl peptidase IV a really important molecule in T cell activation of a certain rat strain?
Immunobiology194, 429-442. PubMed Europe PubMed DOI
Li,J., Wilk,E. and Wilk,S.
Aminoacylpyrrolidine-2-nitriles: potent and stable inhibitors of dipeptidyl-peptidase IV (CD 26)
Arch Biochem Biophys323, 148-154. PubMed Europe PubMed DOI I
Shibuya-Saruta,H., Sugiyama,M. and Kasahara,Y.
Colorimetrical rate assay for urinary dipeptidyl peptidase IV (DPPIV) activity using a new substrate
J Clin Lab Anal9, 113-118. PubMed Europe PubMed DOI A I

1994

Bernard,A.M., Mattei,M.G., Pierres,M. and Marguet,D.
Structure of the mouse dipeptidyl peptidase IV (CD26) gene
Biochemistry33, 15204-15214. PubMed Europe PubMed DOI
[YEAR:11-11-1994]Boduszek,B., Oleksyszyn,J., Kam,C.M., Selzler,J., Smith,R.E. and Powers,J.C.
Dipeptide phosphonates as inhibitors of dipeptidyl peptidase IV
J Med Chem37, 3969-3976. PubMed Europe PubMed DOI I
Borloo,M. and De Meester,I.
Dipeptidyl peptidase IV: development, design, synthesis and biological evaluation of inhibitors
Verh K Acad Geneeskd Belg56, 57-88. PubMed Europe PubMed I
Ikehara,Y., Ogata,S. and Misumi,Y.
Dipeptidyl-peptidase IV from rat liver
Methods Enzymol244, 215-227. PubMed Europe PubMed DOI V
Ohkubo,I., Huang,K., Ochiai,Y., Takagaki,M. and Kani,K.
Dipeptidyl peptidase IV from porcine seminal plasma: purification, characterization, and N-terminal amino acid sequence
J Biochem116, 1182-1186. PubMed Europe PubMed I

1993

[YEAR:15-8-1993]David,F., Bernard,A.M., Pierres,M. and Marguet,D.
Identification of serine 624, aspartic acid 702, and histidine 734 as the catalytic triad residues of mouse dipeptidyl-peptidase IV (CD26). A member of a novel family of nonclassical serine hydrolases
J Biol Chem268, 17247-17252. PubMed Europe PubMed

1992

Barrett,A.J. and Rawlings,N.D.
Oligopeptidases, and the emergence of the prolyl oligopeptidase family
Biol Chem Hoppe Seyler373, 353-360. PubMed Europe PubMed
Darmoul,D., Lacasa,M., Baricault,L., Marguet,D., Sapin,C., Trotot,P., Barbat,A. and Trugnan,G.
Dipeptidyl peptidase IV (CD 26) gene expression in enterocyte-like colon cancer cell lines HT-29 and Caco-2. Cloning of the complete human coding sequence and changes of dipeptidyl peptidase IV mRNA levels during cell differentiation
J Biol Chem267, 4824-4833. PubMed Europe PubMed
[YEAR:15-6-1992]Fujiwara,T., Tsuji,E., Misumi,Y., Takami,N. and Ikehara,Y.
Selective cell-surface expression of dipeptidyl peptidase IV with mutations at the active site sequence
Biochem Biophys Res Commun185, 776-784. PubMed Europe PubMed DOI
Misumi,Y., Hayashi,Y., Arakawa,F. and Ikehara,Y.
Molecular cloning and sequence analysis of human dipeptidyl peptidase IV, a serine proteinase on the cell surface
Biochim Biophys Acta1131, 333-336. PubMed Europe PubMed DOI
Ogata,S., Misumi,Y., Tsuji,E., Takami,N., Oda,K. and Ikehara,Y.
Identification of the active site residues in dipeptidyl peptidase IV by affinity labeling and site-directed mutagenesis
Biochemistry31, 2582-2587. PubMed Europe PubMed DOI I
[YEAR:1-12-1992]Tsuji,E., Misumi,Y., Fujiwara,T., Takami,N., Ogata,S. and Ikehara,Y.
An active-site mutation (Gly633 - >Arg) of dipeptidyl peptidase IV causes its retention and rapid degradation in the endoplasmic reticulum
Biochemistry31, 11921-11927. PubMed Europe PubMed DOI K

1991

[YEAR:15-2-1991]Flentke,G.R., Munoz,E., Huber,B.T., Plaut,A.G., Kettner,C.A. and Bachovchin,W.W.
Inhibition of dipeptidyl aminopeptidase IV (DP-IV) by Xaa-boroPro dipeptides and use of these inhibitors to examine the role of DP-IV in T-cell function
Proc Natl Acad Sci U S A88, 1556-1559. PubMed Europe PubMed I

1990

[YEAR:5-2-1990]Tiruppathi,C., Ganapathy,V. and Leibach,F.H.
Evidence for tripeptide-proton symport in renal brush border membrane vesicles. Studies in a novel rat strain with a genetic absence of dipeptidyl peptidase IV
J Biol Chem265, 2048-2053. PubMed Europe PubMed K

1989

Ogata,S., Misumi,Y. and Ikehara,Y.
Primary structure of rat liver dipeptidyl peptidase IV deduced from its cDNA and identification of the NH2-terminal signal sequence as the membrane-anchoring domain
J Biol Chem264, 3596-3601. PubMed Europe PubMed

1984

[YEAR:1-11-1984]Harada,M., Hiraoka,B.Y., Fukasawa,K.M. and Fukasawa,K.
Chemical modification of dipeptidyl peptidase IV: involvement of an essential tryptophan residue at the substrate binding site
Arch Biochem Biophys234, 622-628. PubMed Europe PubMed
[YEAR:28-2-1984]Heins,J., Neubert,K., Barth,A., Canizaro,P.C. and Behal,F.J.
Kinetic investigation of the hydrolysis of aminoacyl p-nitroanilides by dipeptidyl peptidase IV from human and pig kidney
Biochim Biophys Acta785, 30-35. PubMed Europe PubMed
Umezawa,H., Aoyagi,T., Ogawa,K., Naganawa,H., Hamada,M. and Takeuchi,T.
Diprotins A and B, inhibitors of dipeptidyl aminopeptidase IV, produced by bacteria
J Antibiot (Tokyo)37, 422-425. PubMed Europe PubMed I

1983

[YEAR:20-4-1983]Erickson,R.H., Bella,A.M., Jr., Brophy,E.J., Kobata,A. and Kim,Y.S.
Purification and molecular characterization of rat intestinal brush border membrane dipeptidyl aminopeptidase IV
Biochim Biophys Acta756, 258-265. PubMed Europe PubMed
[YEAR:22-11-1983]Miura,S., Song,I.S., Morita,A., Erickson,R.H. and Kim,Y.S.
Distribution and biosynthesis of aminopeptidase N and dipeptidyl aminopeptidase IV in rat small intestine
Biochim Biophys Acta761, 66-75. PubMed Europe PubMed DOI
Morita,A., Chung,Y.C., Freeman,H.J., Erickson,R.H., Sleisenger,M.H. and Kim,Y.S.
Intestinal assimilation of a proline-containing tetrapeptide. Role of a brush border membrane postproline dipeptidyl aminopeptidase IV
J Clin Invest72, 610-616. PubMed Europe PubMed DOI
[YEAR:15-10-1983]Saison,M., Verlinden,J., Van Leuven,F., Cassiman,J.J. and Van Den Berghe,H.
Identification of cell surface dipeptidylpeptidase IV in human fibroblasts
Biochem J216, 177-183. PubMed Europe PubMed

1982

[YEAR:1-10-1982]Bella,A.M., Jr., Erickson,R.H. and Kim,Y.S.
Rat intestinal brush border membrane dipeptidyl-aminopeptidase IV: kinetic properties and substrate specificities of the purified enzyme
Arch Biochem Biophys218, 156-162. PubMed Europe PubMed
Feller,A.C., Heijnen,C.J., Ballieux,R.E. and Parwaresch,M.R.
Enzymehistochemical staining of T mu lymphocytes for glycyl-proline-4-methoxy-beta-naphthylamide-peptidase (DAP IV)
Br J Haematol51, 227-234. PubMed Europe PubMed
[YEAR:5-3-1982]Hama,T., Okada,M., Kojima,K., Kato,T., Matsuyama,M. and Nagatsu,T.
Purification of dipeptidyl-aminopeptidase IV from human kidney by anti dipeptidyl-aminopeptidase IV affinity chromatography
Mol Cell Biochem43, 35-42. PubMed Europe PubMed
[YEAR:17-12-1982]Ichinose,M., Maeda,R., Fukuda,T., Watanabe,B., Ishimaru,T., Izumi,M., Miyake,S. and Takamori,M.
Partial purification and characterization of glycylprolyl dipeptidyl aminopeptidase in porcine pancreas
Biochim Biophys Acta719, 527-531. PubMed Europe PubMed
Yoshimoto,T., Kita,T., Ichinose,M. and Tsuru,D.
Dipeptidyl aminopeptidase IV from porcine pancreas
J Biochem92, 275-282. PubMed Europe PubMed

1980

Barth,A., Mager,H., Fischer,G., Neubert,K. and Schwarz,G.
[Structure-activity relationship in the enzymatic hydrolysis of dipeptide aryl amides by dipeptidyl peptidase IV]
Acta Biol Med Ger39, 1129-1142. PubMed Europe PubMed
Iijima,K.I., Takei,T., Hino,M. and Hayakawa,T.
A new fluorescence assay for dipeptidylpeptidase IV using tripeptide L-prolyl-L-prolyl-L-alanine as substrate
J Biochem Biophys Methods3, 89-96. PubMed Europe PubMed DOI A
Kreil,G., Haiml,L. and Suchanek,G.
Stepwise cleavage of the pro part of promelittin by dipeptidylpeptidase IV. Evidence for a new type of precursor-product conversion
Eur J Biochem111, 49-58. PubMed Europe PubMed

1979

[YEAR:15-9-1979]Fukasawa,K.M., Fukasawa,K. and Harada,M.
Immunochemical identity of dipeptidyl aminopeptidase IV from pig serum, liver, submaxillary gland and kidney
Experientia35, 1142-1143. PubMed Europe PubMed
[YEAR:3-4-1979]Gossrau,R.
[Peptidases II. Localization of dipeptidylpeptidase IV (DPP IV). Histochemical and biochemical study]
Histochemistry60, 231-248. PubMed Europe PubMed L
[YEAR:5-3-1979]Kato,T., Iwase,K., Nagatsu,T., Hino,M., Takemoto,T. and Sakakibara,S.
A new assay of X-prolyl dipeptidyl-aminopeptidase activity in human serum with glycylproline p-phenylazoanilide as substrate
Mol Cell Biochem24, 9-13. PubMed Europe PubMed A
[YEAR:26-2-1979]Krutzsch,H.C. and Pisano,J.J.
Preparation of dipeptidyl aminopeptidase IV for polypeptide sequencing
Biochim Biophys Acta576, 280-289. PubMed Europe PubMed

1978

[YEAR:21-7-1978]Fukasawa,K.M., Fukasawa,K. and Harada,M.
Dipeptidyl aminopeptidase IV, a glycoprotein from pig kidney
Biochim Biophys Acta535, 161-166. PubMed Europe PubMed
[YEAR:15-7-1978]Heymann,E. and Mentlein,R.
Liver dipeptidyl aminopeptidase IV hydrolyzes substance P
FEBS Lett91, 360-364. PubMed Europe PubMed DOI
[YEAR:15-3-1978]Kato,T., Nagatsu,T., Kimura,T. and Sakakibara,S.
Studies on substrate specificity of X-prolyl dipeptidyl-aminopeptidase during new chromogenic substrates, X-Y-p-nitroanilides
Experientia34, 319-320. PubMed Europe PubMed P
Kato,T., Nagatsu,T., Kimura,T. and Sakakibara,S.
Fluorescence assay of X-prolyl dipeptidyl-aminopeptidase activity with a new fluorogenic substrate
Biochem Med19, 351-359. PubMed Europe PubMed A
[YEAR:7-8-1978]Kato,T., Nagatsu,T., Fukasawa,K., Harada,M., Nagatsu,I. and Sakakibara,S.
Successive cleavage of N-terminal Arg1--Pro2 and Lys3-Pro4 from substance P but no release of Arg1-Pro2 from bradykinin, by X-Pro dipeptidyl-aminopeptidase
Biochim Biophys Acta525, 417-422. PubMed Europe PubMed P
Kullertz,G., Fischer,G. and Barth,A.
[Catalytic mechanism of dipeptidyl-peptidase IV]
Acta Biol Med Ger37, 559-567. PubMed Europe PubMed
Wolf,B., Fischer,G. and Barth,A.
[Kinetics of dipeptidyl-peptidase IV]
Acta Biol Med Ger37, 409-420. PubMed Europe PubMed

1976

Hino,M., Fuyamada,H., Hayakawa,T., Nagatsu,T. and Oya,H.
X-Prolyl dipeptidyl-aminopeptidase activity, with X-proline p-nitroanilides as substrates, in normal and pathological human sera
Clin Chem22, 1256-1261. PubMed Europe PubMed
[YEAR:1-7-1976]Kenny,A.J., Booth,A.G., George,S.G., Ingram,J., Kershaw,D., Wood,E.J. and Young,A.R.
Dipeptidyl peptidase IV, a kidney brush-border serine peptidase
Biochem J157, 169-182. PubMed Europe PubMed

1975

[YEAR:9-7-1975]Hino,M., Nagatsu,T., Kakumu,S., Okuyama,S., Yoshii,Y. and Nagatsu,I.
Glycylprolyl beta-naphthylamidase activity in human serum
Clin Chim Acta62, 5-11. PubMed Europe PubMed

1974

Oya,H., Harada,M. and Nagatsu,T.
Peptidase activity of glycylprolyl beta-naphthylamidase from human submaxillary gland
Arch Oral Biol19, 489-491. PubMed Europe PubMed

1972

[YEAR:28-2-1972]Oya,H., Nagatsu,I. and Nagatsu,T.
Purification and properties of glycylprolyl beta-naphthylamidase in human submaxillary gland
Biochim Biophys Acta258, 591-599. PubMed Europe PubMed

1970

Hopsu-Havu,V.K., Jansen,C.T. and Jarvinen,M.
A human serum aminopeptidase capable of splitting juxtaterminal bonds involving proline. Basic characteristics, normal values and clinical variations
Clin Chim Acta28, 25-36. PubMed Europe PubMed

1968

Hopsu-Havu,V.K., Rintola,P. and Glenner,G.G.
A hog kidney aminopeptidase liberating N-terminal dipeptides. Partial purification and characteristics
Acta Chem Scand22, 299-308. PubMed Europe PubMed
[YEAR:15-4-1968]Nagatsu,I., Nagatsu,T. and Yamamoto,T.
Hydrolysis of amino acid beta-naphthylamides by aminopeptidases in human parotid salva and human serum
Experientia24, 347-348. PubMed Europe PubMed DOI

1967

Hopsu-Havu,V.K. and Sarimo,S.R.
Purification and characterization of an aminopeptidase hydrolyzing glycyl-proline-naphthylamide
Hoppe Seylers Z Physiol Chem348, 1540-1550. PubMed Europe PubMed

1966

Hopsu-Havu,V.K. and Glenner,G.G.
A new dipeptide naphthylamidase hydrolyzing glycyl-prolyl-beta-naphthylamide
Histochemie7, 197-201. PubMed Europe PubMed DOI