$VAR1 = undef;

Summary for peptidase S01.308: matriptase-2

Names
MEROPS Name	matriptase-2
Other names	dJ1170K4.2 protein, Mer-S01AAA peptidase, Mername-AA035 peptidase, transmembrane protease, serine 6, TMPRSS6 g.p. (Homo sapiens)

Domain architecture

MEROPS Classification
Classification	Clan PA >> Subclan PA(S) >> Family S1 >> Subfamily A >> S01.308
Holotype	matriptase-2 (Homo sapiens), Uniprot accession Q8IU80 (peptidase unit: 568-802), MERNUM MER0005278
History	Identifier created: MEROPS 3.30 (20 July 1999)

Activity
Catalytic type	Serine
NC-IUBMB	Not yet included in IUBMB recommendations.
Activity status	human: active (Velasco et al., 2002) mouse: putative
Other databases	TREEFAM	http://www.treefam.org/family/TF330647
Cleavage site specificity	Explanations of how to interpret the following cleavage site sequence logo and specificity matrix can be found here.
Cleavage pattern	-/-/-/Rk/-/-/- (based on 162 cleavages)

Specificity matrix

Amino acid	P4	P3	P2	P1	P1'	P2'	P3'	P4'
Gly	15	8	12	0	21	14	23	10
Pro	9	12	17	0	0	8	9	16
Ala	10	17	16	0	9	30	11	13
Val	4	14	9	0	9	17	17	13
Leu	8	5	15	0	7	13	16	12
Ile	5	9	9	0	10	16	6	16
Met	1	2	3	0	2	3	2	4
Phe	1	5	4	0	0	8	3	4
Tyr	1	0	3	0	1	2	1	1
Trp	1	0	0	0	1	0	0	0
Ser	14	10	7	0	10	10	12	13
Thr	8	13	11	0	7	8	11	8
Cys	0	3	2	0	2	2	0	0
Asn	7	10	9	0	3	5	6	4
Gln	4	11	11	0	9	11	10	8
Asp	5	1	2	0	0	0	8	10
Glu	4	2	3	0	0	2	4	8
Lys	7	12	18	1	50	6	18	16
Arg	10	10	2	161	14	3	2	3
His	1	0	4	0	5	2	1	1