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Literature for peptidase S01.308: matriptase-2

Summary Gene structure Alignment Tree Sequences Sequence features Distribution Literature Substrates

(Topics flags: A Assay, M Mutation, P Specificity, I Inhibitor, K Knockout, V Review. To select only the references relevant to a single topic, click the link above. See explanation.)

    2024
  1. Huang,D.W., He,G.Q., Guo,X., Wan,Z., Gao,J. and Yang,R.
    Iron-Refractory Iron Deficiency Anemia with Novel TMPRSS6 Mutation
    Indian J Pediatr91, 311-311. PubMed  Europe PubMed DOI
  2. Zuo,Y., Bai,J., Bai,H., Tian,S., Sun,H., Shi,Z., Yu,P., Gao,G., Li,Y. and Chang,Y.Z.
    Transmembrane serine protease 6, a novel target for inhibition of neuronal tumor growth
    Cell Death Dis15, 49-49. PubMed  Europe PubMed DOI
    3. 2023
  3. Al-Jamea,L.H., Woodman,A., Heiba,M., Elshazly,S.A., Ben Khalaf,N., Al-Yami,F.S., Bilal Waheed,K., Al Mutair,A., Alsedi,A., Quiambao,J.V., Alzahrani,F.M., Albaqami,W.F., Al Qahtani,F.H., Mohammed Aljarah,N., Fathallah,D.M. and Halim Deifalla,A.
    TMPRSS6 gene mutations in six Saudi families with iron refractory iron deficiency anemia
    Gene851, 146977-146977. PubMed  Europe PubMed DOI
  4. Wu,Q., Li,S., Zhang,X. and Dong,N.
    Type II Transmembrane Serine Proteases as Modulators in Adipose Tissue Phenotype and Function
    Biomedicines11, PubMed  Europe PubMed DOI  V
    5. 2022
  5. Dion,S.P., Desilets,A., Lemieux,G. and Leduc,R.
    Functionally impaired isoforms regulate TMPRSS6 proteolytic activity
    PLoS ONE17, e0273825-e0273825. PubMed  Europe PubMed DOI
    6. 2021
  6. Schmidt,P.J., Fitzgerald,K., Butler,J.S. and Fleming,M.D.
    Global loss of Tfr2 with concomitant induced iron deficiency greatly ameliorates the phenotype of a murine thalassemia intermedia model
    Am J Hematol96, 251-257. PubMed  Europe PubMed DOI  K
  7. Vadolas,J., Ng,G.Z., Kysenius,K., Crouch,P.J., Dames,S., Eisermann,M., Nualkaew,T., Vilcassim,S., Schaeper,U. and Grigoriadis,G.
    SLN124, a GalNac-siRNA targeting transmembrane serine protease 6, in combination with deferiprone therapy reduces ineffective erythropoiesis and hepatic iron-overload in a mouse model of beta-thalassaemia
    Br J Haematol PubMed  Europe PubMed DOI
    8. 2020
  8. Belot,A., Gourbeyre,O., Palin,A., Rubio,A., Largounez,A., Besson-Fournier,C., Latour,C., Lorgouilloux,M., Gallitz,I., Montagner,A., Polizzi,A., Regnier,M., Smati,S., Zhang,A.S., Diaz-Munoz,M.D., Steinbicker,A.U., Guillou,H., Roth,M.P., Coppin,H. and Meynard,D.
    Endoplasmic reticulum stress controls iron metabolism through TMPRSS6 repression and hepcidin mRNA stabilization by RNA-binding protein HuR
    Haematologica PubMed  Europe PubMed DOI
  9. Cakmakli,S., Kaplan,C., Uzunoglu,M., Buyukbayram,M., Gorgulu,E., Zarif,N.O. and Keskin,E.Y.
    A novel homozygous nonsense mutation (p.Y78*) in TMPRSS6 gene causing iron-refractory iron deficiency anemia (IRIDA) in two siblings
    Turk J Pediatr62, 103-108. PubMed  Europe PubMed DOI  M
  10. Enns,C.A., Jue,S. and Zhang,A.S.
    The ectodomain of matriptase-2 plays an important non-proteolytic role in suppressing hepcidin expression in mice
    Blood PubMed  Europe PubMed DOI
  11. Paszti-Gere,E., Szombath,G., Gutschow,M., Steinmetzer,T. and Szekacs,A.
    3-Amidinophenylalanine-derived matriptase inhibitors can modulate hepcidin production in vitro
    Naunyn Schmiedebergs Arch Pharmacol393, 511-520. PubMed  Europe PubMed DOI  I
    12. 2019
  12. Beliveau,F., Tarkar,A., Dion,S.P., Desilets,A., Ghinet,M.G., Boudreault,P.L., St-Georges,C., Marsault,E., Paone,D., Collins,J., Macphee,C.H., Campobasso,N., Groy,A., Cottom,J., Ouellette,M., Pope,A.J. and Leduc,R.
    Discovery and development of TMPRSS6 inhibitors modulating hepcidin levels in human hepatocytes
    Cell Chem Biol26, 1559-1572. PubMed  Europe PubMed DOI  I
  13. Damalanka,V.C. and Janetka,J.W.
    Recent progress on inhibitors of the type II transmembrane serine proteases, hepsin, matriptase and matriptase-2
    Future Med Chem11, 743-769. PubMed  Europe PubMed DOI  I
  14. Mao,P., Wortham,A.M., Enns,C.A. and Zhang,A.S.
    The catalytic, stem, and transmembrane portions of matriptase-2 are required for suppressing the expression of the iron-regulatory hormone hepcidin
    J Biol Chem294, 2060-2073. PubMed  Europe PubMed DOI
    15. 2018
  15. Dion,S.P., Beliveau,F., Desilets,A., Ghinet,M.G. and Leduc,R.
    Transcriptome analysis reveals TMPRSS6 isoforms with distinct functionalities
    J Cell Mol Med22, 2498-2509. PubMed  Europe PubMed DOI
  16. Folgueras,A.R., Freitas-Rodriguez,S., Ramsay,A.J., Garabaya,C., Rodriguez,F., Velasco,G. and Lopez-Otin,C.
    Matriptase-2 deficiency protects from obesity by modulating iron homeostasis
    Nat Commun9, 1350-1350. PubMed  Europe PubMed DOI  M
  17. Gitlin-Domagalska,A., Mangold,M., Debowski,D., Ptaszynska,N., Legowska,A., Gutschow,M. and Rolka,K.
    Matriptase-2: monitoring and inhibiting its proteolytic activity
    Future Med Chem10, 2745-2761. PubMed  Europe PubMed DOI  I
  18. Mangold,M., Gutschow,M. and Stirnberg,M.
    A short peptide inhibitor as an activity-based probe for matriptase-2
    Pharmaceuticals (Basel)11, PubMed  Europe PubMed DOI  I
    19. 2017
  19. Gitlin-Domagalska,A., Debowski,D., Legowska,A., Stirnberg,M., Okonska,J., Gutschow,M. and Rolka,K.
    Design and chemical syntheses of potent matriptase-2 inhibitors based on trypsin inhibitor SFTI-1 isolated from sunflower seeds
    Biopolymers108, PubMed  Europe PubMed DOI  I
  20. Pinto,J., Nobre de Jesus,G., Palma Anselmo,M., Goncalves,L., Bras,D., Madeira Lopes,J., Meneses,J., Victorino,R. and Faustino,P.
    Iron refractory iron deficiency anemia in dizygotic twins due to a novel TMPRSS6 gene mutation in addition to polymorphisms associated with high susceptibility to develop ferropenic anemia
    J Investig Med High Impact Case Rep5, 2324709617701776-2324709617701776. PubMed  Europe PubMed DOI  M
  21. St-Georges,C., Desilets,A., Beliveau,F., Ghinet,M., Dion,S.P., Colombo,E., Boudreault,P.L., Najmanovich,R.J., Leduc,R. and Marsault,E.
    Modulating the selectivity of matriptase-2 inhibitors with unnatural amino acids
    Eur J Med Chem129, 110-123. PubMed  Europe PubMed DOI  I
  22. Wahedi,M., Wortham,A.M., Kleven,M.D., Zhao,N., Jue,S., Enns,C.A. and Zhang,A.S.
    Matriptase-2 suppresses hepcidin expression by cleaving multiple components of the hepcidin induction pathway
    J Biol Chem292, 18354-18371. PubMed  Europe PubMed DOI
    23. 2016
  23. Beckmann,A.M., Maurer,E., Lulsdorff,V., Wilms,A., Furtmann,N., Bajorath,J., Gutschow,M. and Stirnberg,M.
    En route to new therapeutic options for iron overload diseases: matriptase-2 as a target for Kunitz-type inhibitors
    Chembiochem17, 595-604. PubMed  Europe PubMed DOI
  24. Beckmann,A.M., Glebov,K., Walter,J., Merkel,O., Mangold,M., Schmidt,F., Becker-Pauly,C., Gutschow,M. and Stirnberg,M.
    The intact Kunitz domain protects the amyloid precursor protein from being processed by matriptase-2
    Biol Chem397, 777-790. PubMed  Europe PubMed DOI
  25. Beckmann,A.M., Gilberg,E., Gattner,S., Huang,T.L., Vanden Eynde,J.J., Mayence,A., Bajorath,J., Stirnberg,M. and Gutschow,M.
    Evaluation of bisbenzamidines as inhibitors for matriptase-2
    Bioorg Med Chem Lett26, 3741-3745. PubMed  Europe PubMed DOI  I
  26. Haussler,D., Mangold,M., Furtmann,N., Braune,A., Blaut,M., Bajorath,J., Stirnberg,M. and Gutschow,M.
    Back cover: Phosphono bisbenzguanidines as irreversible dipeptidomimetic inhibitors and activity-based probes of matriptase-2 (Chem. Eur. J. 25/2016)
    Chemistry22, 8704- DOI  I
  27. Sal,E., Keskin,E.Y., Yenicesu,I., Bruno,M. and De Falco,L.
    Iron-refractory iron deficiency anemia (IRIDA) cases with 2 novel TMPRSS6 mutations
    Pediatr Hematol Oncol33, 226-232. PubMed  Europe PubMed DOI  M
    28. 2015
  28. Gitlin,A., Debowski,D., Karna,N., Legowska,A., Stirnberg,M., Gutschow,M. and Rolka,K.
    Inhibitors of matriptase-2 based on the trypsin inhibitor SFTI-1
    Chembiochem16, 1601-1607. PubMed  Europe PubMed DOI
  29. Jackle,F., Schmidt,F., Wichert,R., Arnold,P., Prox,J., Mangold,M., Ohler,A., Pietrzik,C.U., Koudelka,T., Tholey,A., Gutschow,M., Stirnberg,M. and Becker-Pauly,C.
    Metalloprotease meprin beta is activated by transmembrane serine protease matriptase-2 at the cell surface thereby enhancing APP shedding
    Biochem J470, 91-103. PubMed  Europe PubMed DOI
  30. McDonald,C.J., Ostini,L., Bennett,N.C., Subramaniam,N., Hooper,J., Velasco,G., Wallace,D.F. and Subramaniam,V.N.
    Functional analysis of matriptase-2 mutations and domains: insights into the molecular basis of iron-refractory iron deficiency anemia
    Am J Physiol Cell Physiol308, 539-547. PubMed  Europe PubMed DOI  M
  31. Poggiali,E., Andreozzi,F., Nava,I., Consonni,D., Graziadei,G. and Cappellini,M.D.
    The role of TMPRSS6 polymorphisms in iron deficiency anemia partially responsive to oral iron treatment
    Am J Hematol90, 306-309. PubMed  Europe PubMed DOI  M
  32. Rausa,M., Ghitti,M., Pagani,A., Nai,A., Campanella,A., Musco,G., Camaschella,C. and Silvestri,L.
    Identification of TMPRSS6 cleavage sites of hemojuvelin
    J Cell Mol Med19, 879-888. PubMed  Europe PubMed DOI  P
  33. Schmidt,P.J., Racie,T., Westerman,M., Fitzgerald,K., Butler,J.S. and Fleming,M.D.
    Combination therapy with a Tmprss6 RNAi-therapeutic and the oral iron chelator deferiprone additively diminishes secondary iron overload in a mouse model of beta-thalassemia intermedia
    Am J Hematol90, 310-313. PubMed  Europe PubMed DOI  K
  34. Stirnberg,M., Maurer,E., Arenz,K., Babler,A., Jahnen-Dechent,W. and Gutschow,M.
    Cell surface serine protease matriptase-2 suppresses fetuin-A/AHSG-mediated induction of hepcidin
    Biol Chem396, 81-93. PubMed  Europe PubMed DOI
    35. 2014
  35. Barre,O., Dufour,A., Eckhard,U., Kappelhoff,R., Beliveau,F., Leduc,R. and Overall,C.M.
    Cleavage specificity analysis of six type II transmembrane serine proteases (TTSPs) using PICS with proteome-derived peptide libraries
    PLoS ONE9, e105984-e105984. PubMed  Europe PubMed DOI  P
  36. De Falco,L., Silvestri,L., Kannengiesser,C., Moran,E., Oudin,C., Rausa,M., Bruno,M., Aranda,J., Argiles,B., Yenicesu,I., Falcon-Rodriguez,M., Yilmaz-Keskin,E., Kocak,U., Beaumont,C., Camaschella,C., Iolascon,A., Grandchamp,B. and Sanchez,M.
    Functional and clinical impact of novel TMPRSS6 variants in iron-refractory iron-deficiency anemia patients and genotype-phenotype studies
    Hum Mutat35, 1321-1329. PubMed  Europe PubMed DOI  M
  37. Duchene,D., Colombo,E., Desilets,A., Boudreault,P.L., Leduc,R., Marsault,E. and Najmanovich,R.
    Analysis of subpocket selectivity and identification of potent selective inhibitors for matriptase and matriptase-2
    J Med Chem57, 10198-10204. PubMed  Europe PubMed DOI  I
  38. Gnana-Prakasam,J.P., Baldowski,R.B., Ananth,S., Martin,P.M., Smith,S.B. and Ganapathy,V.
    Retinal expression of the serine protease matriptase-2 (tmprss6) and its role in retinal iron homeostasis
    Mol Vision20, 561-574. PubMed  Europe PubMed
  39. Jiang,J., Yang,J., Feng,P., Zuo,B., Dong,N., Wu,Q. and He,Y.
    N-glycosylation is required for matriptase-2 autoactivation and ectodomain shedding
    J Biol Chem289, 19500-19507. PubMed  Europe PubMed DOI
  40. Nai,A., Pellegrino,R.M., Rausa,M., Pagani,A., Boero,M., Silvestri,L., Saglio,G., Roetto,A. and Camaschella,C.
    The erythroid function of transferrin receptor 2 revealed by TMPRSS6 inactivation in different models of transferrin receptor 2 knockout mice
    Haematologica99, 1016-1021. PubMed  Europe PubMed DOI  K
  41. Wang,C.Y., Meynard,D. and Lin,H.Y.
    The role of TMPRSS6/matriptase-2 in iron regulation and anemia
    Front Pharmacol5, 114-114. PubMed  Europe PubMed DOI  V
  42. Willemetz,A., Lenoir,A., Deschemin,J.C., Lopez-Otin,C., Ramsay,A.J., Vaulont,S. and Nicolas,G.
    Matriptase-2 is essential for hepcidin repression during fetal life and postnatal development in mice to maintain iron homeostasis
    Blood124, 441-444. PubMed  Europe PubMed DOI
  43. Wysocka,M., Gruba,N., Miecznikowska,A., Popow-Stellmaszyk,J., Gutschow,M., Stirnberg,M., Furtmann,N., Bajorath,J., Lesner,A. and Rolka,K.
    Substrate specificity of human matriptase-2
    Biochimie97, 121-127. PubMed  Europe PubMed DOI  P
    44. 2013
  44. Bartnikas,T.B., Steinbicker,A.U., Campagna,D.R., Blevins,S., Woodward,L.S., Herrera,C., Bloch,K.D., Justice,M.J. and Fleming,M.D.
    Identification and characterization of a novel murine allele of Tmprss6
    Haematologica98, 854-861. PubMed  Europe PubMed DOI  M
  45. De Falco,L., Sanchez,M., Silvestri,L., Kannengiesser,C., Muckenthaler,M.U., Iolascon,A., Gouya,L., Camaschella,C. and Beaumont,C.
    Iron refractory iron deficiency anemia
    Haematologica98, 845-853. PubMed  Europe PubMed DOI  M
  46. Guo,S., Casu,C., Gardenghi,S., Booten,S., Aghajan,M., Peralta,R., Watt,A., Freier,S., Monia,B.P. and Rivella,S.
    Reducing TMPRSS6 ameliorates hemochromatosis and beta-thalassemia in mice
    J Clin Invest123, 1531-1541. PubMed  Europe PubMed DOI  K
  47. Jaspers,A., Caers,J., Le Gac,G., Ferec,C., Beguin,Y. and Fillet,G.
    A novel mutation in the CUB sequence of matriptase-2 (Tmprss6) is implicated in iron-resistant iron deficiency anaemia (IRIDA)
    Br J Haematol160, 564-565. PubMed  Europe PubMed DOI  M
  48. Maurer,E., Gutschow,M. and Stirnberg,M.
    Hepatocyte growth factor activator inhibitor type 2 (HAI-2) modulates hepcidin expression by inhibiting the cell surface protease matriptase-2
    Biochem J450, 583-593. PubMed  Europe PubMed DOI
  49. Roetto,A. and Porto,G.
    A novel mutation in the CUB sequence of matriptase-2 (TMPRSS6) is implicated in iron-resistant iron deficiency anaemia - response to Jaspers etal
    Br J Haematol160, 566-567. PubMed  Europe PubMed DOI  M
  50. Schmidt,P.J., Toudjarska,I., Sendamarai,A.K., Racie,T., Milstein,S., Bettencourt,B.R., Hettinger,J., Bumcrot,D. and Fleming,M.D.
    An RNAi therapeutic targeting Tmprss6 decreases iron overload in Hfe(-/-) mice and ameliorates anemia and iron overload in murine beta-thalassemia intermedia
    Blood121, 1200-1208. PubMed  Europe PubMed DOI  K
  51. Stirnberg,M. and Gutschow,M.
    Matriptase-2, a regulatory protease of iron homeostasis: possible substrates, cleavage sites and inhibitors
    Curr Pharm Des19, 1052-1061. PubMed  Europe PubMed
  52. Tuhkanen,H., Hartikainen,J.M., Soini,Y., Velasco,G., Sironen,R., Nykopp,T.K., Kataja,V., Eskelinen,M., Kosma,V.M. and Mannermaa,A.
    Matriptase-2 gene (TMPRSS6) variants associate with breast cancer survival, and reduced expression is related to triple-negative breast cancer
    Int J Cancer133, 2334-2340. PubMed  Europe PubMed DOI  M
  53. Webb,S.L., Sanders,A.J., Mason,M.D. and Jiang,W.G.
    Matriptase-2 inhibits HECV motility and tubule formation in vitro and tumour angiogenesis in vivo
    Mol Cell Biochem375, 207-217. PubMed  Europe PubMed DOI
    54. 2012
  54. Choi,H.S., Yang,H.R., Song,S.H., Seo,J.Y., Lee,K.O. and Kim,H.J.
    A novel mutation Gly603Arg of TMPRSS6 in a Korean female with iron-refractory iron deficiency anemia
    Pediatr Blood Cancer58, 640-642. PubMed  Europe PubMed DOI  M
  55. Dosa,S., Stirnberg,M., Lulsdorff,V., Haussler,D., Maurer,E. and Gutschow,M.
    Active site mapping of trypsin, thrombin and matriptase-2 by sulfamoyl benzamidines
    Bioorg Med Chem20, 6489-6505. PubMed  Europe PubMed DOI  I
  56. Guillem,F., Kannengiesser,C., Oudin,C., Lenoir,A., Matak,P., Donadieu,J., Isidor,B., Mechinaud,F., Aguilar-Martinez,P., Beaumont,C., Vaulont,S., Grandchamp,B. and Nicolas,G.
    Inactive matriptase-2 mutants found in IRIDA patients still repress hepcidin in a transfection assay despite having lost their serine protease activity
    Hum Mutat33, 1388-1396. PubMed  Europe PubMed DOI  M
  57. Maurer,E., Sisay,M.T., Stirnberg,M., Steinmetzer,T., Bajorath,J. and Gutschow,M.
    Insights into matriptase-2 substrate binding and inhibition mechanisms by analyzing active-site-mutated variants
    ChemMedChem7, 68-72. PubMed  Europe PubMed DOI
  58. Ramsay,A.J., Kwarciak,A., Hooper,J.D., Lopez-Otin,C. and Velasco,G.
    Matriptase-2
    [ISSN:978-0-12-407742-3]3, 2975-2983. DOI
    59. 2011
  59. Antalis,T.M., Bugge,T.H. and Wu,Q.
    Membrane-anchored serine proteases in health and disease
    Prog Mol Biol Transl Sci99, 1-50. PubMed  Europe PubMed DOI  V
  60. Beliveau,F., Brule,C., Desilets,A., Zimmerman,B., Laporte,S.A., Lavoie,C.L. and Leduc,R.
    Essential role of endocytosis of the type II transmembrane serine protease TMPRSS6 in regulating its functionality
    J Biol Chem286, 29035-29043. PubMed  Europe PubMed DOI
  61. Finberg,K.E., Whittlesey,R.L. and Andrews,N.C.
    Tmprss6 is a genetic modifier of the Hfe-hemochromatosis phenotype in mice
    Blood117, 4590-4599. PubMed  Europe PubMed DOI  M
  62. Krijt,J., Fujikura,Y., Ramsay,A.J., Velasco,G. and Necas,E.
    Liver hemojuvelin protein levels in mice deficient in matriptase-2 (Tmprss6)
    Blood Cells Mol Dis47, 133-137. PubMed  Europe PubMed DOI
  63. Lenoir,A., Deschemin,J.C., Kautz,L., Ramsay,A.J., Roth,M.P., Lopez-Otin,C., Vaulont,S. and Nicolas,G.
    Iron-deficiency anemia from matriptase-2 inactivation is dependent on the presence of functional Bmp6
    Blood117, 647-650. PubMed  Europe PubMed DOI
  64. Nai,A., Pagani,A., Silvestri,L., Campostrini,N., Corbella,M., Girelli,D., Traglia,M., Toniolo,D. and Camaschella,C.
    TMPRSS6 rs855791 modulates hepcidin transcription in vitro and serum hepcidin levels in normal individuals
    Blood118, 4459-4462. PubMed  Europe PubMed DOI
  65. Sato,T., Iyama,S., Murase,K., Kamihara,Y., Ono,K., Kikuchi,S., Takada,K., Miyanishi,K., Sato,Y., Takimoto,R., Kobune,M. and Kato,J.
    Novel missense mutation in the TMPRSS6 gene in a Japanese female with iron-refractory iron deficiency anemia
    Int J Hematol94, 101-103. PubMed  Europe PubMed DOI  M
  66. Webb,S.L., Sanders,A.J., Mason,M.D. and Jiang,W.G.
    Type II transmembrane serine protease (TTSP) deregulation in cancer
    Front Biosci16, 539-552. PubMed  Europe PubMed  V
    67. 2010
  67. Altamura,S., D'Alessio,F., Selle,B. and Muckenthaler,M.U.
    A novel TMPRSS6 mutation that prevents protease auto-activation causes IRIDA
    Biochem J431, 363-371. PubMed  Europe PubMed DOI  M
  68. Cuijpers,M.L., Wiegerinck,E.T., Brouwer,R., de Witte,T.J. and Swinkels,D.W.
    [Iron deficiency anaemia due to a matriptase-2 mutation]
    Ned Tijdschr Geneeskd154, A1038-A1038. PubMed  Europe PubMed  M
  69. De Falco,L., Totaro,F., Nai,A., Pagani,A., Girelli,D., Silvestri,L., Piscopo,C., Campostrini,N., Dufour,C., Al Manjomi,F., Minkov,M., Van Vuurden,D.G., Feliu,A., Kattamis,A., Camaschella,C. and Iolascon,A.
    Novel TMPRSS6 mutations associated with iron-refractory iron deficiency anemia (IRIDA)
    Hum Mutat31, E1390-E1405. PubMed  Europe PubMed DOI  M
  70. Finberg,K.E., Whittlesey,R.L., Fleming,M.D. and Andrews,N.C.
    Down-regulation of Bmp/Smad signaling by Tmprss6 is required for maintenance of systemic iron homeostasis
    Blood115, 3817-3826. PubMed  Europe PubMed DOI  M
  71. Sanders,A.J., Webb,S.L., Parr,C., Mason,M.D. and Jiang,W.G.
    The type II transmembrane serine protease, matriptase-2: possible links to cancer?
    Anticancer Agents Med Chem10, 64-69. PubMed  Europe PubMed
  72. Sisay,M.T., Steinmetzer,T., Stirnberg,M., Maurer,E., Hammami,M., Bajorath,J. and Gutschow,M.
    Identification of the first low-molecular-weight inhibitors of matriptase-2
    J Med Chem53, 5523-5535. PubMed  Europe PubMed DOI  I
  73. Stirnberg,M., Maurer,E., Horstmeyer,A., Kolp,S., Frank,S., Bald,T., Arenz,K., Janzer,A., Prager,K., Wunderlich,P., Walter,J. and Gutschow,M.
    Proteolytic processing of the serine protease matriptase-2: identification of the cleavage sites required for its autocatalytic release from the cell surface
    Biochem J430, 87-95. PubMed  Europe PubMed DOI
  74. Tanaka,T., Roy,C.N., Yao,W., Matteini,A., Semba,R.D., Arking,D., Walston,J.D., Fried,L.P., Singleton,A., Guralnik,J., Abecasis,G.R., Bandinelli,S., Longo,D.L. and Ferrucci,L.
    A genome-wide association analysis of serum iron concentrations
    Blood115, 94-96. PubMed  Europe PubMed DOI
    75. 2009
  75. Beliveau,F., Desilets,A. and Leduc,R.
    Probing the substrate specificities of matriptase, matriptase-2, hepsin and DESC1 with internally quenched fluorescent peptides
    FEBS J276, 2213-2226. PubMed  Europe PubMed DOI  A  P
  76. Benyamin,B., Ferreira,M.A., Willemsen,G., Gordon,S., Middelberg,R.P., McEvoy,B.P., Hottenga,J.J., Henders,A.K., Campbell,M.J., Wallace,L., Frazer,I.H., Heath,A.C., de Geus,E.J., Nyholt,D.R., Visscher,P.M., Penninx,B.W., Boomsma,D.I., Martin,N.G., Montgomery,G.W. and Whitfield,J.B.
    Common variants in TMPRSS6 are associated with iron status and erythrocyte volume
    Nat Genet41, 1173-1175. PubMed  Europe PubMed DOI  M
  77. Chambers,J.C., Zhang,W., Li,Y., Sehmi,J., Wass,M.N., Zabaneh,D., Hoggart,C., Bayele,H., McCarthy,M.I., Peltonen,L., Freimer,N.B., Srai,S.K., Maxwell,P.H., Sternberg,M.J., Ruokonen,A., Abecasis,G., Jarvelin,M.R., Scott,J., Elliott,P. and Kooner,J.S.
    Genome-wide association study identifies variants in TMPRSS6 associated with hemoglobin levels
    Nat Genet41, 1170-1172. PubMed  Europe PubMed DOI
  78. Cui,Y., Wu,Q. and Zhou,Y.
    Iron-refractory iron deficiency anemia: new molecular mechanisms
    Kidney Int76, 1137-1141. PubMed  Europe PubMed DOI
  79. Edison,E.S., Athiyarath,R., Rajasekar,T., Westerman,M., Srivastava,A. and Chandy,M.
    A novel splice site mutation c.2278 (-1) G>C in the TMPRSS6 gene causes deletion of the substrate binding site of the serine protease resulting in refractory iron deficiency anaemia
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