Literature for peptidase S01.480: HtrA peptidase (Chlamydia trachomatis-type)

Summary Alignment Tree Sequences Sequence features Distribution Literature Substrates

(Topics flags: P Specificity, I Inhibitor, U Therapeutic. To select only the references relevant to a single topic, click the link above. See explanation.)

2024

Phillips,M.J.A., Huston,W.M., McDonagh,A.M. and Rawling,T. 4-Chloroisocoumarins as Chlamydial Protease Inhibitors and Anti-Chlamydial Agents Molecules (2024) 29 PubMed Europe PubMed DOI PMC EPMC

2019

Agbowuro,A.A., Hwang,J., Peel,E., Mazraani,R., Springwald,A., Marsh,J.W., McCaughey,L., Gamble,A.B., Huston,W.M. and Tyndall,J.D.A. Structure-activity analysis of peptidic Chlamydia HtrA inhibitors Bioorg Med Chem (2019) 27, 4185-4199. PubMed Europe PubMed DOI I

2018

Backert,S., Bernegger,S., Skorko-Glonek,J. and Wessler,S. Extracellular HtrA serine proteases: an emerging new strategy in bacterial pathogenesis Cell Microbiol (2018) , e12845-e12845. PubMed Europe PubMed DOI

2015

Ong,V.A., Lawrence,A., Timms,P., Vodstrcil,L.A., Tabrizi,S.N., Beagley,K.W., Allan,J.A., Hocking,J.S. and Huston,W.M. In vitro susceptibility of recent Chlamydia trachomatis clinical isolates to the CtHtrA inhibitor JO146 Microbes Infect (2015) 17, 738-744. PubMed Europe PubMed DOI U I

2013

Gloeckl,S., Ong,V.A., Patel,P., Tyndall,J.D., Timms,P., Beagley,K.W., Allan,J.A., Armitage,C.W., Turnbull,L., Whitchurch,C.B., Merdanovic,M., Ehrmann,M., Powers,J.C., Oleksyszyn,J., Verdoes,M., Bogyo,M. and Huston,W.M. Identification of a serine protease inhibitor which causes inclusion vacuole reduction and is lethal to Chlamydia trachomatis Mol Microbiol (2013) 89, 676-689. PubMed Europe PubMed DOI I
Marsh,J.W., Lott,W.B., Tyndall,J.D. and Huston,W.W. Proteolytic activation of Chlamydia trachomatis HTRA is mediated by PDZ1 domain interactions with protease domain loops L3 and LC and beta strand beta5 Cell Mol Biol Lett (2013) 18, 522-537. PubMed Europe PubMed DOI

2012

Gloeck,S., Tyndall,J.D., Stansfield,S.H., Timms,P. and Huston,W.M. The active site residue V266 of chlamydial HtrA is critical for substrate binding during both in vitro and in vivo conditions J Mol Microbiol Biotechnol (2012) 22, 10-16. PubMed Europe PubMed DOI P

2011

Huston,W.M., Tyndall,J.D., Lott,W.B., Stansfield,S.H. and Timms,P. Unique residues involved in activation of the multitasking protease/chaperone HtrA from Chlamydia trachomatis PLoS ONE (2011) 6, e24547-e24547. PubMed Europe PubMed DOI PMC EPMC
Wu,X., Lei,L., Gong,S., Chen,D., Flores,R. and Zhong,G. The chlamydial periplasmic stress response serine protease cHtrA is secreted into host cell cytosol BMC Microbiol (2011) 11, 87-87. PubMed Europe PubMed DOI
Zhong,G. Chlamydia trachomatis secretion of proteases for manipulating host signaling pathways Front Microbiol (2011) 2, 14-14. PubMed Europe PubMed DOI PMC EPMC

2007

Huston,W.M., Swedberg,J.E., Harris,J.M., Walsh,T.P., Mathews,S.A. and Timms,P. The temperature activated HtrA protease from pathogen Chlamydia trachomatis acts as both a chaperone and protease at 37 degrees C FEBS Lett (2007) 581, 3382-3386. PubMed Europe PubMed DOI